7results about How to "Addressing Insufficient Sensitivity" patented technology

The invention relates to the technical field of medical informatics, in particular to a pain management-oriented physiological signal real-time monitoring and intervention system, which comprises a determination module for determining the abnormal tendency of a stimulation window updated in real time at each updating moment to obtain an abnormal tendency sequence; the determination module is also used for determining similar fluctuation segments in the abnormal tendency sequence; the determination module is also used for determining an abnormal process factor of the physiological sensing signal at the current moment based on the abnormal tendency difference value and the length of each similar fluctuation section; the determination module is also used for determining a trigger factor for evaluating the abnormal pain state at the current moment according to the abnormal process factors of each physiological sensing signal at the current moment and the previous moment, and performing normalization processing on the trigger factor to obtain a normalized trigger factor; and the intervention module is used for carrying out visualization and intervention on the pain degree of the target user based on the normalized trigger factor. According to the invention, the physiological signal abnormity identification accuracy and sensitivity are improved.

This invention relates to the field of mechanical equipment fault detection technology, and more particularly to a five-coil differential electromagnetic induction online monitoring system for oil abrasive particles. The system includes a five-coil oil abrasive particle detection sensor, a signal acquisition module, a signal processing module, a power supply module, and a high-frequency excitation module. The five-coil oil abrasive particle detection sensor comprises a first excitation coil, a second excitation coil, a third excitation coil, a first induction coil, and a second induction coil, all connected in series. This invention is less susceptible to interference from external environmental magnetic fields such as geomagnetism and mechanical vibrations, meeting industrial requirements. The sensor structure can be designed for different pipe diameters according to the oil circuit of the mechanical equipment, making it suitable for monitoring oil circuits with different throughputs, thus solving the problem of insufficient sensitivity in existing inductive monitoring technology for large-diameter pipelines.

This application discloses a method and system for preventing dragging of rail transit vehicle doors based on contact-type sensitive edge resistance detection. The method includes: acquiring train zero-speed signals, door closing and locking status signals, and isolation status signals; and using a controller to determine whether to activate sensitive edge detection based on the combined logic of the acquired signals. When sensitive edge detection is activated, the controller detects the resistance change of the sensitive edge, and converts the detected sensitive edge resistance signal into a voltage signal via a resistance sampling circuit inside the controller. The voltage value corresponding to the converted voltage signal is used as a decision variable. If the decision variable corresponding to the sensitive edge meets a first preset condition, it is determined that the sensitive edge has been triggered and an object is being clamped. The controller then controls the disconnection of the safety relay contacts to cut off the train traction circuit, and simultaneously triggers an alarm device to issue an audible and visual warning signal. This application can reliably identify and lock soft, thin objects clamped by the vehicle, eliminating the risk of dragging.

The present application relates to the field of biotechnology, and particularly relates to a fluorescent probe for targeted detection of lysosomal calcium ions, and a preparation method and application thereof. The lysosomal calcium ion fluorescent probe of the present application utilizes a mature calcium ion chelating group precursor, and introduces a specific lysosome-targeting fluorescent group in the structure through a triple bond. Under the action of a hydrolytic enzyme inside the lysosome, the calcium ion chelating group precursor is hydrolyzed, and then chelates with calcium ions, thereby significantly enhancing the fluorescence signal. The probe effectively avoids the interference of magnesium ions and an acidic environment, and realizes high specificity targeted imaging of lysosomal calcium ions. In vitro experiments show that the fluorescent probe can effectively anchor the lysosome, is not affected by lysosomal calcium leakage, can accurately reflect changes in the lysosomal calcium level, and is suitable for in situ detection of lysosomal calcium homeostasis. Further, the present application verifies the feasibility of the probe in detecting changes in the lysosomal calcium level in vivo through acute lung injury and pulmonary fibrosis models.

The invention discloses a method for detecting pesticides, heavy metals and active ingredients of traditional Chinese medicinal materials, and relates to the technical field of traditional Chinese medicinal material detection. The method comprises the steps of pretreatment of the traditional Chinese medicinal materials, preparation of liquid medicine, detection of the liquid medicine and post-treatment of medicine residues of the liquid medicine. A self-made multifunctional solid-phase extraction column is combined for purification treatment, and the multifunctional solid-phase extraction column can effectively remove impurities in supernate through reasonable silica gel, Flory silica and activated carbon filling combination and filling amount setting, so that the enrichment and selective separation effects on target pesticide components are improved; meanwhile, accurate detection of various pesticide residues in the traditional Chinese medicinal materials can be achieved, especially the trace pesticide residues can also reach a low detection limit, the increasingly strict pesticide residue limit standard requirement is effectively met, and the problem that an existing detection method is insufficient in sensitivity is solved.

The present application relates to the technical field of medical informatics, and in particular to a physiological signal real-time monitoring and intervention system for pain management, which comprises: a determination module configured to determine the abnormal tendency of a real-time updated stimulation window at each update time to obtain an abnormal tendency sequence; the determination module is further configured to determine similar fluctuation segments in the abnormal tendency sequence; the determination module is further configured to determine an abnormal progress factor of the physiological sensing signal at the current time based on the abnormal tendency difference and the length of each similar fluctuation segment; the determination module is further configured to determine a trigger factor for evaluating the abnormal pain state at the current time according to the abnormal progress factors of each physiological sensing signal at the current time and the last time, and to normalize the trigger factor to obtain a normalized trigger factor; and an intervention module configured to visualize and intervene in the pain degree of a target user based on the normalized trigger factor. The present application improves the accuracy and sensitivity of physiological signal anomaly recognition.

This invention provides a physical simulation experimental device and method for fine exploration of water-bearing sections in underground rock strata. The device includes a water storage tank connected to a water pump. The water pump is connected to one end of multiple water supply valves via a one-way valve. Each water supply valve has a corresponding rock chamber at its other end. These rock chambers are vertically mounted on the sidewall of a simulated borehole pipe. Flange end caps are installed at both ends of the simulated borehole pipe. A return water inlet sealing head is installed on the flange end cap at the tail end of the simulated borehole pipe. The return water inlet sealing head is connected to the water storage tank via a return water valve. An energy storage and voltage regulator is also installed between the water storage tank and one end of the multiple water supply valves. An armored optical fiber cable for acoustic wave sensing is coaxially installed inside the simulated borehole pipe. This invention can effectively simulate various geological and hydrological conditions in actual underground rock strata environments. By analyzing the variation patterns of acoustic signals, it improves the accuracy of exploration of water-bearing sections, providing reliable technical support for coal mine water hazard prevention and safe production.