270 results about "Metal chelation" patented technology

Chelating and binding chemicals to a medical implant, and therapeutic applications. Implantable metal chelated surface and chemical coated medical implant device—drug (or biological moiety) coated or drug eluting stent, prosthesis, or other, includes a medical implant component having metal surface (M) with chemical entity (X) bound via chelator (C) chelated to the metal surface in an (M)-(C)-(X) configuration. Chelator or/and chemical entity—drug (or biological moiety), linker bonded to a drug (or biological moiety), other, are bound at surface concentration greater than 100 picograms per cm². Manufacturing the implantable medical device. Medical implant system including medical implant component and delivery device for delivering and implanting medical implant component in a subject. Implanting the medical device. Preventing or/and treating medical conditions, such as restenosis or/and thrombosis, by implanting the medical device, wherein activity of bound chemical entity exhibits efficacy towards the medical condition.

The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

Functionalized polymers are mixed with pesticides to form semi-stable complexes with desirable field properties: reduced leaching in soil, improved leaf retention (rainfastness), selective unloading to roots and convenient packaging and application. Pesticides that may be so complexed include herbicides, insecticides (including compounds controlling non-insect arthropods and nematodes), bacteriocides, rodenticides, and fungicides. Polymers with which they may be complexed include derivatives of carbohydrates, amides, imines, alkanes, vinyls, styrenes or glycols. The polymers may be functionalized with chemical groups that exhibit ionic (amines, carboxyls), hydrophobic, complexing (e.g. metal chelating) and ligand binding interactions. The variously functionalized polymers may be mixed, grafted, or fused to obtain optimal properties. The polymer/pesticide formulations may be applied as granules, as suspensions or solutions in sprays, as foams, or as coats for seeds and fertilizers. The formulations may be applied to foliage, soil, irrigation water, construction materials (plastics, wood), seeding materials, grains, and buildings.

The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N′N′-tetraacetic acid), wherein the chelating moiety has been modified from a tetraacetic acid moiety to a tri- di- or monoacetic moiety. This change in acetic acid groups on the metal chelating moiety results in the selective bindings of zinc ions in the presence of calcium ions, both of which are present in biological fluids and intracellular cytosolic fluid and organelles.

A method for producing an electrophotographic toner comprising the steps of: (1) mixing a water-insoluble organic solvent, an oil-soluble dye capable of chelating with a metal, a metal compound and water to form an oil-soluble dye dispersion, (2) removing the organic solvent from the oil-soluble dye dispersion to form colored microscopic particles, and (3) adding an emulsion thermoplastic resin to the colored microscopic particles so as to associate the particles with slow coagulation.

The invention relates to a method for preparing heavy metal chelating resin, in particular to a method for preparing silica gel supported dithiocarbamate heavy metal chelating resin and adsorption of heavy metals such as lead, cadmium, copper, mercury and the like by the resin. The method comprises the following steps of: reacting carbon disulfide with a polyamine compound to generate a dithiocarbamate compound; and grafting the dithiocarbamate compound onto the surface of silicon dioxide, wherein a halogen group is modified on the surface of the silicon dioxide. By the method, the adsorption capacity of dithiocarbamate chelating resin is effectively improved; and the problem that silica gel is dissolved due to too high alkalinity of a reaction system (pH value is more than 11), or the dithiocarbamate compound cannot be generated through reaction due to too low alkalinity (the pH value is less than 10) when a dithiocarbamate functional group is prepared by reacting the silica gel with the carbon disulfide in the conventional synthetic route is solved, wherein an amino group is modified on the surface of the silica gel.

The invention provides a trace metal element chelation fertilizer in lignin and application thereof. The trace metal element chelation fertilizer in the lignin is a mixture of lignosulfonate and metal element chelates and shows the following physical-chemical characteristics of: 1, appearance: white powder; and 2, stability parameters of chelate: the average coordination number x is between 0.9 and 1.95 and the stability constant 1gK is between 0.6 and 2.10; and 3, the metallic chelation rate is 10 to 13.55 percent. The lignosulfonate-metal element chelation fertilizer is prepared by performing oxidative modification reaction on paper-making waste liquid lignosulfonate and metal elements such as iron, zinc and copper which serve as raw materials, and the chelation property of lignin ammonium is quantitatively described by measuring the stability of the chelates of lignin ammonium-Fe and lignin ammonium-Zn. The industrial lignin and the metal elements form the 'lignin-metal elements' chelates, and the obtained chelates are dried to form solid products or the obtained chelates after proper concentration can be mixed with other kinds of fertilizers to prepare various compound fertilizers.

The present invention relates to high purity ulinastatin and its medicine composition and their preparation process. Specially, the high purity ulinastatin in 50,000 U/ml concentration has optical absorption value at 405 nm not exceeding 0.05 and human urea kininogenase content not exceeding 0.0003 PNAU. The present invention purifies ulinastatin product through adsorption with hydrophobic column, purification in hydrophilic column, combination with metalloprotein in metal chelating column and elution with buffering phosphate solution.

The invention discloses a high molecular heavy metal chelating flocculant and a preparation method thereof. The high molecular heavy metal chelating flocculant is prepared by the following steps of: quaternizing diallyl methylamine and epoxy chloropropane in an organic solvent, and grafting polyethylene polyamine onto molecules by performing epoxy group ring opening with polyethylene polyamine; decolorizing with active carbon, and evaporating and concentrating to obtain a diallyl quaternary ammonium salt monomer solution; polymerizing through a free radical aqueous solution to synthesize a diallyl quaternary ammonium salt polymer; and reacting with carbon bisulfide and sodium hydroxide. The high molecular heavy metal chelating flocculant is characterized in that: each structural unit of ahigh molecular chain is provided with a positive charge and a plurality of strong chelation groups -CSS- with negative charges, so that the defect of non-uniform positive charge distribution of the conventional ampholytic chelating flocculant is avoided, neutralization of negative charges produced in a floc forming process is facilitated, a floc structure is improved, the formation and growth of floc are promoted, the heavy metal ion chelating capability and flocculating settling performance are enhanced, and the size of sediments is reduced.

The invention discloses a polyvinyl tetrazole separation medium and a preparation method thereof. The polyvinyl tetrazole separation medium has a structurally general formula shown in the specification. The separation medium of the invention can be obtained by modifying polyvinyl tetrazole on the surfaces of silica gel, agarose or polystyrene microspheres. The separation medium of the invention has double functions of separating an ion-exchange chromatograph and a metal-chelating chromatograph. The medium is used for the ion-exchange separation chromatograph and the metal-chelating chromatograph of a protein, and has the characteristics of high protein adsorption capacity, quality, activity, and recovery rate.

The invention provides a multifunctional plastic with an anti-microbial effect, an oxidation resistance and a metal-chelating property and a preparation method thereof. The plastic material is mainly prepared from the following raw materials in parts by weight: 6%-10% of active anti-microbial agent, 2%-6% of active antioxidant, 3%-8% of metal-chelating agent and the balance of macromolecule resin base membrane. The modified resin substrate has certain anti-microbial effect, oxidation resistance and metal-chelating property. A novel application material is supplied for the products, such as, electronic cigarette, and the fields, such as, food packaging. The plastic has certain various characteristic functions; on the basis of improvement for the inherent performance of the products, the plastic is endowed with a more practical characteristic; the guarantee period of the products is prolonged and the application thereof is improved, so that the market value is promoted; the original raw material cost is lowered; the market space is expanded and the incoming is increased.

The invention provides modified oligonucleotides of formula (I), comprising at least one metal chelator which provides a powerful tool for study of the pharmacokinetics of siRNA and its correlation with in vivo activity. The chelated metals provide luminescent properties enable detection of the oligonucleotides through the use of time-resolved fluorescent quenching based on energy transfer from the metal ion to a nonfluorescent quencher which can be used as non-isotopic labels of oligonucleotides for diagnostics and evaluation of cellular uptake.

The present invention relates to a high-load agarose chromatography media comprising a shell and an inner core, the shell portion is covalently bonded with linear macromolecules such as glucan and the like, the shell portion and the inner core portion are coupled with ligands, and ligand species include metal ions, hydrophobic ligands, ion exchange groups and proteins, and the like. The present invention also includes a preparation method of the high-load agarose chromatography media. For example, the load of histidine tagged (His-tagged) recombinant protein of a metal chelated chromatography media prepared by the method is about 2.5 times of that of conventional media. The high-load agarose chromatography media has good prospects in the fields of biological separation and purification.

The invention discloses a compound disinfectant for livestock and poultry raising environment and mainly comprises o-phthalaldehyde and deka-methonium bromide. The compound disinfectant comprises the components by weight percent: 0.05-1% of o-phthalaldehyde, 0.0001-0.05% of deka-methonium bromide, 1-5% of cosolvent, 0.001-0.1% of metal chelating agent, 0.001-1% of stable inhibitor and balance water; and the sum of the weight percent of the components in the scheme is 100%. By compounding the o-phthalaldehyde and the deka-methonium bromide, the compound disinfectant not only reduces the using quantity of the o-phthalaldehyde, the inconvenience for the field application caused by contamination and the irritation of disinfection for animals, but also avoids the disadvantage that the o-phthalaldehyde can not effectively kill bacterial spores. The compound disinfectant can be applied to air and ground sterilization of livestock and poultry for the animals in livestock and poultry houses, and air, ground, excrement and water sterilization of an animal farm. The compound disinfectant has the characteristics of efficiently killing environmental microorganism as well as low irritation, low corrosiveness and simple and convenient field application.

The invention provides a metal chelated chromatography filling preparing method, combined of 4% cross-linked agarose gel and iminodiacetic acid. Compared with existing similar products, it has an outstanding advantage in velocity of flow and molecule exclusion limit, properly applied to industrial-scale protein purification.

The invention belongs to the technical field of heavy metal environmental governance, and discloses a method for preparing a porous polymer microsphere with a heavy metal chelating function, porous poly glycidyl methacrylate polymer microspheres are prepared by free radical emulsion polymerization, and heavy metal chelating functional groups are used for modification of the surface of the microspheres and the surface of holes for establishment of heavy metal chelating adsorption channels to prepare the porous polymer microsphere with the heavy metal chelating function. The porous polymer microsphere with the heavy metal chelating function has the advantages of large specific surface area, many heavy metal chelating sites, and high efficiency, stability and durability of adsorption and removal of heavy metals, and can be conveniently bonded to the surface of a substrate.

The invention provides a heavy metal chelating resin, the synthesis of which comprises two steps: (1) bisxanthate synthesis: dissolving a certain amount of potassium hydrate into water to prepare water solution with concentration being 30-32%; cooling potassium hydrate solution to 4-6 Deg. C, adding glycol with its weight being 0.5-1.7 tines of that of glycol potassium hydrate, reacting for 25-35 minutes; cooling continuously to 1-3 Deg. C, adding carbon bisulphide with its weight being 1.4-1.6 times of that of potassium hydrate, stirring at room temperature for 3-5 hours; vacuum distilling, filtering and washing with alcohol isopropylicum, drying and getting bisxanthate; (2) resin synthesis: dissolving bisxanthate in N,N-dimethyl formamide solution thoroughly, stirring at room temperature and adding N- dimethyl formamide solution containing terephthaloyl chloride with its weight being 0.5-0.8 ties of that of bisxanthate potassium salt, stirring continuously for 3-4 hours, adding water, sucking, washing with distilled water and acetone, drying and getting final product. The chelating ability of chelating resin is strong and so it is used for treating wastewater containing heavy metal.