The invention provides a fully-automatic clothes folding machine and belongs to the technical field of electric appliances. The fully-automatic clothes folding machine comprises a case with an inner cavity, a plurality of clothes hangers, a conveying mechanism, a receiving and folding mechanism, two mechanical hands, a transverse clothes folding mechanism, a control system and a turndown mechanism, wherein the conveying mechanism is used for conveying the clothes hangers to the case, the receiving and folding mechanism is positioned in the case and is used for receiving and folding the clothes hangers, an inlet allowing clothes and the clothes hangers to enter is formed in one side of the case, the inner cavity is partitioned into an upper inner cavity body and a lower inner cavity body by a partition board, the mechanical hands are positioned in the upper inner cavity body of the case and arranged on two sides of the conveying mechanism respectively, and the turndown mechanism is capable of enabling the partition board to turn down. Each mechanical hand comprises a hand portion and a moving mechanism, wherein the moving mechanism is capable of enabling the hand portion to move up and down, clamp shoulder portions of the clothes to rotate and move back and forth relative to the clothes conveying direction under control of the control system. The fully-automatic clothes folding machine solves the problem that an existing clothes folding process mostly needs to be completed manually, and is automatic and high in automation degree, so that labor load of people can be relieved greatly.