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44 results about "Tazarotene" patented technology
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Tazarotene is used to treat psoriasis or acne.
Topical preparation for treating acne and hirsutism
An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, and preferably one or more low irritability constituents that enhance penetration of the extract into hair follicle sebaceous glands. The low irritability penetration aid may be selected from the group consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, tazarotene, beta hydroxy acids (salicylic acid), azelaic acid, and alpha hydroxy acids (glycolic acid) as well as polyolprepolymer-2.
Owner:GOODMAN DAVID S
Topical preparation for treating acne and hirsutism
An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, in combination with two classes of low irritability penetrating agents that enhance penetration of the extract into hair follicles and sebaceous glands. The low irritability penetration agents are selected from the group (A) comedolytics consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, and tazarotene, and (B) keratinolytics consisting of the beta hydroxy acid, salicylic acid, and the alpha hydroxy acid, glycolic acid. Polyolprepolymer-2 may be incorporated into the preparation as well.
Owner:GOODMAN DAVID S
Complex external medicine for treating acne
InactiveCN1528328AStrong receptor selectivityClearly targetedTetracycline active ingredientsAerosol deliveryTreatment acneTherapeutic effect
The present invention relates to a compound medicine for external application for curing acne. Its composition contains the following two active components: (wt%) 0.01-2% of tazarotene and 0.25-5% of antimicrobial. Said compound medicine can be made into emulsifiable paste or gel or liniment or film preparation. Said compound medicine has the following therapeutic functions: dissolving keratotic plug, regulating keratosis, resisting microbe, relieving inflammation and reducing secondary factor of sebaceous secretion, so that it can obtain obvious therapeutic effect.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Prevention and treatment of inflammatory conditions
ActiveUS20140187504A1Rapid recruitmentSuppresses in vitro proliferationBiocidePeptide/protein ingredientsAlcoholic cirrhosisTazarotene
The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.
Owner:GRI BIO INC
Complex external medicine for treating psoriasis
InactiveCN1528313ALess irritatingClear targetOrganic active ingredientsPeptide/protein ingredientsExternal applicationIrritation
The present invention relates to a compound medicine for external application for curing psoriasis. It is characterized by that in the matrix carrier of said compound medicine for external application are contained the following effective active components: (wt%) tazarotenje 0.025-0.1% and cortical hormone 0.01-0.2%. Its therapeutic effect is good, and it has no adverse reaction.
Owner:CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
Combination of dapsone with other Anti-acne agents
InactiveUS20110117182A1Good curative effectCosmetic preparationsBiocideEffective treatmentActive ingredient
A composition suitable for topical application that contains at least two active ingredients, one of these being dapsone and one selected from the group consisting of adapalene, tazarotene and treinion for the effective treatment of acne and other dermatological conditions.
Owner:ALLERGAN INC
Process for the preparation of Tazarotene
ActiveUS7273937B2Conveniently preparedImprove purification effectOrganic chemistryDeoxygenationTazarotene
Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
Owner:SOLMAG SPA
Medicinal composition for treating psoriasis
InactiveCN1478478ASignificant effectLow incidence of adverse reactionsOrganic active ingredientsDermatological disorderMedicineAdrenal gland
A composite medicine in the form of ointment and gels for treating psoriasis contains Tazhuluoding, betamethasone dipropionate and pharmacologically receptable auxiliary. Its advantages are high curative effect and high safety.
Owner:CHONGQING HUAPONT PHARMA
Pharmaceutical compositions comprising silica microspheres
A topical composition which includes a silica microspheres and an active ingredient in the amount of 0.01 to 15.0% w / w wherein the active ingredient is selected from adapalene, an antibiotic, tazarotene, tretinoin, a retinoid, or any combination thereof. The topical composition may also include benzoyl peroxide as an active ingredient. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.
Owner:SOL GEL TECH
Tazarotene and corticosteroid treatment for psoriasis
The present invention provides a method for treating proliferative skin diseases comprising the administration of an effective amount of tazarotene and an effective amount of a corticosteroid. This invention is especially useful for treating psoriasis.
Owner:VISION PHARMA +1
Process for the preparation of Tazarotene
ActiveUS20060205950A1Conveniently preparedMild reaction conditionsOrganic chemistryDeoxygenationTazarotene
Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
Owner:SOLMAG SPA
Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman
An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride and an amido-group containing compound of the general formula wherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and R1 and R2 can be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of R1 and R2 together with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a β-chloro vinyl carbonyl compound intermediate of the general formula wherein R has the aforestated meanings; and (b) reacting the β-chloro vinyl carbonyl compound intermediate with an alkali metal to provide the 4,4-dimethyl-6-ethynylthiochroman.
Owner:GLENMARK GENERRICS LTD
Topical compositions with stable solubilized selective retinoids and/or tetracycline-class antibiotics
Topical compositions for dermatological use are described. The topical compositions generally comprise a selective retinoid, such as tazarotene or adapalene, and / or a tetracycline-class antibiotic, such as minocycline or doxycycline, and a monohydric aliphatic alcohol. The compositions may further comprise a divalent cation, such as magnesium, calcium, or zinc, and an antioxidant, such as a sulfite or a thiosulfate. The composition may further comprise a carboxylate ester solvent.
Owner:BIOPHARMX
Method for separation and determination of two medicine contents and related substances in tazarotene-betamethasone cream
ActiveCN106918676AEfficient separationSeparation assay is validComponent separationBetamethasoneSolvent
The present invention belongs to the field of analytical chemistry, and relates to a method for separation and determination of two medicine contents and related substances in a tazarotene-betamethasone cream. According to the method, a reagent composition for solid-liquid separation and determination of two medicine contents and related substances in a tazarotene-betamethasone cream comprises an acidic aqueous solution system and acetonitrile, wherein the acidic aqueous solution system comprises an acidic additive, methanol and water; and by using the reagent composition, the two medicine contents and the related substances in the tazarotene-betamethasone cream can be simultaneously separated and determined through high performance liquid chromatography. According to the present invention, the method has good reproducibility, the solvent peak does not interfere with the determination of the two medicine contents and the related substances in the tazarotene-betamethasone cream during the detection, the two medicines and the related substances in the tazarotene-betamethasone cream can be effectively separated, the separation degree is more than 2.0, the detection result is accurate and reliable, and the important significance is provided for the achievement of the quality control of the tazarotene-betamethasone cream.
Owner:CHONGQING HUAPONT PHARMA
Tazarotene and corticosteroid treatment for psoriasis
The present invention provides a method for treating proliferative skin diseases comprising the administration of an effective amount of tazarotene and an effective amount of a corticosteroid. This invention is especially useful for treating psoriasis.
Owner:ALLERGAN INC
Complex external medicine for treating acne
InactiveCN1210041CStrong receptor selectivityClearly targetedTetracycline active ingredientsAerosol deliveryTreatment acneTazarotene
The invention relates to a compound external medicine for treating acne. It is characterized in that: the matrix carrier of the compound external drug contains the following two effective active ingredients (weight percentage): 0.01-2% of tazarotene, and 0.25-5% of antibacterial drugs; the effective active ingredient contained in the compound external drug After mixing with a base carrier, it forms a cream or gel or a liniment or film. The advantage of the present invention is that: the present invention contains two main components of retinoic acid and antibacterial for treating acne in the form of a compound preparation, so as to simultaneously exert three (and above) curative effects (dissolving horn plugs, regulating keratinization, Antimicrobial, anti-inflammation, secondary factors to reduce sebum secretion, etc.), played a complementary and synergistic effect in pharmacology.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Prevention and treatment of inflammatory conditions
ActiveUS9949996B2Suppression of anti-tumor immunityHydroxy compound active ingredientsPeptide/protein ingredientsSteatosisFatty liver
The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.
Owner:GRI BIO INC
Skin Solution with Solubilized Bakuchiol
PendingUS20180064777A1Small sizeReduce skin problemsCosmetic preparationsSalicyclic acid active ingredientsWater basedBenzoyl peroxide
A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.
Owner:ENVY MEDICAL
Method for preparing tazarotene without copper iodide
ActiveCN109081835AEasy to recycleShort reaction timeOrganic chemistryPalladium catalystReaction temperature
The invention provides a method for preparing tazarotene without copper iodide. Palladium catalysts and triphenylphosphine are added into specific organic solvents and stirred, replacement in nitrogenis performed, 4, 4-dimethyl thiochroman-6-radical-acetylene, 6-chloro-ethyl nicotinate and acid-binding agents are added to perform reaction. The method is environmentally friendly, the catalysts areeasily recycled, and waste water containing heavy metal is not generated. Compared with the prior art, the method is short in reaction time and reaction temperature. A product prepared by the methodis high in yield and purity and stable in quality.
Owner:CHONGQING HUABANGSHENGKAI PHARM
Ointment for lowering clinical application side effects of tazarotene
InactiveCN106860454AGood treatment effectSignificant effectOrganic active ingredientsAerosol deliverySide effectMedicine
The invention discloses an ointment for lowering clinical application side effects of tazarotene, belonging to the technical field of external ointments. The ointment is proportionally composed of a component A and a component B, wherein the component A is 1% tazarotene cream, and the component B is a Chinese herbal medicine extract. The clinical test proves that the ointment can obviously enhance the verruca plantaris treatment effect, and can also obviously lower the side effects in clinical application.
Owner:沂南县迎辉农业开发有限公司
Tazarotene with low dimer impurity for treating acne or psoriasis
The present invention relates to a method of treating acne or psoriasis by topically administering Tazarotene substantially free of dimer impurity of formula 4,4-dimethyl-6-[4-(4,4-dimethylthiochroman-6-yl)-buta-1,3-diynyl]-thiochroman.
Owner:SUN PHARMA INDS
Tazarotene derivatives
The presently described subject matter relates to new derivatives of tazarotene that also exhibit retinoid activity, pharmaceutical compositions comprising the derivatives, method of treating skin disorders with the pharmaceutical compositions, and process of making the derivatives.
Owner:STIEFEL LABORATORIES
Pharmaceutical composition of compound clindamycin and tazarotene lipid complex
ActiveCN103405781AImprove retentionLong onset timeOrganic active ingredientsAerosol deliveryClindamycin PhosphatePhospholipid
The invention provides a lipid complex of tazarotene and clindamycin phosphate. The lipid complex is prepared mainly by utilizing synthetic phospholipids and stearamide, is wrapped with tazarotene and is further mixed with the clindamycin to prepare cream and gel which are mainly used for treating acne vulgaris. The lipid complex is simple in preparation technique, and the stability of pharmaceuticals can be ensured in the preparation process; compared with the common cream and gel, the lipid complex has the advantages that the skin medicine retention volume is higher, the content of medicine in local skins can be increased, and the therapeutic index can be improved.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Pharmaceutical composition for treating hyperproliferative skin disease and preparation of pharmaceutical composition
ActiveCN102988987BGood synergyImprove efficacyOrganic active ingredientsAerosol deliveryDiseaseTazarotene
The invention belongs to the field of pharmacy and particularly relates to a pharmaceutical composition for treating hyperproliferative skin disease and a preparation of the pharmaceutical composition. The pharmaceutical composition comprises the following components by weight percent: 0.001-0.01% (W / W) of calcipotriene, 0.05-2% (W / W) of tazarotene and 0.05-2% (W / W) of adrenocortical hormone.
Owner:XIAN LIBANG PHARMA
Combination of dapsone with other Anti-acne agents
InactiveUS20110305747A1Good curative effectBiocideCosmetic preparationsEffective treatmentBULK ACTIVE INGREDIENT
A composition suitable for topical application that contains at least two active ingredients, one of these being dapsone and one selected from the group consisting of adapalene, tazarotene and treinion for the effective treatment of acne and other dermatological conditions.
Owner:ALLERGAN INC
Medicinal composition for treating psoriasis
InactiveCN1210034CSignificant effectLow incidence of adverse reactionsOrganic active ingredientsDermatological disorderCurative effectAdrenal gland
The invention provides a pharmaceutical composition for treating psoriasis, and its preparation forms include ointment and gel. The pharmaceutical composition contains 0.05%-0.5% (w / w) of tazarotene, 0.05%-2.5% (w / w) of adrenocorticosteroids and other pharmaceutically acceptable auxiliary agents. The adrenocortical hormone drug is preferably betamethasone dipropionate. The pharmaceutical composition of the invention has remarkable curative effect on psoriasis and good safety.
Owner:CHONGQING HUAPONT PHARMA
Tazarotene gelata and preparation method thereof
InactiveCN104138353ASimple processImprove stabilityOrganic active ingredientsAerosol deliveryCyclodextrinBULK ACTIVE INGREDIENT
The invention discloses a tazarotene gelata and a preparation method thereof. The preparation is prepared form the active ingredient tazarotene and auxiliary materials. The auxiliary materials include methyl cyclodextrin and sodium alginate. The preparation method includes: dissolving methyl cyclodextrin in water, adding a prescribed amount of quantity of tazarotene, conducting stirring for dissolving so as to obtain a solution I; dissolving sodium alginate and a bacteriostatic agent in water to obtain a solution II; and mixing the two solutions and stirring the mixture evenly, thus obtaining the gelata. The tazarotene gelata provided by the invention has the advantages of simple preparation process, good gel stability, few variety of auxiliary materials, and easy coating.
Owner:江苏小林制药有限公司
Method for separation and determination of two drugs and related substances in tazarotene betamethasone cream
ActiveCN106918676BEfficient separationSeparation assay is validComponent separationDrug contentFluid phase
Owner:CHONGQING HUAPONT PHARMA
Pharmaceutical composition of compound clindamycin and tazarotene lipid complex
ActiveCN103405781BImprove retentionLong onset timeOrganic active ingredientsAerosol deliveryClindamycin PhosphatePhospholipid
The invention provides a lipid complex of tazarotene and clindamycin phosphate. The lipid complex is prepared mainly by utilizing synthetic phospholipids and stearamide, is wrapped with tazarotene and is further mixed with the clindamycin to prepare cream and gel which are mainly used for treating acne vulgaris. The lipid complex is simple in preparation technique, and the stability of pharmaceuticals can be ensured in the preparation process; compared with the common cream and gel, the lipid complex has the advantages that the skin medicine retention volume is higher, the content of medicine in local skins can be increased, and the therapeutic index can be improved.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis
InactiveCN100441183CEffective activityAvoid bad consequencesOrganic active ingredientsAerosol deliveryDiseaseAntibacterial activity
The present invention relates to compound 13-hexyl berberine hydrochloride and its congener 13-hexyl palmatine hydrochloride to prepare external skin anti-allergic, inflammatory, eczema, dermatitis and other skin diseases and anti-immune, inflammatory and proliferative drugs Uses of psoriasis medications. At the same time, because of its antibacterial activity, it also has a good therapeutic effect on eczema and dermatitis associated with infection. The external application of cream with 13-hexylberberine hydrochloride or 13-hexylpalmatine hydrochloride as the active ingredient has similar therapeutic effect on psoriasis as that of intermediate-acting corticosteroids and chemical antipsoriatic drug tazarotene, but not It can cause adverse reactions such as corticosteroids, and its simple and compound formulations should have unique effects in the treatment of psoriasis.
Owner:CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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