The invention discloses a
betamethasone dipropionate nano freeze-dried
powder injection and a preparation method thereof. The freeze-dried
powder injection comprises the following components in percentage by weight: 6%-12% of
betamethasone dipropionate, 20%-54% of a supporting agent, 11%-37% of a suspending aid and 21%-50% of a freeze-
drying protective agent. The preparation method comprises the following steps: taking a good
solvent containing
betamethasone dipropionate and a supporting agent as a good
solvent phase, taking an
aqueous solution containing a suspending aid and a freeze-
drying protective agent as an anti-
solvent phase, respectively pumping out the good solvent phase and the anti-solvent phase through a
peristaltic pump, colliding with fluid in the micro-channel, collecting in a container, stirring, and performing
microfiltration, filling, pre-freezing and freeze-
drying to obtain the product. The product prepared by the invention is small in active
drug particle size and loose in texture, and can be quickly dissolved after being added with water to recover the original characteristics of the liquid
medicine; the product improves the
curative effect of the
medicine, expands the range of dosage forms, is convenient to store and transport, and fully meets the requirements of storage and treatment.