10 results about "Chlorin e6" patented technology

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

The application discloses a kind of photothermal-photodynamic synergistic antibacterial multifunctional probe and its preparation method and application, and is related to biomedical antibacterial field.The antibacterial probe includes gold-silver alloy hollow nanoparticles and photosensitizer modified on the surface of the gold-silver alloy hollow nanoparticles, and the photosensitizer for photodynamic antibacterial effect is chlorin e6 (Ce6).The antibacterial probe in the application has simple synthesis steps, excellent photothermal properties and photodynamic effect, has a significant effect on antibacterial growth, and has good biocompatibility, and can be used for the skin surface of animal tissue to carry out antibacterial effect.

A preparation method of a long afterglow nanoprobe platform capable of loading different modules. A chromium-doped zinc gallium indate long afterglow nanoprobe platform is synthesized by a hydrothermal method, a photosensitizer chlorin e6 module is loaded by using an amide condensation reaction, manganese dioxide modules with glutathione and pH / H2O2 dual response are prepared on the surface of the chromium-doped zinc gallium indate long afterglow nanoprobe platform by stirring in a potassium permanganate solution and adding into a sodium citrate solution, a polydopamine module is loaded in a tris-hydroxymethyl aminomethane hydrochloride buffer solution containing hydrochloric acid dopamine to improve biocompatibility, and a DOX module is loaded on the long afterglow nanoprobe platform in a π-π stacking manner, so that different functional modules of near-infrared imaging, fluorescence imaging, photodynamic effect, photothermal effect and drug loading can be loaded alone or simultaneously, multifunctional synergistic effect is realized, and the long afterglow nanoprobe platform is applied to the preparation of a tumor microenvironment prevention and monitoring preparation or a drug.

The present application relates to the technical fields of nanomedicine and functional nanomaterials, and discloses a mesoporous core-shell structure nanoenzyme with multiple enzyme activities as well as a preparation method and application thereof, the nanoenzyme takes gold nanorods as an inner core and iridium and its oxide as an outer shell, the outer shell is modified by polyethylene glycol and then loaded with a photosensitizer chlorin e6 to form an AuNR@Ir / IrO2-PEG / Ce6 nanoenzyme, the nanoenzyme has high catalase (CAT) activity, can decompose hydrogen peroxide (H2O2) in a tumor microenvironment and generate oxygen (O2) in situ, effectively improves the treatment effect of photodynamic therapy (PDT), and through the synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) combined with photoacoustic imaging function, provides a brand-new diagnosis and treatment integrated solution for efficient treatment and microenvironment regulation of tumors, and effectively makes up for the defects of insufficient enzyme activity and low photothermal conversion efficiency of the prior art.

Treatment compositions and methods for treating and / or preventing human hair thinning or hair loss comprising applying a chlorin treatment composition to an area of skin / scalp in need of treatment. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.02 to 0.1% by weight of a chlorin, preferably a copper chlorin. A density and / or diameter of hair in an area being treated may be increased by at least 5%, more preferably at least 15%. Immune privilege in an area being treated may also be restored as measured by change in certain immunoglobulin antibodies.

The application belongs to the technical field of biological medicine preparation, and particularly relates to a chlorin e6-loaded nanocluster activated by X-rays and a preparation method thereof. Hydroxyethyl starch and succinic anhydride are reacted in the presence of N,N-dimethylaminopyridine to obtain carboxylated hydroxyethyl starch, zinc oxide nanoparticles are assembled on the carboxylated hydroxyethyl starch to form zinc oxide nanoclusters, and then chlorin e6 is assembled on the zinc oxide nanoclusters. The obtained zinc oxide nanocluster loaded with chlorin e6 has a cluster structure, can generate singlet oxygen under X-ray irradiation, and can play an X-ray-induced photodynamic therapy role, and has potential application value in the photodynamic therapy of deep tumors.

The invention discloses a nano material with photodynamic and sonodynamic combined antibacterial effects and a preparation method and application thereof, and the nano material is prepared by loading eugenol and chlorin e6 on a metal organic framework material with a zeolite topological structure. The ternary nano composite material prepared by the invention can synergistically enhance photodynamic and sonodynamic effects, and active oxygen ROS is fully utilized. The material prepared by the invention has a remarkable antibacterial effect on staphylococcus aureus and escherichia coli, and has a remarkable inhibition effect on bacterial biofilms. The prepared material has multiple antibacterial mechanisms such as the bacteriostatic effect of natural antibacterial components, the bacteriostatic effect of ROS generated by photodynamic force and the penetrating effect improved by ultrasound, the antibacterial spectrum is widened, the overall antibacterial efficacy is enhanced, the used material is in the food grade, the overall preparation method is simple and easy to implement, and a new thought is provided for food bacteriostasis and preservation.

The application provides a preparation method of protein-coated ZIF structure loaded with chlorin e6 and manganese dioxide, which comprises the following steps: dissolving zinc nitrate hexahydrate and copper nitrate trihydrate in a methanol solution to obtain a mixed solution A; dissolving 2-methylimidazole in a methanol solution to obtain a solution B; stirring the solution B at room temperature, adding the mixed solution A into the solution B, continuing to react, adding chlorin e6, centrifuging, and forming a ZIF structure loaded with chlorin e6; dissolving a protein in water, adjusting pH to 7, adding potassium permanganate, uniformly stirring, and forming a protein-coated manganese dioxide compound aqueous solution; resuspending the ZIF structure loaded with chlorin e6, adding into the protein-coated manganese dioxide compound aqueous solution, uniformly stirring, centrifuging, resuspending, and forming protein-coated ZIF structure loaded with chlorin e6 and manganese dioxide nanoparticles.

The invention relates to the technical field of nano medicine and functional nano materials, and discloses a mesoporous core-shell structure nano enzyme with multi-enzyme activity and a preparation method and application thereof.According to the nano enzyme, a gold nanorod serves as an inner core, iridium and iridium oxide serve as a shell, the shell is modified through polyethylene glycol and then loaded with a photosensitizer chlorin E6, and AuNR (at) Ir / IrO2-PEG / Ce6 nano enzyme is formed; the compound has efficient catalase (CAT) activity, hydrogen peroxide (H2O2) in a tumor microenvironment can be decomposed, oxygen (O2) can be generated in situ, the treatment effect of photodynamic therapy (PDT) is effectively improved, meanwhile, the photoacoustic imaging function is combined with the synergistic effect of the photodynamic therapy (PDT) and photothermal therapy (PTT), and the photoacoustic imaging effect is improved. A brand new diagnosis and treatment integrated solution is provided for efficient treatment and microenvironment regulation of tumors, and the defects of insufficient enzyme activity and low photothermal conversion efficiency in the prior art are effectively overcome.

The application belongs to the technical field of biological medicine, and particularly relates to a neutrophil biomimetic vesicle nano preparation for targeting colorectal cancer and a preparation method and application thereof. The application provides a neutrophil biomimetic vesicle nano preparation for targeting colorectal cancer, wherein the neutrophil biomimetic vesicle nano preparation comprises neutrophil biomimetic vesicles, tumor-targeting peptides and photosensitizers; the tumor-targeting peptides are modified on the surface of the neutrophil biomimetic vesicles; the photosensitizers are loaded in the neutrophil biomimetic vesicles; and the photosensitizers comprise chlorin e6. The neutrophil biomimetic vesicle nano preparation has a stable core-shell structure, can effectively protect the activity of the photosensitizers, prevent leakage and aggregation quenching of the photosensitizers, and specifically enriches the photosensitizers (Ce6) in tumor cells, so that targeted delivery of the drug is realized. The problems of poor targeting of the existing photosensitizers, large toxic and side effects, short circulation time of the synthetic nano carriers, poor biocompatibility and the like are solved.