16 results about "MISCELLANEOUS ANTIBIOTICS" patented technology

The invention provides a disulfide compound of formula (I) as defined in the claims for use as a medicament, including its use as an antimicrobial agent, such as an antibacterial agent; and its use in the treatment of cancer. The invention also provides a pharmaceutical composition per se comprising a disulfide compound of formula (I) and one or more other antibiotics, in particular aminoglycoside antibiotics, including the compound fradiomycin, as well as the use of said pharmaceutical composition as a medicament, including its use as an antimicrobial agent.

The invention constructs a biosensor which responds to the apramycin concentration and generates obvious fluorescence signal change, and provides a biosensor skeleton which can be adapted to other antibiotics. Specifically, the invention relates to the expression cassette comprising the apramycin resistance gene sequence, the apramycin resistance gene sequence comprising the expression cassette, a method for preparing the apramycin biosensor, and application of the apramycin biosensor to detection of a bacterial strain for producing apramycin. The method accelerates the step of screening the high-yield apramycin strain, provides a biosensor skeleton for screening other antibiotics, and potentially accelerates the screening of the antibiotic high-yield strain with the corresponding resistance gene.

The invention discloses an aromatic polyketone compound as well as a preparation method and application thereof. The compound GaB (3) has an effect of treating infection of multiple drug-resistant bacteria. The compound is obtained by being separated from a secondary metabolite of the symbiotic Streptomyces sp.QHH-9511 of licheniformis, and the compound 2, the compound 3, the compound 4 and the compound 5 are new compounds. According to the present invention, the research results show that the GaB can effectively sterilize a variety of drug-resistant bacteria (methicillin-resistant staphylococcus aureus, vancomycin-resistant enterococcus, carbapenem-resistant acinetobacter baumannii, multi-drug-resistant pseudomonas aeruginosa, multi-drug-resistant salmonella, and the like); in addition, the compound has the characteristics of broad-spectrum sterilization, biofilm formation inhibition and low-frequency drug resistance, and can be combined with other antibiotics to cope with super bacteria. Mechanism research shows that GaB is combined with glucosamine-6-phosphate synthetase (GlmS) to prevent synthesis of cell walls so as to play an antibacterial role, and a plurality of constructed living body models show that the compound can effectively reduce the content of bacteria in a body and promote wound repair and has in-vivo medication safety. The research result shows that the GaB can be used as a safe and effective novel pilot natural active small molecule for resisting infection of multiple drug-resistant bacteria.

The application discloses an anti-ENR nanobody, a coding gene, a cELISA detection method and purposes, and belongs to the technical field of biology. The amino acid sequence of the anti-ENR nanobody is shown as SEQ ID NO. 1, and the nucleic acid sequence for coding the anti-ENR nanobody is shown as SEQ ID NO. 2. A new type of competitive ELISA (cELISA) is established by screening the specific nanobody against ENR from an immunized bactrian camel library. When detecting the enrofloxacin residue in animal-derived food, the method has high sensitivity and specificity, can detect the ENR residue as low as 6.49 ng / mL in the sample, and has no cross reaction with other antibiotics. It is shown that the cELISA established in the application is a simple, rapid, sensitive and low-cost immunodetection method, and has great application prospect in the detection of ENR residue in animal-derived food.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The invention successfully constructs a high-sensitivity colorimetric detection method for tobramycin based on flower-like copper sulfide nano enzyme on the basis of peroxidase-like activity of CuS nano enzyme. The flower-like copper sulphide (CuS) nano-enzyme is successfully prepared through a coprecipitation method, the flower-like copper sulphide (CuS) nano-enzyme can catalyze a 3, 3 ', 5, 5'-tetramethyl benzidine-hydrogen peroxide system chromogenic reaction under the acidic condition, and a brand-new colorimetric system for detecting tobramycin is constructed by utilizing the inhibition characteristic of tobramycin on the system. Experimental results show that under the optimal conditions (pH = 4, reaction time 30 min, H220.8 mM, TMB 3.5 mM, and enzyme concentration 15 [mu] g / mL), the detection linear range of the method to the tobramycin is 1 ng / mL-1 mg / mL, the lowest detection concentration is 1 ng / mL, and the sensing system has good specificity to other antibiotics and can effectively distinguish the tobramycin from other antibiotics. The invention not only provides a rapid, sensitive and low-cost new method for detecting tobramycin in water, but also opens up a new thought for antibiotic detection in the fields of environmental monitoring and food safety.

The present invention discloses bis(benzylisoquinoline) alkaloid compounds, their synthesis, a combination and composition for activity against TLR4 receptors. The compounds of the present invention also show synergistic effect with other antibiotics.

The invention provides a pyridine oxazolidinone derivative or a pharmaceutical salt thereof as well as a preparation method and application of the pyridine oxazolidinone derivative, and belongs to the technical field of medicine synthesis. The pyridine oxazolidinone derivative and the pharmaceutically acceptable salt thereof provided by the invention have excellent antibacterial activity, inhibit formation of a 70S initial compound by targeting 23S rRNA of a bacterial ribosome 50S subunit, enable synthesis of bacterial protein to be retarded in an initial stage and further play an antibacterial effect, do not have the problem of cross resistance with other existing antibiotics, and have good application prospects. The compound can be used for preparing anti-gram-positive bacterium drugs. The preparation method of the pyridine oxazolidinone derivative and the medicinal salt of the pyridine oxazolidinone derivative is simple in step, convenient to operate and high in feasibility.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application has the use in preparing the product for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The invention discloses nucleic acid aptamers for specifically recognizing florfenicol, thiamphenicol and chloramphenicol, and the nucleic acid aptamers are base sequences shown as SEQ ID NO.1 or SEQ ID NO.3 in a sequence table, or base sequences with the homology of more than 70% with the SEQ ID NO.1, or base sequences with the homology of more than 40% with the SEQ ID NO.3. The invention further discloses a preparation method of the nucleic acid aptamers for specifically recognizing florfenicol, thiamphenicol and chloramphenicol. Experiments prove that the nucleic acid aptamer can specifically recognize all amide alcohol antibiotics clinically used by veterinarians, and is not interfered by ampicillin and other antibiotics. The compound has wide application in the fields of food safety, environmental safety and the like, can be used for preparing a sensor or a detection kit for specifically recognizing florfenicol, thiamphenicol and chloramphenicol, and has important significance in preliminary screening of amido alcohol antibiotic residues and pollution in large-batch food and environmental samples; and a new recognition element is provided for establishing a rapid, simple, cheap and sensitive florfenicol, thiamphenicol and chloramphenicol detection method at the same time.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

Provided are lactivicin compounds of Formula (I) and pharmaceutically acceptable salts of the compounds of Formula (I), wherein the compounds include antibiotics suitable for use alone or in combination with beta-lactamase inhibitors and / or other antibiotics, including beta-lactam and non-beta-lactam antibiotics, for the treatment or prevention of bacterial infections,

The invention belongs to the field of biological medicine, and particularly relates to application of a biphenyl compound in resisting drug-resistant bacteria and a product. The invention provides an application of 2, 4-dihydroxy-4 '-pentylbiphenyl and / or 3, 5-dihydroxy-4'-pentylbiphenyl in preparation of a product for resisting drug-resistant bacteria, and a preparation method of the 2, 4-dihydroxy-4 '-pentylbiphenyl. The result of the embodiment shows that compared with other antibiotics such as penicillin, ceftaroline fosamil, oxacillin and levofloxacin, the 2, 4-dihydroxy-4 '-pentylbiphenyl and / or the 3, 5-dihydroxy-4'-pentylbiphenyl can effectively inhibit various drug-resistant bacteria, and the effect is good. The 3, 5-dihydroxy-4 '-pentylbiphenyl can damage cell nucleuses by destroying cell membranes so as to achieve an antibacterial effect, and has a remarkable inhibition effect on MRSA (Methicillin-Resistant Staphylococcus Aureus). The 2, 4-dihydroxy-4 '-pentylbiphenyl and the 3, 5-dihydroxy-4'-pentylbiphenyl disclosed by the invention are used for resisting drug-resistant bacteria, can effectively inhibit or kill various drug-resistant bacteria, and have a good effect.

Described are analogs of aztreonam and disulfiram of Formula I, II, and III. These compounds can be used to treat bacterial infections in a subject. Also disclosed is the use of aztreonam and disulfiram for treating H. pylori infections. Combinations of the disclosed analogs and / or aztreonam and disulfiram with additional antibiotics and proton pump inhibitors are also disclosed.

The invention belongs to the technical field of biosensors, and discloses a composite material for kanamycin SERS (Surface Enhanced Raman Scattering) detection as well as a preparation method, application and a use method of the composite material. According to the invention, an ultra-sensitive aptamer-containing core-shell type SERS probe and a Fe3O4 (at) MoS2 (at) Ag-Apt capture probe are prepared, the capture probe can rapidly and effectively capture low-concentration Kana, and the capture probe is combined with the aptamer-containing core-shell type SERS probe to obtain a sandwich type SERS biosensor with two nanoflowers combined with double aptamers, so that the detection of the Kana is completed; a new strategy is provided for Kana detection, and reference is provided for detection of other antibiotic residues. The portability of the SERS detection platform meets the requirement of on-site rapid detection, an effective technical means is provided for food safety monitoring, and the SERS detection platform is expected to be widely applied to various fields.

The invention belongs to the technical field of prevention and control strain experiments, and discloses a screening method for screening probiotic yeast for resisting multi-drug-resistant escherichia coli in primitive forests. According to the method, information statistics and experimental verification are combined, and dominant probiotic yeast strains with a remarkable inhibition effect on multi-drug-resistant escherichia coli (MDR E. coli) are systematically screened and determined. The screened strain not only contains main bacteriostatic active compounds, but also defines related genes for generating the substances, so that technical support can be provided for subsequent large-scale production, and a reference method is provided for screening other antibiotic-resistant pathogenic bacterium control strains.