Complex external medicine for treating acne

A technology for external use of drugs and compound prescriptions, applied in the directions of drug combination, drug delivery, medical preparations containing active ingredients, etc. Chemotactic activity of leukocytes, reduction of incentives to stimulate sebum secretion, and mild skin irritation effects

Inactive Publication Date: 2004-09-15
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main problem with unilateral therapy is that it has a single effect and can only target 1-2 disease links at most (such as antibacterial plus anti-inflammatory, or antibacterial plus anti-angular suppository)
In addition, most of the above-mentioned acne keratolytic drugs have local irritation and / or allergic effects, and benzoyl peroxide has a strong oxidative effect. If they are composed of compound preparations, the quality is not easy to stabilize, which will cause fluctuations in the concentration and curative effect of compatible drugs. Storage conditions, shelf life and use Convenience and other aspects are greatly affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The effective active ingredients of this embodiment adopt tazarotene 0.1% (percentage by weight, the same below) and clindamycin hydrochloride (or phosphoric acid) 1%, and the base carrier adopts cetyl alcohol, vaseline, liquid paraffin, monostearic acid Glycerides, glycerin, solubilizers, emulsifiers, ethylparaben and distilled water.

Embodiment 2

[0018] The effective active ingredients of this example are tazarotene 0.05% and erythromycin 2%, and the matrix carrier is cetyl alcohol, vaseline, liquid paraffin, glycerol monostearate, glycerin, solubilizer, emulsifier, hydroxybenzene Ethyl esters and distilled water.

Embodiment 3

[0020] First, the two effective active ingredients and 0.1% of ethyl hydroxybenzoate in Example 1 or Example 2 are dissolved in the solubilizer; Vaseline, 8-12% of the total amount of liquid paraffin, 5-10% of the total amount of glyceryl monostearate and an appropriate amount of emulsifier are mixed and heated to 80-85°C; Mix distilled water and heat to 80-85°C, and emulsify it with the mixture of cetyl alcohol, vaseline, liquid paraffin, glycerol monostearate and emulsifier; leave the emulsified mixture from the heat source, stir and cool to 65°C At the same time, a solubilizer containing two effective active ingredients and ethyl paraben is added, and stirred evenly to form a cream.

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PUM

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Abstract

The present invention relates to a compound medicine for external application for curing acne. Its composition contains the following two active components: (wt%) 0.01-2% of tazarotene and 0.25-5% of antimicrobial. Said compound medicine can be made into emulsifiable paste or gel or liniment or film preparation. Said compound medicine has the following therapeutic functions: dissolving keratotic plug, regulating keratosis, resisting microbe, relieving inflammation and reducing secondary factor of sebaceous secretion, so that it can obtain obvious therapeutic effect.

Description

Technical field: [0001] The invention relates to a medicine for external use for treating acne, in particular to a compound medicine for external use for treating acne. Background technique: [0002] Acne is a chronic disease of the sebaceous glands. It can be divided into inflammatory and non-inflammatory acne. It is the second most common disease in dermatology. The incidence rate accounts for about 7-10% of skin diseases. The age of the disease covers 11-30 years old, men and women Anyone can suffer. [0003] It is now known that the following four pathogenic factors and links play a key role in the occurrence, development and outcome of acne: 1. The microbial action in the hair follicle and sebaceous unit, first is the anaerobic Propionibacterium acnes, and the second is the aerobic bacteria Predominant pyogenic bacteria such as epidermis and Staphylococcus aureus, it is believed that Saccharomyces is also involved in the pathogenesis; 2, androgen and sebaceous gland hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K9/70A61K31/4436A61K31/496A61K31/5383A61K31/65A61K31/7028A61K31/7048A61P17/10
Inventor 郑家润张崇璞李新宇陈沄高纪伟唐美育徐兰芳
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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