Moulded tablet based on 3D printing mold and prepared from photo-curing material

A light-curing material, 3D printing technology, applied in additive processing, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Rate-adjustable effects

Inactive Publication Date: 2020-07-17
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the preparation of high-hardness molded sheets by 3D printing molds and light-cured materials.

Method used

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  • Moulded tablet based on 3D printing mold and prepared from photo-curing material
  • Moulded tablet based on 3D printing mold and prepared from photo-curing material
  • Moulded tablet based on 3D printing mold and prepared from photo-curing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1. Ibuprofen molded tablet

[0024] Step 1, establishment and printing of ibuprofen mold impression sheet mold model: use 3D modeling software to set up a circular ibuprofen impression sheet mold model complementary to the shape of ibuprofen impression sheet, consisting of the middle part of the mold, the base and its Press the cover to form and save it as an STL format file; input the STL file into the slicing software, obtain the slicing file, and transfer it to the photocuring method for 3D printing, and use the photosensitive resin as the material to print the ibuprofen mold. After the mold is printed, use The residual liquid photosensitive resin on the mold surface is rinsed with absolute ethanol, and dried to obtain the ibuprofen impression sheet mold;

[0025] Step 2. Preparation of ibuprofen molded tablets: Weigh 93 parts of ibuprofen and 7 parts of N-vinylpyrrolidone containing Irgacure 2959 in parts by weight, mix well, fully stir until completely m...

experiment example 1

[0030] Experimental example 1. Mold printing method

[0031] Step 1. Use 3D modeling software to build a circular model of the middle part of the mold that is complementary to the shape of the mold, and save it as an STL file; input the STL file into the slicing software, and after obtaining the slicing file, transfer it to the photocuring 3D Printing, using photosensitive resin as the material to print candy molds, after the mold is printed, rinse the residual liquid photosensitive resin on the surface of the mold with absolute ethanol, and obtain the stamped sheet mold after drying;

[0032] Step 2: Use 3D modeling software to build a model of the middle part of the circular mold that is complementary to the shape of the mold and save it as an STL file; use the STL file to print with polylactic acid PLA on the fused deposition method 3D printing to obtain the mold piece mold;

[0033] Step 3: Stick the mold printed with SLA and FDM on the conductive tape, spray gold on the su...

experiment example 2

[0035] Experimental Example 2. Advantages of Ibuprofen Imprinted Tablets Compared with Common Compressed Tablets

[0036] According to Example 1, molded tablets of various shapes can be prepared. When special groups such as the elderly or children take medicine, the cartoon pattern can reduce children’s fear of taking medicine, and the tablet conforming to ergonomics can reduce the swallowing of medicine by the elderly. difficult question. The in vitro release experiment shows that the imprinted tablet has a longer release time than the compressed tablet and has a sustained release effect, which can reduce the side effects caused by the sudden release of the drug. The long-term release of the ibuprofen imprinted tablet can continue to play a role and reduce the patient's medication. times. In addition, compared with compressed tablets, molded tablets use very few excipients, which can reduce the toxic and side effects caused by excipients and improve the incompatibility of dr...

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Abstract

The invention discloses a moulded tablet based on a 3D printing mold and prepared from a photo-curing material. The moulded tablet contains a polymer formed by medicaments and a photo-curing material.The moulded tablet can be designed into various shapes, sizes and colors according to users and disease treatment requirements, can be used in special environments or special patients, has the effectof slowly releasing the medicaments, and can be used for preventing and treating diseases.

Description

technical field [0001] The invention relates to the fields of manufacturing and biomedicine, and in particular to an impression sheet prepared based on a 3D printing mold and light-cured materials. Background technique [0002] Tablets are common preparations, which can be divided into oral tablets, oral tablets, external tablets, etc. according to the location of use. Oral tablets can be divided into ordinary tablets and coated tablets. Ordinary tablets generally refer to tablets that are compressed with a tablet machine after mixing drugs and excipients. Coated tablets refer to tablets coated with a film outside the ordinary tablet. The purpose of coating is to increase the stability of the drug in the tablet, mask the bad smell of the drug, improve the appearance of the tablet, etc. Coated tablets can be divided into sugar-coated tablets, film-coated tablets, and enteric-coated tablets. Oral tablets can be divided into buccal tablets and sublingual tablets. Buccal ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/32A61K45/00A61K31/192B33Y70/10B33Y80/00
CPCA61K9/2027A61K9/2072A61K9/2095A61K45/00A61K31/192B33Y70/00B33Y80/00
Inventor 金义光方荣震杜丽娜
Owner ACADEMY OF MILITARY MEDICAL SCI
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