Nanometer fiber slow-releasing system and its prepn process and application

A nanofiber and system technology, applied in the field of biomedical materials, can solve the problems of inability to achieve biological effects, loss of biological activity, inactivation, etc., and achieve the effects of inducing reproduction and differentiation, improving drug release rate and widening range.

Inactive Publication Date: 2006-03-01
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since growth factors are generally easy to lose their biological activity in the presence of water and at room temperature, the direct use of growth factors will often be inactivated due to the environment in the body, and the desired biological effect cannot be achieved.

Method used

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  • Nanometer fiber slow-releasing system and its prepn process and application
  • Nanometer fiber slow-releasing system and its prepn process and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1) Dissolve PLGA and mefcine with a mass ratio of 100:1 in a mixed solvent of DMF / THF (1 / 1) to form an electrospinning solution, and the concentration of PLGA is 0.1 g / mL;

[0032] 2) Electrospinning the prepared electrospinning solution, the control voltage is 15KV, the flow rate of the spinning solution is 5ml / h, and a nanofiber film product with a fiber diameter of 80-800nm ​​is obtained;

[0033] 3) The obtained nanofiber film is used for postoperative tissue anti-adhesion, which can prevent inflammation and complications caused by local tissue adhesion.

Embodiment 2

[0035] 1) Dissolve PLLA and Mephicin with a mass ratio of 100:1 in a mixed solvent of DMF / dichloromethane (1 / 1.5) to prepare an electrospinning solution, wherein the concentration of PLLA is 0.1 g / mL;

[0036] 2) Electrospinning the prepared electrospinning solution, the control voltage is 30KV, the flow rate of the spinning solution is 15ml / h, and a nanofiber film product with a diameter of 100-1000nm is obtained;

[0037] 3) The obtained nanofiber film is used for postoperative tissue anti-adhesion, which can prevent inflammation and complications caused by local tissue adhesion.

Embodiment 3

[0039]1) Dissolve PLA-PEG and mephixen with a mass ratio of 50:1 in an acetone solution to prepare an electrospinning solution, wherein the concentration of PLA-PEG is 0.2 g / mL.

[0040] 2) Electrospinning the prepared electrospinning solution, the control voltage is 10KV, the flow rate of the spinning solution is 1ml / h, and a nanofiber film product with a diameter of 100-800nm ​​is obtained;

[0041] 3) The obtained nanofiber film is used for postoperative tissue anti-adhesion to prevent inflammation and complications caused by local tissue adhesion.

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Abstract

The present invention relates to medicine material technology, and is especially one kind of antiphlogistic medicine and growth factor slow releasing system and its preparation process and application. The prepared nanometer fiber medicine carrying film may be used in surgical operation to resist inflammation as skin tissue engineering rack. As post-operational adhesion resisting film, the present invention is biodegradable and biocompatible and has antiphlogistic effect. At the same time, medicine is combined with growth factor in controlled release speed and used in skin tissue engineering to prevent inflammation and to release growth factor promoting skin cell regeneration and healing simultaneously. The present invention has wide application foreground in post-operational adhesion prevention and skin tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a drug and growth factor slow-release system for postoperative anti-adhesion or skin tissue repair, a preparation method and application thereof. Background technique [0002] Polymer materials and their composites have been widely used in modern medicine, and biodegradable and absorbable polymers are currently one of the ideal biomedical polymer materials. Electrospinning is a new technology that can easily and efficiently prepare nanofibers. It generates a jet flow by applying a high electric field to a polymer solution or solution. The jet is stretched while the solvent volatilizes to form fibers with a diameter of 3-5000nm. Electrospun fibers have achieved many applications in the field of functional materials, especially in the field of biomedicine, such as tissue engineering scaffolds, wound dressings, and surgical isolation membranes. In the field...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K38/18A61K45/06A61K47/34A61P29/00D01D1/02
Inventor 任杰诸静顾书英任天斌
Owner TONGJI UNIV
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