189results about How to "Clearly targeted" patented technology

The invention discloses a traffic scene multi-target classification method, to be specific, discloses a traffic scene classification method based on a multi-scale convolution neural network. The traffic scene classification method is characterized in that recessive characteristics based on the multi-scale convolution neural network are extracted; and an optimal covering segmentation tree is acquired. During the realizing of the traffic scene classification, the multi-scale convolution neural network is adopted, and the excellent recessive characteristics having the invariance property are effectively extracted from an original image in different scales, and by comparing with the single-scale convolution neural network, the acquisition of the abundant and effective characteristic information of the image is realized. The effective information extracted by the convolution neural network is combined with the original segmentation tree of the image to form an optimal purity price tree, and the covering having the optimal purity is carried out, and therefore a clearer target contour is acquired, and the classification accuracy is increased. The RGB-D is used as the convolution neural network input, and by comparing with the conventional RGB convolution neural network input, the training characteristic is additionally provided with the depth information, and the classification of the input image is more accurate.

The invention discloses a method for carrying out in-situ repairing on blood coagulation factor F8/F9. The method comprises the following steps: in a target genome sequence, selecting the mutation sites of blood coagulation factor as the gene sites for in-situ repairing; designing the binding sites of nuclease of sgRNA sequence of a CRISPR/Cas system; designing a homologous recombinant repairing donor sequence for in-situ repairing; delivering nuclease protein and/or sgRNA and the nucleotide sequence of the homologous recombinant repairing donor to the gene sites of in-situ repairing by a delivering carrier; generating damages to the genome DNA by the nuclease on the gene in-situ repairing sites; and inserting the homologous recombinant repairing donor sequence into the gene in-situ repairing sites so as to repair the gene or supplement the expression of gene. The in-situ repairing of mutation sites of blood coagulation factor can be applied to the clinic, and the method has the advantages of precise induction, safer and controllable process, and definite target.

The invention provides an individualized orthodontic arch wire curve interactive adjustment method, and relates to the field of orthodontic arch wire bending and forming. According to the method, based on actual tooth position information of a patient, through adjustment of bracket straight line segment positions, change of transition curve segment shapes and selection of the insertion positions and types of special function curves, forming and bending of an individualized orthodontic arch wire is realized. The technical points are selection of patient data, setting of compensation values, setting of transition curve segments, and position adjustment of insertion of the special function curves and bracket straight line segments. The individualized orthodontic arch wire curve interactive adjustment method provided by the invention can be used for digital forming and individualized forming of orthodontic arch wires, and provides a necessary bending algorithm for bending an orthodontic arch wire by automation equipment.

The invention provides an identification method for illegal cooking oil, and mainly solves the problems in the present identification method for illegal cooking oil. The identification method disclosed by the invention is mainly that: the mass fraction for palmitoleic acid occupying the total amount of fatty acid in grease is detected to identify whether the oil is illegal cooking oil or not; and in the practical detection, a sample is detected by adopting a gas chromatograph-mass spectrometer or a gas chromatography after being saponated and performed with methyl esterification, so as to identify whether the oil is illegal cooking oil or not after adopting peak area or peak height normalization quantitation. The method has the characteristics of definite target spot, strong feature, simplicity in operation, strong repeatability, application in quick detection and the like.

The invention relates to the field of medicines, specifically to an integrin blocker which inhibits generation of tumor vasculature and has integrin endophilicity and binding capacity. The blocker is a polypeptide. The integrin blocker polypeptide can be used to treat solid tumor. The integrin blocker can be applied in the preparation of medicines for treating tumor. The sequence of the integrin blocker is Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro (the sequence contains two disulfide bonds and the pairing manner is 1-4 and 2-3). The invention is characterized in that the tumor origins from primary or secondary cancer and sarcoma of human head and neck, brain, thyroid, pancreas, lung, liver, oesophagus, stomach, mammary gland, kidney, gallbladder, colon or rectum, ovary, uterus, cervix, prostate, bladder and testis. According to the invention, treatment spectrum of the integrin blocker is greatly expanded, novel thinking and prospect are provided for drug development, and the integrin blocker polypeptide AP25 has substantial social value and market value.

The invention relates to human sDR5-Fc recombinant fusion protein and application of the human sDR5-Fc recombinant fusion protein to preparation of medicine for preventing and treating drug induced liver injury. Through long-time study of the inventor, the protein gene sequence is selected again, and the novel human sDR5-Fc recombinant fusion protein provided by the invention is obtained. Through a great number of experiments, the human sDR5-Fc recombinant fusion protein can obviously reduce the serum transaminase level in various mouse drug induced liver injury models; the liver pathologic damage is reduced; the liver cell apoptosis rate is obviously reduced; the mouse survival ratio is improved. The human sDR5-Fc recombinant fusion protein is used as novel candidate medicine for preventing and treating the drug induced liver injury; the treatment range is wide; targets are specific; the action is special and fast; the curative effect is obvious; the safety is high; great development potential is realized.

The present invention relates to an application of indirubin derivative (IO) in the preparation of medicine for curing neural retrograde disease, specially, it relates to an application of indirubin derivative in the preparation of medicine for curing Parkinson's disease. Said invention uses the indirubin derivative as inhibitor and utilizes three kinds of mediated and died kinases of JNK/CDK5/GSK3 beta which are inhibited by said indirubin derivative as clear target to develop the invented new medicine.

A ginger extract mainly containing the volatile oil of ginger and gingerol for preparing medicines to treat heart failure, myocardial ischemia, atherosclerosis, etc is prepared from the dried ginger through pulverizing, supercritical CO2 fluid extracting and separation.

The present invention relates to a compound medicine for external application for curing psoriasis. It is characterized by that in the matrix carrier of said compound medicine for external application are contained the following effective active components: (wt%) tazarotenje 0.025-0.1% and cortical hormone 0.01-0.2%. Its therapeutic effect is good, and it has no adverse reaction.

The invention relates to a medicinal mixture for treating cardiovascular diseases, which comprises (by weight portions) ginger extract 100 and dried orange peel extract 1-100 mainly containing ginger volatile oil, gingerol and dried orange peel volatile oil.

The invention provides a detecting method and an application of the extraneous activity of the RNA polymerase relied on by the hepatitis C virus RNA, which relates to an secure and practical establishing method for the detection of the activity extraneous detection of the RNA polymerase relied on by the hepatitis C virus RNA, and the application relates to the genetic engineering technology and the nanometer segregation enrichment and RNA related technology field. The invention expresses the soluble NS5B protein through the utilization of the genetic engineering technology, and prepares the nanometer magnetic particle. One end of a RNA template is fixed on the nanometer magnetic particle, and added in the 96 hole reaction plate micromesh, and added with NS5B protein to compose a RNA duplication system, and a duplicated RNA double chain on the nanometer magnetic particle is mixed with marked biological elements. After the RNA is duplicated, the nanometer magnetic particle is attached at the micromesh bottom through an external magnetic field magnet, after repeatedly cleaning and attaching, the nanometer magnetic particle is combined with the marked combining factor of the horse radish peroxidase, after attaching and cleaning, the substrate constant of the horse radish peroxidase is added to develop color. New NS5B protease activity inhibitor can be screened from a traditional Chinese storeroom and a compound storeroom by the established method.

The invention provides application of a sesquiterpene compound 6-OAP in preparation of STAT3 inhibitors and in treatment of diseases unusually relevant to STAT3, and a pharmaceutical composition for treatment of diseases unusually relevant to STAT3. The pharmaceutical composition contains 6-OAP. 6-OAP can quickly combine with STAT3, can significantly inhibit phosphorylation of STAT3 in a cell and animal tumor-bearing model and significantly inhibit the activity of STAT3 induced by inflammatory factors, and has no significant toxic and side effect on other normal tissues. With the advantages of proper dose, significant curative effect, definite action target, and low toxic and side effects, etc., the 6-OAP has wide anticancer and anti-inflammatory application prospects clinically.

The invention relates to a specific blocking agent of a Toll-like receptor 9 (TLR9). The blocking agent is a nonmethylated CpG nucleotide sequence segment, the core structure of which is a CGCG nucleotide sequence, and the length of the nonmethylated CpG nucleotide sequence segment is 12-30 nucleotides. The blocking agent can be specifically combined with the TLR9, can block the combination between other irritant aglucons and the TLR9 and inhibit the proinflammatory effect mediated by the receptor, and can be used for the adjuvant treatment of inflammatory resistance and allergy resistance and the preparation of an experiment reagent of immune inflammation.

The invention provides milky tea with the function of reducing blood sugar and blood fat, which comprises 10-50% (weight) of milk, 0.3-10% (weight) of tea powder and 0.03-40% (weight) of combination of xylo-oligosaccharide and L-araba sugar. The milky tea uses the combination of xylo-oligosaccharide and L-araba sugar, has the effect of synergistically inhibiting activity of alpha-glucosidase to reduce blood sugar of the human bodies, and has the effect of aiming at lipase activity and cholesteryl ester activity to synergistically enhance inhibition functions to reduce blood fat. In addition, the milky tea uses the combination of xylo-oligosaccharide and L-arabinose, can restrain sediment and has the effect of a clarifying agent.

The invention provides a drug for preventing and treating alopecia and belongs to the technical field of drug preparation. The drug for preventing and treating alopecia contains the following effective constituent: compound of more than one of flavonoids compound for reducing capillary permeability, calcium and vitamin C. The compound provided by the invention can be used for achieving the purposes of effectively preventing and treating alopecia and promoting the hair growth, is safe, is wide in universality, is effective in treatment and is suitable for treatment of androgen alopecia.

The invention relates to the field of medicines and discloses a pharmaceutical composition for treating cardiovascular diseases. The composition comprises piceatannol 3'-O-glucoside, polydatin and a piceatannol 3'-O-glucoside derivative. Research found that the composition significantly improves the area of cerebral infarction and the area of myocardial ischemia after ischemia-reperfusion, fundamentally improves various damages caused by ischemia for patients with ischemic cardiovascular diseases, and has a good clinical application prospect.

The invention provides a peptide with a pancreatic lipase inhibitor effect. The sequence of the peptide is selected from SEQ ID NO.1-5; the invention also provides application of the peptide in preparation of medicines, foods and health-care products for treating hyperlipemia. The peptide is a plant-derived, non-toxic and harmless natural substance, and experiments prove that the peptide has remarkable pancreatic lipase inhibitory activity and lipid-lowering effect; the compound is clear in action mechanism and definite in target spot, is expected to become a substitute medicine for preventing and treating hyperlipemia, and has a good market prospect in the industries of medicine and functional food.

The invention discloses a traditional Chinese medicine composition for treating sicca syndrome, and a preparation method and use thereof. The traditional Chinese medicine composition is prepared from22-35 parts by weight of radix scrophulariae, 20-30 parts by weight of radix ophiopogonis, 18-26 parts by weight of radix rehmanniae, 25-38 parts by weight of radix puerariae, 15-25 parts by weight ofrhizoma atractylodis and 12-18 parts by weight of root bark of the peony tree. The traditional Chinese medicine composition is remarkable in sicca syndrome treatment effect.

The invention discloses an area energy photon counting image fusion algorithm based on an adaptive threshold value, and belongs to the technical field of image fusion. The method is characterized by comprising the following steps of step 1001, carrying out redundant wavelet transformation; step 1002, calculating regional energy, neighborhood mean square error, matching degree and self-adaptive threshold value; step 1003, calculating a weighting coefficient and an enhancement factor; step 1004, calculating a matching degree; step 1005, judging a matching degree and a self-adaptive threshold value; step 1006, when the matching degree is smaller than a self-adaptive threshold value, selecting an enhancement value of a pixel point of an area with high energy as a corresponding pixel point value in the fusion image; step 1007, if the matching degree is greater than or equal to a self-adaptive threshold value, adopting a weighted area energy method; and step 1008, obtaining a photon countingfusion image. Through the algorithm, the problems of unclear contour, serious noise, photon counting image information redundancy under extremely weak illumination, unclear details and the like of afusion image obtained through a regional energy fusion method are solved.

The invention provides an identification method for illegal cooking oil. According to the identification method, the fraction of the mass of heptadecanoic acid in grease to the total mass of fatty acid is determined so as to confirm if oil is the illegal cooking oil. During actual detection, the method includes subjecting a sample to saponification and methylation, determining by means of gas chromatography-mass spectrometry, obtaining a mass spectrometry total ion chromatogram under the setting chromatographic condition and mass spectrometry condition, quantifying by means of a peak area or peak height normalization method, and judging if the oil is the illegal oil according to the mass fraction. The identification method has the advantages of being explicit in target, obvious in characteristic, easy to operate, high in reproducibility, applicable to fast detection, and the like.

The present invention is one kind of wet sterilized towel used for couple's sexual life and its making process. The wet sterilized towel is used for couple's sexual life, and can kill germs effectively, treating premature ejaculation, strengthen penis erection, improve blood microcirculation and strengthen immunity.

The invention discloses application of nitraria plant or nitraria plant extract to preparation of medicine for inhibiting fatty acid synthase, healthcare products, food or daily use chemical. The enzyme activity experimental result shows that nitraria sibirica pall powder and the extract have a remarkable inhibiting effect on fatty acid synthase. The nitraria sibirica pall extract has a higher ability to inhibit fatty acid synthase than known fatty acid synthase inhibitor quercetin.

The invention discloses a liquid chromatography-mass spectrometry screening method for a multi-target antithrombotic substance based on a dried blood spot sample, and belongs to the field of drug screening. The method comprises the following steps of preparing a rehydrated dry blood spot sample, optionally selecting a plurality of substrates of key target enzymes involved in thrombosis processes,mixing a plurality of substrate standard solutions with a substance to be screened, adding a mixture into the rehydrated dry blood spot sample, treating a reaction solution, and carrying out liquid chromatography-mass spectrometry analysis to screen to obtain a substance with multi-target antithrombotic activity. The screening method of the invention has the advantages of simplicity and rapidness,high accuracy, high specificity, a large number of samples can be continuously analyzed, the antithrombotic substance capable of inhibiting one or more target enzymes at the same time can be screenedout at the same time according to the screening method, action targets of the screened active substance are clear, and a theoretical basis is laid for subsequent drug development. Reagents are easy to obtain, the operation automation degree is high, clinical popularization and promotion are easy, and the commercial value is high.

The invention discloses a small-molecular compound/combination for preventing, delaying or reversing the aging of cells, tissues, organs and bodies, a product thereof, and a use of the compound/combination and the product. The small-molecular compound/combination includes at least one of a DNMT inhibitor, an HMT inhibitor, a histone demethylase inhibitor, a TGF-beta inhibitor, a WNT/beta-catenin agonist, a cAMP agonist, a lysine deacetylase inhibitor, an RAR agonist and an ROCK inhibitor. The small-molecular compound or the combination thereof is adopted to prevent, delay or reverse the agingof cells, tissues, organs and bodies and prolong the telomere length of the cells, and has the advantages of clear action target, clear, mature and stable composition, and accuracy in regulation of the anti-aging process; and the quality control and the large-scale production of the small-molecular compound are easy. The bodies or cells do not express dry genes in the action process, so the safetyis high; and the small-molecular compound and the combination thereof can be easily absorbed by the bodies, can prevent, delay and reverse the aging at the overall level of cells, tissues, organs andbodies, and is of great significance to delaying the process of human aging and improving the health state and the life quality.