181 results about "Orthoester" patented technology

The present invention relates to fragrance delivery systems which comprise: A) from about 0.01% by weight of a pro-fragrance component which comprises pro-fragrances or pro-accords selected from at least two of the following: i) aldehyde and ketone releasing pro-fragrances, preferably an oxazolidine pro-fragrance; ii) β-amino pro-fragrances; and iii) orthoester pro-accords; and B) the balance carries and others adjunct ingredients.

Provided herein are methods and compositions for generating acids for use downhole, for example, to break fluid-loss control pills. The delayed-release acid breakers of the present invention comprise orthoesters and/or poly(orthoesters).

A hybrid contact lens includes a substantially rigid center portion and a substantially flexible skirt portion connected to the center portion. The skirt portion is formed using xerogels compatible with diluents comprising at least one selected from polylactic acid, polyglycolic acid, lactide, glycolide, a polyacetal, a cyclic acetal, a polyketal, a cyclic ketal, a polyorthoester, a cyclic orthoester, di-t-butyl-dicarbonate, tris(trimethylsilyl)amine, and 2,2,2-trifluoroacetamide. These diluents are formulated to function as a stand-in for water in the xerogel polymer, allowing the xerogel to form and bond to the rigid center portion in its fully expanded state. Upon hydration of the hybrid lens, substantially little dimensional change, and thus substantially little distortion, is obtained in the skirt portion. The diluents of the present invention further preserve the mechanical integrity of the xerogel, allowing the xerogel to be machined to final shape, improving the dimensional tolerances which can be achieved in the hybrid lens.

In one embodiment, the present invention provides a method of reducing the viscosity of a viscosified treatment fluid comprising contacting the viscosified treatment fluid with an acid generated from an orthoester composition that comprises an orthoester. In another embodiment, the present invention provides a method of reducing the pH of a viscosified treatment fluid comprising providing an orthoester composition that comprises an orthoester; contacting the viscosified treatment fluid with the orthoester composition; allowing the orthoester to generate a generated acid; and allowing the generated acid to at least partially reduce the pH of the viscosified treatment fluid. Embodiments of fracturing and gravel packing methods also are disclosed.

The invention relates to a catalytic composition comprising: a first component which is at least a component with one or more metals from groups 3A, 4A, 5A, 6A, 7A, 8, 1B, 2B, 3B, 4B; and a second component selected from (1) at least one ionic liquid which consists of a compound formed by cations and anions and which is a liquid at ambient temperature, (ii) a matrix to which the first component is bound or on which it is supported, and (iii) a combination of the two. The invention relates to the use of said catalytic composition in a method for the insertion of carbon dioxide into an organic compound and, preferably, a compound selected from epoxides, acetals and orthoesters. The invention also relates to catalytic compositions comprising said metallic compounds.

A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention provides water-soluble polymers bearing a terminal carboxylic acid or ester thereof, intermediates and reagents useful in carrying out the method, as well as gels, pharmaceutical formulations, conjugates related to the described water-soluble polymer derivatives.

A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed.

In an embodiment, a method is provided including the steps of: (A) introducing a well fluid comprising an electron-poor orthoester into a well; and (B) allowing or causing the electron-poor orthoester to hydrolyze to produce an acid and an alcohol in the well. In another embodiment, a water-based well fluid is provided, the well fluid including: (A) a continuous aqueous phase having a pH of a least 6; (B) an electron-poor orthoester; and (C) a viscosity-increasing agent.

The invention provides a fluid for use in a subterranean formation penetrated by a wellbore, the fluid comprising: (a) water; (b) an orthoester; and (c) a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the following formula:

wherein R is an alkyl group or aryl group, and wherein X and Y are each independently at least one. The invention also provides a method of fracturing a subterranean formation, comprising the step of forming a foamed fracturing fluid comprising water; an orthoester; a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the formula above; and a gas. The method also provides the step of introducing the foamed fracturing fluid into a subterranean formation at a pressure sufficient to create a fracture in the subterranean formation.

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.

The invention relates to a coating composition wherein orthoester groups block the hydroxyl groups of the poly(meth)acrylate wherein the orthoester groups can be removed through hydrolysis in order to facilitate cross-linking through reaction with isocyanate compounds. The invention also relates to a process for curing the aforementioned coating composition. The invention also relates to a process for coating substrates wherein a clear coat comprising the aforementioned coating composition is coated over a base coat. The invention also relates to a process for blocking the hydroxyl groups of a poly(meth)acrylate compound through reaction with an orthoester compound.

The invention provides a method for synthesizing difluprednate from a sterol fermentation product. The sterol fermentation product, namely 9 Alpha-hydroxyl-androstane-1,4-diene-3,17-diketone (9 Alpha-OH-AD) obtained by fermenting phytosterol of which the content in byproducts of the grease industry is very high, serves as a starting raw material. The method comprises the following 15 reaction steps in total: dehydrating steride 9-hydroxyl to form a double-bond; adding 17-carbonyl with acetylene; dehydrating; producing 21-copper carbonyl under an acid condition; epoxidizing 16,17-double bond; oxidizing periodide and introducing 21-hydroxyl; performing ring opening on 16,17 Alpha-epoxy hydrobromate; hydrogenating for removing 16 Beta bromine; forming a ring on orthoester; performing ring opening; esterifying; epoxidizing 9,11-double bond-Beta; enolizing and esterifying; performing ring opening on 6-electrophilic fluoro; and performing ring opening on 9,11-epoxy fluoro. According to the method, steride 17 Alpha and 21-dyhydroxyl are efficiently built by means of periodide oxidization, epoxide ring-opening and debromination and an important intermediate type 11 compound is obtained; in the whole process, a large quantity of heavy metal pollutant chromium which is generated when producing corticoid medicines in the traditional industry is effectively avoided, so that the method is green, environment-friendly and suitable to industrialized production.

The invention pertains to a coating composition comprising a) a first compound comprising at least one bicyclo-orthoester group, p0 b) a second compound comprising at least two isocyanate groups, and c) a third compound comprising at least one thiol group. The invention also relates to a process for curing the present coating composition. More particularly, the latent hydroxyl groups of the bicyclo-orthoester groups have to be deblocked and reacted with the isocyanate-groups of the second compound if the present coating composition is to be cured.

The present invention relates to binder compositions containing sulphonate-functional polyisocyanates and one or more polyorthoester and/or bicyclo orthoester groups which are either chemically incorporated into the sulphonate-functional polyisocyanates or present in admixture with the sulphonate-functional polyisocyanates. The present invention also relates to a process for preparing these binder compositions from either OH functional polyorthoesters or from bicyclo orthoesters, and to coating, adhesive and sealant compositions containing the binder compositions of the invention.

The invention provides a non-aqueous electrolyte including: lithium salt, a non-aqueous solvent and an additive which includes trimethsilane isocyanate and orthoester. The invention also provides a lithium ion battery containing the non-aqueous electrolyte. The trimethsilane isocyanate and the orthoester serve as special additives in the electrolyte, which effectively improve high-temperature performance of the battery. The non-aqueous electrolyte with equal-amount addition of the special additives, compared with non-aqueous electrolytes with other common additives in the prior art, can greatly improve the high-temperature performance of the produced battery.

The invention relates to a synthesis method of an amphiphilic block polymer of which the side chain contains acid-sensitive matrixes (ortho-esters), a delivery carrier thereof and a pH-sensitive controlled-release micelle pharmaceutical composition containing an activator. The pharmaceutical composition can be a partial controllable delivery preparation formulation or an injectable preparation formulation for the activator. Hydrophobic medicines can be loaded in the micelle easily by using a simple method, and the polymeric pharmaceutical composition can greatly improve the intracellular transmission efficiency of medicines and the killing efficiency of cancer cells.