115 results about "Polymicrobial Infections" patented technology

The invention relates to the technical field of intelligent medical diagnosis, in particular to a clinical microbial infection intelligent diagnosis system and method based on multi-omics data fusion, and the method comprises the steps: collecting and processing time sequence multi-omics data, and generating a transient infection state snapshot vector; constructing a time sequence state transition model, inputting the instantaneous infection state snapshot vector into the time sequence state transition model, and predicting and generating a future state vector; respectively calculating a pathogen threat index and a host imbalance index based on the future state vector; generating a comprehensive risk score based on the pathogen threat index and the host imbalance index, and determining an early warning grade according to a preset early warning grade threshold; generating a hierarchical intervention strategy based on the early warning level in combination with the pathogen threat index and the host disorder index; outputting a grading intervention strategy as a specific diagnosis and treatment suggestion; according to the invention, prospective early warning is realized, and the situation that the optimal treatment opportunity is delayed due to the change of waiting indexes is effectively avoided.

The invention relates to low dose compositions and peptides or peptide sequences that induce an immune response in an animal or a mammal that is protective against infection by one or more pathogens, and the antibodies generated. In addition, the invention relates to immunogenic composition and vaccines comprising compositions and peptide sequences or antibodies, and to methods for treating and preventing an infection in animals and mammals such as humans.

Disclosed embodiments relate to wound care materials and methods that comprise a self-gelling composition, configured to form a gel upon contacting fluid. The self-gelling composition is a substantially homogeneous mixture, and comprises fluid-absorbent particles loaded with iodine-based antimicrobial agent, a dehydrated hydrogel powder, and a polymer base, configured to allow dispensing the self-gelling composition from a syringe or tube and to prevent the self-gelling composition from gelling prior to contacting fluid. The gel performs one or more of the following tasks during a wear time, when applied at the wound: absorbing fluid or exudate, releasing iodine-based antimicrobial agent, achieving antimicrobial activities at the wound, remaining structurally integral and cohesive, protecting the wound from exposure to microorganisms, and facilitating healing. After a wear time of at least three days, the gel can be removed in two pieces or less and leave less than 5% residue by weight.

The invention provides a method of preparing a vaccine composition. The method includes infecting gene-edited porcine endogenous retrovirus (PERV) negative swine cells with a microorganism which expresses at least one protein antigen capable of inducing protective immunity in an animal against an infectious agent; culturing the infected cells in culture medium to propagate the microorganism; and harvesting the propagated microorganism from the culture medium to obtain a fraction comprising a PERV free antigen for use in immunizing an animal against the infectious agent.

The invention provides a method of preparing a vaccine composition. The method includes infecting gene-edited porcine endogenous retrovirus (PERV) negative swine cells with a microorganism which expresses at least one protein antigen capable of inducing protective immunity in an animal against an infectious agent; culturing the infected cells in culture medium to propagate the microorganism; and harvesting the propagated microorganism from the culture medium to obtain a fraction comprising a PERV free antigen for use in immunizing an animal against the infectious agent.

This invention relates to a vulnerary multifunctional composition, based on unripe coffee cherries (peel, mucilage, beans and silverskin), seed extract of Trigonella foenum-graecum, with one or more tissue-inducing molecules derived from the secondary metabolites of both plants. The unexpected and surprising ability of this new composition to solve the problems of chronic non-healing wounds addresses a long felt unmet need in the medical arts. Through a multifaceted approach, it combats microbial infections, reduces chronic inflammation, counters oxidative stress, enhances immune responses, promotes angiogenesis, regulates protease activity, stimulates collagen deposition, increases growth factor availability, facilitates cell migration, and prevents persistent infections. These novel integrated therapies represent a breakthrough in addressing macroscopic wound healing while targeting the underlying microscale mechanisms. This invention also relates to methods for preparing, using, and administering the multifunctional composition for timely healing in mammals with various skin lesions.

The present invention relates to anti-CLEC12A antibodies and the antigen-binding fragments thereof. The present invention further relates to pharmaceutical compositions and diagnostic tests comprising the anti-CLEC12A antibodies or antigen binding fragments thereof, and the uses of such antibodies for the treatment and diagnosis of microbial infections.

The application relates to the technical field of biological medicine, and particularly discloses CpG oligodeoxynucleotides and application thereof. The CpG oligodeoxynucleotide has a sequence as shown in any one of SEQ ID NO. 3-6, 9, and preferably has a sequence as shown in SEQ ID NO. 3-6. The CpG oligodeoxynucleotide can effectively activate the immune system of a human body or an animal, has the functions of preventing and treating pathogenic microorganism infection in a broad spectrum, has the function of improving the immunogenicity of a common vaccine, and can be applied as a human or animal vaccine adjuvant.

The present invention provides stable antimicrobial and disinfectant compositions comprising use of a solid precursor of an oxidized state of chlorine. The invention also provides on-demand storage and mixing vessels and methods for preparing and delivering on demand formulations. In addition, the invention provides antiviral, antibiotic and general antimicrobial uses, in vivo, on surfaces and via spray applications.

The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.

The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and / or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using the same.

The present disclosure allows for an anaerobic biofilm also known as a beneficial biofilm, to be grown on a hydrophilic substrate surface and contained within the varied surface and surface-accessible interior of the substrate. This allows for the anaerobic biofilm to remain intact and functional while being exposed to an aerobic environment. The present disclosure further allows for the constituent microbes to interact with an oxygen-rich surrounding without perishing. The present disclosure allows anaerobic biofilm constituent microbes to exist side-by-side with aerobic biofilm constituent microbes and employ various mechanisms to starve or eliminate unhealthy biofilms and sessile and free-floating unwanted microbes, and / or deliver substances to soil to improve soil health or to the body to assist in repair of injuries such as microbial infections, lesions, tumors, cuts, abrasions, burns, and nerve damage.

The present invention includes methods of using improved compositions and improved compositions comprising thermally stable plant juice soluble vegetable proteins for resisting pathogenic effects; the improvements include that the composition comprising heat stable plant juice soluble vegetable proteins is essentially a water insoluble concentrated substance free of components that are more soluble in plant juice, and is enriched in heat stable proteins of plant juice; dosage forms prepared from the composition are useful for adiponectin agonist action for reducing the risk of one or more conditions selected from the group consisting of type II diabetes, hyperlipidemia, atherosclerosis, hypertension, heart disease and obesity, and are useful for antimicrobial action for reducing the risk of one or more conditions selected from the group consisting of type II diabetes, hyperlipidemia, atherosclerosis, hypertension, heart disease and obesity. The present invention relates to antimicrobial agents for reducing the risk of or treating microbial infections in plants and animals with or without synergy with other antimicrobial agents. The present invention includes a composition substantially characterized by the infrared absorption spectrum provided in the present invention.

The present disclosure relates to an extracellular vesicle including an antigen protein or a gene encoding the antigen protein and use thereof, and more particularly, to: an extracellular vesicle including an antigen protein derived from a virus, a microorganism, or cancer cells, or a gene encoding the antigen protein; or a vaccine composition for the prevention or treatment of a viral infection, a microbial infection, or cancer, the vaccine composition including the extracellular vesicle. The extracellular vesicle or the vaccine composition including the extracellular vesicle, according to the present disclosure, is a platform that has stability and an excellent effect of inducing an antigen-specific immune response and can be applied to various diseases, and thus is expected to be effectively used in the field of development of a vaccine for the prevention or treatment of various diseases, including microbial infections or cancer.

The invention relates to small molecule compounds that are useful as antimicrobial agents, pharmaceutical compositions comprising the compounds, and the use of the compounds in the treatment of subjects with microbial infections.

The present disclosure provides a method for treating sepsis caused by a microorganism infection. The disclosure also relates to a method for identifying and discovering compounds useful in treating sepsis as well as a method for determining appropriate approaches for treating sepsis. In particular, the methods of the disclosure are based on the discovery by the present inventor that sepsis is caused by exotoxin(s) of microorganism or by constitutive proteins that function as exotoxins as in the case of viruses.

The invention is applicable to the technical field of bioengineering, and provides a streptococcus suis bacteriophage antibacterial protein Lys8387 as well as a preparation method and application thereof, and the amino acid sequence of the streptococcus suis bacteriophage antibacterial protein Lys8387 is shown as SEQ ID NO.2. A novel bacteriophage antibacterial protein capable of playing splitting and depolymerizing double activities on streptococcus suis is constructed through a genetic engineering technology, and the lyase is novel in sequence, shows strong bactericidal activity on multi-drug-resistant streptococcus suis, can be independently used or compounded with other substances for use, or can be prepared into an enzyme preparation, and can be used for preparing an antibacterial agent for multiple drug-resistant streptococcus suis. The compound not only has bactericidal activity on streptococcus suis, but also has a degradation effect on capsular polysaccharide of streptococcus suis, K2 type klebsiella pneumoniae and the like, and a thought is provided for preparing a medicine for preventing and treating diseases caused by infection of microorganisms such as streptococcus suis and the like.

The invention discloses a pathogenic microorganism infection immune feature recognition system and method, belongs to the technical field of immune feature recognition, and aims to solve the problems of incomplete feature extraction, weak model generalization ability, poor adaptability to novel pathogenic microorganisms and the like due to the fact that a traditional immune feature recognition technology mostly adopts single-dimensional features or a traditional machine learning model. In order to solve the problems of low recognition accuracy, high false positive rate and difficulty in meeting actual requirements of clinical diagnosis and epidemic situation monitoring in the prior art, the pathogenic microorganism infection immune feature recognition system comprises a data acquisition module, a data preprocessing module, a multi-dimensional immune feature extraction module, a fusion deep learning recognition model module and a result output and verification module, according to the method, through a deep learning architecture fused by Transform, CNN and LSTM, the long-distance dependency relationship, local features and time sequence features among the features are captured at the same time, optimization strategies such as transfer learning and regularization are combined, and the recognition accuracy and generalization ability of the model can be significantly improved.

The present invention concerns a pharmaceutical composition comprising glucono-δ-lactone, which is suitable for use in the treatment of vaginal microbial infections.

The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.

Methods for identifying and providing information about inhibiting growth of polymicrobial infections, including but not limited to providing statistics or information about the likelihood of success in inhibiting growth of a polymicrobial infection with particular compositions or therapeutic solutions. The methods herein feature detection and identification of organisms of the polymicrobial sample (e.g., polymicrobial infection), phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial sample (e.g., polymicrobial infection) in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic / therapeutic susceptibility or resistance for particular known polymicrobial samples (e.g.. polymicrobial infections) in order to provide information related to the likelihood of success of one or more therapeutic solutions for the polymicrobial sample (e.g.. polymicrobial infection).

The invention belongs to the field of wash supplies, and particularly relates to a Chinese prickly ash wash supply and a preparation method thereof, the Chinese prickly ash wash supply comprises the following components in percentage by weight: 1-50% of Chinese prickly ash juice or Chinese prickly ash juice derivative as an active component, 0.05%-0.5% of zanthoxylum bungeanum essential oil, wherein the zanthoxylum bungeanum essential oil is a by-product of preparation of Through the synergistic compatibility of a water-oil dual-zanthoxylum bungeanum active system and the traditional Chinese medicine extracts such as cacumen biotae and radix polygoni multiflori preparata, the product can synchronously realize the functions of expelling parasites, deodorizing, resisting bacteria, growing hair, blackening hair, caring scalp and the like. Wherein discomfort caused by microbial infection and parasites is solved through the powerful antibacterial and parasite-expelling effects of the pepper essential oil, deep maintenance of hair growing, hair blacking and scalp conditioning is achieved through cooperation of the pepper juice and the traditional Chinese medicine extract, multiple products do not need to be matched, and the all-around washing and caring requirements are met. The shampoo meets the dual use requirements of pets and human beings, and can be widely applied to hair washing, bathing, hair care, skin cleaning and other scenes.

The invention relates to the technical field of pathogenic microorganism infection detection, and provides a respiratory flora marker for assisting in predicting chlamydia psittaci infection and application of the respiratory flora marker. The respiratory tract flora markers comprise Candida glabrata, Lactobacillus paracasei, and Lactobacillus rhamnosus, and the respiratory tract flora markers comprise Candida glabrata, Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus paracasei, and Lactobacillus rhamnosus. The respiratory flora marker for aided prediction of chlamydia psittaci infection is applied to preparation of a kit for aided diagnosis of severe pneumonia caused by chlamydia psittaci infection, has high sensitivity and high specificity, reduces misdiagnosis and missed diagnosis, can effectively evaluate the risk of severe illness of a patient suffering from chlamydia psittaci infection, and has a good application prospect in the treatment of severe pneumonia caused by chlamydia psittaci infection. Therefore, medical intervention can be carried out as soon as possible, and great clinical application value is achieved.

The present application relates to the technical field of intelligent medical diagnosis, in particular to a clinical microorganism infection intelligent diagnosis system and method based on multi-omics data fusion, comprising: collecting and processing time-series multi-omics data to generate a snapshot vector of instantaneous infection state; constructing a time-series state transition model, inputting the snapshot vector of instantaneous infection state into the time-series state transition model, predicting and generating a future state vector; based on the future state vector, respectively calculating a pathogen threat index and a host disorder index; based on the pathogen threat index and the host disorder index, generating a comprehensive risk score, and determining an early warning level according to a preset early warning grading threshold; based on the early warning level, and combining the pathogen threat index and the host disorder index, generating a graded intervention strategy; outputting the graded intervention strategy as specific diagnosis and treatment suggestions; the present application realizes prospective early warning, effectively avoiding the delay of the best treatment opportunity due to waiting for index changes.

In alternative embodiments, manufactured products are provided that are made or manufactured as medical devices, such as inhalers, ionizers, asthma "blower-type" devices, nebulizers or nasal spray devices, respirators or respirators, warm air or hot air delivery devices, and / or CPAP (continuous positive air pressure) devices or equivalents, a drug delivery system for delivering a drug or one or combination of drugs, and optionally also warm or hot air, and optionally also ionized air. The manufactured product is used for treating, preventing and improving microbial infection, slowing down the progress of microbial infection, reducing the severity of microbial infection or preventing microbial infection. In alternative embodiments, a manufactured product as provided herein administers a combination or mixture of one or more drugs by inhalation, for example by using an aerosol, aerosol, liquid or powder formulation for inhalation.

An application of a Bacillus Calmette-Guérin (BCG)-based outer membrane vesicle (OMV) trained immunity inducer in preparation of an immunotherapeutic drug for sepsis is provided. The disclosure isolates and collects OMVs secreted by BCG bacteria to obtain a BCG-based OMV trained immunity inducer (designated as B-OMVs). The B-OMVs combines distinct advantages of both BCG and OMVs while circumventing their respective drawbacks. The developed B-OMVs exhibits characteristics such as being non-replicative, non-infectious, and of low toxicity, resulting in minimal impact on the organism and high safety. In addition, the B-OMVs demonstrates a more moderate yet effective immunomodulatory capacity. It can induce trained immunity, enhance the body's resistance to microbial infections, reduce the need for antibiotics, and more effectively improve the prognosis of sepsis.

The utility model discloses a device for hatching, separating and collecting fertilized eggs of diptychus maculatus and newly hatched larvae, which comprises a hatching assembly used for hatching the fertilized eggs of the diptychus maculatus. The first water pump assembly is used for forming upward water flow above the fertilized eggs in the hatching assembly and creating a still water or micro-flowing water environment for the fertilized eggs at the same time; the two ends of the flow guide groove are connected with the hatching assembly and the separation and collection assembly respectively, and after the fertilized eggs are hatched into newly hatched larvae, the newly hatched larvae enter the separation and collection assembly through the flow guide groove; the separating and collecting assembly is used for collecting newly hatched fry; the second water pump assembly is used for conveying the aquaculture water to the separating and collecting assembly. The device is used for large-scale separation of fertilized eggs and newly hatched fries, collection of floating fries is considered, the hatching rate of the fertilized eggs and the survival rate of the newly hatched fries can be effectively improved, and the risk that the fertilized eggs and the newly hatched fries are infected by pathogenic microorganisms such as water mildew and ichthyophthirius multifiliis is reduced. In addition, fertilized eggs and newly hatched larva fishes which stop developing and are attached to the hatching plates in the hatching box are cleaned by adding the attaching plates, and the hatching success rate is effectively increased.

The present invention provides new storable and stable disinfectant compositions comprising use of a solid precursor of an oxidized state of chlorine. The component in the device is devoid of stability issues, since the solid precursors are instantly to be dissolved in a pharmaceutically-acceptable diluent, adjuvant, or carrier, and combined with an activator (e.g. acetic acid or its salts), optionally combined with a viscosity enhancer, optionally combined with a dye. The main product is generated by breaking or opening seals, barriers or ports between an optional number of compartments in a multi-compartment device to mix the contents in the compartments, followed by gently squeezing or shaking the device to generate the disinfectant solution, wherein the resulting solutions can be taken out through a cap, port or opening on the multi-compartment device. The resulting compositions are useful disinfectants for treating a broad spectrum of pathogenic bacterial and / or viral, fungal or parasitic pathogens, denoted microbials.

The invention relates to the technical field of microbial infection treatment and molecular biology, and provides a method for inhibiting formation of a staphylococcus aureus biofilm, which is realized by inhibiting nitrosation modification of MgrA protein in staphylococcus aureus so as to inhibit formation of the biofilm. The inhibitor is nitric oxide synthase and is used for inhibiting nitrosation modification of the MgrA protein; the nitrosation modification for inhibiting the MgrA protein is realized by applying a nitric oxide synthase (NOS) inhibitor; the invention reveals that the staphylococcus aureus endogenous nitric oxide can promote the formation of a biofilm by modifying and regulating the 12th cysteine of the protein MgrA for the first time; based on the target spot, research proves that the MgrA modification level can be effectively reduced and the removal of the biofilm can be enhanced through multiple means such as gene mutation, NOS inhibitor or combination of the NOS inhibitor and antibiotics, and a new strategy and a potential drug development approach are provided for preventing and treating staphylococcus aureus intractable biofilm infection.