Sustained release microspheres of polyethylene glycol-polylactic acid entrapped betamethasone dipropionate and preparation method thereof
A technology of metasone dipropionate and polyethylene glycol, which is applied in the field of biomedicine, can solve the problems of poor water solubility of betamethasone dipropionate and the influence of PLGA, and achieves good drug packaging effect, reduced side effects and high drug efficacy. Effect
Active Publication Date: 2014-02-26
SHANDONG UNIV
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Problems solved by technology
Betamethasone dipropionate is poorly water-soluble, and long-term use of large doses of hormone drugs will cause various adverse reactions in the human body, such as sodium and water retention, edema, hypertension, hypokalemia, etc., which make betamethasone dipropionate Esters are limited in their application
E.Horisawa (E.Horisawa, T.Hirota, et al.Pharmaceutical Research, 2002, 19) used poly(lactic-co-glycolic acid) (PLGA) copolymers to prepare microparticles loaded with drug betamethasone sodium phosphate, which can prolong the drug resistance However, the degradation products of PLGA are all acidic substances, and the accumulation of a large amount of local acidic substances affects the clinical application of PLGA
Method used
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Embodiment 1
[0044] Embodiment 1, methoxypolyethylene glycol: lactide=1:5; the number average molecular weight of methoxypolyethylene glycol is 2×10 3 ;
Embodiment 2
[0045] Embodiment 2, methoxypolyethylene glycol: lactide=1:15; the number average molecular weight of methoxypolyethylene glycol is 2×10 3 ;
Embodiment 3
[0046] Embodiment 3, methoxypolyethylene glycol: lactide=1:25; the number average molecular weight of methoxypolyethylene glycol is 2×10 3 ;
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Abstract
The invention relates to sustained release microspheres of polyethylene glycol-polylactic acid entrapped betamethasone dipropionate and a preparation method thereof. The sustained release microspheres are prepared from degradable high-molecular biomaterial polyethylene glycol-polylactic acid entrapped betamethasone dipropionate by an O/W type emulsification-solvent evaporation process, and are used for treating inflammatory diseases. The sustained release microspheres of polyethylene glycol-polylactic acid entrapped betamethasone dipropionate, provided by the invention, can regulate the release of a drug, prolong the action time of the drug, reduce the administration times, reduce the side effects of the drug and improve the drug effect. The preparation method provided by the invention is simple and reliable, can guarantee the product quality and application effect, and facilitates industrial production.
Description
technical field [0001] The invention relates to a polyethylene glycol-polylactic acid macromolecule biomaterial slow-release microsphere loaded with anti-inflammatory drug betamethasone dipropionate and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Polyethylene glycol-polylactic acid (PEG-PLA) is a biodegradable polymer material with amphiphilic properties, good biocompatibility and long half-life in vivo. This kind of biological material is applied to microsphere drug loading, which can realize the long circulation in the body, and can release the drug slowly, prolong the action time of the drug, reduce the frequency of administration, and reduce the side effects of the drug. [0003] Betamethasone dipropionate (BDP) is a steroid hormone drug, which is mostly used in the treatment of anti-inflammatory and rheumatoid arthritis and other inflammatory diseases. Betamethasone dipropionate is poorly water-soluble, a...
Claims
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IPC IPC(8): A61K9/16A61K31/573A61K47/34A61P29/00A61P19/02
Inventor 朱庆增吴玉姝齐峰
Owner SHANDONG UNIV
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