The invention discloses a method for treatment of indoor air pollution by combination of photocatalytic plasma and ultrasonic. The method includes the following steps: 1, a plasma discharge reactor is used to produce plasma free radicals, a strong electric field and ultraviolet light; 2, PM2.5 is absorbed through the strong electric; 3, the plasma free radicals are harmlessly treated by reaction of the plasma free radicals and VOCs (volatile organic chemcials) in the air; 4, incompletely reacted VOCs is further reacted in the presence of a TiO2 photocatalyst; 5, by-products NOx and O3 produced by the reaction are decomposed by a safe catalyst; 6, water or non-toxic organic absorbent and tail gas are mixed fully by an ultrasonic reactor, and fully react in a filling area, and remaining particles and VOCs are left in the organic absorbent; and 7, a tourmaline loaded nano titanium dioxide filler is used in the filling area. The method has the advantages of low energy consumption, small occupation of land, low noise, wide application range, and safe and reliable operation.