The invention discloses a modeling method for invalidation control parameter of hydrogenation reaction effluent system; wherein, the invalidation control parameter modeling comprises a KP value, the concentration of NH4HS, the theoretical quantity of water injection, the deposition temperature of NH4HS, the deposition temperature of NH4Cl and the mean velocity of air cooler. The modeling method is characterized in that the operation parameters of hydrogenation reaction effluent system are loaded by the DCS control system data base, the material chemical examination analysis data and the principle flow chart of hydrogenation reaction are combined, the modeling is processed according to the concrete invalidation control parameter in the running of hydrogenation reaction effluent system variable condition, and that the KP value, the concentration of NH4HS, the theoretical quantity of water injection, the deposition temperature of NH4HS, the deposition temperature of NH4Cl and the mean velocity of air cooler are determined. The modeling method for invalidation control parameter of hydrogenation reaction effluent system has the advantages of effective monitor of invalidation control parameter of hydrogenation reaction effluent system for field operators, guarding against unplanned shutdown accident caused by invalidation of hydrogenation reaction effluent system, and long cycle, safety and stable running of hydrogenation reaction effluent system.