15results about How to "Clearly targeted" patented technology

The invention relates to an application of a histone H3K18 lactic acid modification related target in preparation of a medicine for preventing or treating atherosclerosis. The invention belongs to the field of biological medicine, and discloses histone acetyltransferase P300 and application of histone H3K18 lactylation (H3K18la) modification mediated by the histone acetyltransferase P300 as a new target spot for treating atherosclerosis (AS). Researches find that in the AS process, lactic acid accumulation in vascular smooth muscle cells (VSMCs) up-regulates H3K18la through P300 catalysis, and then the pathological phenotype of the VSMCs is induced, and plaque development is promoted. H3K18la can be reduced and the phenotype can be improved by inhibiting LDHA and MCT1 in vitro or knocking out a P300 gene; the P300 for in-vivo targeted inhibition of the VSMCs can significantly reduce the artery plaque. Therefore, the P300 and H3K18la inhibitors can be used for preparing the anti-atherosclerosis medicine.

The application discloses a metal component welding stress dynamic regulation method and system based on digital twinning, relates to the intelligent control technical field of a welding process, and comprises the following steps: collecting original welding signals in a welding process in real time, and synchronously constructing a welding process digital twinning body interacting with the original welding signals; simulating and calculating the prototype stress field distribution of a metal component inside a current welding stage in the twinning body; generating welding energy dynamic regulation instructions according to the comparison between the distribution and a preset stress threshold interval, and calculating instant welding energy correction parameters to be fed to a welding execution mechanism to adjust energy input; after adjustment, collecting updated signals again to drive the twinning body to perform simulation verification, obtaining a verified stress field distribution, and performing closed-loop calibration on the aforementioned correction parameters based on the verified stress field distribution, so that the calibrated parameters are used for dynamic regulation in subsequent stages. The application realizes real-time perception, prediction and active accurate control of welding internal stress.

The application relates to the field of biological medicine, and particularly relates to application of kaempferol-3-O-acacia di-saccharide-7-O-rhamnose glycoside in preparation of a medicine for preventing and / or treating diseases related to glycolipid metabolism disorder. The compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof can be used for treating diseases such as type 2 diabetes, insulin resistance, hyperglycemia, hyperlipidemia and non-alcoholic fatty liver disease. The compound can significantly reduce intracellular glucose, triglyceride and total cholesterol levels, and can play a role by activating an AKT signal pathway, so as to improve glycolipid metabolism disorder and has potential clinical application value.

The invention relates to the technical field of aquaculture and biology, in particular to an SIFamide neuropeptide gene and application of the SIFamide neuropeptide gene in promoting growth of litopenaeus vannamei. The litopenaeus vannamei SIFamide gene is shown as a nucleotide sequence of SEQ ID NO: 1. The SIFamide neuropeptide gene is applied to the growth and intestinal peristalsis of the litopenaeus vannamei. The nucleotide sequence of the interference fragment for inhibiting the SIFamide neuropeptide gene is as shown in SEQ ID NO: 4. After the nucleotide sequence (double-stranded RNA) of the interference fragment is applied to the litopenaeus vannamei in an intramuscular injection manner, the weight increase of the litopenaeus vannamei is obviously accelerated and the intestinal peristalsis frequency is obviously improved under the condition that the expression of the SIFamide gene is inhibited. According to the method, damage to the litopenaeus vannamei is small, normal ingestion, molting, inhabiting and other behaviors of the litopenaeus vannamei are not affected, and the action effect is stable.

The application discloses a metal component welding stress dynamic regulation method and system based on digital twinning, relates to the intelligent control technical field of a welding process, and comprises the following steps: collecting original welding signals in a welding process in real time, and synchronously constructing a welding process digital twinning body interacting with the original welding signals; simulating and calculating the prototype stress field distribution of a metal component inside a current welding stage in the twinning body; generating welding energy dynamic regulation instructions according to comparison between the distribution and a preset stress threshold interval, and calculating instant welding energy correction parameters to be fed to a welding execution mechanism to adjust energy input; after adjustment, collecting updated signals again to drive the twinning body to perform simulation verification, obtaining a verified stress field distribution, and performing closed-loop calibration on the aforementioned correction parameters based on the verified stress field distribution, so that calibrated parameters are formed and used for dynamic regulation in subsequent stages. The application realizes real-time perception, prediction and active accurate control of welding internal stress.

This invention relates to the field of agricultural biotechnology, and in particular to... Sr10618 Genes and their encoded proteins, their application in regulating resistance to white mold disease in peppers, primer pairs, recombinant viral silencing vectors and methods. Related factors in pepper plant resistance to white mold disease. Sr10618 The nucleotide sequence of the gene is shown in SEQ ID NO.1. Sr10618 The amino acid sequence of the protein encoded by the gene is shown in SEQ ID NO.2. A method for improving the resistance of pepper plants to white mold disease is also provided, including silencing the white mold pathogen effector. Sr10618 The expression of the gene in pepper plants, the Sr10618 The nucleotide sequence of the gene is shown in SEQ ID NO.1. (The above...) Sr10618 The application of genes and their encoded proteins, amplification primer pairs, recombinant silencing vectors, and methods to improve the resistance of pepper plants to white mold disease can regulate the resistance of pepper plants to white mold disease.

This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.

This invention discloses the application of the small molecule compound Z2114502286 in the preparation of drugs for the prevention and treatment of liver-related diseases. This invention reveals for the first time that Z2114502286 is a THBS2-specific small molecule inhibitor and verifies its feasibility in preventing and treating liver fibrosis by targeting and inhibiting the THBS2 protein. Through virtual screening and molecular docking, this compound can directly bind to the THBS2 protein. In vitro and in vivo studies show that this compound inhibits THBS2-mediated HSC activation in a concentration- and time-dependent manner, inhibits ECM deposition in a mouse model of liver fibrosis, downregulates the expression of fibrosis-related genes, and alleviates liver inflammation and macrophage infiltration. Simultaneously, the targeted efficacy was verified in a transgenic mouse model specifically expressing human THBS2, demonstrating significant clinical translational value. Furthermore, it exhibits bioavailability and safety at effective dosages, showing broad clinical application prospects.

The application discloses application of methylated gossypol in preparation of a coronavirus inhibitor. The application provides application of at least one of a compound as shown in a formula I, a solvate of the compound, a pharmaceutically acceptable salt of the compound, a solvate of the pharmaceutically acceptable salt of the compound in preparation of the coronavirus inhibitor. The compound provided by the application has the advantages of clear target, high safety, significantly improved inhibitory activity, potential for wide application and potential therapeutic effect on diseases caused by the novel coronavirus.

This invention relates to the field of coal mine gas geological disaster prevention and intelligent identification technology, and discloses a method and system for intelligent identification and graded early warning of underground gas geological anomalies in coal mines. The method includes: S1, collecting multi-source heterogeneous monitoring data in the target area of ​​the coal mine and performing standardization processing and spatiotemporal benchmark unification; S2, constructing a multi-dimensional feature fingerprint database based on historical or accumulated standardized datasets; S3, acquiring real-time multi-source monitoring data for the current tunneling or exploration process and extracting its features; based on the multi-dimensional feature fingerprint database, using evidence theory to fuse and calculate multiple extracted real-time feature evidences to obtain a comprehensive confidence assessment result for the existence of a specific type of gas geological anomaly in the undiscovered area ahead; S4, generating graded early warning information based on the comprehensive confidence assessment result and a preset risk level threshold. This invention achieves advanced identification, risk assessment, and targeted early warning of geological disasters such as underground gas outbursts.

This invention relates to a drug for the prevention and / or treatment of T-cell acute lymphoblastic leukemia and its application. The active ingredient in the drug is anserin P-3, with the molecular formula C32H43ClN2O9. Anserin P-3 specifically targets the oncogene C-MYC, demonstrating significant efficacy against T-cell acute lymphoblastic leukemia and showing promising application prospects in the clinical treatment of this disease.

This invention discloses the application of MIF gene silencing in the preparation of drugs for treating premature rupture of membranes (PPROM), belonging to the fields of biomedicine and molecular biology. By collecting fetal membrane tissues from patients with PPROM and normal controls, this invention found that the expression level of MIF protein and the concentration of PGE2 were significantly increased in the PPROM group. Further investigation using siRNA technology to silence the MIF gene in human amniotic epithelial cells revealed that MIF silencing significantly reduced PGE2 levels. This invention is the first to demonstrate that MIF gene silencing can effectively treat PPROM by reducing PGE2 (inhibiting uterine contractions). This invention also provides a pharmaceutical composition containing MIF siRNA. This invention provides a novel molecular target and therapeutic strategy for the treatment of PPROM, with broad clinical application prospects.

The invention provides an application of BAPTA-AM in preparation of a medicine for improving dental fluorosis. The BAPTA-AM is used for preparing the medicine for improving the dental fluorosis. The BAPTA-AM provided by the invention can be used for promoting normal mineralization of enamel by correcting calcium homeostasis of glazing cells and reversing mitochondrial injury induced by sodium fluoride, so that a brand-new candidate substance and a clear action target are provided for drug treatment of dental fluorosis.

The application discloses CsPHO1;H3 The application relates to the fields of plant genetic engineering and vegetable breeding technology, and discloses application of a gene in improving photosynthetic efficiency and energy metabolism of cucumber seedlings. CsPHO1;H3 The application proves for the first time that overexpression of the gene can positively improve photosystem II efficiency and net photosynthetic rate of cucumber, and can improve TP, ATP and ATP / ADP, and optimize cell energy state, and the photosynthetic improvement is not dependent on stomatal regulation, and does not increase transpiration water consumption, and the plant is more stable and stronger in resistance. The application has clear gene function, and the obtained cucumber seedlings are stable in traits, and can be directly used for cucumber transgenic breeding, gene editing breeding and molecular marker assisted breeding.

This invention discloses a miRNA belonging to the field of biotechnology. The miRNA is pal-miR-133a-3p, and its nucleotide sequence is shown in SEQ ID NO. 1. The target gene of pal-miR-133a-3p is C1QTNF6, and the nucleotide sequence of the target gene C1QTNF6 is shown in SEQ ID NO. 2. This invention also discloses the application of the miRNA in regulating C1QTNF6 gene expression and its application in preparing products that regulate the expression of this gene. The pal-miR-133a-3p of this invention can inhibit the expression of C1QTNF6, affect adipocyte differentiation, and thus regulate lipid synthesis, showing potential application value in the regulation of duck lipid metabolism and differentiation. Furthermore, the regulatory product prepared using this miRNA can achieve targeted regulation of the C1QTNF6 gene with precise and efficient regulatory effects.