19 results about "Chlorin e6" patented technology

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

The application discloses a kind of photothermal-photodynamic synergistic antibacterial multifunctional probe and its preparation method and application, and is related to biomedical antibacterial field.The antibacterial probe includes gold-silver alloy hollow nanoparticles and photosensitizer modified on the surface of the gold-silver alloy hollow nanoparticles, and the photosensitizer for photodynamic antibacterial effect is chlorin e6 (Ce6).The antibacterial probe in the application has simple synthesis steps, excellent photothermal properties and photodynamic effect, has a significant effect on antibacterial growth, and has good biocompatibility, and can be used for the skin surface of animal tissue to carry out antibacterial effect.

A preparation method of a long afterglow nanoprobe platform capable of loading different modules. A chromium-doped zinc gallium indate long afterglow nanoprobe platform is synthesized by a hydrothermal method, a photosensitizer chlorin e6 module is loaded by using an amide condensation reaction, manganese dioxide modules with glutathione and pH / H2O2 dual response are prepared on the surface of the chromium-doped zinc gallium indate long afterglow nanoprobe platform by stirring in a potassium permanganate solution and adding into a sodium citrate solution, a polydopamine module is loaded in a tris-hydroxymethyl aminomethane hydrochloride buffer solution containing hydrochloric acid dopamine to improve biocompatibility, and a DOX module is loaded on the long afterglow nanoprobe platform in a π-π stacking manner, so that different functional modules of near-infrared imaging, fluorescence imaging, photodynamic effect, photothermal effect and drug loading can be loaded alone or simultaneously, multifunctional synergistic effect is realized, and the long afterglow nanoprobe platform is applied to the preparation of a tumor microenvironment prevention and monitoring preparation or a drug.

The application belongs to the technical field of photosensitizer design, and particularly relates to a design method and application of a guanidinium salt modified photosensitizer. The design method comprises the following steps: providing a guanidinium salt and a fluorescent molecule, wherein the fluorescent molecule has an electron donor and an electron acceptor structure; and covalently coupling the fluorescent molecule and the guanidinium salt to obtain a guanidinium salt modified photosensitizer. The method changes the position of the guanidinium salt in the molecular structure to make the absorption and emission spectrum of the molecule red shift, increases the total active oxygen yield by increasing the number of guanidinium salts, and successfully prolongs the triplet state lifetime of the photosensitizer and improves the active oxygen yield by changing the number and position of the guanidinium salt. The covalent coupling of the fluorescent molecule without active oxygen and the guanidinium salt makes the final photosensitizer 2AG-TPABT have higher singlet oxygen and superoxide anion yield than the commercialized chlorin e6. The synthesis steps of the application are simple, the molecular structure does not contain heavy metals, the cost is low, and the application can be suitable for other fluorescent molecules without active oxygen.

The invention belongs to the technical field of preparation of organic-inorganic hybrid nano materials, and particularly relates to a rare earth composite nano material as well as a preparation method and application thereof. Two photosensitizers, namely chlorin e6 and rose bengal, are simultaneously modified on the surface of the Na-based rare earth nano-particles through ligand exchange, so that an efficient photodynamic treatment effect is realized. The Na-based rare earth nanoparticles with the core-shell-shell structure are synthesized, and the Na-based rare earth nanoparticles with the core-shell-shell structure have relatively strong red and green light emission under the excitation of 1550 nm laser. The light scattering of the 1550nm laser in the biological tissue is extremely small, so that the penetration depth and the focusing capability of the laser can be improved, and the photodynamic treatment of the deep tissue is expected to be realized. Photosensitizers, namely chlorin e6 and rose bengal, are directly modified on the surfaces of the nanoparticles through ligand exchange reaction, and compared with a method of coating with an amphiphilic surfactant or loading with silicon dioxide, the energy transfer efficiency between rare earth ions and the photosensitizers can be remarkably improved, and the photodynamic effect is improved.

The present application relates to the technical fields of nanomedicine and functional nanomaterials, and discloses a mesoporous core-shell structure nanoenzyme with multiple enzyme activities as well as a preparation method and application thereof, the nanoenzyme takes gold nanorods as an inner core and iridium and its oxide as an outer shell, the outer shell is modified by polyethylene glycol and then loaded with a photosensitizer chlorin e6 to form an AuNR@Ir / IrO2-PEG / Ce6 nanoenzyme, the nanoenzyme has high catalase (CAT) activity, can decompose hydrogen peroxide (H2O2) in a tumor microenvironment and generate oxygen (O2) in situ, effectively improves the treatment effect of photodynamic therapy (PDT), and through the synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) combined with photoacoustic imaging function, provides a brand-new diagnosis and treatment integrated solution for efficient treatment and microenvironment regulation of tumors, and effectively makes up for the defects of insufficient enzyme activity and low photothermal conversion efficiency of the prior art.

The invention belongs to the technical field of supramolecular artificial light capture luminescent catalytic materials, and discloses a water-phase multistage FRET artificial light capture system based on supramolecular assembly and a preparation method and application thereof. The preparation method comprises the following steps: by taking a sulfonate compound TPESF as a guest molecule and an energy donor and a water-soluble cation column [5] arene compound CP5 as a host molecule, forming supramolecular nanoparticles through host-guest interaction, and encapsulating an energy acceptor dye 4, 7-bis (thiophene-2-yl)-2, 1, 2, 3, 4-tetramethyl-3-piperidine-2-one, so as to obtain the energy acceptor dye. The method comprises the following steps: forming a water-phase nano-catalyst with multi-step continuous energy transfer capability from 2, 3-diazosulfide (DBT), sulfo rhodamine 101 (SR101) and chlorin E6 (Ce6), and catalyzing methyl phenyl sulfide under illumination to generate methyl phenyl sulfoxide. The prepared light capture catalytic system has high energy transfer efficiency and antenna effect after multi-step continuous energy transfer, can efficiently convert light energy into chemical energy, and can be applied to preparation of efficient artificial light capture materials.

Treatment compositions and methods for treating and / or preventing human hair thinning or hair loss comprising applying a chlorin treatment composition to an area of skin / scalp in need of treatment. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.02 to 0.1% by weight of a chlorin, preferably a copper chlorin. A density and / or diameter of hair in an area being treated may be increased by at least 5%, more preferably at least 15%. Immune privilege in an area being treated may also be restored as measured by change in certain immunoglobulin antibodies.

The application belongs to the technical field of biological medicine preparation, and particularly relates to a chlorin e6-loaded nanocluster activated by X-rays and a preparation method thereof. Hydroxyethyl starch and succinic anhydride are reacted in the presence of N,N-dimethylaminopyridine to obtain carboxylated hydroxyethyl starch, zinc oxide nanoparticles are assembled on the carboxylated hydroxyethyl starch to form zinc oxide nanoclusters, and then chlorin e6 is assembled on the zinc oxide nanoclusters. The obtained zinc oxide nanocluster loaded with chlorin e6 has a cluster structure, can generate singlet oxygen under X-ray irradiation, and can play an X-ray-induced photodynamic therapy role, and has potential application value in the photodynamic therapy of deep tumors.

Treatment compositions and methods for treating and / or preventing human hair thinning or hair loss comprising applying a chlorin treatment composition to an area of skin / scalp in need of treatment. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.02 to 0.1% by weight of a chlorin, preferably a copper chlorin. A density and / or diameter of hair in an area being treated may be increased by at least 5%, more preferably at least 15%. Immune privilege in an area being treated may also be restored as measured by change in certain immunoglobulin antibodies.

The present invention relates to a bacteria-targeted microneedle patch, preparation and application, and belongs to the field of biomedicine. In the present invention, the microneedle patch is composed of gelatinase-responsive antibacterial nanoparticles Ce6@GNP-Van and methacrylated hyaluronic acid (HAMA) hydrogel matrix. The enzyme-responsive antibacterial nanoparticles Ce6@GNP-Van use type A gelatin as raw material, synthesize enzyme-responsive gelatin nanoparticles (GNPs) by a two-step desolvation method, and load the photosensitizer dihydrochlorin e6 (Chlorin e6, Ce6) therein, and then modify vancomycin on its surface to obtain, apply the antibacterial nanoparticles to the microneedle patch, and prepare enzyme-responsive microneedles. The present invention combines antibacterial treatment with a microneedle drug delivery system to meet the requirements of precise bacterial targeting and stimulus-responsive drug release, thereby providing a new strategy for the treatment of abscess wounds.

The present invention relates to chlorin e6 analogs and pharmaceutically acceptable salts thereof, and compositions comprising chlorin w6 analogs and pharmaceutically acceptable salts thereof. The chlorin e6 analogs and pharmaceutically acceptable salts thereof are suitable for use in photodynamic therapy, cytoluminescence therapy, and photodynamic diagnosis, for example, for the treatment or detection of tumors or antiviral treatment. The present invention also relates to the use of chlorin e6 analogs and pharmaceutically acceptable salts thereof in the manufacture of phototherapeutic or photodiagnostic agents, and to methods of photodynamic therapy, cytoluminescence therapy, or photodynamic diagnosis, for example, for the treatment or detection of tumors or antiviral treatment. [Formula 1] TIFF2025539865000117.tif70159

The invention discloses a nano material with photodynamic and sonodynamic combined antibacterial effects and a preparation method and application thereof, and the nano material is prepared by loading eugenol and chlorin e6 on a metal organic framework material with a zeolite topological structure. The ternary nano composite material prepared by the invention can synergistically enhance photodynamic and sonodynamic effects, and active oxygen ROS is fully utilized. The material prepared by the invention has a remarkable antibacterial effect on staphylococcus aureus and escherichia coli, and has a remarkable inhibition effect on bacterial biofilms. The prepared material has multiple antibacterial mechanisms such as the bacteriostatic effect of natural antibacterial components, the bacteriostatic effect of ROS generated by photodynamic force and the penetrating effect improved by ultrasound, the antibacterial spectrum is widened, the overall antibacterial efficacy is enhanced, the used material is in the food grade, the overall preparation method is simple and easy to implement, and a new thought is provided for food bacteriostasis and preservation.

The application provides a preparation method of protein-coated ZIF structure loaded with chlorin e6 and manganese dioxide, which comprises the following steps: dissolving zinc nitrate hexahydrate and copper nitrate trihydrate in a methanol solution to obtain a mixed solution A; dissolving 2-methylimidazole in a methanol solution to obtain a solution B; stirring the solution B at room temperature, adding the mixed solution A into the solution B, continuing to react, adding chlorin e6, centrifuging, and forming a ZIF structure loaded with chlorin e6; dissolving a protein in water, adjusting pH to 7, adding potassium permanganate, uniformly stirring, and forming a protein-coated manganese dioxide compound aqueous solution; resuspending the ZIF structure loaded with chlorin e6, adding into the protein-coated manganese dioxide compound aqueous solution, uniformly stirring, centrifuging, resuspending, and forming protein-coated ZIF structure loaded with chlorin e6 and manganese dioxide nanoparticles.

The invention relates to the technical field of nano medicine and functional nano materials, and discloses a mesoporous core-shell structure nano enzyme with multi-enzyme activity and a preparation method and application thereof.According to the nano enzyme, a gold nanorod serves as an inner core, iridium and iridium oxide serve as a shell, the shell is modified through polyethylene glycol and then loaded with a photosensitizer chlorin E6, and AuNR (at) Ir / IrO2-PEG / Ce6 nano enzyme is formed; the compound has efficient catalase (CAT) activity, hydrogen peroxide (H2O2) in a tumor microenvironment can be decomposed, oxygen (O2) can be generated in situ, the treatment effect of photodynamic therapy (PDT) is effectively improved, meanwhile, the photoacoustic imaging function is combined with the synergistic effect of the photodynamic therapy (PDT) and photothermal therapy (PTT), and the photoacoustic imaging effect is improved. A brand new diagnosis and treatment integrated solution is provided for efficient treatment and microenvironment regulation of tumors, and the defects of insufficient enzyme activity and low photothermal conversion efficiency in the prior art are effectively overcome.

Treatment compositions and methods for treating and / or preventing human hair thinning or hair loss comprising applying a chlorin treatment composition to an area of skin / scalp in need of treatment. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.02 to 0.1% by weight of a chlorin, preferably a copper chlorin. A density and / or diameter of hair in an area being treated may be increased by at least 5%, more preferably at least 15%. Immune privilege in an area being treated may also be restored as measured by change in certain immunoglobulin antibodies.

The application belongs to the field of neurosciences, and particularly relates to a reagent for damaging vestibular hair cells and a method for constructing a vestibular hair cell damage model. The application provides a reagent for damaging vestibular hair cells, which comprises a solvent and, added in the solvent, 0.01 mg / mL-0.02 mg / mL chlorin e6 and 0.02 mg / mL-0.08 mg / mL PEG-PLGA. The chlorin e6 is a naturally occurring photosensitizer, which has strong absorption capacity in the near-infrared region and the visible light region and good fluorescence characteristics. The PEG-PLGA is a biocompatible degradable polymer material, and the use of the material to prepare nanoparticles can increase the water solubility of the nanoparticles and reduce the decomposition and aggregation of the reagent, thereby increasing the stability of the reagent. The construction of the vestibular hair cell damage model can damage the vestibular receptors in the horizontal semicircular canal without affecting the hearing function, significantly inhibit the vestibular function, and provide a train of thought for the vestibular research of balance and hearing.

The present invention discloses a calcium / iron-based nanomotor loaded with chlorin e6, as well as its preparation method and application, belonging to the field of biomaterials for tumor treatment. The nanomotor of the present invention is prepared as follows: an iron ion / 3,3'-dithiodipropionylhydrazide complex is formed on the surface of nano-CaO2 particles to obtain core-shell calcium / iron nanoparticles; and chlorin e6 and hydrazide-modified hyaluronic acid are loaded onto the calcium / iron nanoparticles to obtain the chlorin e6-loaded calcium / iron-based nanomotor. This nanomotor exhibits light-driven motility, oxygen supply, glutathione scavenging, photodynamic / chemodynamic effects, and tumor targeting, and can be used in the preparation of highly effective anti-tumor drugs.

The application belongs to the technical field of biological medicine, and particularly relates to a neutrophil biomimetic vesicle nano preparation for targeting colorectal cancer and a preparation method and application thereof. The application provides a neutrophil biomimetic vesicle nano preparation for targeting colorectal cancer, wherein the neutrophil biomimetic vesicle nano preparation comprises neutrophil biomimetic vesicles, tumor-targeting peptides and photosensitizers; the tumor-targeting peptides are modified on the surface of the neutrophil biomimetic vesicles; the photosensitizers are loaded in the neutrophil biomimetic vesicles; and the photosensitizers comprise chlorin e6. The neutrophil biomimetic vesicle nano preparation has a stable core-shell structure, can effectively protect the activity of the photosensitizers, prevent leakage and aggregation quenching of the photosensitizers, and specifically enriches the photosensitizers (Ce6) in tumor cells, so that targeted delivery of the drug is realized. The problems of poor targeting of the existing photosensitizers, large toxic and side effects, short circulation time of the synthetic nano carriers, poor biocompatibility and the like are solved.