54results about How to "Reduce death" patented technology

The invention relates to a whole intestine flora transplantation strategy and a nanometer packaging method and application thereof. According to the method disclosed by the invention, the transplantation of the whole intestinal flora is realized by mainly utilizing the combined transplantation of the intestinal fluid flora and the fecal flora, so that the micro-ecology of the whole intestinal tract is more comprehensively, accurately and efficiently regulated and controlled, and a better flora transplantation treatment effect is achieved. The microflora (microcapsules) is encapsulated by a safe biological material, the encapsulating process is simple in process and short in time consumption, intestinal bacteria in different shapes can be simultaneously encapsulated, and the method is not only suitable for encapsulating oxygen-resistant bacteria and facultative anaerobic bacteria, but also suitable for encapsulating intestinal flora including strict anaerobic bacteria, and has the advantages of being simple in process and low in cost. According to the preparation method, death of intestinal bacteria in the preparation process can be reduced, erosion of gastric acid and the like to the intestinal bacteria can be resisted, the survival rate of the bacteria and the colonization efficiency of the bacteria in host intestinal tracts can be remarkably improved, and the microbial transplantation treatment effect is further enhanced.

The utility model relates to the technical field of side slope maintenance, and discloses a side slope protection device with water storage and irrigation functions, which comprises a side slope body, the top of the side slope body is fixedly connected with a water storage mechanism, and the left side of the side slope body is fixedly connected with an auxiliary mechanism; the water storage mechanism comprises a water storage tank, the water storage tank is fixedly connected to the top of the slope, and a first filter screen is arranged at the top of the water storage tank. According to the side slope protection device with the water storage and irrigation functions, by arranging the water storage mechanism, in the using process, rainfall at the top of the side slope body can be collected under the action of a water storage tank, so that the amount of rainfall flowing down the side slope is reduced, and water and soil loss is reduced; and under the action of a first water pump, hollow rods and water outlet holes, vegetation of the side slope body can be irrigated in the non-rainy season, so that death of the vegetation of the side slope body is reduced, the side slope body is protected, and in addition, the side slope body can be protected under the action of the hollow rods and the transverse rods.

The utility model discloses a revetment reinforcing device for water and soil conservation, which comprises a side slope, an outer frame movably connected to the front of the side slope, a fixing plate fixedly connected to the outer wall of the outer frame, a fixing hole formed in the top of the fixing plate, a cross beam movably connected to the inner wall of the outer frame, a protective net movably connected to the bottom of the cross beam, and a revetment arranged on one side of the side slope. A wall is movably connected to the top of the revetment, a containing cavity is formed in the top of the revetment, green plants are arranged on the inner wall of the outer frame, a longitudinal beam is movably connected to one side of the cross beam, a mounting plate is fixedly connected to the outer wall of the cross beam, and mounting holes are formed in the outer wall of the mounting plate. The device has the advantages of being reasonable in structural design, not prone to moving, good in protection effect and the like, and therefore the problems and defects of an existing device are effectively solved.

The invention belongs to the technical field of biomedicine, and provides application of inhibition of Caspase-8 expression in preparation of a medicine for improving macrophage pan-apoptosis. The invention also discloses an application of the NLK gene in preparation of a medicine for improving Caspase-8 dependent macrophage pan apoptosis. In-vitro experiments prove that under the state of sepsis, up-regulated NLK can regulate and control generation of Caspase-8-dependent macrophage pan apoptosis through protein interaction; through NLK knockout, the occurrence of Caspase-8 dependent pan apoptosis can be inhibited, and the death of macrophages is effectively reduced. Therefore, the research results show that the target regulation of Caspase-8-dependent pan apoptosis by intervening the NLK gene is expected to provide benefits for the treatment of sepsis; and a new method is provided for clinical treatment of sepsis.

The invention belongs to the technical field of microecological preparations, and particularly provides a microcapsule wall material which comprises the following components in percentage by mass of water: 4-6% of denatured protein, 1.5-2.5% of sodium alginate and 1.5-2.5% of calcium carbonate. The protein comprises at least one of whey protein isolate and soybean protein isolate. Based on the microcapsule wall material, the invention provides the acid-resistant, cholate-resistant and heat-resistant lactic acid bacteria microcapsule and the preparation method thereof. According to the microcapsule wall material provided by the invention, the protein raw material is subjected to denaturation pretreatment and then is compounded with the sodium alginate and the calcium carbonate, so that compared with the traditional wall material sodium alginate, the microcapsule wall material provided by the invention has the advantages that the embedding rate and the stability can be improved, and the acid resistance, cholate resistance, heat resistance and storage stability of an embedded product are also greatly improved.

The invention provides a method suitable for inhibiting toxic weed ligularia virgaurea and promoting growth of forage grasses loved by cattle and sheep in alpine degraded pastures. Aiming at the defects of the existing physical and chemical weeding methods, the technical scheme of applying the ligularia virgaurea inhibitor and the nitrogen fertilizer is combined, so that the growth of the ligularia virgaurea is effectively inhibited, meanwhile, the growth of forage grass loved by cattle and sheep is promoted, and the ecological comprehensive treatment concept of treating grass with grass is realized. Experimental results show that the method can significantly reduce the biomass and coverage of ligularia virgaurea and improve the biomass and coverage of forage grasses loved by cattle and sheep, and is of great significance to treatment and improvement of toxic weeds, especially high and cold degraded pastures with dominant ligularia virgaurea. The method has the characteristics of simple operation, environmental protection and high efficiency, and is suitable for treatment and improvement of high and cold degraded pastures.

The invention relates to the technical field of crab cleaning, in particular to quick crab cleaning equipment which comprises an operation table, a fixed inclined plate is fixed to the top end of the operation table, a round rod is fixed to the bottom end of the fixed inclined plate, a cleaning brush is arranged on one side of the round rod, and a connecting rod is fixed to one side of the cleaning brush; a first cleaning roller and a second cleaning roller are rotatably inserted into the L-shaped column, a first gear fixedly sleeves the surface of the first cleaning roller, a second gear fixedly sleeves the surface of the second cleaning roller, a square column is fixed to one side of the moving plate, and a bidirectional ball screw is rotatably inserted into the square column through threads. Through cooperative use of the fixed inclined plate, the cleaning brush, the round rod, the second cleaning roller and the moving block, the purpose of cleaning the back and the abdomen of a crab at the same time can be achieved, the device can clean the back and the abdomen of the crab at the same time, and the cleaning efficiency can be improved.

The invention belongs to the technical field of biological medicines, and particularly relates to a thiophenol compound as well as a preparation method and application thereof. The prepared thiophenol compound is applied to human kidney cells HK-2 and living mice, it is found that the compound can remarkably inhibit peroxidation of cell membrane lipid molecules induced by hypoxia-reoxygenation and further induce cell ferroptosis, and the thiophenol compound has a long-term stable inhibition effect. By pretreating the compound, the levels of creatinine and urea nitrogen in serum after kidney injury can be remarkably reduced, which indicates that the compound can relieve acute kidney injury. Besides, the compound prepared by the invention is used for pretreatment, so that kidney external marrow region injury caused by ischemia-reperfusion is remarkably relieved, lesions such as renal tubular epithelial cell necrosis and the like are effectively relieved, and a new treatment strategy is provided for ferroptosis inhibitors when the compound is applied to kidney ischemia-reperfusion injury repair.

The invention discloses a fermentation packaging device for biological fertilizer processing, and belongs to the technical field of fertilizer processing. The fermentation packaging device comprises a fermentation mechanism, a conveying mechanism is arranged below the fermentation mechanism, and a packaging mechanism is fixedly connected to the surface of the conveying mechanism. The invention aims to solve the problem that in the prior art, a traditional fermentation device is difficult to provide a stable living environment for a bio-fertilizer after the bio-fertilizer fermentation is completed, and achieves the technical effects that the packaging mechanism and the conveying mechanism are arranged, so that after the bio-fertilizer fermentation is completed, the bio-fertilizer can be conveniently and rapidly packaged; the packaging barrel is continuously conveyed to the bottom of the fermentation tank through the conveying mechanism, the fermented bio-fertilizer can directly enter the packaging barrel from the discharging opening, when the packaging barrel is conveyed to the position below the packaging mechanism, the top of the packaging barrel is covered with the sealing cover through the packaging mechanism, packaging of the fermented bio-fertilizer is completed, and after the bio-fertilizer is fermented, the fermentation efficiency is improved. A stable survival environment can be entered, and the death of beneficial microorganisms is reduced.

This utility model relates to the field of aquaculture technology, specifically a buffer-type salmon and trout transfer device, including a conveying chamber with a fish storage box fixedly connected inside. This utility model features a first transport trough, a second transport trough, a rotating shaft, and a turntable. When the operator pulls the second transport trough outward, a slider inside the trough moves outward, extending the second transport trough so that its length contacts the water surface, reducing salmon and trout mortality due to height limitations. Pressing down on the second transport trough causes the first transport trough to rotate downward, which in turn causes the rotating shaft to rotate, allowing the second transport trough to contact the water surface. Pulling up the lifting block raises the gate, allowing the salmon and trout to flow from the fish storage box into the first transport trough. The cushioning effect of the rubber pad reduces salmon and trout mortality and improves the device's efficiency.

The invention relates to the technical field of pecan prevention and treatment, in particular to a bactericide composition for preventing and treating pecan root rot and application of the bactericide composition. According to the technical scheme, the bactericide composition comprises a component A, a component B and a component C in percentage by weight, the bactericide composition of the component A is suitable for treating slight or preventive root rot, the bactericide composition of the component B is suitable for treating medium-degree root rot, and the bactericide composition of the component C is suitable for treating severe or refractory root rot. According to the severity of the illness state, corresponding bactericide components are selected for root irrigation treatment. According to the bactericide composition disclosed by the invention, through specific proportioning and component selection, the survival and reproduction of pathogenic bacteria can be reduced aiming at the pathogenic bacteria of the pecan root rot, so that the occurrence and spreading of diseases are controlled.

The utility model relates to a bird collision prevention glass curtain wall which comprises a glass module, a main body of the glass module is composed of an outer glass curtain wall body and an inner glass curtain wall body, the outer glass curtain wall body is arranged at the front end of the inner glass curtain wall body, the upper end of the inner glass curtain wall body is fixedly connected with a fixing table, and matrix bird repelling patterns are arranged between the outer glass curtain wall body and the inner glass curtain wall body. The lifting mechanism comprises a reel pipe arranged above the inner glass curtain wall, one end of the reel pipe is fixedly connected with a driving shaft, the outer side of the driving shaft is rotationally connected with a rotating shaft in a meshed mode, a bead pulling chain is arranged on the outer side of the rotating shaft, a tail frame is arranged on the outer side of the bead pulling chain, and the tail frame and the bead pulling chain are arranged in a matched mode; the pull bead chain drives the rotating shaft to rotate when being pulled in the tail frame and the rotating shaft, the positions of the matrix bird repelling patterns are adjusted by arranging the pull-up mechanism, so that people are not affected by the matrix bird repelling patterns on the view when wanting to see the scenery outside the glass, and meanwhile, the irradiation area of the sun can also be increased.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating or preventing respiratory failure. The traditional Chinese medicine composition comprises 1-3 parts of honey-fried ephedra, 1-10 parts of semen armeniacae amarae, 1-6 parts of platycodon grandiflorum, 1-6 parts of radix peucedani, 1-6 parts of thunberg fritillary bulb, 1-6 parts of radix stemonae, 1-3 parts of oroxylum indicum, 1-10 parts of radix glehniae and 1-3 parts of liquorice. The composition disclosed by the invention can be used for effectively relieving severe dysfunction of lung ventilation or ventilation and improving effective gas exchange, and can be used for treating or preventing respiratory failure.

This invention discloses a chitosan-based hydrogel contraceptive material, its preparation method, and its applications, relating to the field of contraceptive materials technology. The material comprises: perfluoroalkyl chain modified chitosan: 1-5 wt%; sodium β-glycerophosphate: 3-10 wt%; polyacrylic acid: 0.5-3 wt%; spermicide: 0.1-5 wt%; silver nanoparticles: 0.01-0.1 wt%; chitosan oligosaccharide: 0.1-1 wt%; lactic acid bacteria metabolites: 0.05-0.5 wt%; and lactic acid aqueous solution: balance to 100%. The thermosensitive gelation mechanism of this invention utilizes perfluoroalkyl chain modified chitosan, which is a material with a lowest critical solution temperature (LCST) of 37°C. The complex interaction between the spermicide and the gel matrix consists of intermolecular van der Waals forces and hydrogen bonds.

The invention discloses the application of pine pollen polysaccharide in preventing and treating atopic eczema, and belongs to the technical field of atopic eczema prevention and treatment. The pine pollen polysaccharide is prepared by the following method: adding broken wall masson pine pollen to petroleum ether, heating and refluxing extraction, collecting filter residue by suction filtration, drying and removing solvent, and obtaining defatted masson pine pollen; heating and refluxing extraction of defatted masson pine pollen with 95% ethanol, collecting filter residue by suction filtration, and drying and removing residual solvent to obtain impurity-removed masson pine pollen; adding water to the impurity-removed masson pine pollen, heating and boiling, repeatedly extracting and combining filtrates, heating and concentrating to obtain a concentrated solution; removing protein from the concentrated solution, precipitating with alcohol, centrifuging and precipitating, and freezing and decompressing to obtain pine pollen polysaccharide. Pine pollen polysaccharide is used to prevent and treat atopic eczema. Pine pollen polysaccharide comes from natural plants. Compared with traditional drugs, pine pollen polysaccharide has higher safety and lower side effects, and is particularly suitable for long-term use and sensitive populations such as infants and young children.

The invention relates to an application of Fgl2 gene knockout in antagonism of new coronavirus. In the technical scheme provided by the invention, a new crown infected mouse model is established through two SARS-CoV-2 mouse adaptive strains, namely, an MA17 strain and an MASCp36 strain, and it is verified that virus infection can promote Fgl2 expression up-regulation and fibrinogen deposition in mouse lung tissues; in addition, an SARS-CoV-2 mouse adaptive strain MA17 is utilized to infect an Fgl2 gene knockout mouse to prove that the Fgl2 gene knockout can antagonize lung inflammation infiltration, tissue damage, thromboembolism, fibrinogen deposition and fibrosis formation caused by virus infection, so that the occurrence of severe case and death of the mouse is reduced.

The invention provides an application of URB597 in preparation of a medicine for treating chronic traumatic encephalopathy. The URB597 inhibits neuronal ferroptosis through an endocannabinoid-ACSL4 axis so as to relieve cognitive impairment after CTE. The URB597 disclosed by the invention can inhibit the activity of fatty acid amide hydrolase and increase the level of endocannabinoid AEA in the brain, and the AEA has the capability of reducing neuronal ferroptosis by directly combining and interacting with 447-site serine (Ser447) of acyl coenzyme a synthetase long-chain family member 4 (ACSL4). The effect of remarkably improving the cognitive function of the chronic traumatic encephalopathy is reflected. Aiming at the effect of the URB597, the URB597 can be applied to preparation of medicines for treating chronic traumatic encephalopathy.

The invention discloses enterococcus faecium, a microbial inoculum as well as application and a method of the enterococcus faecium, the enterococcus faecium is enterococcus faecium TC3 and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the enterococcus faecium is CCTCC NO: M 20242431. The invention also provides a microbial inoculum, wherein the microbial inoculum contains the enterococcus faecium TC3, and the enterococcus faecium TC3 can be used for preparing the microbial inoculum. Before a healthy pig is inoculated with a porcine reproductive and respiratory syndrome vaccine, the enterococcus faecium TC3 or the microbial inoculum is fed to the healthy pig, and then the healthy pig is inoculated with the porcine reproductive and respiratory syndrome vaccine, so that the effect performance of the pig inoculated with the porcine reproductive and respiratory syndrome vaccine can be improved, the antibody positive rate of the pig inoculated with the porcine reproductive and respiratory syndrome vaccine is increased, and the economic benefit of the pig is improved. The protection rate of the pigs inoculated with the porcine reproductive and respiratory syndrome vaccine is increased, the antibody dispersion of the pigs inoculated with the porcine reproductive and respiratory syndrome vaccine is reduced, and the survival rate of the pigs infected with the porcine reproductive and respiratory syndrome virus after the pigs inoculated with the porcine reproductive and respiratory syndrome vaccine is increased.

This invention relates to the field of halloysite (HNTs) applications and discloses a preparation process for a brain delivery system based on halloysite HNTs. The process involves co-incubating halloysite with Aβ fibers (senile plaques) in vitro to provide the halloysite's role in degrading Aβ fibers (senile plaques). The halloysite undergoes tubularization and amino modification, followed by NHS-PEG processing. 5000 -MAL binds the RVG29 peptide to the surface of HNTs; NHS-PEG 5000 The NHS group in the MAL reacts with the amino group of halloysite after amination to form a stable amide bond, and the MAL group reacts with the thiol group of the RVG29 peptide to form a stable thioether bond, thereby achieving the modification of halloysite with the RVG29 peptide. Utilizing the positive charge of the halloysite lumen, negatively charged siRNA is directly loaded into the tube through electrostatic interaction to prepare SH-RVG / siRIPK1 material, which has the dual effects of degrading Aβ fibers (senile plaques) and slowing down neuronal death, and can be used for the treatment of AD.

The invention discloses an application of ilicin A in preparation of a medicine for preventing and treating ischemic heart disease, and belongs to the technical field of ilicin A. An experiment for improving heart functions of a mouse I / R model by the ilicin A is carried out, and male C57BL / 6 mice (with the age of 6-8 weeks; according to the method, 70 mice (the weight is 20 + / -2g) are bred in a constant-temperature and constant-humidity environment, the illumination / darkness period is 12 hours and lasts for one week, food and water are obtained without limitation, all male mice are randomly grouped as follows: a false operation group (n = 10), an I / R group (n = 15), an ilicin A group (30 and 60 mg / kg) and a captopril group (20 mg / kg), the mice in the ilicin A group and the captopril group are subjected to intragastric administration every day five days before the model is established, and the mice in the captopril group are subjected to intragastric administration every day. And the isopyknic contrast solution is applied to the false operation group and the I / R group.

This utility model relates to the field of horticultural energy conservation and environmental protection technology, and in particular to a water-saving irrigation device, including a water storage tank and a support frame. The support frame is a frame structure, with the water storage tank fixed to its upper end by a steel strap. Multiple sets of water outlet pipes are evenly distributed longitudinally at the bottom of the water storage tank. A water delivery hose is sealed to the bottom of one set of water outlet pipes. The left end of the water delivery hose is connected to a fixed water pipe via a sealed connector. An integrated irrigation ring pipe is located at the left end of the fixed water pipe. Multiple sets of water outlet pipes are evenly distributed at the bottom of the irrigation ring pipe. A control box is fixedly connected to the right end of the fixed water pipe. A sliding and adjustable positioning rod is inserted inside a sliding sleeve, and a soil moisture sensor is installed at the lower end of the positioning rod. This utility model uses a soil moisture sensor to detect the soil moisture of potted plants in real time and accurately. Combined with an irrigation system, it can automatically control irrigation according to a preset humidity threshold, achieving automatic quantitative irrigation, providing a suitable growth environment for potted plants, and reducing maintenance costs.

The invention discloses an mCuS (at) lm antibacterial nano cage as well as a preparation method and application of the mCuS (at) lm antibacterial nano cage. The mCuS (at) lm antibacterial nano cage takes hollow mesoporous nano copper sulfide nanoparticles as a core, a bacterial copper death amplifying agent and a cell copper death inhibitor are entrapped in the hollow mesoporous nano copper sulfide nanoparticles through electrostatic adsorption self-assembly, and the surfaces of the hollow mesoporous nano copper sulfide nanoparticles are further coated with bionic cell membranes, so that the mCuS (at) lm antibacterial nano cage is obtained. The nanometer cage is the mCuS (at) lm antibacterial nanometer cage. The mCuS (at) lm antibacterial nano cage surface biomimetic membrane highly expresses proteins related to microbial recognition and uptake, can effectively neutralize inflammatory factors in the environment, and has a potential infection targeting effect. The bacterial copper death amplifying agent is used for enhancing bacterial copper death, and the cell copper death inhibitor is used for retarding host cell copper death, so that the bacterial killing effect and the antibacterial effect are improved under the condition that the biological safety is improved.

The invention discloses application of pine pollen polysaccharide in prevention and treatment of atopic eczema, and belongs to the technical field of atopic eczema prevention and treatment. The pine pollen polysaccharide is prepared by the following method: adding wall-broken masson pine pollen into petroleum ether, performing heating reflux extraction, performing suction filtration to collect filter residues, and drying to remove a solvent to obtain degreased masson pine pollen; heating, refluxing and extracting the degreased pinus massoniana pollen by using 95% ethanol, carrying out suction filtration, collecting filter residues, and drying to remove a residual solvent, so as to obtain impurity-removed pinus massoniana pollen; adding water into the impurity-removed masson pine pollen, heating and boiling, repeatedly extracting, combining filtrate, and heating and concentrating to obtain a concentrated solution; and removing protein from the concentrated solution, and carrying out alcohol precipitation, centrifugal separation and precipitation, freezing and drying under reduced pressure to obtain the pollen pini polysaccharide. The pine pollen polysaccharide is used for preventing and treating the atopic eczema, the pine pollen polysaccharide is derived from natural plants, and compared with traditional medicines, the pine pollen polysaccharide has higher safety and lower side effects and is particularly suitable for sensitive people such as infants and the like after being used for a long time.

The invention relates to the technical field of biological medicine, in particular to application of an Orai1 protein inhibitor in preparation of a medicine for treating coronary artery calcification. By using the Orai1 protein inhibitor, coronary artery calcification can be accurately treated, the occurrence proportion of serious coronary artery calcification is reduced, and economic and social burdens brought by surgical treatment are relieved. Besides, the Orai1 protein inhibitor can also improve and inhibit acute myocardial ischemia symptoms caused by factors such as coronary vessel and myocardial cell calcification, calcium overload and the like, the myocardial infarction area is reduced, and death caused by acute myocardial ischemia is reduced.

The present invention provides a breakwater for seaweed heat resistance and water retention, which belongs to the technical field of breakwaters and comprises a main structure and a plurality of sealing plates; the main structure is provided with a plurality of first water-permeable holes at intervals; each of the first water-permeable holes penetrates the main structure along the thickness direction; a plurality of sealing plates are arranged on the inner side of the main structure and close to the bottom thereof; each of the sealing plates corresponds one by one to the first water-permeable holes of the main structure close to the bottom; wherein the diameter of the sealing plates is greater than the diameter of the first water-permeable holes, and the top of the sealing plates is hinged on the main structure; by arranging a plurality of first water-permeable holes on the main structure, it can play a role in breaking waves and allow seawater to enter the inner side of the main structure from the outer side of the main structure; at low tide, the self-weight of the sealing plates is greater than the buoyancy, and the sealing plates can close the first water-permeable holes, thereby reducing the direct sunlight on the seaweed, reducing the death of the seaweed, and improving the heat resistance of the seaweed at low tide.

The invention relates to the technical field of anticoccidial drugs, in particular to a decoquinate-embedded composite preparation and a preparation method thereof. The decoquinate-embedded composite preparation is prepared from the following raw materials in parts by mass: 15 to 35 parts of decoquinate, 5 to 15 parts of organic carrier, 5 to 10 parts of maltodextrin, 0.01 to 0.1 part of beta-CGTase enzyme preparation, 0.01 to 0.1 part of lanthanum chloride, 1 to 3 parts of branched polylysine, 0.01 to 0.1 part of ammonium persulfate, 1 to 3 parts of sodium trimetaphosphate, 20 to 60 parts of glucose and 1 to 8 parts of surfactant, wherein the enzyme activity of the beta-CGTase enzyme preparation is 3000 to 8000 U / g. After decoquinate is loaded twice, the utilization rate of effective components in the medicine is effectively increased, the medicine stability is extremely high, the anti-coccidiosis effect is better than that of a common preparation, meanwhile, the preparation technology is simple and easy to implement, and large-scale production is easy to achieve.

The invention discloses application of aralia saponin A in preparation of a medicine for treating septicopyemia lung injury, and provides an experimental basis and a new strategy for clinically treating septicopyemia-induced acute lung injury and improving the life quality of a patient. According to the application, the effect of the aralia chinensis saponin A on treating septicopyemia lung injury is found for the first time, the molecular mechanism of the aralia chinensis saponin A on resisting inflammation is clarified through experiments, the experiments verify that the aralia chinensis saponin A effectively relieves inflammation, cell death and barrier loss of acute lung injury induced by septicopyemia, and finally the death rate is reduced. The research result also shows that the aralia elata saponin A recovers a PHD2 / HIF-1alpha signal axis in the proinflammatory activated macrophages, so that the protein level of the HIF-1alpha is reduced, the proinflammatory activation of the macrophages in the septicopyemia is inhibited, the inflammation development is resisted, and the lung injury of mice with the septicopyemia is relieved.

The application discloses a nano material for targeting and driving resuscitation of dying cells, and a preparation method and application thereof. The nano material is a nano platelet vesicle with phosphatidylserine exposed to the outer layer of the membrane after nanoization and centrifugal treatment. The material is obtained by separating and enriching platelets from peripheral blood, then nanoizing the platelets, and then inducing the phosphatidylserine on the platelet membrane to evert through high-speed centrifugation. The material is used for preparing a medicine for promoting tissue repair, and the medicine promotes resuscitation of dying cells by targeting the dying cells and enhancing the membrane repair capacity of the dying cells, so as to promote tissue repair, including repair of orthopedic, muscle, skin, spinal cord or visceral tissue, especially repair of diabetic foot, skin avulsion injury, ischemic skin flap or spinal cord injury. The resuscitation of dying cells is promoted successfully without intervention of lysis programmed cell death initiation, so that the problems of off-target effect and treatment paradox existing in current mainstream small molecule inhibitor strategy are effectively solved.

The application relates to the technical field of medicines, and particularly discloses a mitochondrion transfer promoter and application of the mitochondrion transfer promoter in preparation of medicines for preventing and treating post-CIRI mitochondrion dysfunction, wherein the active component of the promoter is decocted liquid of blue cloth and pyrola calliantha, and the mass ratio of the blue cloth to the pyrola calliantha is 2-4:1-2. The mitochondrion transfer promoter is prepared by decocting and extracting the blue cloth and the pyrola calliantha, animal experiments are conducted, it is found that the mitochondrion transfer promoter can significantly improve CIRI induced by cerebral middle artery ischemia-reperfusion, reduce a neurological function defect score, reduce a cerebral infarction volume, and it is proved by HE and Nissl staining that the mitochondrion transfer promoter can effectively improve neuron morphology and reduce neuron death. The mitochondrion transfer promoter can improve mitochondrion function, reduce oxidative stress, and enhance blood-brain barrier endothelial function, and has important clinical significance and practical value.

The invention belongs to the technical field of medicines, and particularly relates to application of Orexin-A in inhibiting lipid peroxidation. The invention provides the application of Orexin-A in inhibiting lipid peroxidation for the first time. The application of the OXA in the in-vitro cerebral hemorrhage model shows the potential of the OXA in relieving cell damage, inhibiting ferroptosis and regulating neuroinflammation. The application shows how the OXA realizes the protection effect by influencing a specific signal channel (such as SRC / FAK / ERK1). Multiple roles of the OXA in neuroprotection are disclosed, and a deeper theoretical basis is provided for clinical application of the OXA.