21 results about "Orthoester" patented technology

The invention provides a preparation method and application of a modified PVC adsorbent for gold extraction of carbonaceous gold ore, and belongs to the technical field of organic polymer materials and resource utilization. Based on construction of a hydroxylation-xanthate esterification reaction and bifunctional adsorption sites, a series of chemical modification paths of acetate nucleophilic substitution-hydrolysis-carbon disulfide alkali treatment are established, and xanthate functional groups with high reaction activity are accurately constructed on an inert PVC framework. Sulfur atoms in xanthate groups of the modified PVC are excellent electron donors and can generate strong chemical adsorption with metal impurities or polar sites on the surface of carbon, meanwhile, Van der Waals interaction between a main chain of the modified PVC and the carbon is reserved, and unmodified PVC or single hydroxylated PVC does not have the synergism of chemical adsorption and physical adsorption, so that the modified PVC can be used for preparing the carbon-modified PVC composite material, and the carbon-modified PVC composite material can be used for preparing the carbon-modified PVC composite material. And leap-type improvement of the adsorption capacity and selectivity of organic carbonaceous in minerals is realized.

A slow-reaction recyclable epoxy resin system for structural composites and a process of recycling the composites made therefrom are disclosed. The system includes an epoxy resin component including: a high purity epoxy resin selected from a high purity bisphenol A epoxy resin, a high purity bisphenol F epoxy resin, and combinations thereof, where the high purity epoxy resin is in a range of from 20 wt% to 95 wt% of the total weight of the cyclopentene resin component; a standard epoxy resin selected from a standard bisphenol A epoxy resin, a standard bisphenol F epoxy resin, and combinations thereof, where the standard epoxy resin is in the range of from 1 wt% to 50 wt% of the total weight of the epoxy resin component; and a curing agent component including a curing agent having at least one cleavage bond selected from a group including an acetal bond, a ketal bond, a formal bond, an orthoester bond, or a siloxy bond. The pot life of the slow-reaction recyclable epoxy resin system is greater than 540 minutes at 25 DEG C.

A treatment composition comprising at least one fragrance raw material and an esteramine or a salt thereof, which may be obtained by a process using a catalytic amount of at least one orthoester, and a method for treating an article or surface, optionally comprising treating the article or surface with such treatment composition in the presence of water.

To provide an injection chemical composition that can achieve both curability in water and foaming and curability in non-water environments, even after being exposed to high temperature and high humidity environments. [Solution] An injection solution composition comprising a first agent (A) and a second agent (B), wherein the first agent (A) comprises an aqueous solution of sodium silicate (A-1), an organic polyol (A-2), and a tertiary amine catalyst (A-3), and the second agent (B) comprises an organic polyisocyanate containing a mixture of diphenylmethane diisocyanate and polymethylene polyphenyl polyisocyanate having 3 or more isocyanate functional groups (B-1), or a reaction product (B-1') of an active hydrogen group-containing compound and a mixture (B-1), at least one acid component (B-2) selected from the group consisting of phosphate monoesters and phosphate diesters, and at least one hydrolyzable component (B-3) selected from the group consisting of orthoester compounds and acetal compounds.

The present invention aims to provide a radiosensitive linear composition, a hardened film, a method for manufacturing the same, a semiconductor element, a display element, and a polymer that can produce a film with excellent adhesion. A radiosensitive linear composition comprises: a polymer containing a structural unit (I) having a base represented by formula (1), a photoacid generator, and an orthoester compound. In formula (1), R... 1 It can be a hydrogen atom, a halogen atom, a hydroxyl group, or an alkoxy group having 1 to 6 carbon atoms. R 2 and R 3 Each of the following can be independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group with 1 to 6 carbon atoms, an alkyl group with 1 to 10 carbon atoms, or a phenyl group. "*" indicates a bond.

The present application relates to the technical field of nickel-based catalyst, and discloses a diimine ligand, a preparation method and application thereof, wherein the raw materials for preparing the diimine ligand contain acenaphthenequinone, a protective agent, substituted aniline and a catalyst, the protective agent is selected from one or more than two of ortho ester, amine, hydrazine and substituted hydrazine; and the molar ratio of the acenaphthenequinone, the protective agent, the substituted aniline and the catalyst is 1:(0.5-3):(1.6-2.4):(0.1-10). In the present application, a certain amount of protective agent is added to the reaction system, the acenaphthenequinone is reacted with the ortho ester or low-molecular-weight amine to generate ketal or imine, the ketal or imine is separated or not separated, and then reacted with the substituted aniline to generate the target product diimine ligand, no water is generated in the synthesis reaction of the diimine ligand, the balance can be effectively promoted to the forward reaction, and the reaction yield is improved.

This invention discloses a cross-linked nanoprodrug, a nano-self-assembled hydrogel precursor tablet prepared therefrom, and its applications. The nano-self-assembled hydrogel precursor tablet of this invention is prepared by direct compression of the cross-linked nanoprodrug or by compression of a cross-linked nanoprodrug mixed with a drug-loaded orthoester compound. It exhibits high nanodrug content, enhanced nanoparticle release, and high storage and transport stability, as well as good patient compliance. This nano-self-assembled hydrogel precursor tablet responds to the pH gradient environment of the gastrointestinal tract. In acidic gastric juice, through protonation of functional groups, it forms a three-dimensional network structure of nano-self-assembled hydrogel mediated by hydrogen bonds. Subsequently, it stably passes through the small intestine into the colon. In the alkaline colonic environment, its functional groups deprotonate, hydrogen bonds break, and the drug is efficiently released under the electrostatic repulsion between nanoparticles and the synergistic repulsion of the orthoester compound. While preferentially adhering to colonic lesions through electrostatic interactions, it significantly improves the targeted and synergistic therapeutic effect on CRC.

The present application relates to a kind of preparation methods of 3,4-dihydroxy-5-methoxybenzoic acid methyl ester, with gallic acid as raw material, it is reacted with trimethyl orthoformate or trimethyl orthoacetate, trimethyl orthoformate or trimethyl orthoacetate can realize the protection of adjacent diphenol hydroxyl on one hand, on the other hand, carboxyl esterification and 5-hydroxyl are methylated, form the methyl ester of 5-phenolic hydroxyl methylation and 3,4-orthoester protection benzoic acid shown in formula 1a or formula 1b, further by acidic solution treatment, deprotection is carried out, and the target product 3,4-dihydroxy-5-methoxybenzoic acid methyl ester is prepared.The preparation method is mild in reaction condition, process is simple, easy to operate, product yield and purity are high, solve the wastewater problem in borax protection method, and avoid using toxic dimethyl sulfate for methylation, process condition is simple, easy to operate, convenient for industrialization, with very high application value.

The invention discloses a pH-responsive supramolecular salicylic acid nanogel and a preparation method and application thereof, and the pH-responsive supramolecular salicylic acid nanogel comprises the following preparation raw materials by mass: 3-30% of salicylic acid; 0.6 to 1.5 percent of orthoester; 30 to 50% of poloxamer; 0.5 to 5.0 percent of polyhydric alcohol; 0.5-1% of a surfactant; and the balance solvent. Through supramolecular design, salicylic acid molecules and a precursor containing a pH sensitive group (orthoester) are integrally constructed into a nanogel network through non-covalent self-assembly, so that the contradiction between solubility and irritation of high-concentration salicylic acid is fundamentally solved; the prepared pH-responsive supramolecular salicylic acid nanogel can realize the synergistic effects of stable loading of high-concentration salicylic acid, targeted response release of an inflammatory site and low skin irritation, and the preparation process is simple, convenient and environment-friendly, is suitable for industrial production, and has a wide application prospect in the field of functional skin care products.

The present disclosure provides for methods of producing analgesia in a subject. In some cases, methods produce analgesia in a subject undergoing arthroscopic subacromial decompression surgery. The present disclosure also relates to improved sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises bupivacaine N-oxide at a level less than 1 wt %, based on weight of the composition. In some cases, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

Alkene carbonate-based anhydrous cooling fluids have low toxicity and electrical conductivity, and high heat capacity. The fluids provide corrosion protection to cooling systems and remain liquid below -30°C. Furthermore, the fluids exhibit low viscosity at low temperatures. Some formulations contain dehydrating orthoesters.

A composition comprising (a) a therapeutic agent or a pharmaceutically acceptable salt thereof; (b) a PEG (polyethylene glycol)-monoorthoester-lipid; (c) an amphiphilic lipid; (d) a cationic lipid and / or a [beta]-alanyl-prolyl-cysteine methyl ester; and optionally (e) a steroid and / or ceramide and / or DOPE. The composition is used as a medicament.

A method for the manufacture of high purity xanthate continuously in a system of reactors in a liquid organic medium by reacting caustic and alcohol to form alcoholate in a large circulating charge of previously reacted alcoholate at an elevated temperature, preferably no more than 110° C. A portion of the alcoholate is continuously withdrawn, cooled preferably to no more than 35° C. and rapidly dispersed with carbon disulfide to form xanthate in a large circulating charge of previously reacted xanthate while maintaining precise temperature control. Average contact time with byproduct water is 10 minutes. The product is continuously withdrawn and immediately dried to obtain in excess of 95% pure product.

The present application belongs to the technical field of mineral flotation, and particularly relates to N-substituted carbamoyl xanthate flotation collector and preparation method and application. Halogenated acyl compound is used as bridging structure, and fatty amine and xanthate are introduced into two ends thereof. Compared with the prior art, the present application has the beneficial effects that the flotation collector molecule of the present application contains two functional groups of amide group and xanthate group, and the synergistic effect of the two functional groups makes the collector molecule form stable adsorption on the surface of chalcopyrite, compared with the traditional flotation collector Z-200 or xanthate, the recovery rate of the flotation collector of the present application on chalcopyrite is better under the same low dosage condition. The flotation collector of the present application can realize efficient flotation of chalcopyrite under the natural pH condition of ore pulp; a one-pot two-step method is used, and water is used as solvent, so that the use of organic solvent is avoided; the reaction condition is mild, the operation process is less, and the product yield can be up to 94% or more, which is beneficial to industrial production.

The application discloses a preparation method of fezolinetant, and belongs to the technical field of medicinal chemistry. The cheap and easily obtained 2-halogenated-3-methyl pyrazine is used as a raw material in the route, and is sequentially reacted with hydrazine hydrate and ortho ester, and then is subjected to a hydrogenation reduction reaction to generate compound 4; the compound 4 is subjected to chiral resolution or chiral separation and condensation reaction with p-fluorobenzoyl halide to obtain intermediate compounds 5 or 5' and new intermediate compound 6. The compound 6 is reacted with a halogenating reagent to obtain compound 7; the compound 7 is subjected to Suzuki coupling reaction with compound 8 to obtain the compound fezolinetant of formula A; the route is simple in reaction, high in preparation efficiency, and the reaction yield of each step can be higher than 90%; the reaction condition is not harsh, the operation is safe, the post-treatment is simple, and the environmental pollution is small. The route is suitable for large-scale production, can obtain high-chiral products, and the chiral purity of the final product is as high as 99.5%, and has good market value and far-reaching practical significance.

A treatment composition that includes at least one perfume raw material and an esteramine or salt thereof, the esteramine or salt thereof may be obtained by a process of using catalytic amounts of at least one orthoester; and methods of treating an article or a surface, wherein the method comprises treating the article or surface with such treatment composition, optionally in the presence of water.

This application relates to the application and method of using orthoester compounds, and a vacuum insulation panel, belonging to the field of drying materials technology. The application includes using orthoester compounds as liquid desiccants. Orthoester compounds readily react with water at room temperature, efficiently capturing trace amounts of moisture in the system. Simultaneously, the reaction of orthoester compounds with water generates corresponding alcohols and esters. The generated alcohols and esters evaporate completely at low temperatures, leaving no residue, thus facilitating drying at low temperatures. Therefore, orthoester compounds can be used as liquid desiccants to efficiently remove trace amounts of moisture from the system at low temperatures, thereby improving drying efficiency.

The invention relates to a preparation method of methyl 3, 4-dihydroxy-5-methoxybenzoate, gallic acid is used as a raw material and reacts with trimethyl orthoformate or trimethyl orthoacetate, on one hand, the trimethyl orthoformate or trimethyl orthoacetate can protect o-diphenolic hydroxyl, on the other hand, the trimethyl orthoformate or trimethyl orthoacetate can also protect the o-diphenolic hydroxyl, and on the other hand, the trimethyl orthoformate or trimethyl orthoacetate can also protect the o-diphenolic hydroxyl; on the other hand, carboxyl esterification and 5-hydroxyl methylation can be performed to form 5-phenolic hydroxyl methylated and 3, 4-orthoester protected methyl benzoate as shown in a formula 1a or a formula 1b, and further acid solution treatment and deprotection are performed to prepare the target product 3, 4-dihydroxy-5-methoxy methyl benzoate. The preparation method is mild in reaction condition, simple in process, convenient to operate and high in product yield and purity, solves the problem of wastewater in a borax protection method, avoids using highly toxic dimethyl sulfate for methylation, is simple in process condition, convenient to operate and convenient to industrialize, and has extremely high application value.

To provide an injection chemical composition that can achieve both curability in water and foaming and curability in non-water environments, even after exposure to a high-humidity environment. [Solution] An injection solution composition comprising a first agent (A) containing an organic polyol and a second agent (B) containing an organic polyisocyanate, wherein the first agent (A) comprises an aqueous solution of sodium silicate (A-1), an organic polyol (A-2), and a tertiary amine catalyst (A-3), and the second agent (B) comprises an organic polyisocyanate containing a mixture of diphenylmethane diisocyanate and polymethylene polyphenyl polyisocyanate having 3 or more isocyanate functional groups (B-1), or a reaction product (B-1') of an active hydrogen group-containing compound and the mixture (B-1), and at least one hydrolyzable component (B-2) selected from the group consisting of orthoester compounds and acetal compounds.

Provided is a lung disease drug delivery carrier. The lung disease drug delivery carrier includes a disc particle having a diameter of 2 μm to 4 μm. The disc particle is injected into the human body. The disc particle includes a polymer selected from the group consisting of polyglycolic acid (PGA), polylactide (PLA), polyglycolide (PG), polyphosphazene, polyiminocarbonate, polyphosphoester, polyanhydride, polyorthoester, and combinations thereof, polylactide-co-glycolide (PLGA), and a drug. The disc particle is decomposed after 24 hours after being injected into the human body and delivers or releases the drug into a lung. The lung disease drug delivery carrier is accumulated in the lung, and the lung disease includes pulmonary fibrosis.