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38results about How to "Sufficient dynamic range" patented technology

Control method of automatic gain in power line carrier communication network

The invention discloses a control method of an automatic gain in a power line carrier communication network, and belongs to the technical field of power line carriers. The control method relates to a front end low noise amplifier, an active band-pass filter, a programmable gain amplifier, an analog-digital conversion unit and an automatic gain control unit. The method comprises the steps that an input carrier signal passes through the front end low noise amplifier, lower noise amplification is conducted on the input signal firstly, and after band-pass filtering, the carrier signal with a high signal-to-noise ratio is obtained; the carrier signal is amplified through the programmable gain amplifier, an initial gain value of the programmable gain amplifier is set to be the maximum value in a preset reference range, analog-digital conversion is conducted on the input carrier signal after the input carrier signal is amplified, sampling is conducted on the converted carrier signal, and median filtering is conducted on an obtained sampling signal to obtain average intensity of the carrier signal; and the gain of the programmable gain amplifier can be adjusted according to a difference between the average intensity of the carrier signal and the preset reference range.
Owner:北京中宸微电子有限公司

Analysis of proteins from biological fluids using mass spectrometric immunoassay

InactiveUS20060127948A1Sufficient dynamic rangeBiological testingImmunoassaysDrug targetMass spectrometric immunoassay
Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound compounds are rinsed from the extraction devices using a series of buffer and water rinses, after which the wild type protein (and / or its variants) are eluted directly onto a target in preparation for analysis such as matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS). Mass spectrometry of the eluted sample then follows with the retained proteins identified via accurate molecular mass determination. Protein and variant levels can be determined using quantitative methods in which the protein / variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to a working curves constructed from samples containing known concentrations of the protein or variants. Such MSIA devices, kits and methods have significant application in the fields of; basic research and development, proteomics, protein structural characterization, drug discovery, drug-target discovery, therapeutic monitoring, clinical monitoring and diagnostics, as well as in the high throughput screening of large populations to establish and recognize protein / variant patterns that are able to differentiate healthy from diseased states.
Owner:INTRINSIC BIOPROBES

Analysis of proteins from biological fluids using mass spectrometric immunoassay

InactiveUS20060121533A1Solve the lack of dynamic rangeSufficient dynamic rangeBiological testingImmunoassaysDrug targetMass spectrometric immunoassay
Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound compounds are rinsed from the extraction devices using a series of buffer and water rinses, after which the wild type protein (and/or its variants) are eluted directly onto a target in preparation for analysis such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Mass spectrometry of the eluted sample then follows with the retained proteins identified via accurate molecular mass determination. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to a working curves constructed from samples containing known concentrations of the protein or variants. Such MSIA devices, kits and methods have significant application in the fields of; basic research and development, proteomics, protein structural characterization, drug discovery, drug-target discovery, therapeutic monitoring, clinical monitoring and diagnostics, as well as in the high throughput screening of large populations to establish and recognize protein/variant patterns that are able to differentiate healthy from diseased states.
Owner:INTRINSIC BIOPROBES
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