An amplifier is disclosed, having an input stage connected to an output stage. The input stage is connected between a positive supply rail and a ground rail and has an input terminal arranged to receive an input signal. The output stage is connected between a positive supply rail and a negative supply rail and has an output terminal. The output stage is adapted to generate an output signal, which is dependent on a received input signal, at the output, and is further adapted such that, in use, a quiescent voltage at the output terminal is at a selected value between a voltage on the positive supply rail and a voltage on the negative supply rail. For driving a grounded load, the quiescent output voltage is preferably zero volts. In preferred embodiments, the input and output stages are formed on a common substrate using CMOS technology, the output stage including one or more NMOS devices having a triple-well structure. A corresponding method of driving a grounded load is also disclosed.