BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure

A technology for liver failure and derivatives, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2010-01-27
HENGXING PHARMA INST HEFEI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no specific drug for LF (see: Chinese Medical Association Infectious Diseases Branch Liver Failure and Artificial Liver Group, Chinese Medical Association Liver Diseases Branch Severe Liver Disease and Artificial Liver Group Diagnosis and Treatment Guidelines for Liver Failure

Method used

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  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure
  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure
  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure

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Embodiment Construction

[0026] BAPTA reacts with acetoxymethyl to form acetoxymethoxytetranitrile (BAPTA-AM). BAPTA-AM is highly fat-soluble and works in cells through the cell membrane, so it is also called "cell permeable". sex". HXB-08 is the water-soluble disodium salt of BAPTA, the molecular formula is C 42 h 62 N 2 O 12 Na 2 . In view of the fact that intracellular calcium overload is the ultimate path to cell death caused by various reasons, directly and rapidly reducing intracellular free calcium concentration, reducing or eliminating calcium overload is an effective and primary way to rescue endangered cells and reduce cell damage.

[0027] Pharmacodynamic study of BAPTA derivatives: According to various models of liver failure in mice, in vivo and in vitro experiments were carried out, the research is as follows:

[0028] 1. BAPTA derivatives to CCl 4 Observation on the therapeutic effect of acute liver failure (ALF) in mice:

[0029] In this experiment, CCl 4 Induce ALF in mice, a...

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Abstract

The invention discloses a BAPTA and an application of derivant thereof, in particular an application in rescuing and treatment medicines of hepatic failure.

Description

technical field [0001] The present invention relates to the use of a class of compounds and derivatives thereof, in particular to the use of BAPTA and derivatives thereof. Background technique [0002] Viral hepatitis is a virus-infected autoimmune disease, and its final result is severe liver damage leading to liver failure (Liver failure, LF) and death. Liver disease is one of the most common human diseases. my country is In countries with a high incidence of viral hepatitis, the mortality rate from liver failure is as high as 60-90%. At present, there is no specific drug for LF (see: Chinese Medical Association Infectious Diseases Branch Liver Failure and Artificial Liver Group, Chinese Medical Association Liver Diseases Severe Liver Diseases and Artificial Liver Group Diagnosis and Treatment Guidelines for Liver Failure. Chinese Journal of Infectious Diseases 2006 ; 12(24):422-446). Therefore, the research and development of effective drugs for LF to reduce the mortalit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/25A61P1/16
Inventor 刘经星魏伟宋必卫付再林
Owner HENGXING PHARMA INST HEFEI
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