59 results about "Biomimetic membranes" patented technology

The invention relates to a moisturizing composition, and a preparation method and application thereof, which belong to the field of cosmetics. The moisturizing composition is prepared from the following components in parts by weight: 1.0 to 5.0 parts of sodium hyaluronate, 2.0 to 10.0 parts of carboxymethyl deacetyl chitosan, 30.0 to 60.0 parts of dendrobium officinale extract, and 25.0 to 67.0 parts of deionized water. The moisturizing composition can well form a netted natural biomimetic membrane with skin, the sodium hyaluronate performs the water supplementation and moisturizing in the biomimetic membrane, the carboxymethyl deacetyl chitosan forms a biomimetic sterile membrane, so that natural moisturizing factors such as the sodium hyaluronate can be effectively locked, the water loss rate is decreased; and the dendrobium officinale polysaccharide is combined with the natural biomimetic sterile membrane, so that the moisturizing lasting property after long-term use can be further improved, the restoration effect is improved, and the dryness and allergy problems of the skin can be fundamentally solved. The moisturizing composition has multidimensional efficacy such as moisturizing function, restoration function and skin barrier increasing function.

The present invention discloses a water membrane comprising a lipid bilayer supported on a single side thereof on a water permeable dense support layer, this lipid bilayer being composed of one or more lipids and aquaporin proteins are embedded therein, further wherein the water permeable dense support layer is impermeable to the lipids and to the aquaporin proteins. Also are provided a method for the preparation of these membranes and uses thereof in water filtration applications.

The invention concerns a method for producing a biomimetic membrane, a biomimetic membrane and the applications of said membrane. Said biomimetic membrane (10) has one or several through pores (24) and is characterised in that it is formed of at least two different micro-machinable materials one of which forms the wall (23) of said pore(s), whereas the other or others of said materials form(s) the remainder of said membrane. Applications: performing studies on the dynamic and functional properties of biological membranes; manufacture of biocatalysis microsystems and detection or dosing of substances.

Disclosed herein is a membrane scaffold comprising a planar material having a hydrophobic surface and a functional area comprising a plurality of apertures. The apertures have a diameter of from about 80 μm to about 3000 μm and the rims of the apertures comprise bulges extending above and/or below the surface level of the planar material. The membrane scaffold is useful in the preparation of a composite biomimetic membrane wherein functional channel forming molecules have been incorporated in said membrane.

The invention discloses a preparation method for a chitosan-based biomimetic membrane material with an asymmetric structure, and the preparation method comprises the following steps of dispersing chitosan into acetic acid aqueous solution, adding absolute methanol and acetic anhydride for reacting after the chitosan is completely dissolved, and then, centrifugally removing sediment; dropping in alkaline solidification liquid under stirring condition, and filtering to obtain chitosan microgel; adding the chitosan microgel in glycerin solution, injecting the solution in a mold, and standing and draining water, freeze-drying one part to obtain a chitosan-based porous sponge material, and drying the other part to obtain a chitosan-based dense membrane material; bonding the chitosan-based porous sponge material and the chitosan-based dense membrane material to obtain the chitosan-based biomimetic membrane material with asymmetric structure. The preparation method provided by the invention has the advantages that the preparation technology is simple, the prepared chitosan-based biomimetic membrane material has a porous sponge structure and a dense membrane material structure, the chitosan-based biomimetic membrane material is not curly when encountering water, guiding bone regeneration performance is good, and the chitosan-based biomimetic membrane material is degradable and controllable and can be widely used as a guided bone tissue regeneration membrane material in treatment of the fields such as dental implant, osteoarthritis, bone defect, and the like.

The present invention relates to a method for producing man-made devices which have the properties and functions of biological membranes and membrane proteins, and to the structure of such devices.

Briefly, in one aspect of the invention, natural or genetically engineered proteins are incorporated into a polymeric vesicle that is conjugated to a thread to form a vesicle-thread conjugate. The engineered protein is preferably a transmembrane protein embedded in the wall of the polymeric vesicle. The vesicle-thread conjugate is then formed into a membrane or thin fabric having a wide variety of inherent functionality, including the ability to selectively transport and/or filter compounds between fluids. By selecting proteins with specific properties, membranes can be fabricated with a defined functionality including molecular scale addressability via directed electrostatic, electromagnetic, and chemical forces.

The invention provides a biomimetic membrane for removing aflatoxins, and a preparation method and treatment method of the biomimetic membrane. The biomimetic membrane comprises a microporous membrane, a dopamine coating coats the microporous membrane, polyethyleneimine is grafted to the dopamine coating, and enzyme molecules are adsorbed onto the polyethyleneimine. The method comprises the following steps of firstly coating the microporous membrane with poly-dopamine, then grafting the polyethyleneimine, and finally adsorbing the enzyme molecules through the polyethyleneimine. Enzymes adsorbed onto the biomimetic membrane can be unceasingly desorbed and released into feed liquid in the process of performing catalytic degradation on the aflatoxins, so that the polyethyleneimine is exposedto continue adsorbing the aflatoxins until a saturated state is obtained, and the total aflatoxins removing rate is greater than 80%. The adsorbed aflatoxins are eluted with aqueous alkali, so that regeneration and repeated use of the biomimetic membrane are realized, and 50% or above of the eluted aflatoxins can be degraded in the aqueous alkali. The preparation technology of the biomimetic membrane disclosed by the invention is simple, enzyme catalysis, enzyme slow release, membrane adsorption and alkali treatment are combined, and the removal rate of the aflatoxins can be increased.

The invention discloses a preparation method of a biomimetic material, in particular relates to a method for preparing the composition material of poly-aspartic acid or the derivatives, chitosan, lecithin and calcium-phosphate compound. The method first compounds poly-aspartic acid or the derivatives with different side chains, and then makes the poly-aspartic acid or the derivatives with different side chains, chitosan, lecithin, calciferous solution and crosslinking agent mix, react and settle down under a certain temperature and pH value. The obtained product has the properties of biomimetic membrane materials and is an environment-friendly biomimetic material. The material has the function of absorbing heavy metals and some organics, can be used for removing heavy metals, chlorinated hydrocarbon, organic pigment and dye, and can be widely applied to pharmaceutical industry, food industry, printing and dyeing industry, waste water treatment and other fields.

The present invention provide methods for preparing nanostructured membranes. The methods include: providing a substrate with a charged silanized surface; forming a multilayered membrane containing at least two polyelectrolytes; inducing polyelectrolyte phase separation; crosslinking the multilayered membrane; and covalently linking the multilayered membrane to the silanized surface. Methods for fabricating membrane replicas are also disclosed, as well as devices such as cell- and tissue-culture substrates that contain the membranes and membrane replicas. Resulting materials exhibit topographic features and compliance of the extracellular matrix in vivo.

The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to modification of the membrane surface with a combination of at least one extracellular matrix protein, at least one extracellular matrix (proteo-) glycan, and at least one heparin-binding growth factor. The invention further relates to a method for preparing said modified or coated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such membrane for the cultivation of cells, in particular adherent cells.

The invention discloses a flow identification nano vesicle used for cell capture. The nano vesicle is characterized in that the nano vesicle includes a sphere structure formed by natural cell membranes or biomimetic membranes through wrapping; and the interfaces of the membranes are modified with specific recognition molecules through physical, chemical or biological action. A method by using thenano vesicle to capture circulating tumor cells is also provided. A microfluidic chip is provided and modified with the nano vesicle; and a method by using the microfluidic chip to capture the circulating tumor cells is provided as well. Through the using of liquidity-enhanced multivalent strategies, the efficient, selective and mild capturing of the circulating tumor cells can be realized.

The present invention relates to biomimetic membrane compositions and methods for making and using them.

The invention discloses a schisanlactone E targeted drug delivery system. The system comprises schisanlactone E, Prussian blue nanoparticles, a biomimetic membrane wrapping layer and a hyaluronic acid modification layer. The invention also discloses a preparation method of the targeted drug delivery system. The preparation method comprises the following steps: synthesizing Prussian blue nanoparticles; preparing a biomimetic membrane; preparing Prussian blue loaded schisanlactone E nanoparticles from Prussian blue nanoparticles and schisanlactone E; preparing biological biomimetic membrane coated Prussian blue loaded hemoglobin nanoparticles by using the biomimetic membrane and the Prussian blue loaded schisanlactone E nanoparticles; and performing hyaluronic acid modification to obtain the schisanlactone E targeted drug delivery system. The schisanlactone E targeted drug delivery system can accurately deliver schisanlactone E to the attack part of arthritis so as to prolong the retention time of the drug at the attack part of arthritis and ensure the safety and effectiveness of treatment. Furthermore, the invention further discloses application of the schisanlactone E targeted drug delivery system in preparation of anti-rheumatoid arthritis drugs.

The invention provides a preparation method of a simulated leather grain surface layer fiber biomimetic material with good hygienic property. The preparation method comprises the following steps that(1), an electrostatic spinning solution is prepared; (2), split leather is pretreated; and (3), electrostatic spinning is carried out. According to the scheme of the preparation method of the simulated leather grain surface layer nanofiber biomimetic material, a reasonable manufacturing process is adopted, so that the preparation method is suitable for all spinning solutions which can be applied to electrostatic spinning; and by preparing reasonable manufacturing process parameters, nanofibers with stable and reliable quality are obtained, and a dermis grain surface layer structure is simulated.

The invention provides a method of manufacturing electrochemical sensor array for evaluation of the free radical over-oxidative capacity of the environment. The method overcomes the shortage in the prior art, provides an electro-chemical sensor array for measuring free radical lipid over-oxidation of the environment and a method which is quick and easy, low in cost, easy to popularize, field applicable and persistent for evaluating the free-radical over-oxidation capacity and durability of the environment. The novelty of the method is that, although the bilayer phospholipid membrane bio-membrane sensor is currently the most active frontier field in biomedicine, the biomimetic membrane electrochemical sensor array and electrochemical method used for the determination of the free radical over-oxidative capacity in field environment cannot make any discoveries.

The present invention relates to the field of biomimetic membranes with artificial water channels, in particular their use in the production and management of drinking water. The invention relates to a biomimetic membrane with an artificial water channel, a synthesis method of the biomimetic membrane and application of the biomimetic membrane in brackish water and seawater desalination, ultrapure water production or pollutant filtration.

The invention discloses a bionic nano material as well as a preparation method and application thereof. The invention relates to a biomimetic nano material which comprises cerium dioxide, polyacrylic acid, chlorin e6, cinobufagin and a biomimetic membrane, the polyacrylic acid is coated on the surface of the cerium dioxide to synthesize the nano material, the cinobufagin and the chlorin e6 are loaded on the surface of the nano material through physical adsorption and chemical bond combination to obtain a nano composite material, the outer layer of the nano composite material is coated with the biomimetic membrane to obtain the biomimetic nano material, and the invention further provides a preparation method which is easy to operate and easy for large-scale production of the biomimetic nano material. The biomimetic nanomaterial disclosed by the invention has relatively good stability, dispersity and safety, is long in oxygen production strategy duration time, can still keep an effective photodynamic killing effect in an oxygen-deficient environment, is beneficial to reducing side effects of chemotherapeutic drugs and enhancing tumor enrichment efficiency of the chemotherapeutic drugs, and is applied to anti-tumor treatment of photodynamic therapy combined with chemotherapy.

The invention discloses an NIR response type biomimetic membrane nano vesicle and a construction method and application thereof. The construction method comprises the following steps of S1, collecting tumor cells, and obtaining a tumor cell membrane solution through a freeze thawing method, gradient centrifugation and resuspension in sequence; S2, adopting a solvent diffusion method to obtain a thermosensitive lipid drug delivery system; and S3, mixing the tumor cell membrane solution with a thermosensitive lipid drug delivery system, and performing extruding and filtering by using a liposome extruder to obtain the NIR response type biomimetic membrane nano vesicle. The NIR response type biomimetic cell membrane nano vesicle prepared by the method provided by the invention has a tumor efficient homologous targeting function, further blocks a PD-1/PD-L1 pathway, reverses a tumor immunosuppression state for a long time, synergistically exerts anti-tumor immune response, and inhibits growth of primary tumors and metastases.

Methods of fabricating a membrane comprising proteoliposomes having protein water channels are provided herein. The method may include providing a porous substrate, depositing a solution containing proteoliposomes on the porous substrate, and then contacting the porous substrate with an aqueous monomer solution and an organic monomer solution to form a selective layer on the porous substrate embedding the proteoliposomes. The method may include depositing the aqueous monomer solution, then the solution containing the proteoliposomes, then the organic monomer solution, to form the selective layer. The present disclosure also describes the membrane and a system operable to accommodate both methods.