The invention discloses a joint optimization regulation system for cascade hydropower stations. The system comprises a remote centralized monitoring system, a water regulation automation system, a tele-meter reading system and a remote image monitoring system, wherein the remote centralized monitoring system and the water regulation automation system are connected after being safely isolated by a hardware firewall, thus realizing the logic isolation, message filtering and access control of the two areas; the water regulation automation system and the tele-meter reading system are connected by an RS-232 serial port; and the remote centralized monitoring system, the water regulation automation system and the tele-meter reading system are all provided with a WEB releasing sub-system which is connected with the remote image monitoring system through a router with a fireproof wall. With the adoption of the joint optimization regulation system provided by the invention, the safety of the system can be improved, the centralized unified management and scheduling can be realized, the number of management persons can be reduced, and the cascade joint scheduling benefits can be improved.