9results about How to "Good industrialization potential" patented technology

The present application relates to a kind of spectral analysis system and method, specifically, a kind of laser-induced breakdown spectroscopy analysis system and method based on suspended electrode and filter paper.The system includes filter paper, adjustable sample stage, high-voltage discharge device, suspended electrode, laser ablation device and spectral signal acquisition and analysis device.The present application uses suspended electrode to change the distribution characteristics of high-voltage electric field, increase local electric field line density and electric field intensity, improve the collision frequency of charged particles in plasma, so as to further enhance the detection sensitivity of LIBS to trace elements, and reduce its detection limit.High-voltage discharge device is used to excite laser plasma again, to improve the detection and analysis ability of target elements.Filter paper enrichment method is used for pretreatment of the sample to be measured, which can effectively reduce the interference of liquid matrix on plasma spectral signal, and improve the sensitivity and stability of detection signal.

This invention belongs to the field of aluminum alloy materials technology, and relates to a high-strength and ductile aluminum alloy and its preparation method. The alloy comprises, by mass fraction: 2-6% Mg, 0.4-0.9% Mn, 0.2-0.6% Si, 0.05-0.15% Sn, Fe≤0.15%, Ti≤0.1%, with the balance being Al. By introducing Sn, a low-melting-point MgSiSn primary phase is formed in the as-cast stage, and transforms from a continuous network to a discontinuous granular structure during homogenization heat treatment, weakening the adverse effects of brittle intermetallic compounds at grain boundaries. Simultaneously, Sn dissolved in the aluminum matrix forms a nanoscale MgSiSn precipitate during homogenization, serving as a heterogeneous nucleation core for the Mn-containing second phase, lowering its nucleation energy barrier, and promoting high-density, fine, and uniform precipitation, thereby achieving a synergistic improvement in the alloy's strength and ductility.

The application belongs to the technical field of nuclear fuel cycle and nuclear waste liquid treatment. The application reports a kind of carboxyl-substituted o-phenanthroline water-soluble ligand based on selective masking of part of trivalent actinide under high acidity conditions, and under optimal conditions, the separation coefficient of trivalent europium can reach 120 in 1.5M nitric acid; the separation coefficient of trivalent cerium can reach 4.4. The single crystal structure of the complex is a double metal dimer structure, which guarantees the high acidity tolerance and high selectivity of the ligand. The synthesis of the ligand involved in the application is simple, the extraction efficiency is high, and the extraction mode is novel; the related content will greatly promote the design and performance optimization of water-soluble lanthanum, lanthanum, actinium and actinium separation ligand.

The invention discloses a preparation method and application of a probiotic-entrapped collagen composite nano-carrier. The preparation method is characterized by comprising the following steps: mixing a fish gelatin protein solution and a polysaccharide solution, adjusting the pH value to be alkaline, heating to carry out glycosylation reaction, and purifying to obtain glycosylated fish gelatin protein. Mixing and emulsifying the glycosylated fish gelatin protein solution serving as a water phase and the oil phase by adopting a reversed-phase emulsification method to form a W / O type emulsion; adding a probiotic bacterial suspension, uniformly stirring, adding a cross-linking agent, carrying out a cross-linking reaction, carrying out solid-liquid separation, washing, and drying, so as to obtain the probiotic-entrapped collagen composite nano-carrier; the preparation method has the advantages that precise and slow-release release in intestinal tracts is realized, and the survival rate and bioavailability of probiotics are remarkably improved.

This application discloses a soluble microneedle composition of a GLP-1R agonist and its preparation method, belonging to the field of biomedical technology. It includes a needle body material and a base material. The needle body material contains a small molecule GLP-1R agonist, a penetration enhancer, and a soluble polymeric backbone material, and may further include pH adjusters, humectants, and stabilizers. The base material is composed of polylactic acid, polylactic acid-glycolic acid copolymer, cross-linked polyhyaluronic acid, cross-linked gelatin, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer, N-(2-hydroxypropyl)methacrylamide polymer, or combinations thereof. Through injection, centrifugation, and drying, an integrated microneedle structure with mechanical strength and rapid dissolution is formed. It can pierce the stratum corneum of the skin to form microchannels and rapidly dissolve and release oxaliplatin subcutaneously, achieving transdermal delivery, effectively reducing gastrointestinal exposure and first-pass metabolism, and improving drug utilization and medication adherence.

The application discloses a method for preparing a chiral biphenyl-substituted propanol compound by using alcohol dehydrogenase, and the alcohol dehydrogenase is used to catalyze a biphenyl-substituted propanone reaction to generate a target product. The alcohol dehydrogenase is derived from Leifsonia sp., the amino acid sequence of the alcohol dehydrogenase is shown as SEQ ID NO. 1, and the nucleotide sequence of the alcohol dehydrogenase is shown as SEQ ID NO. 2. Under the optimized alcohol dehydrogenase catalytic reaction condition, (S)-1-(4-biphenyl)-3-chloro-2-propanol is synthesized, the substrate concentration is 100 g / L, the reaction conversion rate is greater than 99%, and the chiral purity is greater than 99.5% ee, and the method has good industrial application value. R is hydrogen, halogen, alkyl, alkoxy, hydroxyl or the like.

This invention belongs to the field of materials heat treatment technology, specifically relating to a heat treatment method, microstructure, and microstructure control method for α-solidified TiAl alloy castings. This method targets α-solidified TiAl alloy castings with unstable lamellar microstructure obtained from metal mold casting. It involves hot isostatic pressing under high temperature and high pressure conditions, utilizing the high-pressure environment to promote atomic diffusion and eliminate casting defects, completely transforming the unstable lamellar microstructure into a stable near-γ microstructure dominated by blocky γ phase. This step replaces the traditional process of water quenching and oil quenching, which are highly prone to cracking and are necessary to destroy the stable lamellar structure. Subsequently, seven cycles of "heating-short-time holding-air cooling" are performed in the upper part of the α+γ two-phase region below the α phase transformation point of the alloy, utilizing the cyclic phase transformation from γ to α to (α+γ) to achieve successive grain splitting and refinement. This invention eliminates the risk of stress cracking during heat treatment at its source, is suitable for complex thin-walled castings, and can obtain a fine-grained near-lamellar microstructure.

The application discloses an anti-resonant fiber optimization design method and system for infrared waveband transmission, and belongs to the technical field of optical fiber communication, and comprises the following steps: constructing an air-core anti-resonant fiber model for cooperatively optimizing limited loss and bending loss in a target infrared waveband, wherein the air-core anti-resonant fiber model has a five-tube nested structure; selecting a group of key structure parameters to be optimized; determining the theoretical value range of the large-circle wall thickness and the small-circle wall thickness based on the anti-resonant optical principle, and combining with the preparation process constraint to determine the common feasible domain of all the key structure parameters; and cooperatively optimizing through phased parameterization scanning, wherein the optimization parameter subspace is determined through coarse scanning, and the optimal structure parameter combination meeting the preset loss threshold is screened out in the subspace through fine scanning. According to the application, the fiber structure parameters are cooperatively optimized in the 808 nm waveband, the limited loss and the bending loss are significantly reduced, and good process feasibility is ensured.

The application belongs to the technical field of biocatalytic synthesis of steroid drugs, and particularly relates to a dehydrogenase, a gene, an engineering bacterium and application, the amino acid sequence of the dehydrogenase is SEQ ID NO. 1 or SEQ ID NO. 2, the dehydrogenase has high dehydrogenation activity, high stereoselectivity and strong regioselectivity, and no other conformation impurities are generated; the engineering bacterium can efficiently secrete the dehydrogenase, and effectively improves the conversion efficiency of a substrate, especially for a substrate 6-methy format (11beta, 17alpha-dihydroxy-6alpha-methylpregna-1, 4-diene-3, 20-diketone), which is low in cost and has significant industrialization potential; the dehydrogenase mutant has clear physicochemical properties, and the method of whole cell catalysis is used, so that the cumbersome step of enzyme purification is omitted, and the cost is reduced and the operation is simple.