The invention provides a synthesis method of
calcium ion selective chelating agents and relates to a synthesis method of biological medicaments. According to the synthesis method, 1, 2-bi(2-aminophenoxy) ethane is used as raw materials to take two steps of reaction:
esterification reaction and acidification reaction, 2-bi(2-aminophenoxy) ethane-N, N, N', N'-quadrol(2a,
BAPTA) is synthesized, and the structure of compounds 2a is shown by IR, 1HNMR. Through regulating the mixture ratio and the catalyst consumption, the mol ratio of 1, 2-bi(2-aminophenoxy) ethane to methyl bromoacetate to diisopropylethylamine is 1:5.2:5.2, the yield of the 2-bi(2-aminophenoxy) ethane-N, N, N', N'-quadrol methyl ester(1a,
BAPTA methyl ester) is 86 percent, and the purity is 97.45 percent. A chemical purification method is adopted, the
BAPTA purity can reach 99 percent, and the yield can reach 94 percent at the purity. The method has the advantages that the production cost is reduced, the process steps are optimized, and in addition, the quality and the yield are improved.