22 results about "Thiocarboxylic acid" patented technology

This invention relates to a polytetrafluoroethylene (PTFE) exhibiting both high wear resistance and a low coefficient of friction, and its preparation method, belonging to the field of polymer materials technology. This invention utilizes a thiol coupling agent to modify the surface of halloysite nanotubes, grafting thiol groups onto the surface of the halloysite nanotubes. Simultaneously, an acyl chloride with a long-chain fluorocarbon, a side-chain tetrazolium, and a thioether structure is synthesized. The acyl chloride is then reacted with the modified halloysite nanotubes, bonding the organic acyl chloride to the surface of the halloysite nanotubes via thiocarboxylic acid ester chemical bonds. The long-chain fluorocarbon, side-chain tetrazolium, thioether, and thiocarboxylic acid ester organic groups synergistically work with the inorganic halloysite nanotubes to form functional structures with different hierarchical gradients. The long-chain fluorocarbon can improve the affinity between halloysite nanotubes and PTFE, the thioether and thiocarboxylic acid esters on the main chain can play a reinforcing and toughening role, and the tetrazolium groups on the side chain can play a rigid-flexible role, thereby improving the mechanical, tribological, and dielectric properties of the PTFE material.

The invention discloses a drug design strategy for releasing hydrogen sulfide based on enzymolysis of thiocarbonyl and application of the drug design strategy in indole parent nucleus drug modification, a hydrogen sulfide prodrug is characterized in that an existing drug with a carboxylic acid structure is vulcanized to form a thiocarboxylic acid structure, and the thiocarboxylic acid structure can release H2S under an enzyme catalysis condition; thiocarboxylic acid can be hydrolyzed by esterase and released to obtain hydrogen sulfide, toxic and side effects of existing drugs are improved by means of anti-inflammation, myocardial protection, gastrointestinal tract protection and the like of hydrogen sulfide, physiological functions of hydrogen sulfide are exerted at the same time, and clinical application of hydrogen sulfide is achieved.

The invention relates to a metal surface alloying treatment method, a metal interconnection layer side wall alloying treatment method, a metal interconnection layer and a display panel. The treatment method comprises the following steps: preparing an acidic electrolyte containing first metal ions, and carrying out electrolytic treatment on the electrolyte by taking second metal as a cathode; in the electrolytic treatment process, an inhibitor is added into the electrolyte; wherein the inhibitor comprises a thiocarboxylic acid material, and the reducibility of the second metal is higher than that of hydrogen. First metal ions are firstly deposited to form loose first metal; and a small amount of ions are also dissolved out from the second metal and are continuously subjected to atomic-level co-deposition with the ions of the first metal under the electrolysis action, a uniform alloy layer is formed, and alloying treatment of the surface of the second metal is achieved. The added inhibitor is gradually decomposed, the dielectric constant of the electrolyte is gradually reduced, and the codeposition reaction is automatically terminated when the dielectric constant is reduced to a certain value. Therefore, the method does not need high-temperature treatment, and the alloying treatment effect is controllable and stable.

Provided is a method for producing a 3-mercaptocarboxylic acid under industrially advantageous conditions. The present invention is a method for producing a 3-mercaptocarboxylic acid represented by formula (1), the method comprising the following steps (A) and (B). Step (A): A step for obtaining a thiocarboxylic acid ester by adding a thiocarboxylic acid to a carbon-carbon unsaturated bond of an alpha, beta-unsaturated carboxylic acid. Step (B): a step for adding water and an acid catalyst to the thiocarboxylic acid ester to perform a hydrolysis reaction, wherein the hydrolysis reaction is performed under conditions in which the amount of the acid catalyst during the reaction is 0.025-0.68 equivalent relative to the amount of the thiocarboxylic acid ester and the amount of the water is 1.0 equivalent or more relative to the amount of the thiocarboxylic acid ester. (R1-R3 each independently represents a hydrogen atom or an alkyl group having 1-5 carbon atoms)

The invention relates to the technical field of synthesis of organic compounds, in particular to a synthesis method of polyvaline. The invention discloses a synthesis method of polyvaline, which comprises the following steps: S100, adding valine N-thiocarboxylic anhydride, an initiator and an organic solvent into a reactor, and mixing and stirring to obtain a first reactant; s200, performing ultrasonic reaction on the first reactant to obtain a second reactant; and S300, precipitating the second reactant in an extraction agent, filtering, and drying in vacuum to obtain polyvaline. The synthetic method of the polyvaline is efficient, controllable and stable, and the prepared polyvaline has the characteristics of narrow molecular weight distribution, good solubility, excellent processability and the like, and has wide application prospects in the biomedical fields of drug delivery, tissue engineering, biosensors and the like.

This invention discloses a thiocarboxylic acid ester silane coupling agent for the modification of rubber substrates. This solution addresses the core contradiction in existing natural rubber-based green low-VOC tire formulations: the difficulty in simultaneously achieving deep VOC emission reduction and improving the interfacial, mechanical, and dynamic properties of the rubber compound. It also resolves issues such as high levels of silane hydrolysis byproducts and residues, poor interfacial bonding and dispersibility between silane and fillers, the tendency to exacerbate VOC emissions by improving filler agglomeration, insufficient compatibility between the formulation and silane reaction characteristics, and inadequate process control. Ultimately, in high-wear-resistant heavy-duty tire tread applications, the total VOC emission of the rubber compound is ≤0.28 mg / m³, tensile strength ≥29 MPa, tear strength ≥98 kN / m, and Akron abrasion ≤0.17 cm³ / 1.61 km; in green low rolling resistance tire tread applications for new energy vehicles, the total VOC emission of the rubber compound is ≤0.22 mg / m³, tensile strength ≥28 MPa, tanδ ≤0.10 at 60℃, tanδ ≥0.35 at 0℃, and wet skid resistance meets EU Tire Labelling Act Class A.

The invention discloses a drug design strategy for releasing hydrogen sulfide based on enzymolysis of thiocarbonyl and application of the drug design strategy in diclofenac drug modification, according to the hydrogen sulfide prodrug, an existing drug with a carboxylic acid structure is vulcanized to form a thiocarboxylic acid structure, and the thiocarboxylic acid structure can release H2S under the enzyme catalysis condition; thiocarboxylic acid can be hydrolyzed by esterase and released to obtain hydrogen sulfide, toxic and side effects of existing drugs are improved by means of anti-inflammation, myocardial protection, gastrointestinal tract protection and the like of hydrogen sulfide, physiological functions of hydrogen sulfide are exerted at the same time, and clinical application of hydrogen sulfide is achieved.

The present invention relates to a process for preparing a polythiol from a polyene, as well as polythiol compositions obtained from cycloaliphatic or isocyanurate-type polyenes. The process for preparing a polythiol comprises the following steps: a) reacting a polyene with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent to obtain a reaction medium comprising a polythioester and said at least one solvent; b) deprotection of the polythioester obtained in step a) to obtain a polythiol, wherein steps a) and b) are carried out in a one-pot synthesis. Figure: None

The present invention relates to a process for preparing a polythiol from a terpene or a terpene derivative, as well as polythiol compositions and novel polythiols. The process comprises the following steps: a terpene or a terpene derivative is reacted with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent, so as to obtain a reaction medium comprising a polythioester and said at least one solvent; a deprotection step is carried out on the polythioester obtained in step a), so as to obtain a polythiol; wherein steps a) and b) are carried out in one-pot synthesis.

Disclosed are novel salts of C4-carboxylic acid-substituted and C4-carbonothioate-substituted tryptamine derivative compounds and pharmaceutical and recreational drug formulations containing the same. The pharmaceutical formulations may be used to treat brain neurological disorders.

This invention discloses a method for preparing sulfur-containing polymers based on isomerization-driven irreversible ring-opening polymerization. The method includes: in an organic solvent, in the presence of a main catalyst, carrying out a polymerization reaction of one or more monomers; wherein the main catalyst is an anionic or cationic catalyst; the anionic catalyst is a phosphononitrile base, guanidine organic base, amidine organic base, N-heterocyclic carbene organic base, N-heterocyclic olefin organic base, carboxylate, or thiocarboxylate; the cationic catalyst is a zwitterionic catalyst, a neutral Lewis acid catalyst, or a protic acid (ester) catalyst; and the monomer is a five-membered ring skeleton compound as shown in Formula I. This method provides convenience for the industrial production of environmentally friendly sulfur-containing polymer materials. The synthesized sulfur-containing polymer has advantages such as high molecular weight, wide-range tunable physical properties, and excellent degradability, and can be used as plastics, rubber, elastomers, fibers, and other products.

The invention relates to a graphene lubricant with a self-repairing function and a preparation method thereof, and belongs to the technical field of lubricants, the lubricant comprises graphene oxide sheets with surfaces grafted with thiocarboxylate groups, base oil compounded by poly-alpha olefin and ester oil according to a ratio of 3.8: 1-4.5: 1, and a boron coordination modified polyisobutylene succinimide dispersant; when a lubricating film is broken, the exposed graphene oxide is driven by shearing force to be subjected to lamellar recombination, meanwhile, sulfur atoms and a metal substrate form sigma-coordinate bonds, and a gradient lubricating structure is reconstructed; the surface of the graphene oxide sheet is grafted with a specific sulfur-containing group, sheet layer recombination is triggered by utilizing mechanical shearing force during friction fracture, and meanwhile, sulfur atoms and metal are subjected to spontaneous coordination bonding, so that the self-repairing effect is achieved.

The present invention relates to a process for preparing a polythiol from a polyene, and also to a polythiol composition obtained from a cycloaliphatic polyene or an isocyanurate polyene. The process for preparing a polythiol comprises the steps of: a) reacting a polyene with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent to obtain a reaction medium comprising a polythioacid ester and at least one solvent; b) carrying out a step of deprotecting the polythioacid ester obtained in step a) to obtain a polythiol; wherein the step a) and the step b) are carried out in one-pot synthesis.

A method for preparing alkoxysilyl-containing thiocarboxylic acid esters is provided, which comprises reacting a thioester with an alkali metal, alkaline earth metal, or trisubstituted ammonium salt of a mercapto-functional alkoxysilane and / or an alkoxysilyl-functional thiolate, which method uses economical and readily available reagents, avoids the use of phosgene or thionyl chloride reagents, and produces recyclable by-products.

The application discloses a random copolymer containing glycine residues and proline residues and a synthesis method thereof, and belongs to the technical field of polymer chemistry. The random copolymer is a kind of collagen-like protein, which is obtained by solution polymerization of glycine-N-thiocarboxylic anhydride monomers and proline-N-thiocarboxylic anhydride monomers, or glycine-N-thiocarboxylic anhydride monomers, proline-N-thiocarboxylic anhydride monomers and a third amino acid-N-thiocarboxylic anhydride monomer. The random copolymer has a unit composition similar to that of collagen, and has controllable molecular weight, narrow molecular weight distribution, adjustable composition, solubility in water and common organic solvents, biodegradability, good processing performance, and can further improve and enrich the properties by introducing or changing the third amino acid unit. The random copolymer has a wide application prospect in the fields of biological medicine or cosmetics.

The present invention relates to a process for preparing a polythiol from a terpene or a terpene derivative, as well as a polythiol composition and a novel polythiol. The method comprises the following steps: a)-reacting a terpene or a terpene derivative with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent, in order to obtain a reaction medium comprising a polythioacid ester and at least one solvent; b) deprotecting the polythioacid ester obtained in stage a) in order to obtain a polythiol; wherein the stage a) and the stage b) are carried out in one-pot synthesis.

The invention discloses a drug design strategy for releasing hydrogen sulfide based on enzymolysis of thiocarbonyl and application of the drug design strategy in terminal carboxylic acid drug modification, according to the hydrogen sulfide prodrug, an existing drug with a carboxylic acid structure is vulcanized to form a thiocarboxylic acid structure, and the thiocarboxylic acid structure can release H2S under the enzyme catalysis condition; thiocarboxylic acid can be hydrolyzed by esterase and released to obtain hydrogen sulfide, toxic and side effects of existing drugs are improved by means of anti-inflammation, myocardial protection, gastrointestinal tract protection and the like of hydrogen sulfide, physiological functions of hydrogen sulfide are exerted at the same time, and clinical application of hydrogen sulfide is achieved.

The invention discloses a method for anhydrous production of thiocarboxylate silane by using industrial tail gas hydrogen sulfide, which comprises the following steps: 1) introducing the industrial tail gas hydrogen sulfide into an alcohol-alkali solution for reaction to obtain an alcohol solution of alkali sulfide; 2) adding acyl halide into the alcoholic solution of the alkali sulfide for reaction to obtain an alcoholic solution of thiocarboxylic acid alkali; 3) adding haloalkyl silane into the alcohol solution of the thiocarboxylic acid alkali for reaction to obtain a mixed solution of thiocarboxylic ester silane and salt; and desalting and dealcoholizing to obtain the target product thiocarboxylate silane. According to the method, the target product thiocarboxylate silane can be obtained with high yield under the condition that a phase transfer catalyst is not added.

The present invention relates to a process for preparing polythiols from polyenes, and to polythiol compositions obtained from alicyclic polyenes or isocyanurate-type polyenes. a) A step of reacting a polyene with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent to obtain a reaction medium containing a polythioester and the at least one organic solvent, and b) A step of performing a deprotection step to obtain a polythiol, which includes step a), Steps a) and b) are carried out by one-pot synthesis. Preparation process for polythiols.

The invention discloses a random copolymer containing glycine residues and proline residues and a synthesis method of the random copolymer, and belongs to the technical field of high polymer chemistry, the random copolymer is a collagen-like protein, and a glycine-N-thiocarboxylic acid anhydride monomer and a proline-N-thiocarboxylic acid anhydride monomer are added to prepare the random copolymer containing the glycine residues and the proline residues. The random copolymer is obtained by carrying out solution polymerization on a first amino acid-N-thiocarboxylic acid anhydride monomer, a second amino acid-N-thiocarboxylic acid anhydride monomer or a glycine-N-thiocarboxylic acid anhydride monomer, a proline-N-thiocarboxylic acid anhydride monomer and a third amino acid-N-thiocarboxylic acid anhydride monomer, has a unit composition similar to that of collagen, is controllable in molecular weight, narrow in molecular weight distribution and adjustable in composition, and can be dissolved in water and common organic solvents; the amino acid derivative is biodegradable, has good processability, can further improve and enrich the properties by introducing or changing a third amino acid unit, and has wide application prospects in the field of biological medicines or cosmetics.

The present invention relates to a process for preparing polythiols from terpenes or terpene derivatives, as well as to polythiol compositions and novel polythiols. The process is a) A step of reacting a terpene or terpene derivative with a thiocarboxylic acid in the presence of oxygen (O2) and at least one organic solvent to obtain a reaction medium containing a polythioester and the at least one organic solvent, and b) A step to obtain a polythiol by carrying out a deprotection step of the polythioester obtained in step a). Includes, Steps a) and b) are performed in one-pot synthesis.

The invention discloses a transmission lubricant composition and its preparation and application. The transmission lubricant composition comprises, by mass, 0.1 to 0.5 parts of a phosphorus-containing agent; 0.4 to 1.5 parts of a thiocarboxylate additive; 0.3 to 0.6 parts of an antioxidant; 1.0 to 2.0 parts of an antioxidant and an anti-corrosion additive; 1.25 to 1.95 parts of a detergent; 1.5 to 2.5 parts of an ashless dispersant; 0.005 to 0.03 parts of an anti-foaming agent; and the balance of base oil. The phosphorus-containing agent is triphenyl thiophosphate; and the thiocarboxylate additive is a dialkyl thiodicarboxylate or a dialkyl dithiodicarboxylate. The present invention compounds triphenyl thiophosphate with a thiocarboxylate additive to produce a lubricating oil composition exhibiting excellent high extreme pressure properties and outstanding copper corrosion protection performance. The lubricating oil composition achieves an FZG (A10 / 16.6R / 90) rating greater than 12, while achieving level 1 in a long-cycle copper sheet corrosion test (150°C, 168 hours). The wear loss in an FE8 bearing test is less than 1 mg, making the lubricating oil composition suitable for lubrication of integrated electric drive axles of commercial vehicles.