66results about How to "Improve intake efficiency" patented technology

The invention belongs to the field of biotechnology, and specifically, relates to a tumor-targeting double-drug carrying and delivery system and a preparation method thereof. The tumor-targeting double-drug carrying and delivery system adopts high-molecular materials, polyethylene glycol, a polypeptide, a treatment gene and a chemotherapeutic drug, wherein the polypeptide is utilized as a targeting head and the high-molecular materials are utilized as base high-molecular carriers. The preparation method comprises that the chemotherapeutic drug of adriamycin and the like are inserted into double chains of the treatment gene to form a gene-chemotherapeutic drug compound; and through electrostatic interaction between the gene chemotherapeutic compound and the base high-molecular carriers, the tumor-targeting double-drug carrying and delivery system which simultaneously carries the treatment gene and the chemotherapeutic drug is obtained. The high-molecular materials are novel polypeptide-modified high-molecular materials, are selected by a phage display technology, and can enter into cells by endocytosis, and thus the gene and chemotherapeutic drug intake capability of tumor cells are improved and safety is improved. The polypeptide (T7) as the targeting head has advantages belonging to transferrin, can effectively avoid interferences from endogenous transferrin, has high targeting and treatment efficiency, is easy for preparation, and can be further developed and be utilized for targeting treatment on other tumor tissue.

This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstrictive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.

The invention belongs to the technical field of biotechnology, and relates to a tumor-targeted diagnosis nuclear magnetic resonance contrast agent and a preparation method thereof. The tumor-target diagnosis nuclear magnetic resonance contrast agent is prepared from a high molecular material, polyethylene glycol, a polypeptide, a dual-function ligand and gadolinium chloride by taking the polypeptide as a target head group, taking the tree-like high polymer material as a basic high molecular vector and connecting a small molecular contrast agent to the surface. In the invention, a polypeptide-modified high molecular material screened by using a phage display technology enters cells in an endocytic way, so that the introjection of the contrast agent by tumor cells is increased, and the characteristic of high safety is achieved. The target head group polypeptide used in the invention has the advantages of transferrin, can be used for effectively avoiding the interference of endogenous transferrin, has high targeting and diagnosing efficiencies, is simple to prepare, and can be further applied to target diagnosis of other tumor tissues.

The present invention relates to a metallocene complex and a method for manufacturing an olefin polymer. The present invention provides a metallocene complex with which homopolypropylene that has a high melting point can be manufactured in homopolymerization of propylene, and a method for manufacturing olefin polymers using same. The metallocene complex is represented by general formula (I). (Thedefinitions of the substituents in formula (I) are the same as set forth in the Specification).

The invention belongs to the field of microbial biotechnologies and environmental biotechnologies, in particular relates to salt-tolerant Rhodococcus sp. JH, a biological emulsifier generated by fermenting the Rhodococcus sp. JH and application of the Rhodococcus sp. JH in the bioremediation of petroleum polluted saline-alkali soil. The salt-tolerant Rhodococcus sp. JH is a Rhodococcus sp. JH strain, is preserved in the China general microbiological culture collection (CGMCC) on November fourth, 2009 and has CGMCC No.3388. Biological emulsifier-contained fermenting liquor which is produced by fermenting and culturing the CGMCC No.3388 bacterium provided by the invention in an inorganic salt culture medium using hydrocarbon as a unique carbon source can be directly applied to the petroleum polluted saline-alkali soil to improve the degrading rate of microorganisms on petroleum hydrocarbon and the bioremediation of the petroleum polluted saline-alkali soil.