11results about How to "Reduce death" patented technology

This utility model relates to the field of aquaculture technology, specifically a buffer-type salmon and trout transfer device, including a conveying chamber with a fish storage box fixedly connected inside. This utility model features a first transport trough, a second transport trough, a rotating shaft, and a turntable. When the operator pulls the second transport trough outward, a slider inside the trough moves outward, extending the second transport trough so that its length contacts the water surface, reducing salmon and trout mortality due to height limitations. Pressing down on the second transport trough causes the first transport trough to rotate downward, which in turn causes the rotating shaft to rotate, allowing the second transport trough to contact the water surface. Pulling up the lifting block raises the gate, allowing the salmon and trout to flow from the fish storage box into the first transport trough. The cushioning effect of the rubber pad reduces salmon and trout mortality and improves the device's efficiency.

This invention discloses a chitosan-based hydrogel contraceptive material, its preparation method, and its applications, relating to the field of contraceptive materials technology. The material comprises: perfluoroalkyl chain modified chitosan: 1-5 wt%; sodium β-glycerophosphate: 3-10 wt%; polyacrylic acid: 0.5-3 wt%; spermicide: 0.1-5 wt%; silver nanoparticles: 0.01-0.1 wt%; chitosan oligosaccharide: 0.1-1 wt%; lactic acid bacteria metabolites: 0.05-0.5 wt%; and lactic acid aqueous solution: balance to 100%. The thermosensitive gelation mechanism of this invention utilizes perfluoroalkyl chain modified chitosan, which is a material with a lowest critical solution temperature (LCST) of 37°C. The complex interaction between the spermicide and the gel matrix consists of intermolecular van der Waals forces and hydrogen bonds.

The invention relates to an application of Fgl2 gene knockout in antagonism of new coronavirus. In the technical scheme provided by the invention, a new crown infected mouse model is established through two SARS-CoV-2 mouse adaptive strains, namely, an MA17 strain and an MASCp36 strain, and it is verified that virus infection can promote Fgl2 expression up-regulation and fibrinogen deposition in mouse lung tissues; in addition, an SARS-CoV-2 mouse adaptive strain MA17 is utilized to infect an Fgl2 gene knockout mouse to prove that the Fgl2 gene knockout can antagonize lung inflammation infiltration, tissue damage, thromboembolism, fibrinogen deposition and fibrosis formation caused by virus infection, so that the occurrence of severe case and death of the mouse is reduced.

This invention relates to the field of halloysite (HNTs) applications and discloses a preparation process for a brain delivery system based on halloysite HNTs. The process involves co-incubating halloysite with Aβ fibers (senile plaques) in vitro to provide the halloysite's role in degrading Aβ fibers (senile plaques). The halloysite undergoes tubularization and amino modification, followed by NHS-PEG processing. 5000 -MAL binds the RVG29 peptide to the surface of HNTs; NHS-PEG 5000 The NHS group in the MAL reacts with the amino group of halloysite after amination to form a stable amide bond, and the MAL group reacts with the thiol group of the RVG29 peptide to form a stable thioether bond, thereby achieving the modification of halloysite with the RVG29 peptide. Utilizing the positive charge of the halloysite lumen, negatively charged siRNA is directly loaded into the tube through electrostatic interaction to prepare SH-RVG / siRIPK1 material, which has the dual effects of degrading Aβ fibers (senile plaques) and slowing down neuronal death, and can be used for the treatment of AD.

This utility model relates to the field of horticultural energy conservation and environmental protection technology, and in particular to a water-saving irrigation device, including a water storage tank and a support frame. The support frame is a frame structure, with the water storage tank fixed to its upper end by a steel strap. Multiple sets of water outlet pipes are evenly distributed longitudinally at the bottom of the water storage tank. A water delivery hose is sealed to the bottom of one set of water outlet pipes. The left end of the water delivery hose is connected to a fixed water pipe via a sealed connector. An integrated irrigation ring pipe is located at the left end of the fixed water pipe. Multiple sets of water outlet pipes are evenly distributed at the bottom of the irrigation ring pipe. A control box is fixedly connected to the right end of the fixed water pipe. A sliding and adjustable positioning rod is inserted inside a sliding sleeve, and a soil moisture sensor is installed at the lower end of the positioning rod. This utility model uses a soil moisture sensor to detect the soil moisture of potted plants in real time and accurately. Combined with an irrigation system, it can automatically control irrigation according to a preset humidity threshold, achieving automatic quantitative irrigation, providing a suitable growth environment for potted plants, and reducing maintenance costs.

The application discloses a nano material for targeting and driving resuscitation of dying cells, and a preparation method and application thereof. The nano material is a nano platelet vesicle with phosphatidylserine exposed to the outer layer of the membrane after nanoization and centrifugal treatment. The material is obtained by separating and enriching platelets from peripheral blood, then nanoizing the platelets, and then inducing the phosphatidylserine on the platelet membrane to evert through high-speed centrifugation. The material is used for preparing a medicine for promoting tissue repair, and the medicine promotes resuscitation of dying cells by targeting the dying cells and enhancing the membrane repair capacity of the dying cells, so as to promote tissue repair, including repair of orthopedic, muscle, skin, spinal cord or visceral tissue, especially repair of diabetic foot, skin avulsion injury, ischemic skin flap or spinal cord injury. The resuscitation of dying cells is promoted successfully without intervention of lysis programmed cell death initiation, so that the problems of off-target effect and treatment paradox existing in current mainstream small molecule inhibitor strategy are effectively solved.

The application relates to the technical field of medicines, and particularly discloses a mitochondrion transfer promoter and application of the mitochondrion transfer promoter in preparation of medicines for preventing and treating post-CIRI mitochondrion dysfunction, wherein the active component of the promoter is decocted liquid of blue cloth and pyrola calliantha, and the mass ratio of the blue cloth to the pyrola calliantha is 2-4:1-2. The mitochondrion transfer promoter is prepared by decocting and extracting the blue cloth and the pyrola calliantha, animal experiments are conducted, it is found that the mitochondrion transfer promoter can significantly improve CIRI induced by cerebral middle artery ischemia-reperfusion, reduce a neurological function defect score, reduce a cerebral infarction volume, and it is proved by HE and Nissl staining that the mitochondrion transfer promoter can effectively improve neuron morphology and reduce neuron death. The mitochondrion transfer promoter can improve mitochondrion function, reduce oxidative stress, and enhance blood-brain barrier endothelial function, and has important clinical significance and practical value.

The present application relates to the field of aquaculture breeding technology, and discloses an indoor cement pool artificial breeding method for east wind snail, which comprises the following steps: storing east wind snail egg sacs after disinfecting water body by ultraviolet rays, removing infected egg sacs, and performing specific water flow replacement 24 hours before hatching; feeding the larvae with a nutrient agent containing clostridium aceticum protein and agaricus blazei polysaccharide every day after hatching, feeding the larvae with monosomic algae such as chrysomonad, tetraselmis, chlorella, etc. in the early stage, and feeding the larvae with shelled algae in the middle stage until the larvae are attached and metamorphosed; keeping the breeding pool continuously aerated and controlling parameters such as dissolved oxygen, salinity, temperature and pH value of the water body during the breeding period, and finally collecting the snail seedlings to end the breeding. The indoor cement pool artificial breeding method for east wind snail provided by the present application is suitable for one or more of fasciolaria fasciolaris and mud east wind snail, and can effectively improve the success rate and seedling quality of indoor cement pool breeding of east wind snail.

The invention relates to the field of animal husbandry, in particular to a method for improving the production performance of yak milk in a high and cold pasturing area in the grazing and lactation period. The invention provides a mixed feed for improving the production performance of yak milk in a high and cold pasturing area in a grazing and lactation period. The composition comprises a protein feed, a fiber feed and a juicy feed, the mass ratio of the protein feed to the fiber feed to the juicy feed is 2: 5: 3. When the mixed formula feed provided by the invention is used for feeding the yaks in the lactation period under the traditional natural grassland grazing condition in the high and cold pasturing area, the lactation yield and quality of the yaks can be remarkably improved.

This utility model discloses a cell culture flask for preventing contamination, relating to the field of cell culture flask technology. It includes a mother flask and a daughter flask, each with an installation tube fixedly connected to one side. A connecting tube is provided between the two installation tubes, and a clamping assembly is provided on one side of each installation tube. The connecting tube is fixedly connected to the installation tube via the clamping assembly. This utility model employs the above structure, installing a baffle at the sealing cap. A HEPA filter and a filter screen are installed inside the baffle. The filter screen performs preliminary filtration of large particles in the air, and the HEPA filter efficiently filters out micron-sized particles, including most microorganisms. This significantly reduces the risk of microorganisms entering the culture flask and contaminating the cells, ensuring a sterile environment for cell culture, reducing cell death or mutation due to contamination, thereby improving the purity of the gas entering the flask and preventing harmful gases or impurities from affecting cell culture.

The present application belongs to the field of medicine and biotechnology, and particularly relates to the use of matrine in the preparation of a medicine for preventing or treating radiation damage. The radiation damage includes skin damage, lung damage, intestinal damage, hematopoietic damage, reproductive function damage, and delaying aging caused by radiation. The radiation includes non-ionizing radiation and ionizing radiation. The medicine further comprises other medicines for preventing or treating radiation damage. In the screening of anti-radiation medicines based on various cell models, it is found that matrine has a repair-promoting effect on small intestinal mucosal epithelial cell damage caused by radiation; through a mouse radiation damage model, it is found that matrine can effectively protect the body, reduce the death caused by a lethal dose of Co-60 gamma rays, and delay aging caused by radiation. Matrine has a good clinical application prospect in preventing or treating radiation damage, and has no obvious toxic side effects.