40results about How to "Adjustable release rate" patented technology

The invention discloses a baicalin thermosensitive gelatin and a preparation method and use thereof. The baicalin thermosensitive gelatin is prepared by the following steps: (1) taking the following components in percentage by weight: 0.6 to 15 percent of baicalin, 10 to 24 percent of poloxamer 407, 1 to 10 percent of poloxamer 188, 55.8 to 81.17 percent of solvent, 0 to 5 percent of viscosity modifier, and 0 to 0.2 percent of preservative; and (2) dissolving the baicalin and the preservative into the solvent, slowly adding the poloxamer 407 and the poloxamer 188 with stirring, mixing uniformly, adding the viscosity modifier, mixing uniformly, and placing the mixture into freely flowable semitransparent solution to prepare the baicalin thermosensitive gelatin. The baicalin thermosensitive gelatin is flowable liquid at normal temperature, which generates reversible phase change if affected by the body temperature after contacting with a mucous membrane or body fluid. Therefore, the medicament is tightly attached to the mucosal tissue, which is hard to leak. After the phase change is generated in the body fluid, the release rate of the medicament can be controlled.

The present invention relates to medicine material technology, and is especially one kind of antiphlogistic medicine and growth factor slow releasing system and its preparation process and application. The prepared nanometer fiber medicine carrying film may be used in surgical operation to resist inflammation as skin tissue engineering rack. As post-operational adhesion resisting film, the present invention is biodegradable and biocompatible and has antiphlogistic effect. At the same time, medicine is combined with growth factor in controlled release speed and used in skin tissue engineering to prevent inflammation and to release growth factor promoting skin cell regeneration and healing simultaneously. The present invention has wide application foreground in post-operational adhesion prevention and skin tissue engineering.

A controlling and releasing composite fertilizer nutrient releasing model and production are disclosed. The production is carried out by potassium chloride reacting with phosphoric acid and concentrated sulfuric acid, recovering hydrogen chloride, two products reacting, adding urine to obtain mixed slurry of potassium sulfate and urea phosphate, adding stabilizer and flowing-performance improver, reacting with urea to obtain ammonium phosphate mixing melt in melting boiler, regulating NPK proportion, adding functional additive, combing releasing mechanism with instant releasing, frame slow releasing and surface controllable releasing, granulating, coating, computing fertilizer proportion, and obtaining controllable releasing composite fertilizer. Its advantages include low cost, regulating releasing period and no environmental pollution.

The invention discloses a magnesium ammonium phosphate-urea slow-release fertilizer and a preparing method thereof, and belongs to the technical field of resource comprehensive utilization. The methodincludes the following steps of firstly, grinding magnesium ammonium phosphate and modified starch into small particles, and conducting evenly mixing to form a magnesium ammonium phosphate and modified starch mixture; secondly, placing the mixture obtained in the first step into a disc granulator; thirdly, spraying water on the rotating magnesium ammonium phosphate and modified starch particles through an atomizing method; fourthly, slowing adding the urea ground into small particles to the magnesium ammonium phosphate and modified starch particles in the third step; fifthly, spraying water for granulating; sixthly, repeatedly executing the second step, the third step, the fourth step and the fifth step through the slow adding mode after the material is converted into the particles with the granularity of about 1 mm; seventhly, conducting stable granulating to obtain the magnesium ammonium phosphate-urea slow-release fertilizer. The magnesium ammonium phosphate-urea slow-release fertilizer particles are formed with the magnesium ammonium phosphate particles and the urea particles through the layer-by-layer wrapping mode, and the releasing speed of the urea is effectively controlled.

The invention relates to sustained release microspheres of polyethylene glycol-polylactic acid entrapped betamethasone dipropionate and a preparation method thereof. The sustained release microspheres are prepared from degradable high-molecular biomaterial polyethylene glycol-polylactic acid entrapped betamethasone dipropionate by an O / W type emulsification-solvent evaporation process, and are used for treating inflammatory diseases. The sustained release microspheres of polyethylene glycol-polylactic acid entrapped betamethasone dipropionate, provided by the invention, can regulate the release of a drug, prolong the action time of the drug, reduce the administration times, reduce the side effects of the drug and improve the drug effect. The preparation method provided by the invention is simple and reliable, can guarantee the product quality and application effect, and facilitates industrial production.

The invention discloses an anti-tumor macromolecular prodrug compound, and a preparation method and application of the anti-tumor macromolecular prodrug compound. The anti-tumor macromolecular prodrug compound is prepared from heparin or a derivative-a doxorubicin type macromolecular prodrug of the heparin and a hyaluronic acid-natural active component type macromolecular prodrug in a compounding way. The invention also provides the preparation method of the anti-tumor macromolecular prodrug compound and the application of the anti-tumor macromolecular prodrug compound in preparing anti-tumor drugs. Compared with the prior art, by compounding two kinds of macromolecular prodrugs, not only are multiple tumor targeting properties obtained, but also multi-drug resistance of tumor can be effectively reversed; the two kinds of macromolecular prodrugs work together and are in mutual synergy, so that the treating effect is obviously enhanced.

The invention relates to a 24-hour slow-release tablet of trospium chloride or medicinal salt thereof. The slow-release tablet is a single-layer tablet, and can ensure the release of the trospium chloride or the medicinal salt thereof within at least 24 hours after taking medicine.

The invention discloses a biologically responsive nitric oxide donor type polymer prodrug and a preparation method thereof, wherein the polymer prodrug is obtained by connecting a hydroxyl-containing chemotherapeutic drug and a nitric oxide donor type polycarbonate macromolecule through a tumor microenvironment acid responsive acetal bond, and then the polymer prodrug nano-drug is obtained through self-assembly. According to the invention, chemotherapeutic drugs are modified, and a nitric oxide donor is introduced to a polymer carrier material, so that the nitric oxide donor type polymer prodrug with high drug loading capacity, high stability and biological response is prepared, drug sensitization and synergistic treatment effects are realized, and the prodrug has a wide application prospect in the aspect of efficient anti-tumor.

The invention aims to provide a compound fertilizer containing an additive KNP, which can regulate the release rate of the compound fertilizer to synchronize the fertilizer absorbing rule of crops. The compound fertilizer containing the additive KNP consists of the following components in percentage by weight: 26 to 28 percent of compound fertilizer, 19 to 21 percent of the additive KNP, 0.01 to 0.03 percent of diethyl aminoethyl hexanoate raw powder and 51.98 to 55.98 percent of filling material. Preferably, the compound fertilizer consists of the following components in percentage by weight: 24 percent of compound fertilizer, 20 percent of the additive KNP, 0.02 percent of diethyl aminoethyl hexanoate raw powder and 55.98 percent of filling material. The additive KNP mainly comprises humic acid and amino acid, and the molecular formula of the diethyl aminoethyl hexanoate raw powder is C18H33NO8. The filling material is raw soil or other organic fertilizer or inorganic fertilizer except the compound fertilizer, phosphate fertilizer and potash fertilizer.

The invention discloses a KZO additive-containing fertilizer, which comprises the following components in percentage by weight: 80 to 95 percent of composite fertilizer, and 5 to 20 percent of KZO additive, preferably 85 percent of fertilizer and 15 percent of KZO additive. The KZO additive mainly comprises life peptide, vital peptide, plant gold peptide and diethyl aminoethyl hexanoate raw powder (with a molecular formula of C18H33NO8).

The invention discloses an orthoester miscible pharmaceutical adjuvant, which relates to the field of pharmaceutical adjuvants and is mainly obtained by mixing and dissolving different orthoester compounds according to different proportions or mixing and dissolving orthoester compounds and biocompatible medical polymer materials according to different proportions. The chemical formula I of the orthoester compound is shown in the specification, wherein R represents hydrogen, methyl, ethyl, propyl, isopropyl, butyl or phenyl. The invention also provides a preparation method of the pharmaceutic adjuvant and a local sustained-release drug delivery preparation containing the adjuvant. The invention has the following beneficial effects: the fluidity of the orthoester miscible pharmaceutical adjuvant is adjustable; the degradation rate is adjustable, and the drug release rate is adjustable; a good solvent, which can dissolve small molecule and protein drugs; local injections, cream and ointment can be prepared; the biological compatibility is good, the metabolism is clear, and the clinical conversion use is easy.

The invention discloses medicated candy produced based on a 3D printing mold. The medicated candy is designed in various shapes and colors according to users' needs and disease treatment needs; the medicated candy is convenient to use in the mouth, can pharmaceutically act quickly or slowly, and is suitable for preventing and treating oral diseases or general diseases.

The invention provides a fertilizer containing FHJH. The fertilizer comprises components with the weight percentages as follows: 26 percent to 28 percent of compound fertilizer, 19 percent to 20 percent of additive (FHJH), 0.01 percent to 0.03 percent of diethyl aminoethyl hexanoate raw powder, and 51.98 percent to 55.98 percent of soil filling material; and preferably, the fertilizer comprises the components with the weight percentages as follows: 24 percent of compound fertilizer, 20 percent of additive FHJH, 0.02 percent of diethyl aminoethyl hexanoate raw powder and 55.98 percent of soil filling material. The fertilizer with the additive containing FHJH mainly comprises compound sodium nitrophenolate, fulvic acid potassium, poly-aspartic acid and sustained-release factors; the molecular formula of the diethyl aminoethyl hexanoate raw powder is C18H33NO8; and the soil filling material is raw soil, or other organic fertilizer or inorganic fertilizer except the compound fertilizer, phosphate fertilizer and potash fertilizer.

The present invention discloses a slow-release and micro-organism-inhibition type artificial dermis model and a construction method thereof. The slow-release and micro-organism-inhibition type artificial dermis model comprises a silica gel membrane, a stent layer arranged under the silica gel membrane, and a slow-release layer arranged between the silica gel membrane and the stent layer. The construction method is as follows: the slow-release layer is selected from a bio-cellulose membrane, the bio-cellulose membrane in an expanded state is prepared into a dense bio-cellulose thin membrane byvacuum drying, at the same time, a micro-organism-inhibition agent is retained inside the bio-cellulose thin membrane, and then the bio-cellulose thin membrane is spread flatly on a bottom part of a mold and freeze-dried together with collagen and other stent components to be integrated together; finally, the integrated material is bonded with the silica gel membrane to form the final model; and adesign of the slow-release layer can load the micro-organism-inhibition agent, also can regulate and control a releasing speed of the micro-organism-inhibition agent, enables the micro-organism-inhibition agent to be stably and evenly released, and avoids infection or poisoning during use of artificial dermis.

The invention discloses a packaging structure for regulating the release rate of chlorine dioxide, and relates to the technical field of packaging structures. The packaging structure for regulating the release rate of the chlorine dioxide comprises an activated slow-release layer and a protective controlled-release layer, the activated slow-release layer wraps a solid-phase chlorine dioxide preparation, and the protective controlled-release layer wraps the outer side of the activated slow-release layer; the water vapor transmission rate of the activated slow-release layer is 100-5000 g / (m<2>.24h); and the protective controlled-release layer is provided with one or more air holes. According to the scheme, the activated slow-release layer with high permeability is used for providing good moisture absorption and release characteristic, the protective controlled-release layer has a buffer effect, thus a more stable environment is provided for the activated slow-release layer, the impact ofexternal factors such as air disturbance on the release rate is reduced, and thus the release rate of the chlorine dioxide can be controlled more evenly.

The invention discloses a magnesium ammonium phosphate inorganic-organic binder fertilizer and a preparation method thereof, and belongs to the technical field of comprehensive utilization of resources. Magnesium ammonium phosphate is taken as a wrapping material of the magnesium ammonium phosphate inorganic-organic binder fertilizer; magnesium ammonium phosphate particles and an organic fertilizer are wrapped on the organic fertilizer in a layered form by a modified starch binder and granulated to obtain the magnesium ammonium phosphate inorganic-organic binder fertilizer; the magnesium ammonium phosphate particles and organic fertilizer particles form magnesium ammonium phosphate inorganic-organic binder particles in a layered form; by taking a magnesium ammonium phosphate slow release fertilizer as the wrapping material, the release rate of the organic fertilizer is effectively controlled, and the needs of crops for multi-element nutrients such as nitrogen, phosphorus, magnesium andthe like are satisfied; at the same time, a nutrient release curve of the binder fertilizer shows that the release of nutrient elements is gentle, so that the long-term growth needs of the crops canbe met, and the waste of the fertilizer can be avoided; and the binder fertilizer has no side effects on the crops or the growth environment of the crops, and does not cause soil hardening.

The invention discloses a fertilizer containing additive KCO, which comprises the following compositions in percentage by weight: 85 to 95 percent of fertilizer, and 5 to 20 percent of additive KCO, preferably 85 percent of fertilizer and 15 percent of additive KCO, wherein the additive KCO is prepared from compound potassium nitrophenolate (molecular formula: KC7H6NO4), compound sodium nitrophenolate (C6H4NO3Na) and polyaspartic acid (O-pasp) by way of chelating. The additive KCO-containing fertilizer of the invention has the advantages: the fertilizer can adjust the speed of NPK release, so that the NPK can be absorbed and utilized by the plants better; and the fertilizer can activate invalid phosphorus and invalid environment in the environment, without any side effect; and compared with general fertilizers, by using the fertilizer of the invention, the leaf surfaces of the plants are deep green and does not yellow, therefore, the fertilizer of the invention has a better effect.

Disclosed is a fertilizer containing CAS-SiPEC. Components of the fertilizer comprise, by weight, 26-28% of a composite fertilizer, 19-20% of an additive (CAS-SiPEC), 0.01-0.03% of a raw powder of diethyl aminoethyl hexanoate and 51.98-55.98% of a filling material, and preferably, the components comprise, by weight, 24% of the composite fertilizer, 20% of an additive FHJH, 0.02% of the raw powder of the diethyl aminoethyl hexanoate and 55.98% of the filling material. The fertilizer containing the additive FHJH mainly comprises compound sodium nitrophenolate, potassium fulvic acid, poly aspartic acid and a slow-release factor. The molecular formula of the raw powder of the diethyl aminoethyl hexanoate is C18H33NO8. The filling material is a raw soil or other organic fertilizers or inorganic fertilizers except for a composite fertilizer, a phosphate fertilizer and a potash fertilizer.

The invention discloses a layered microneedle, a layered microneedle contraception system and a preparation method and application of the layered microneedle, the layered microneedle comprises a polystyrene (PS) layer and a polyvinylpyrrolidone (PVP) layer, a needle body of the layered microneedle contraception system comprises nanospheres LNG (at) PCL / F68 and free levonorgestrel (LNG), and the nanospheres LNG (at) PCL / F68 are prepared by mixing the levonorgestrel (LNG), polycaprolactone (PCL) and poloxamer 188 (F68). A certain amount of medicine can be continuously and stably released by adjusting the dosage of F68 or the input amount of medicine LNG, and the requirements of different crowds for contraception duration are met. Meanwhile, due to the removable design of the layered microneedle substrate, the discomfort caused by the fact that other percutaneous preparations such as dressings stay on the skin surface for a long time is avoided, and the embarrassment that a patient uses contraceptive products is avoided.

The long-acting slowly released nitrogen fertilizer consists of ammonium nitrogen fertilizer 22-25 wt%, soil conditioner 19-21 wt%, composite sodium nitrophenolate powder 0.01-0.03 wt% and stuffing 50.98-60.98 wt%. The soil conditioner consists of fulvic acid and amino acid mainly; the composite sodium nitrophenolate powder consists of 5-nitroguaiamar sodium, one-nitrophenol sodium and p-nitrophenol sodium; and the stuffing is soil, organic fertilizer or inorganic fertilizer. The present invention has the beneficial effects of synchronous release of nitrogen with crop' s absorption, high fertilizer utilization rate, effective activation of phosphate and potash fertilizer in soil, no side effect and fertilizer effect higher than that of single nitrogen fertilizer.

The invention discloses a moulded tablet based on a 3D printing mold and prepared from a photo-curing material. The moulded tablet contains a polymer formed by medicaments and a photo-curing material.The moulded tablet can be designed into various shapes, sizes and colors according to users and disease treatment requirements, can be used in special environments or special patients, has the effectof slowly releasing the medicaments, and can be used for preventing and treating diseases.

The invention relates to a NO2-KPAM polyoxygen water storage amphoteric zinc fertilizer, which comprises, by weight, 26-28% of a composite fertilizer, 19-20% of an additive, 0.01-0.03% of 2-diethylaminoethyl hexanoate raw powder, and 51.98-55.98% of an earth fill material, preferably, 24% of a composite fertilizer, 20% of an additive, 0.02% of 2-diethylaminoethyl hexanoate raw powder, and 55.98% of an earth fill material, wherein the fertilizer having the additive containing FHJH mainly comprises compound sodium nitrophenolate, potassium fulvate, polyaspartic acid and a sustained release factor, the molecular formula of the 2-diethylaminoethyl hexanoate raw powder is C18H33NO8, and the earth fill material is original soil or other organic fertilizers or inorganic fertilizers excluding composite fertilizers, phosphorus fertilizers and potassium fertilizers.

The present invention discloses a cultivation method for facilitating winter blooming of water lilies. The cultivation method comprises: (1) applying a base fertilizer into a nutrition bowl in middle and late September and filling the nutrition bowl with pond mud; (2) selecting tubers without viruses and damage and with terminal buds as seed plants; washing the seed plants and then carrying out disinfection treatment on the seed plants; (3) burying the disinfected seed plants into the central position of the nutrition bowl and enabling the terminal buds to be exposed out of the pond mud by 1-2cm; after transplanting the seed plants, immersing the seed plants into a water tank, and injecting water to flood the nutrition bowl by 0-5cm; (4) controlling a water-flooding depth: controlling the water-flooding depth to be 50-65cm at a seedling period, and controlling the water-flooding depth to be 95-115cm at a flower bud period; (5) at the flower bud period, keeping an indoor temperature to be 20-35 DEG C and keeping a water temperature to be 18-25 DEG C; at a blooming period, keeping the indoor temperature to be 20-30 DEG C, keeping the water temperature to be 15-25 DEG C, and controlling the indoor illumination intensity to be 1000-2500lux; and controlling the oxygen content of a water body to be 15-20mg / L. With the adoption of the cultivation method, the blooming quantity can be increased, the flowering phase of the water lilies is prolonged, the economic value of the water lilies is improved and market requirements are met.

The invention relates to a 24-hour slow-release tablet of trospium chloride or medicinal salt thereof. The slow-release tablet is a single-layer tablet, and can ensure the release of the trospium chloride or the medicinal salt thereof within at least 24 hours after taking medicine.

The invention discloses an antibacterial poly (Epsilon- caprolactone) / poly (Epsilon- caprolactone)-REDV / gelatin electro-spinning fibrous coat and a preparation method thereof; the electro-spinning fibrous coat is formed by poly (Epsilon- caprolactone) / poly (Epsilon- caprolactone)-REDV / gelatin fiber with diameter of 200-1200 nm and a plant source antibacterial agent entrapped at the inner part of fiber; the thickness of the film is 50-150 mu m. The preparation method includes steps of dissolving (Epsilon- caprolactone), poly (Epsilon- caprolactone)-REDV and gelatin in trifluoroethanol; dropwise adding glacial acetic acid until the solution is clear; forming electro-spinning solution; then adding plant source antibacterial agent eugenol; using a single-path injection pump electro-spinning device, and applying a static spinning method to obtain the electro-spinning fibrous coat. The electro-spinning fibrous coat has double functions of accelerating endothelialization of the material surface and preventing bacterial, the fibrous coat has application prospect in terms of artificial blood vessel biomedical materials.

The invention discloses a slow-release antibacterial artificial dermis model and a construction method thereof, comprising: a silica gel film, a support layer arranged under the silica gel film, and a slow-release layer disposed between the silica gel film and the support layer; the construction method is as follows : The slow-release layer uses biocellulose film, and the biocellulose film in the expanded state is made into a dense biocellulose film by vacuum drying, while keeping the bacteriostatic agent inside the biocellulose film, and then the biocellulose film is flattened. Lay it on the bottom of the mold and freeze-dry it together with scaffold components such as collagen, and fuse it together; finally, it is bonded with the silica gel film to form the final model; the design of the slow-release layer can not only load antibacterial agents but also control antibacterial agents The release speed ensures the stable and uniform release of the antibacterial agent and avoids infection or poisoning during the use of artificial dermis.

The invention provides a transdermal patch for delivering cannabis sativa active substances. The transdermal patch comprises a lining layer, a medicine carrying layer and a protective layer, wherein the medicine carrying layer is located between the lining layer and the protective layer, the medicine carrying layer is formed by a medicine carrying layer composition, and the medicine carrying layer composition comprises cannabis sativa active ingredients, a matrix material, a tackifier and a penetration enhancer. The transdermal patch for delivering cannabis sativa active substances is based on the ethylene-vinyl acetate copolymer as a matrix material, compared with a rubber transdermal patch and a polyacrylate transdermal patch, the transdermal patch for delivering cannabis sativa active substances has higher transdermal absorption and utilization rate and adjustable drug release rate, is suitable for various indications, and is high in user compliance, and the preparation method is simple and convenient.

The invention discloses an improved low-toxicity high-efficiency orthoester miscible pharmaceutical adjuvant, a preparation method thereof and a local sustained-release drug delivery preparation containing the adjuvant, and relates to the field of pharmaceutical adjuvants. The non-methoxy orthoester compound is obtained by mixing and dissolving non-methoxy orthoester compounds (class I and class II) according to different proportions or mixing and dissolving the orthoester compounds (class I or class II) and a biocompatible medical polymer material according to different proportions. The chemical formula I of the class I orthoester compound is shown in the formula I, and the chemical formula II of the class II orthoester compound is shown in the formula II. The invention further provides a preparation method of the pharmaceutic adjuvant and a local sustained-release drug delivery preparation containing the adjuvant. The invention has the following beneficial effects: the biological safety of the medicinal auxiliary material is improved by adjusting the substituent type and length of the orthoester compound, and the properties of the orthoester miscible medicinal auxiliary material before and after improvement are not changed, and all functions and effects of the orthoester miscible medicinal auxiliary material before structure improvement are included but not limited to.

The invention discloses an intelligent stress-resistant nutrient solution which is composed of following components, by weight, 80-95% of a foliar fertilizer and 5-20% of a TOS additive and preferably is composed of following components, by weight, 85% of the foliar fertilizer and 15% of the TOS additive, wherein the TOS additive mainly comprises a life peptide, an original-energy peptide, a plant golden peptide and a raw powder of diethyl aminoethyl hexanoate which has a molecular formula being C18H33NO8.