Magnetically-controllable delivery system for therapeutic agents
a delivery system and therapeutic agent technology, applied in the field of magnetization controllable delivery systems, can solve the problems of neo-intimal growth or proliferation, major limitation of in-stent restenosis (the re-closing of the vessel), and the ability of known drug delivery vehicles to localize high concentrations of drugs using minimally invasive techniques, etc., to achieve the effect of increasing the degree of magnetization
a delivery system and therapeutic agent technology, applied in the field of magnetization controllable delivery systems, can solve the problems of neo-intimal growth or proliferation, major limitation of in-stent restenosis (the re-closing of the vessel), and the ability of known drug delivery vehicles to localize high concentrations of drugs using minimally invasive techniques, etc., to achieve the effect of increasing the degree of magnetization
US20060041182A1Inactive Publication Date: 2006-02-23DREXEL UNIV
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[0048] The invention was driven by a desire to develop a system capable of targeted delivery of magnetizable particles to a location within a body. Inventors have discovered that magnetizable particles are attracted to regions of the strongest magnetic field gradients and devised a two source system that produces strong and highly localized field gradients inside the body utilizing (1) a magnetizable object implanted in a body as an internal source of a magnetic gradient and (2) an external source of a magnetic field. Unlike the one source systems known in the prior art, this invention utilizes two sources of magnetic influence for targeted delivery of magnetizable particles to areas on the magnetizable object implanted in a body and / or in the near proximity thereto.
[0049] Accordingly, the invention provides a magnetic delivery system for delivering a magnetizable particle to a location in a body, the device comprising a magnetizable object implanted in the body, wherein the magnet...
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A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and / or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and / or a cell to a targeted location in a body.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of the PCT application titled “MAGNETICALLY CONTROLLABLE DRUG AND GENE DELIVERY STENTS” having the application Ser. No. PCT / US2004 / 011861 and filed on Apr. 16, 2004, which claims the benefit of provisional Application No. 60 / 463,505, filed on Apr. 16, 2003, titled MAGNETIZABLE IMPLANTS AND METHODS FOR TARGETED DELIVERY OF MAGNETICALLY SUSCEPTIBLE THERAPEUTIC AGENTS which are incorporated herein in their entireties. [0002] This application claims the benefit of provisional Application No. 60 / 680,833, filed on May 13, 2005, titled METHOD OF MAGNETIC DELIVERY OF CELLS AND BIOLOGICS, which is incorporated herein in its entirety.SPECIFICATION BACKGROUND OF THE INVENTION [0003] 1. Field of Invention [0004] The present invention relates to magnetically controllable delivery systems and methods of using thereof to attract and deliver therapeutic agents attached to, or encapsulated within, magnetic part...
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Patent Timeline
23 Feb 2006
Publication
US20060041182A1
- IPC
- A61N2/10; A61F2/06; A61F2/28; A61F2/82
- CPC
- A61F2/82; A61F2210/009; A61N2/00; A61M37/00; A61N1/30; A61L27/50; A61L31/022; A61L31/14
- Inventors
- FORBES, ZACHARY G.; YELLEN, BENJAMIN B.