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Transdermal patch for delivering cannabis sativa active substances

A technology of transdermal patches and active substances, which is applied in the field of transdermal patches and can solve problems such as low drug delivery rate

Pending Publication Date: 2021-09-14
深圳普洛美康材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the current drug delivery rate of the conventional transdermal patch of cannabis active ingredients is low, and the microneedle technology has not matured to the stage of clinical application, so further improvement is needed

Method used

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  • Transdermal patch for delivering cannabis sativa active substances
  • Transdermal patch for delivering cannabis sativa active substances
  • Transdermal patch for delivering cannabis sativa active substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1 prepares the EVA transdermal patch loaded with cannabidiol

[0056] Weigh respectively 1.8 grams, 5 grams, 10 grams and 15 grams of EVA (VA content 32%) in 4 beakers, respectively add 3 grams of rosin glycerides, 3 grams of azone, 3 grams of glycerin, 1 gram of marijuana Phenol and 30 g of dichloromethane were heated and stirred to dissolve. Then, it is coated on an aluminum foil film of the same area, dried to remove methylene chloride, and then cut into an appropriate size to obtain a drug-loaded layer. Cover the drug-loaded layer with silicone oil paper.

[0057] Take fresh mouse skin, isopropanol: methanol 1:1 as the receiving solution, and use the Franz diffusion cell to test the transdermal accumulation of cannabidiol in the patch. Take 0.5 ml of solution in the pool every hour and replenish with 0.5 ml of fresh solution. Use the same isopropanol:methanol mixture to prepare a gradient solution of cannabidiol, and make a standard curve after HPLC te...

Embodiment 2

[0059] Embodiment 2 prepares the EVA transdermal patch loaded with cannabidiol

[0060] Weigh 0.9 gram, 3 gram, 7.5 gram and 17 gram of rosin glyceride in 4 beakers respectively, add 10 gram of EVA (32% of VA content), 3 gram of azone, 3 gram of glycerin, 1 gram of hemp two respectively Phenol and 30 g of dichloromethane were heated and stirred to dissolve. Then, it is coated on an aluminum foil film of the same area, dried to remove methylene chloride, and then cut into an appropriate size to obtain a drug-loaded layer. Cover the drug-loaded layer with silicone oil paper.

[0061] Take fresh mouse skin, isopropanol: methanol 1:1 as the receiving solution, and use the Franz diffusion cell to test the transdermal accumulation of cannabidiol in the patch. Take 0.5 ml of solution in the pool every hour and replenish with 0.5 ml of fresh solution. Use the same isopropanol:methanol mixture to prepare a gradient solution of cannabidiol, and make a standard curve after HPLC testin...

Embodiment 3

[0063] Embodiment 3 prepares the EVA transdermal patch loaded with cannabidiol

[0064] Weigh 1 gram and 4 grams of cannabidiol respectively in two beakers, respectively add 9 grams of EVA (28 / 400), 3 grams of rosin glyceride, 3 grams of azone, 3 grams of glycerin and 1 gram of cannabidiol, Then add 30 g of dichloromethane, heat and stir to dissolve. Then, it is coated on an aluminum foil film, dried to remove methylene chloride, and then cut into an appropriate size to obtain a drug-loaded layer. Cover the drug-loaded layer with silicone oil paper.

[0065] Take fresh mouse skin, isopropanol: methanol 1:1 as the receiving solution, and use the Franz diffusion cell to test the transdermal accumulation of cannabidiol in the patch. Take 0.5 ml of solution in the pool every hour and replenish with 0.5 ml of fresh solution. Use the same isopropanol:methanol mixture to prepare a gradient solution of cannabidiol, and make a standard curve after HPLC testing. The concentration of...

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Abstract

The invention provides a transdermal patch for delivering cannabis sativa active substances. The transdermal patch comprises a lining layer, a medicine carrying layer and a protective layer, wherein the medicine carrying layer is located between the lining layer and the protective layer, the medicine carrying layer is formed by a medicine carrying layer composition, and the medicine carrying layer composition comprises cannabis sativa active ingredients, a matrix material, a tackifier and a penetration enhancer. The transdermal patch for delivering cannabis sativa active substances is based on the ethylene-vinyl acetate copolymer as a matrix material, compared with a rubber transdermal patch and a polyacrylate transdermal patch, the transdermal patch for delivering cannabis sativa active substances has higher transdermal absorption and utilization rate and adjustable drug release rate, is suitable for various indications, and is high in user compliance, and the preparation method is simple and convenient.

Description

technical field [0001] The present invention relates to transdermal patches for the transdermal delivery of cannabis active ingredients, and more particularly, the present invention relates to transdermal delivery patches of cannabis plant-extracted water-insoluble active ingredients or synthetic congeners or analogues, wherein the cannabis active ingredient The ingredients are absorbed through the skin and act locally or systemically. Background technique [0002] The cannabis plant, or cannabis herb, contains more than 400 chemicals. Among them, there are more than 60 psychoactive ingredients, representative ingredients include tetrahydrocannabinol (THC), tetrahydrocannabinol (THCV) cannabidiol (CBD), cannabidiol (CBDV) cannabinol (CBN) , cannabichromene (CBC); dehydrocannabidiol (CBDL); cannabicyclol (CBL), cannabidiol (CBE), cannabidiol (CBT) and cannabigerol (CBG), etc. Among them, tetrahydrocannabinol is banned or strictly regulated because of its psychoactive effect...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K31/05A61K36/60A61P3/10A61P19/02A61P29/00A61P25/22A61P1/06A61P21/02A61P13/06
CPCA61K9/7023A61K47/32A61K31/05A61K36/60A61P3/10A61P19/02A61P29/00A61P25/22A61P1/06A61P21/02A61P13/06
Inventor 唐键周小楠赵臣
Owner 深圳普洛美康材料有限公司
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