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1070 results about "Polymicrobial Infections" patented technology

Actinomyces can participate in polymicrobial infections involving Bacteroides, Actinobacillus, and Streptococcus. Primary actinomycosis of the breast. Botryomycosis is a rare pyogenic disease with polymicrobial etiology; Staphylococcus aureus is the most commonest one.

Nucleotide mimics and their prodrugs

The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and / or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
Owner:BIOTA SCI MANAGEMENT PTI LTD

Nitric Oxide Device and Method for Wound Healing, Treatment of Dermatological Disorders and Microbial Infections

The present disclosure provides a device having a casing with a barrier surface and a contact surface and a composition in the casing having a nitric oxide precursor and an isolated enzyme or live cell expressing an endogenous enzyme, for converting the nitric oxide gas precursor to nitric oxide gas or having activity on a substrate that produces a catalyst that causes the conversion of the nitric oxide gas precursor to nitric oxide gas. The present disclosure also provides methods and uses for treating wounds, microbial infections and dermatological disorders and for preserving meat products.
Owner:MICROPHARMA

Control of halitosis-generating and other microorganisms in the non-dental upper respiratory tract

Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and / or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treament procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.
Owner:VALENT MEDICAL INC

Compositions and methods for treatment of ear disorders

ActiveUS20110142917A1Reduces and inhibits expression of geneReduce expressionHeavy metal active ingredientsOrganic active ingredientsDiseasePresbycusis
The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.
Owner:QUARK FARMACUITIKALS INC

Topical anti-microbial compositions

Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.
Owner:THE PROCTER & GAMBLE COMPANY +1

Device and method for treatment of wounds with nitric oxide

Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from 160–400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation, and increases collagenase expression to debride necrotic tissue at the wound site. After a first treatment period, a second treatment period at a lower concentration of nitric oxide, preferably ranging from 5–20 ppm may be used to restore the balance of nitric oxide and induce collagen expression aiding in the wound closure.
Owner:SENSORMEDICS +1

Tissue infiltratable prosthetic device incorporating an antimicrobial substance

InactiveUS20050085924A1ProsthesisMuscle tissueProsthesis
The invention relates to prosthetic devices that include antimicrobial substances for reducing microbial infection, and method of using such implants for repairing, reconstructing and / or augmenting a defect or a weakness in a wall of a muscle, tissue or organ.
Owner:CR BARD INC

Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol

The present invention provides a pharmaceutical formulation having thermoreversible properties, comprising: a) an anti-microbial agent; b) a poloxamer mixture containing at least two poloxamer polymers; and c) a hydroxy fatty acid ester of polyethylene glycol, wherein the formulation is a solid at room temperature and is a liquid-gel at body temperature. The thermoreversible pharmaceutical formulation has a viscosity of about 8,500 cP to about 400,000 cP at room temperature, and a viscosity of about 1,000 cP to about 8,000 cP at body temperature and exhibits a hysteresis loop behavior. The present invention further provides a process of preparing as well as a method of treating a microbial infection in a mammal using the same.
Owner:TARO PHARMA INDS

Chitosan wound dressing

A composition is described in which chitosan is prepared in a foamed gel that may be layered onto a suitable backing for use as a wound dressing, or the gel may be directly applied to wounds to effect hemostatic activity as a result of the action of the chitosan. The composition of the foamed chitosan gel has added to it medicaments, which include antimicrobial agents, in order to reduce the risk of microbial infections in wounds where hemostatic agents including the chitosan foamed gel preparation can be applied to effect hemostasis.
Owner:SCHERR GEORGE H

Antimicrobial coatings for medical applications

The invention generally is related to preventing or inhibiting microbial infections on live tissues or in relation to the use of medical articles. In one embodiment, the invention is directed to a method for forming an antimicrobial coating on live tissue or a medical article, such as, for example, a catheter. The method includes applying to a live tissue or a surface of a medical article an aqueous or non-aqueous composition that includes at least one silane of the general formula R1nSi(OR2)4-n wherein, n is an interger of 1 or 2, R1 generally is a lower alkyl group, a C6-C8 aryl group, or a functional group, such as vinyl, acrylic, amino, mercapto, or vinyl chloride functional group, and R2 generally is a lower alkyl group. A partial condensate of a silanol of the formula R1Si(OH)3 also can be used. The composition includes one or more additional ingredients. The method also includes reacting and / or curing the silane, in the presence of the one or more ingredients, thereby forming the antimicrobial coating.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC

Exotic fruit juice and silver-containing beverage

InactiveUS20070269576A1Positive health benefitQuick and convenient source of nutritionFood preparationFruit juicePassion fruit
Fruit drinks and methods for providing positive health benefits to an individual are disclosed and described. In some aspects, a nutritional fruit drink is provided having a fruit juice selected from the group consisting of durian, mangosteen, gac, cili, lycium barbarum, seabuckthorn berry, hawthorn berry, euphoria longana, jujube date, schisandra berry, passion fruit, lychee, tangerine, coconut, rambulan, longkong, carambola, quanara, acai berry, qing mei, quinoa, and mixtures and concentrates thereof, and a silver source. Such fruit drinks can provide added nutrition to the diet while imparting increased protection against microorganismic infections.
Owner:BARTON BRENT +1

Actively sterile surfaces

An actively antimicrobial surface for a substrate and for use in a biologically dynamic environment, such as for treating and preventing microbial infections, including a film consisting of at least an antimicrobial element and another electrochemically nobler element and which forms multitudinous galvanic cells with electrolyte-containing biological fluids, such as body fluids from wounds, etc., for releasing the antimicrobial element at the surface.
Owner:NUCRYST PHARMA

Process for production of actively sterile surfaces

A process for production of an actively antimicrobial surface for a substrate and for use in a biologically dynamic environment, such as for treating and preventing microbial infections, including a film consisting of at least an antimicrobial element and another electrochemically nobler element and which forms multitudinous galvanic cells with electrolyte-containing biological fluids, such as body fluids from wounds, etc., for releasing the antimicrobial element at the surface.
Owner:NUCRYST PHARMA

C3/C3 fluoroquinolone dimmer derivative using oxadiazole as connection chain as well as preparation method and application thereof

The invention discloses a C3 / C3 fluoroquinolone dimmer derivative using oxadiazole as a connection chain as well as a preparation method and an application thereof. The C3 / C3 fluoroquinolone dimmer derivative using oxadiazole as a connection chain is a compound which has the following structural general formula (I), wherein R1 and R1' are independently selected from H, (C1-C10) alkyl, (C3)-(C10) cycloalkyl, (C1)-(C10) haloalkyl and substituted aryl group or substituted heterocyclic aryl group; R2 and R2' are independently selected from H, (C1-C7)alkyl, (C3)-(C7) cycloalkyl, substituted aryl group, substituted heterocyclic aryl group and hydrocarbon acyl or sulfonyl; R3 and R3' are independently selected from H, (C1-C5) alkyl, (C3)-(C5) cycloalkyl, substituted aryl radical or substitutionalheterocyclic aryl radical; and X and Y are independently selected from CH, N or carbon atoms connected with halogen, alkyl, oxyl, sulfenyl, amino, substituted amino, substituted aryl radical or substituted heterocyclic aryl radical. The C3 / C3 fluoroquinolone dimmer derivative using oxadiazole as a connection chain can be used for preparing medicaments for treating tumors and preventing microbialinfection diseases.
Owner:河南省健康伟业生物医药研究股份有限公司

Oral composition for reducing plaque and microbial infections and whitening teeth

A dental mouthwash product, and method of use, comprising a water-soluble chlorite compound in a first solution, a hydrogen peroxide and a physiologically acceptable readily water-soluble oxidizing agent in a second solution, or optionally the oxidizing agent separate from the second solution as a powder, tablet, gel capsule, or liquid, wherein said oxidizing agent oxidizes chlorite to ClO2 within seconds, wherein the three ingredients are mixed to provide the mouthwash product. The mouthwash product may be used for any one or more of the following: as an antimicrobial agent for treating dental disease such as dental caries, plaque, gum disease, and / or bad breath, for strengthening gum and ligament attachments to the teeth, or for whitening teeth.
Owner:SASSON J ALAN

Assembly for the preparation of a medical device having a coating comprising hydrogen peroxide

The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).
Owner:COLOPLAST AS

Control of halitosis-generating and other microorganisms in the non-dental upper respiratory tract

Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and / or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treament procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.
Owner:VALENT MEDICAL INC

Prevention and treatment of skin and nail infections using germicidal light

InactiveUS20060004425A1Disables abilitySuccessfully and prevent infectionDiagnosticsCavity massageBiological bodyNail Infection
A method of prevention and treatment of microbial infections that occur on, or just below, the skin and nails of a person consisting of electromagnetic radiation to inactivate the microbes thus rendering them harmless. The treatment consists of irradiating an area of the skin and nails for a period of time long enough to inactivate the organisms. Some additional features which are not integral to the treatment but increase the safety of the treatment include shielding of non-infected areas from irradiation and a cover to prevent damage to sight which may result from viewing the electromagnetic radiation.
Owner:KERADERM

Antimicrobial Composition

Disclosed herein are antimicrobial compositions comprising an effective concentration of a metal salt combined with a plant extract. In some embodiments the composition comprises a copper salt and / or an iron salt and / or a nickel salt and / or a cobalt salt; and an extract of a plant selected from a group consisting of Punka granatum, Viburnum plicatum, Camellia sinensis, and Acer spp. The invention extends to uses of such compositions as medicaments, and to methods of treating microbial infections. The invention extends to methods for preventing microbial infections by coating objects and surfaces with the compositions.
Owner:NATURE THERAPEUTICS

Topical use of probiotic Bacillus spores to prevent or control microbial infections

Compositions including an isolated Bacillus species, spores or an extracellular product of B. coagulans, suitable for topical application, for inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus are disclosed. Methods of inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus by topical application of compositions that include an isolated Bacillus species, spores or an extracellular product of a B. coagulans strain are disclosed.
Owner:GANEDEN BIOTECH

Topical Use of Probiotic Bacillus Spores to Prevent or Control Microbial Infections

Compositions including an isolated Bacillus species, spores or an extracellular product of B. coagulans, suitable for topical application, for inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus are disclosed. Methods of inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus by topical application of compositions that include an isolated Bacillus species, spores or an extracellular product of a B. coagulans strain are disclosed.
Owner:GANEDEN BIOTECH

Graft polymer and moulded medical articles employing this

The present invention relates to graft polymer which is characterized in that it is formed by graft polymerization of structural units containing. a quaternary ammonium group represented by general formula (A),(R2 and R3 each represent an alkyl group with from 1 to 3 carbons, and R4 represents an alkyl group with from 3 to 18 carbons. X represents at least one type of ion selected from halogen, sulphate, hydroxide and carboxylic acid ions.),preferably to graft polymer where the structural units containing a quaternary ammonium group represented by general formula (A) are structural units which are represented by general formula (I),(R1 represents at least one species selected from hydrogen, the methyl group and the ethyl group, and n represents an integer in the range 1 to 12. A represents at least one species selected from O, S and NR5. R5 represents hydrogen or an alkyl group with 1 to 12 carbons.) orgraft polymer formed by the graft polymerization of structural units containing a quaternary ammonium group and structural units containing an alkoxypolyalkylene glycol moiety represented by the general formula (B),(n represents an integer in the range 1 to 100. R5 represents a straight-chain or branched alkylene group with from 1 to 4 carbons, and R6 represents at least one species selected from hydrogen and straight-chain or branched alkyl groups with from 1 to 4 carbons.).By applying or incorporating the graft polymer to / in medical devices which are left in the body for a long period, it is possible to prevent microbial infection arising via these medical devices.
Owner:TORAY IND INC

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells

A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
Owner:UNIV OF MARYLAND

Interfusion protein of human interleukin 15 and Fe

A human interleukin 15-Fc fusion protein composed of interleukin 15 and the Fc fragment of human immunoglobulin, which are linked via joining peptide, the nucleic acid ofr coding it, the expression carrier containing said nucleic acid, its composite medicine for preventing and treating microbial infection and its preparing process are disclosed.
Owner:上海海欣生物技术有限公司
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