The invention provides a non-magnetic Ti(C, N) base cermet with a gradient structure and a preparation method thereof, belonging to Ti(C, N) base cermets and solving the problem of contradictions between strong toughness and no magnetism of existing Ti(C, N) base cermets, so that the Ti(C, N) base cermet simultaneously has strong toughness and no magnetism. The non-magnetic Ti(C, N) base cermet with the gradient structure is prepared by using TiC, TiN, Ni, Mo2C, WC and Cr3C2 powder as the raw materials and carrying out ball-milling and mixing, die forming, vacuum degreasing, vacuum sintering and hot isostatic pressing surface nitriding. The non-magnetic Ti(C, N) base cermet has good wear resistance, red hardness, impact resistance and chemical stability, has low coefficients of friction with the materials such as iron and steel, silicon carbide and the like, has bending strength not less than 1800MPa, core matrix hardness of 86.0-92.5HRA and surface hardening layer Vickers microhardness of 1800-2050kg/mm<2>, is especially suitable for manufacturing non-magnetic cutting tools, non-magnetic dies and non-magnetic wear-resistant parts, has widened application range and has good popularization and application prospects in the industries such as tools and dies, national defences, military projects and the like.