Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure

A technology for liver failure and derivatives, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2010-01-27
HENGXING PHARMA INST HEFEI
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for LF (see: Chinese Medical Association Infectious Diseases Branch Liver Failure and Artificial Liver Group, Chinese Medical Association Liver Diseases Branch Severe Liver Disease and Artificial Liver Group Diagnosis and Treatment Guidelines for Liver Failure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure
  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure
  • BAPTA and application of derivant thereof in rescuing and treatment medicine of hepatic failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] BAPTA reacts with acetoxymethyl to form acetoxymethoxytetranitrile (BAPTA-AM). BAPTA-AM is highly fat-soluble and works in cells through the cell membrane, so it is also called "cell permeable". sex". HXB-08 is the water-soluble disodium salt of BAPTA, the molecular formula is C 42 h 62 N 2 O 12 Na 2 . In view of the fact that intracellular calcium overload is the ultimate path to cell death caused by various reasons, directly and rapidly reducing intracellular free calcium concentration, reducing or eliminating calcium overload is an effective and primary way to rescue endangered cells and reduce cell damage.

[0027] Pharmacodynamic study of BAPTA derivatives: According to various models of liver failure in mice, in vivo and in vitro experiments were carried out, the research is as follows:

[0028] 1. BAPTA derivatives to CCl 4 Observation on the therapeutic effect of acute liver failure (ALF) in mice:

[0029] In this experiment, CCl 4 Induce ALF in mice, a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a BAPTA and an application of derivant thereof, in particular an application in rescuing and treatment medicines of hepatic failure.

Description

technical field [0001] The present invention relates to the use of a class of compounds and derivatives thereof, in particular to the use of BAPTA and derivatives thereof. Background technique [0002] Viral hepatitis is a virus-infected autoimmune disease, and its final result is severe liver damage leading to liver failure (Liver failure, LF) and death. Liver disease is one of the most common human diseases. my country is In countries with a high incidence of viral hepatitis, the mortality rate from liver failure is as high as 60-90%. At present, there is no specific drug for LF (see: Chinese Medical Association Infectious Diseases Branch Liver Failure and Artificial Liver Group, Chinese Medical Association Liver Diseases Severe Liver Diseases and Artificial Liver Group Diagnosis and Treatment Guidelines for Liver Failure. Chinese Journal of Infectious Diseases 2006 ; 12(24):422-446). Therefore, the research and development of effective drugs for LF to reduce the mortalit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/25A61P1/16
Inventor 刘经星魏伟宋必卫付再林
Owner HENGXING PHARMA INST HEFEI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com