Baicalin thermosensitive gelatin and preparation method and use thereof

Abstract

The invention discloses a baicalin thermosensitive gelatin and a preparation method and use thereof. The baicalin thermosensitive gelatin is prepared by the following steps: (1) taking the following components in percentage by weight: 0.6 to 15 percent of baicalin, 10 to 24 percent of poloxamer 407, 1 to 10 percent of poloxamer 188, 55.8 to 81.17 percent of solvent, 0 to 5 percent of viscosity modifier, and 0 to 0.2 percent of preservative; and (2) dissolving the baicalin and the preservative into the solvent, slowly adding the poloxamer 407 and the poloxamer 188 with stirring, mixing uniformly, adding the viscosity modifier, mixing uniformly, and placing the mixture into freely flowable semitransparent solution to prepare the baicalin thermosensitive gelatin. The baicalin thermosensitive gelatin is flowable liquid at normal temperature, which generates reversible phase change if affected by the body temperature after contacting with a mucous membrane or body fluid. Therefore, the medicament is tightly attached to the mucosal tissue, which is hard to leak. After the phase change is generated in the body fluid, the release rate of the medicament can be controlled.

Description

technical field The invention belongs to the field of pharmaceutical preparations, and relates to a baicalin thermosensitive gel, a preparation method and application. Background technique Baicalin, also known as baicalin, is a flavonoid compound mainly derived from the labiatae plant Scutellaria baicalensis. Molecular formula is C 21 h 18 o 11 , Carboxyl group in the molecule, strong acidity, insoluble in water, insoluble in methanol, ethanol, acetone, soluble in hot acetic acid, slightly soluble in 50% ethanol. Baicalin has many functions such as clearing heat and detoxifying, antibacterial and anti-inflammatory, promoting gallbladder and protecting liver, lowering blood pressure and diuresis, anti-allergic reaction, and chelating metal ions. Baicalin has a wide range of antibacterial properties. In vitro tests have shown that it has inhibitory effects on Gram-positive and negative bacteria. It is clinically used for respiratory infections, acute tonsillitis, acute pha...

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Problems solved by technology

However, after intravenous injection of baicalin, the distribution in the body is fast, the half-life is short, the blood concentration drops rapidly, and the bioavailability is low; oral baicalin is absorbed slowly, irritating to the gastrointestinal mucosa, and the first-pass effect of the liver is obvious.

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