Antibacterial poly(ε-caprolactone)/poly(ε-caprolactone)-REDV/gelatin electrospun fiber membrane and preparation method

A technology of electrospinning fiber and caprolactone, which is applied in the field of biomedical materials, can solve the problems of accelerating endothelialization and antibacterial, and achieves the promotion of adhesion and proliferation, good biocompatibility and biodegradability, and broad application prospects. Effect
CN107217388BInactive Publication Date: 2019-09-06TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2019-09-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an antibacterial poly (Epsilon- caprolactone) / poly (Epsilon- caprolactone)-REDV / gelatin electro-spinning fibrous coat and a preparation method thereof; the electro-spinning fibrous coat is formed by poly (Epsilon- caprolactone) / poly (Epsilon- caprolactone)-REDV / gelatin fiber with diameter of 200-1200 nm and a plant source antibacterial agent entrapped at the inner part of fiber; the thickness of the film is 50-150 mu m. The preparation method includes steps of dissolving (Epsilon- caprolactone), poly (Epsilon- caprolactone)-REDV and gelatin in trifluoroethanol; dropwise adding glacial acetic acid until the solution is clear; forming electro-spinning solution; then adding plant source antibacterial agent eugenol; using a single-path injection pump electro-spinning device, and applying a static spinning method to obtain the electro-spinning fibrous coat. The electro-spinning fibrous coat has double functions of accelerating endothelialization of the material surface and preventing bacterial, the fibrous coat has application prospect in terms of artificial blood vessel biomedical materials.
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Description

technical field

[0001] The invention relates to an antibacterial poly(ε-caprolactone) / poly(ε-caprolactone)-REDV / gelatin electrospun fiber membrane carrying a plant-derived antibacterial agent and a preparation method thereof, belonging to the field of biomedical materials. Background technique

[0002] In recent years, cardiovascular disease has become the leading cause of human death. Using electrospinning film forming technology, by adjusting the electrospinning parameters, an electrospun fiber membrane material with a fiber diameter of several hundred nanometers and a large specific surface area can be prepared, which can simulate the extracellular matrix in structure, which is beneficial to cells. Adhesion, proliferation and migration can be used for cardiovascular remodeling.

[0003] Poly(ε-caprolactone) has good biocompatibility, biodegradability and excellent mechanical properties, and is a commonly used material in the research of small-caliber artificial blood ves...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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