A slow-release antibacterial artificial dermis model and its construction method

A construction method and artificial technology, applied in pharmaceutical formulations, prostheses, coatings, etc., to achieve the effect of avoiding cytotoxicity

Active Publication Date: 2021-06-08
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the deficiencies in the prior art, the object of the present invention is to provide a slow-release antibacterial artificial dermis model and its construction method. A slow-release layer is added between the support layer and the silica gel film layer. The design of the slow-release layer not only It can be loaded with antibacterial agents and can regulate the release rate of antibacterial agents to ensure stable and uniform release of antibacterial agents and avoid infection or poisoning in the process of using artificial dermis

Method used

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  • A slow-release antibacterial artificial dermis model and its construction method
  • A slow-release antibacterial artificial dermis model and its construction method
  • A slow-release antibacterial artificial dermis model and its construction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Antibacterial agent selects a kind of embodiment-silver nitrate of soluble component for use;

[0087] Step 1, the construction of the slow-release layer:

[0088] Because silver nitrate is a water-soluble inorganic salt, when the slow-release layer meets water, the silver ions become free, and driven by the concentration difference, they penetrate the dense fiber structure of the cellulose film and reach the wound surface to play a role in continuous sterilization. Therefore, in this embodiment, a denser and thicker biocellulose film should be selected to ensure the slow release of silver ions.

[0089] Take the density as 10mg / cm 3 A biological cellulose film with a thickness of about 1 cm is soaked in a 5% silver nitrate solution for 10 hours to fully absorb the silver nitrate. Pre-freeze the expanded biological cellulose membrane at -20°C, then transfer it to a vacuum freeze dryer, freeze-dry for 10 hours, make it incompletely freeze-dried and become a film with a...

Embodiment 2

[0099] Antibacterial agent selects a kind of embodiment-sodium zirconium phosphate of micron-sized particle for use;

[0100] Step 1, the construction of slow-release layer;

[0101] Since the particle size of sodium silver zirconium phosphate is relatively micron, it is necessary to choose a biocellulose membrane with a low density and a moderate thickness. To ensure that the sodium zirconium phosphate silver particles can be evenly adsorbed in the biocellulose membrane. When the biological cellulose membrane changes from the expanded state to the thin film state, the pores of the biological cellulose membrane change from micrometer to nanometer, so that the silver zirconium phosphate particles are wrapped between the biological cellulose membranes. Because the biological fiber has the function of absorbing liquid, when the body fluid enters the slow-release layer, the silver ions loaded by sodium zirconium phosphate enter the body fluid and become free, so that they can ent...

Embodiment 3

[0113] Antibacterial agent selects a kind of embodiment of nano-scale particle-nano-silver particle;

[0114] Step 1, the construction of slow-release layer;

[0115] In this embodiment, nano-silver particles are selected as the antibacterial agent, taking into account the adsorption and release of nano-silver. In this embodiment, a biocellulose film with moderate density and thick thickness is selected as the slow-release layer.

[0116] Take the dry weight as 5mg / cm 3 A wet biological cellulose film with a thickness of about 0.8cm ± 0.1cm is soaked in a nano-silver suspension with a concentration of 10% for 10 hours to fully absorb the nano-silver. Pre-freeze the biocellulose membrane in the above-mentioned expanded state at -20°C, then transfer it to a vacuum freeze dryer, freeze-dry for 10 hours, make it incompletely freeze-dried and become a thin film with a thickness of about 1mm, so that the nano-silver particles Encased in cellulose. The biocellulose film was then ...

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Abstract

The invention discloses a slow-release antibacterial artificial dermis model and a construction method thereof, comprising: a silica gel film, a support layer arranged under the silica gel film, and a slow-release layer disposed between the silica gel film and the support layer; the construction method is as follows : The slow-release layer uses biocellulose film, and the biocellulose film in the expanded state is made into a dense biocellulose film by vacuum drying, while keeping the bacteriostatic agent inside the biocellulose film, and then the biocellulose film is flattened. Lay it on the bottom of the mold and freeze-dry it together with scaffold components such as collagen, and fuse it together; finally, it is bonded with the silica gel film to form the final model; the design of the slow-release layer can not only load antibacterial agents but also control antibacterial agents The release speed ensures the stable and uniform release of the antibacterial agent and avoids infection or poisoning during the use of artificial dermis.

Description

technical field [0001] The invention relates to the field of skin tissue engineering, in particular to a slow-release antibacterial artificial dermis model and a construction method thereof. Background technique [0002] The skin wraps the surface of the human body and is in direct contact with the external environment. It is an organ that protects, excretes, regulates body temperature, and senses external stimuli. It is the largest organ in the human body. Various types of skin defect wounds are very common clinically. Currently, the dermal substitutes used for wound treatment mainly include artificial dermis, acellular allogeneic skin, and tissue-engineered artificial dermis containing active cells. Artificial dermis products originally have a wide range of sources, are easy to store and transport, have significant clinical effects and high product safety, and currently occupy a mainstream position in the market. [0003] The artificial dermis used for wound repair usuall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/24A61L27/02A61L27/50A61L27/54
CPCA61L27/025A61L27/20A61L27/24A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2300/602A61L2300/606A61L2400/12C08L1/02
Inventor 张锐鲁建国王姣
Owner ZHENDE MEDICAL CO LTD
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