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66results about How to "Improve intake efficiency" patented technology
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Slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system, and preparation method thereof
InactiveCN103705465AIncrease intakeSmall toxicityPowder deliveryGenetic material ingredientsDendrimerTumor target
The invention belongs to the field of biotechnology, and relates to a slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system, and a preparation method thereof. The slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system is prepared via self-assembly of a slightly acidic environment targeted polypeptide modified dendrimer encapsulated gene, wherein the surface of the dendrimer is rich of amino groups. According to the preparation method, a polypeptide of transmembrane helix protein C derived from bacteria visual purple is used for modifying a high molecular carrier, enrichment and adhesion onto cells is realized via a pH sensitive cell membrane insertion method, and entering into cells is realized via electrostatic adsorption guided endocytosis, so that untaking of tumor cells on drugs is improved, and toxic and side effects are reduced. According to the tumor targeted nano drug delivery system, cell membrane is taken as the target point, and the polypeptide is taken as the target head group in tumor slightly acidic environment, targeting and curing efficiency are high, the preparation method is simple and convenient, and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.
Owner:FUDAN UNIV
Biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle and preparation method thereof
ActiveCN102416181ASignificant photoactivityFast releasePowder deliveryPharmaceutical non-active ingredientsChemical synthesisPolyester
The invention provides a biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle and a preparation method thereof, which relate to the field of novel chemical synthesis medicaments and preparations thereof and are used for solving the problem that a high-polymer-platinum (IV) bonded medicament does not have optical activity in the prior art. In an anticancer medicament, ethylene glycol-b-polyester-b-polylysine serving as a biodegradable triblock copolymer or polyethylene glycol-b-poly(ester-co-carbonic ester) serving as a diblock copolymer is taken as a carrier polymer, and Pt (IV) is a photoactive tetravalent platinum composition coordinated with dihydroxyl in the axial direction. The invention further provides a preparation method of the biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle. The anticancer medicament prepared with the method has remarkable optical activity; under the irradiation of UV (Ultraviolet) of 365 nanometers, Pt (IV) is reduced into Pt (II); a cis-platinum or oxaliplatin antitumor active part is contained; and the mass content of platinum can be up to 10-20 percent.
Owner:吉林市博禹祥实工贸有限公司
Reconstitutable microecological gel for sea cucumber and abalone culture and preparation method thereof
InactiveCN102894219APromote healthy growthImprove intake efficiencyAnimal feeding stuffMicroorganismAdditive ingredient
The invention provides reconstitutable microecological gel for sea cucumber and abalone culture and a preparation method thereof and relates to sea cucumber and abalone breeding feed. The gel comprises, by mass ratio, kelp: nutritional agent: gel fixing agent: moisture=1:0-1: 0.016-0.15:0.2-3. The content of beneficial microorganisms is 1*104-1*1010 per gram. During preparation, the kelp is smashed, water and the nutritional agent are added and mixed evenly, the gel fixing agent is added, the mixture is mixed evenly and boiled, beneficial microbial suspension is added and mixed evenly after the temperature drops to below 50 DEG C, and the mixture is pour into a container to be cooled, solidified and dried so as to obtain the reconstitutable microecological gel for the sea cucumber and abalone culture. The reconstitutable microecological gel is formed by fixing various ingredients through algal polysaccharides, and the gel can be ingested by sea cucumbers or abalones after reconstitution and is used for embedding materials good for growth of the sea cucumbers and the abalones such as probiotics and the nutritional agent. The gel can be used effectively because the gel is prevented from being diluted by seawater.
Owner:THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
Oligoarginine covalently modified chitosan, and preparation method, screening and application thereof
InactiveCN105218699AImprove intake efficiencyEasy to prepareOther foreign material introduction processesVector-based foreign material introductionArginineSynthesis methods
The invention provides a novel carrier CS-g-Rn a series of oligoarginine (Arginine, called R for short, R2-R7) covalently modified chitosan, and an in-vivo and in-vitro application research for preparing nanoparticles through loading DNA and functional siRNA by using the highly effective carrier. The oligoarginine is covalently combined to the free amino group of a chitosan molecule through a one-step synthesis method, the prepared new carrier maintains the safety of chitosan, and the new carrier and nucleic acid with the negatively charged surface undergo complex coacervation to prepare the nanoparticles, so the nucleic acid delivery efficiency is effectively improved. The nanoparticles prepared through loading of the functional siRNA on CS-g-Rn have good treatment effects in vivo and in vitro, and have good application prospect.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Evaporative Cooler and Use Thereof and Gas Turbine System Featuring an Evaporative Cooler
InactiveUS20100101234A1Improve cooling effectImprove wettabilityAnodisationTurbine/propulsion engine coolingEvaporative coolerGas turbines
An evaporative cooler for cooling a gas stream, in particular an air stream, including a number of cooling elements located in a flow channel, is provided. A liquid, preferably water, is supplied by a feed device and will be vaporized or evaporated. In one aspect, the surface of at least one of the cooling elements has hydrophilic properties, at least in one sub-region designed to form a liquid film.
Owner:SIEMENS AG
Carboxymethyl chitosan nanoparticles modified with glycyrrhizic acid, preparation method and application thereof
InactiveCN102357079AAchieve active targetingSmall toxicityPowder deliveryPharmaceutical non-active ingredientsDiseaseHydrophobic polymer
The invention belongs to the technical field of nano materials, and in particular relates to carboxymethyl chitosan nanoparticles modified with glycyrrhizic acid, as well as a preparation method and application thereof. The nanoparticles disclosed by the invention are in a core-shell type; a hydrophobic polymer serves as a kernel packaged medicament; and carboxymethyl chitosan serves as a hydrophilic shell and is covalently linked with hepatic targeting ligand glycyrrhizic acid. The preparation method comprises the following steps of: firstly grating and copolymerizing carboxymethyl chitosan and hydrophobic monomers and self-assembling to form nanoparticles in the action of an initiator; secondly, oxidizing glycyrrhizic acid to obtain a glycyrrhizic acid aldehyde solution, mixing the glycyrrhizic acid aldehyde solution with the nanoparticles at a certain proportion and introducing targeting groups, and carrying out ultrasonic loading on the medicament. Compared with the prior art, the preparation method is simple and easy to control and has good repeatability and better stability and safety; and the targeting property and the tumor-inhabiting effect of the anti-tumor medicament can be strengthened remarkably. The nanoparticles serve as a targeting delivery vector for hydrophobic medicaments or molecular probes and can be used for treatment and diagnosis of liver diseases.
Owner:FUDAN UNIV
Tumor targeted polypeptide-adriamycin amycin derivative as well as preparation method and application thereof
ActiveCN103908677AHigh purityHigh yieldOrganic active ingredientsPharmaceutical non-active ingredientsTumor targetHydrazone
The invention relates to a tumor targeted polypeptide-adriamycin amycin derivative as well as a preparation method and application thereof. The compound is prepared by virtue of the following steps: dissolving polypeptide in a phosphate buffer solution with the pH value of 7.8-8.2; then, dissolving DOXO-EMCH in a solvent to obtain a solution, wherein the polypeptide is T10 peptide or T15 peptide and the solvent is a mixture of water and N,N'-dimethylformamide; dropwise adding the DOXO-EMCH solution into a polypeptide solution; stirring and reacting away from sunlight at room temperature; then, centrifugalizing the solution to remove precipitate to obtain a coarse product; separating and purifying the coarse product by preparative chromatography, and centrifugalizing and concentrating to obtain a fine product T10-DOX-EMCH or T15-DOX-EMCH. According to the adriamycin amycin hydrazone compound provided by the invention, the hydrazone bond is selectively broken in an acidic microenvironment of tumor to release adriamycin amycin with pharmacological activity, so that the curative effect of medicine is improved and the drug tolerance of tumor is reversed.
Owner:南京明捷生物医药检测有限公司
Self-oxygen-supply hollow Prussian blue nanoparticle as well as preparation method and application thereof
ActiveCN113456816AGood light and heat stabilityHigh drug loadingHeavy metal active ingredientsPhotodynamic therapyDrug loading doseTumor cell apoptosis
The invention discloses a self-oxygen-supply hollow Prussian blue nanoparticle and a preparation method and application thereof. The self-oxygen-supply hollow Prussian blue nanoparticle is provided with a hollow Prussian blue nanoparticle body, hemoglobin and IR783 are loaded on a mesoporous shell layer and an internal hollow structure of the hollow Prussian blue nanoparticle body, the drug loading capacity of the hemoglobin is 61.5%-63.5%, and the drug loading capacity of the IR783 is 24.2%-27.5%. The self-oxygen-supply hollow Prussian blue nanoparticle loaded with hemoglobin and IR783 prepared by the invention can improve the condition of insufficient oxygen supply in photodynamic therapy; in addition, since the half-life period of active oxygen generated by the photodynamic therapy is very short and the active oxygen is effective only in a relatively short distance, loading of IR783 with a mitochondrial targeting function is conducted in the invention, the self-oxygen-supply hollow Prussian blue nanoparticle body loaded with hemoglobin and IR783 is conveyed to mitochondria, so a mitochondrial function is destroyed, photodynamic therapy effect is remarkably improved, and tumor cell apoptosis is promoted.
Owner:HUAQIAO UNIVERSITY
Air intake device for watercraft
InactiveUS20060223392A1Suppresses noise generationImprove intake efficiencyWaterborne vesselsMachines/enginesWatercraftAir cleaners
An air intake device for a watercraft adapted to suppress noise generating from an intake system of an engine and can obtain good intake efficiency. The air intake device includes intake ports opening to a side surface of the engine, and an air cleaner located on the rear side of the engine. An outlet of the air cleaner is connected through an intake passage to the intake ports of the engine. An air duct extends from an inlet of the air cleaner along the side surface of the engine to the position corresponding to the front end of the engine. The air duct has a front opening that faces downward.
Owner:HONDA MOTOR CO LTD
Alpha helix cationic polypeptide as well as preparation method and application of alpha helix cationic polypeptide
ActiveCN108003343AEndocytosis into goodExcellent membrane penetrating activityPowder deliveryEnergy modified materialsDiseaseCancer cell
The invention provides an alpha helix cationic polypeptide as well as a preparation method and application of the alpha helix cationic polypeptide. The alpha helix cationic polypeptide takes a photosensitizer porphyrin as a core and alpha helix polypeptides as four arms, and a nucleotide drug prepared from the polymer can be applied to a nucleotide drug delivery system. The polymer provided by theinvention has good biocompatibility, low cytotoxicity and light activation ability. The polymer provided by the invention is self-assembled in a water solution to form nanoparticles which has good stability, biocompatibility and low cytotoxicity; the preparation method is simple and high in repeatability, and the polymer serving as a carrier is not only capable of protecting nucleic acid such asDNA from being degraded, but also capable of being combined with the scale effect of the nanoparticles so as to be used for treating diseases; and in addition, the transfection promoting effect for different cancer cells can be achieved by virtue of the light activation ability.
Owner:SUZHOU UNIV
Antineoplastic hydrogel polypeptide and preparation method
InactiveCN109651512AEliminate side effectsReduce economyPeptide/protein ingredientsAntibody mimetics/scaffoldsCytoplasmAqueous solution
The invention provides antineoplastic hydrogel polypeptide and a preparation method. The polypeptide comprises a self-assembling structural domain at the C end and a killing structural domain at the Nend, and the self-assembling structural domain is connected with the killing structural domain through a flexible structural domain. According to an antineoplastic melittin hydrogel slow-releasing agentia, the antineoplastic hydrogel polypeptide carries antineoplastic active polypeptide to obtain the agentia. The preparation method comprises the following steps that 1), an antineoplastic hydrogelpolypeptide aqueous solution and an antineoplastic active polypeptide aqueous solution are prepared; 2), the antineoplastic hydrogel polypeptide aqueous solution and the antineoplastic active polypeptide aqueous solution which are prepared in the step 1) are mixed to obtain a mixed solution; 3), an NaCl solution is dropwise added into the mixed solution prepared in the step S2 until the concentration of the NaCl solution is 0.9%, and after standing, the antineoplastic melittin hydrogel slow-releasing agentia is prepared. The technical purposes of promotion of the uptaking efficiency of activepolypeptide cells, cytoplasm location, preparation of the antineoplastic hydrogel polypeptide and the preparation method can be achieved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Tumor-targeting double-drug carrying and delivery system and preparation method thereof
InactiveCN102397554BPlay synergistic effectImprove intake efficiencyOrganic active ingredientsMacromolecular non-active ingredientsTumor targetingPolyethylene glycol
Owner:FUDAN UNIV
Anti-tumor macromolecular prodrug compound, and preparation method and application thereof
ActiveCN105797169AGood tumor targetingImprove intake efficiencyHydroxy compound active ingredientsKetone active ingredientsActive componentTherapeutic effect
The invention discloses an anti-tumor macromolecular prodrug compound, and a preparation method and application of the anti-tumor macromolecular prodrug compound. The anti-tumor macromolecular prodrug compound is prepared from heparin or a derivative-a doxorubicin type macromolecular prodrug of the heparin and a hyaluronic acid-natural active component type macromolecular prodrug in a compounding way. The invention also provides the preparation method of the anti-tumor macromolecular prodrug compound and the application of the anti-tumor macromolecular prodrug compound in preparing anti-tumor drugs. Compared with the prior art, by compounding two kinds of macromolecular prodrugs, not only are multiple tumor targeting properties obtained, but also multi-drug resistance of tumor can be effectively reversed; the two kinds of macromolecular prodrugs work together and are in mutual synergy, so that the treating effect is obviously enhanced.
Owner:CHINA PHARM UNIV
Structural molecule for affinity and target cell uptake capability of enhanced integrin receptor and application thereof
ActiveCN107226844AEnhanced target affinityFirmly connectedPeptidesPharmaceutical non-active ingredientsDiseaseNucleotide
The invention discloses a structural molecule for affinity and target cell uptake capability of enhanced integrin receptor. The structural molecule has a molecular structure shown in a formula (I); the structural molecule is obtained by carrying out reaction between two cRGD oligopeptides and 6-aminocaproic acid, glutamate oligopeptide or / and arginine oligopeptide, 8-amino-3,6-dioxaoctanoic acid or 3-maleimidopropionic acid and the like to perform dehydration condensation on amino and carboxyl. According to the structural molecule disclosed by the invention, tumor cells expressing an alpha v beta 3 receptor and neovascular endothelial cells can be specially combined, the carried molecules such as nucleotide enter cytoplasm through receptor-mediated endocytic uptake, so that the uptake efficiency of expression cells of the alpha v beta 3 receptor is improved and the release of the carried molecules from a target cytoplasm endosome is promoted, and therefore, the structural molecule can be applied to preparation of targeted therapy drugs or disease diagnosis tracer agents.
Owner:WUHAN ZEZHI BIOLOGICAL PHARMA
Methods of device-assisted drug delivery
InactiveCN101022771AImprove bioavailability indexHigh speedPharmaceutical delivery mechanismBandagesDiagnostic agentVasoconstrictor Agents
Owner:BIOCHEMICS
Dendritic cell targeted affinity peptide TY peptide and application thereof
ActiveCN109021078APromote maturityImprove intake efficiencyPowder deliveryPeptidesDendritic cellTumor therapy
Belonging to the tumor therapy protein related technical field, the invention specifically relates to a dendritic cell (DC) targeted affinity peptide TY peptide and application thereof. The TY peptideis 12 peptide, and the specific amino acid sequence is TITHFQFGPTVY. Based on the TY peptide, the invention further designs a novel nano-transportation system capable of targeting DC on the basis ofMSN, and loads the model antigen OVA and immunoadjuvant CpG to prepare the nano-carrier MSN(mesoporous silica nanoparticles)-TY / OVA / CpG successfully. Experiments indicate that: the MSN-TY / OVA / CpG canbe effectively ingested by immature DC, thus improving the efficiency of antigen ingestion by DC, promoting the maturation of DC and effectively activating DC, also effectively promoting antigen processing and presentation, stimulating secretion of cytokines, and further triggering antigen-specific CTL immunoreaction and anti-tumor immunoreaction.
Owner:ZHENGZHOU UNIV
Tumor-targeted diagnosis nuclear magnetic resonance contrast agent and preparation method thereof
InactiveCN102397564BImprove intake efficiencyImprove diagnostic efficiencyIn-vivo testing preparationsTumor targetingPolyethylene glycol
The invention belongs to the technical field of biotechnology, and relates to a tumor-targeted diagnosis nuclear magnetic resonance contrast agent and a preparation method thereof. The tumor-target diagnosis nuclear magnetic resonance contrast agent is prepared from a high molecular material, polyethylene glycol, a polypeptide, a dual-function ligand and gadolinium chloride by taking the polypeptide as a target head group, taking the tree-like high polymer material as a basic high molecular vector and connecting a small molecular contrast agent to the surface. In the invention, a polypeptide-modified high molecular material screened by using a phage display technology enters cells in an endocytic way, so that the introjection of the contrast agent by tumor cells is increased, and the characteristic of high safety is achieved. The target head group polypeptide used in the invention has the advantages of transferrin, can be used for effectively avoiding the interference of endogenous transferrin, has high targeting and diagnosing efficiencies, is simple to prepare, and can be further applied to target diagnosis of other tumor tissues.
Owner:FUDAN UNIV
Preparation method of mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for hepatoma cell
ActiveCN104587473AImplement responsive releaseImprove effectivenessDigestive systemPharmaceutical non-active ingredientsSide effectApatite
The invention discloses a preparation method of a mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for a hepatoma cell, belonging to the field of biomedical materials. The invention aims at solving the problems that the current drug carrier is high in toxic and side effects and low in degradability. The preparation method comprises the steps of firstly, preparing a template agent; secondly, preparing a mesoporous hydroxylapatite nanoparticle; thirdly, aminating mesoporous hydroxylapatite; fourthly, carboxylating mesoporous apatite; fifthly, preparing disulfide bond functionalized mesoporous apatite; and sixthly, preparing the mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property. The mesoporous apatite nano-drug carrier prepared by using the preparation method can be used for recognizing hepatoma cells in a targeting way, so that the uptake of the normal tissues to the drug is reduced, and the in-vivo toxic and side effects of the drug are reduced. The drug is regularly and quantitatively introduced to pathological tissues, so that the utilization ratio of the drug is increased.
Owner:HARBIN INST OF TECH
Veterinary enrofloxacin solid lipid nanosuspension and preparation method thereof
ActiveCN107982214AHigh encapsulation efficiencyHigh drug loadingAntibacterial agentsOrganic active ingredientsAntioxidantActive agent
The invention belongs to the technical field of preparation of veterinary drugs and particularly relates to a veterinary enrofloxacin solid lipid nanosuspension and a preparation method thereof. The technological production of a preparation is implemented with a high-pressure homogenization technique. In terms of W / V, a suspension injection is prepared from 12%-35% of a solid lipid substrate, 2%-6% of crude enrofloxacin, 0.2%-4% of an active agent, 0.2%-1% of an antioxidant and the balance of sterile water. The solid lipid substrate is good in physiological compatibility and biodegradable, theencapsulation efficiency and drug loading capacity of nanoparticles are high, the preparation method is simple, the production cost is low, and large-scale industrial production is easy. The solid lipid nanosuspension has an obvious slow-release effect, in-vivo absorption and in-cell intake of active molecules can be increased, clinical administration times can be reduced, and the nanosuspensionis non-irritant to target animals and can be used for preventing and treating bacterial digestive tract and respiratory diseases of pigs and chicken.
Owner:HUAZHONG AGRI UNIV
Preparation method of ultra-small-size iron oxide nanoparticles and application thereof
InactiveCN110680931ADoes not affect positive reinforcement propertiesInefficient uptakeNanomagnetismFerric oxidesPhysical chemistryIron oxide nanoparticles
The invention provides a preparation method of ultra-small-size iron oxide nanoparticles. The method comprises the following steps: dissolving ferric acetylacetonate in diethylene glycol with the concentration of 0.02-0.16 mol / L in the diethylene glycol, carrying out thermal decomposition on ferric acetylacetonate in an inert gas environment at 200-220 DEG C until a reaction system is converted into a black solution from reddish brown, and carrying out steps of heating reflux, cooling, separating and purifying. The invention further provides an application of the ultra-small-size iron oxide nanoparticles prepared by the preparation method in preparation of an MRI cell tracer. The preparation method is simple, the preparation method is simple, various parameters are easy to control, the prepared iron oxide nanoparticles are accurately controlled within the range of 2-5 nm, the prepared iron oxide nanoparticles are very sensitive to the influence of water quantum MRI signals of marked cells, the positive contrast of the ultra-small-size iron oxide nanoparticles serving as a contrast agent is enhanced, and positive enhancement is displayed for magnetically marked cells in an MRI image.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Application of heterocyclic compound containing at least two sulfur atoms to preparation of nano vaccine and prepared nano vaccine
PendingCN113546168AImprove intake efficiencyEnhance cross-presentationAntibacterial agentsOrganic active ingredientsMolecular biologyTGE VACCINE
The invention relates to the technical field of immunotherapy or vaccine prevention and treatment, in particular to a heterocyclic compound containing two or more sulfur atoms and an application of the heterocyclic compound to preparation of a nano vaccine. The invention provides an application of the heterocyclic compound which contains at least two sulfur atoms and can be covalently or non-covalently connected with polypeptide to preparation of the nano vaccine. Nanoparticles prepared by self-assembly of the compound and an antigen can enter dendritic cytoplasm in a transmembrane mode, and the uptake efficiency of the antigen and an immunologic adjuvant is improved. In the process of entering the cells, biodegradation of an enzyme body in lysosome on antigens or nucleic acid adjuvants can be effectively avoided or reduced, so that the nano vaccine disclosed by the invention can efficiently activate the dendritic cells and improve the cross presentation effect on the antigens, further CD8 + T cells can be effectively activated, and proliferation of the T cells can be promoted. Therefore, the nano vaccine provided by the invention can prevent tumor cell proliferation and virus infection by utilizing efficient immune activation and immune regulation effects.
Owner:苏州维益生物科技有限公司
Intake pipe of internal combustion engine
ActiveUS20090101099A1Improve intake efficiencySufficient improvement in intake efficiencyInternal combustion piston enginesAir intakes for fuelEngineeringInternal combustion engine
An intake pipe of an internal combustion engine includes a main flow passage allowing air introduced into the engine to flow therethrough, an upper branch flow passage branching off from the main flow passage and communicating with #2 cylinder, #4 cylinder, and #6 cylinder, a lower branch flow passage branching off from the main flow passage sand communicating with #1 cylinder, #3 cylinder, and #5 cylinder, and a partition wall allowing the upper branch flow passage and the lower branch flow passage to be apart. The partition wall has an end portion that faces the main flow passage. The end portion is formed of a spherical surface. With such a configuration, the intake pipe of the internal combustion engine, which intake pipe provides sufficient improvement in intake efficiency, is provided.
Owner:TOYOTA JIDOSHA KK
Metallocene complex and method for manufacturing olefin polymer
ActiveCN110483670AImprove intake efficiencyHigh melting pointMetallocenesPolymer sciencePolypropylene
Owner:JAPAN POLYPROPYLENE CORP
RI7217 and muscone co-modification DTX long-circulation lipidosome, preparation method and application
PendingCN112675310AImprove intake efficiencyLarge doseOrganic active ingredientsPharmaceutical non-active ingredientsEgg phospholipidsPolythylene glycol
The invention relates to a preparation method of RI7217 and muscone co-modification DTX long-circulation lipidosome. The preparation method comprises the following steps of: S1: firstly, carrying out amination modification on a muscone ring, and enabling the amination muscone and distearoyl phosphatidyl acetamide-N-hydroxy succinimide-polyethylene glycol to react to synthesize and prepare distearoyl phosphatidyl ethanolamine-polyethylene glycol-muscone; and S2: taking distearoyl phosphatidyl ethanolamine-polyethylene glycol-maleimide maleophthalimide, distearoyl phosphatidyl ethanolamine-polyethylene glycol, distearoyl phosphatidyl ethanolamine-polyethylene glycol-muscone copolymers, egg yolk lecithin and cholesterol as materials, preparing the lipidosome by a film dispersion method, and then, through covalent linkage of a maleimide group on the surface of the lipidosome and sulfhydrylation RI7217, preparing RI7217-LP and RI7217-LP-M.
Owner:康爽明
Biomimetic multifunctional lipoprotein nanoparticle modified by biological peptide and preparation method and application thereof
ActiveCN113134097AHigh encapsulation efficiencyImprove bioavailabilityPowder deliveryNervous disorderA lipoproteinBiogenic peptide
The invention discloses a biomimetic multifunctional lipoprotein nanoparticle modified by biological peptide and a preparation method and application thereof, the multifunctional biomimetic lipoprotein nanoparticle is composed of a biomimetic lipoprotein nano-carrier shell modified by biological peptide and a nano-form drug core, and the carrier shell is composed of apolipoprotein bionic peptide, biological peptide and natural phospholipid substitute. The preparation method comprises a film dispersion method and an emulsification evaporation method. The preparation method disclosed by the invention is simple and mild in condition and low in cost, and the prepared biological peptide modified biomimetic multifunctional lipoprotein nanoparticle has the advantages of high drug loading capacity, high biomimetic property, strong penetrability, biological safety, lesion site targeting property, drug loading mode diversity and the like. A nano-drug delivery platform can realize 'diagnosis and treatment integration' and 'multi-mode combined treatment', and can realize timely diagnosis and efficient treatment of complex progressive diseases such as tumors, neurodegenerative diseases and the like.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Preparation method and application of nanocomposite material for inhibiting postoperative tumor recurrence
ActiveCN109528736AEvenly distributedLittle effect on activityOrganic active ingredientsInorganic non-active ingredientsNano compositesBiocompatibility Testing
The invention discloses a preparation method and application of a nanocomposite material for inhibiting postoperative tumor recurrence. The method has the advantages of simple preparation, uniform distribution of nano-drugs, little influence on loaded drug activity and the like. At the same time, the prepared nanocomposite material has good mechanical properties and biocompatibility, and can be implanted in a body for long-term drug sustained release. Polycaprolactone is used as a bulk material, mesoporous silica nanoparticles are used as a drug carrier, doxorubicin is used as a chemotherapeutic drug, the biodegradable nanocomposite material doped with inorganic nano-drugs is prepared by a solvent-free low-temperature ball milling method, doped nanoparticles are uniformly distributed in the bulk polymer material, and the nanocomposite material has mechanical properties of the bulk polymer material. A new method is provided for preparing the nanocomposite material and realizing implantable localized delivery of anticancer drugs, and the nanocomposite material is hopeful to be applied to inhibition of postoperative tumor recurrence.
Owner:NANJING UNIV OF POSTS & TELECOMM
Salt-tolerant Rhodococcus sp. JH for generating biological emulsifier and degrading alkane and application thereof in bioremediation of petroleum polluted saline-alkali soil
InactiveCN101974446BPromote degradationImprove intake efficiencyBacteriaContaminated soil reclamationAlkaneAlkali soil
The invention belongs to the field of microbial biotechnologies and environmental biotechnologies, in particular relates to salt-tolerant Rhodococcus sp. JH, a biological emulsifier generated by fermenting the Rhodococcus sp. JH and application of the Rhodococcus sp. JH in the bioremediation of petroleum polluted saline-alkali soil. The salt-tolerant Rhodococcus sp. JH is a Rhodococcus sp. JH strain, is preserved in the China general microbiological culture collection (CGMCC) on November fourth, 2009 and has CGMCC No.3388. Biological emulsifier-contained fermenting liquor which is produced by fermenting and culturing the CGMCC No.3388 bacterium provided by the invention in an inorganic salt culture medium using hydrocarbon as a unique carbon source can be directly applied to the petroleum polluted saline-alkali soil to improve the degrading rate of microorganisms on petroleum hydrocarbon and the bioremediation of the petroleum polluted saline-alkali soil.
Owner:BINZHOU UNIV
Effective and safe preparation method of oral recombinant human lactoferrin sericin nanoparticles and application
PendingCN111375053AInhibit inflammationSuitable for mass productionPeptide/protein ingredientsDigestive systemOral treatmentEngineering
The invention provides an effective and safe preparation method of oral recombinant human lactoferrin sericin nanoparticles and an application. Uptake efficiency of rhLF cells can be improved, LPS induced macrophage inflammation can be inhibited, and DSS-induced acute colitis can be treated. The sericin nanoparticles containing rhLF are prepared from rhLF transgenic silkworm cocoons as a raw material, by sericin extraction, dialysis and ethanol induction, and are directly used for oral administration treatment of colitis. The sericin nanoparticles are suitable for large-scale production, simple to operate, and high in application value.
Owner:SOUTHWEST UNIVERSITY
Steel ball surface development device and method
ActiveCN104267039AImprove fullyAvoid missing detectionMaterial analysis by optical meansSortingImaging processingMetallurgy
The invention discloses a steel ball surface development device and method. The steel ball surface development device comprises at least two rolling bars, an accommodating groove for supporting a steel ball is formed between the two adjacent rolling bars, the steel ball can roll from one end of the accommodating groove to the other end under the action of self-gravity, and at least one of the two adjacent rolling bars can be used for driving the steel ball so that the steel ball and the rolling bar synchronously roll in the accommodating groove. The device can utilizes self-gravity of the steel ball to drive the steel ball to carry out rolling development along one direction and simultaneously utilize the rolling bars to drive the steel ball to carry out rolling development along the other direction so that the problem that the prior art does not realize complete rolling development thereby producing a high false detecting rate is solved. The method can form a complete steel ball surface image by reduction of shooting frequency thereby improving steel ball surface image taking efficiency, and has small taken image overlapping regions thereby reducing image processing redundancy data and shortening steel ball surface defect identification processing time.
Owner:NINGBO MINGKE MOLD
Glutathione response type double-loading medicine polymer micelle and preparation method and application thereof
ActiveCN108721223AGood water solubilityGood biocompatibilityOrganic active ingredientsPowder deliverySolubilityMetabolite
The invention discloses glutathione response type double-loading medicine polymer micelle and a preparation method and application thereof and belongs to the field of biological medical engineering materials. The preparation method disclosed by the invention is mild and simple and avoids special treatment. The prepared double-loading medicine polymer micelle disclosed by the invention has the advantages of good water solubility and good biocompatibility; furthermore, metabolite of the double-loading medicine polymer micelle is easy to degrade and has smaller toxicity; ingredients of the double-loading medicine polymer micelle are simple, the raw materials are easy to obtain, and the double-loading medicine polymer micelle is hopeful to be widely applied to the field of biological and medical engineering materials. The micelle can be used for wrapping hydrophobic drug; meanwhile, a positive-electricity high molecular material can carry gene medicine through electrostatic interaction toform a double-loading medicine carrier to give play to a synergistic effect. As polypeptide has a modifying effect, the polypeptide has the ability of entering tumor cells; furthermore, gene medicineand hydrophobic medicine can inhibit growth of tumor cells through different mechanisms, so that a treating effect of the polymer micelle to the tumor cells is improved; thus, the double-loading medicine polymer micelle has a wide application prospect in compound chemotherapy for malignant tumors.
Owner:JINAN UNIVERSITY
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