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Novel calcium-ion selective chelating agent and preparation method and application thereof

A calcium ion, selective technology, applied in chemical instruments and methods, organic compound/hydride/coordination complex catalysts, drug combinations, etc. Achieve the effect of good industrial production potential, excellent biological activity, and good yield

Active Publication Date: 2015-10-28
ANHUI HEALSTAR PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But on the other hand, although BAPTA is a calcium ion complexing agent with excellent performance, it cannot penetrate the cell membrane into the cell to exert its medicinal effect because of its high dissociation performance.
In order to overcome this defect, the microinjection method was used to introduce cells, but this is only a basic theoretical research. The experimental method is very difficult and inconvenient to use, so it cannot be practically applied, and especially cannot be applied in the field of medical treatment.

Method used

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  • Novel calcium-ion selective chelating agent and preparation method and application thereof
  • Novel calcium-ion selective chelating agent and preparation method and application thereof
  • Novel calcium-ion selective chelating agent and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example 1

[0056] Preparation Example 1: Preparation of Catalyst C1

[0057] (1) SBA-15 mesoporous molecular sieves were calcined at 500°C for 40 minutes, and then naturally cooled to room temperature to obtain primary treated molecular sieves;

[0058] (2) placing the primary treated molecular sieve in a water vapor atmosphere at 500° C. for 60 minutes to obtain a secondary treated molecular sieve;

[0059] (3) Add secondary treatment molecular sieve and ionic liquid N,N,N',N'-tetramethyl-N,N'-disulfonic acid propylpropylenediamine bisulfate to an appropriate amount of ethyl acetate (where , the mass of the secondary treatment molecular sieve and N,N,N',N'-tetramethyl-N,N'-disulfonic acid propylpropylenediamine bisulfate is 1:0.4), at 40°C Thoroughly stir and mix for 8 hours, then filter, wash the resulting solid with deionized water 2-3 times, and then vacuum-dry to obtain catalyst C1.

preparation example 2

[0060] Preparation Example 2: Preparation of Catalyst C2

[0061] (1) SBA-15 mesoporous molecular sieves were calcined at 520°C for 30 minutes, and then naturally cooled to room temperature to obtain primary treated molecular sieves;

[0062] (2) placing the primary treated molecular sieve in a water vapor atmosphere at 500°C for 70 minutes to obtain a secondary treated molecular sieve;

[0063] (3) Add the secondary treatment molecular sieve and ionic liquid N,N,N',N'-tetramethyl-N,N'-disulfonic acid propylpropylenediamine bisulfate into an appropriate amount of chloroform (wherein, the The mass ratio of the secondary treatment molecular sieve to N,N,N',N'-tetramethyl-N,N'-disulfonic acid propylpropylenediamine bisulfate is 1:0.5), fully Stir and mix for 6 hours, then filter, wash the resulting solid with deionized water for 2-3 times, and then vacuum-dry to obtain catalyst C2.

preparation example 3

[0064] Preparation Example 3: Preparation of Catalyst C3

[0065] (1) SBA-15 mesoporous molecular sieves were calcined at 550°C for 20 minutes, and then naturally cooled to room temperature to obtain primary treated molecular sieves;

[0066] (2) placing the primary treated molecular sieve in a water vapor atmosphere at 500°C for 80 minutes to obtain a secondary treated molecular sieve;

[0067] (3) Add the secondary treatment molecular sieve and ionic liquid N,N,N',N'-tetramethyl-N,N'-disulfonic acid propyl propylene diamine bisulfate into an appropriate amount of benzene (wherein, the The mass ratio of the secondary treatment molecular sieve to N,N,N',N'-tetramethyl-N,N'-disulfonic acid propylpropylenediamine bisulfate is 1:0.6), fully Stir and mix for 4 hours, then filter, wash the resulting solid with deionized water for 2-3 times, and then vacuum-dry to obtain catalyst C3.

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Abstract

The invention provides a novel calcium-ion selective chelating agent as shown in the formula (I) and a preparation method and application thereof. The compound has excellent capacity of ischemia and oxygen deprivation resistance, meanwhile has excellent transcellular capacity serving as a transport substrate of OATP1B1 transport proteins and has very important meaning and potential value in research of BAPTA derivates.

Description

technical field [0001] The invention relates to a pharmaceutical compound and its preparation method and application, more particularly to a novel calcium ion selective chelating agent, its preparation method and application, and belongs to the field of medicinal chemistry. Background technique [0002] Among the multiple causes of cell death, ischemia and hypoxia are the main causes of acute mass cell death in the human body, which lead to the occurrence of many serious diseases, such as ischemic stroke, myocardial infarction leading to the death of brain cells and cardiomyocytes Wait. [0003] In recent years, due to the in-depth research and a lot of efforts of scientists, the research on the mechanism of cell death related to ischemia and hypoxia has also made some progress, which guides the direction for the research and development of drugs that can avoid cell death, and also provides Theoretical basis and practical basis. [0004] During cell death, excess intracell...

Claims

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Application Information

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IPC IPC(8): C07D295/088A61K31/4453A61P9/10A61P1/16A61P13/12A61P1/18A61P35/00B01J31/02
CPCB01J31/0279B01J31/0284B01J31/0292B01J2231/49C07D295/088
Inventor 陈嫣
Owner ANHUI HEALSTAR PHARM CO LTD
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