61 results about "MISCELLANEOUS ANTIBIOTICS" patented technology

Siderophore-photosensitizer conjugates, their synthesis and use in photodynamic antimicrobial therapy (PACT) is disclosed. The advantage of this method is improvement of photodynamic antimicrobial therapy against, for example, pathogenic micro-organisms such as bacteria and fungi. Naturally occurring and synthetically available siderophore structures are conjugated chemically with photoactive compounds such as Chlorin e6 to improve their penetration into bacterial cells and to increase antibacterial efficacy of photosensitizers via microbial proteins that recognize and transport iron-loaded siderophores. In this way, photosensitizers can be transported inside bacteria that otherwise could not cross the cell wall and membranes. Photodynamic activation of photosensitizers inside the cells of pathogenic microbes enables a more effective inhibition of cellular functions than application at the outer side of the cells. The siderophore-transporting systems of microbes are known to be specific for bacteria and fungi. Consequently, siderophore conjugates with photosensitizers are not taken up by mammalian cells and photodynamic effects can thus be exerted specifically on pathogenic microbes. Applications of these conjugates include highly efficient treatment of pathogenic gram-negative and -positive bacteria such as Pseudomonas aeruginosa, Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, treatment of microbial infections that often occur in chronic wounds as well as therapy of other antibiotic resistant microbial infections.

Antibiotics used to cure Uterine Tract Infections have resulted in the growth of MRSA. and other antibiotic resistant bacteria. The CDC guidelines state “Disposable diapers cause 95% of all UTI'S”. The procedures used for “prevention” are ineffective because millions of bacteria in incontinence garments continue to double every 20 minutes. Silver ions in bandages are used to cure severly damaged skin, such as in burns. The best two in a large scale test achieved results in just 30 minutes. This Invention uses silver ions in linings next to the skin to stop the growth of over 250 kinds of infectious bacteria on it's surface and the body parts it touches. It achieves results in 30 minutes, equal to the most highly rated bandages . . . for every level of incontinence for both sexes.

The invention discloses a rabbit monoclonal antibody based ciprofloxacin residue analysis enzyme-linked immune adsorption kit. In the ciprofloxacin detection, the IC50 value of the kit is 1.41ng/mL, the linear fitting equation of an inhibition ratio curve is y = 0.0239x - 1.3159, the detection range is between 0.19 and 10ng/mL, and the lowest detection limit is 0.095ng/mL. The ciprofloxacin antibody in the kit has higher specificity, and has lower crossing-over rate with other quinolone micromolecules; and the cross reaction rates between the ciprofloxacin antibody and enrofloxacin, ofloxacin, norfloxacin, fleroxacin or pefloxacin are 28.8 percent, 13.1 percent, 11 percent, 22.6 percent and 20.4 percent respectively. The ciprofloxacin antibody has no cross reaction with other antibiotics and sulfanilamide medicaments. The kit is suitable for detecting ciprofloxacin residue in samples of milk, urine and the like. The kit can detect samples on a large scale at the same time, is convenient and quick, has quite important realistic significance for on-site supervision and trace analysis, meanwhile greatly reduces the detection cost, and has potential economic value.

PCT No. PCT/ES97/00065 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/34902 PCT Pub. Date Sep. 25, 1997Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and preferably over 2000 Dalton is described. For example cephalosporin-G of increased purity, represented by a 6-8% increase in the HPLC titre, with a reduction of 50% in absorbance, is obtained using this technique. The invention makes it possible for the purified products to be used directly in the synthesis of other antibiotic compounds without the need for intermediate isolation.

The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are of the general formula

An ultra-sensitive electrochemical sensor, based on ordered mesoporous carbon-chitosan (OMC-CS) and gold nano particles-streptavidin (AuNPs-SA), is used for detecting kanamycin (KAN). The AuNPs-SA immobilizes a DNA chain (biotin labeling) by means of the biotin-streptavidin interaction; when being combined with KAN, a DNA 2 chain containing a KAN aptamer is labeled by ferrocene so as to enhance current signal on the surface of an electrode. Some factors that influence the performance of the aptamer sensor are optimized, so that the aptamer sensor has a wide linearity in the range from 1*10<-10> to 4*10<-6> M; detection limit of the KAN can be lowered to 47.2 pM. The aptamer sensor has electrochemical performances such as excellent stability, sensitivity and repeatability. Without interference of competitive analogues, the aptamer sensor shows excellent specificity; besides, the aptamer sensor has been successfully applied to detection of KAN in practical milk samples. The method is hopeful to have more potential to detect more other types of antibiotics.

Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R¹-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R² SEQ ID NO: 1 or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.

The invention belongs to the technical field of biology, and relates to a bacteriostatic-activity enhanced streptococcus-suis bacteriophage elysin and a preparing method thereof.A lySMP coding area gene sequence serves as a template, and is subjected to random mutation through error-prone PCR, then PCR products are connected with pET-28a (+) to be subjected to induction expression in BL21, and elysin with activity 1.8 times that of LySMP is obtained with the 96-hole-plate screening method; the most suitable pH and the most suitable temperature of the elysin are measured through a 96 hole plate.As the elysin has the advantages that acting is rapid, resistance is not prone to generation, and the elysin has the synergic sterilization effect with other antibiotics, the elysin is a potential bactericide; the effect of the elysin as the effective bactericide on resisting to the streptococcus-suis infection can be further researched through the obtained elysin, and contribution can be made in the control aspect of streptococcus suis.

The invention discloses a method for simultaneously detecting 103 antibiotics in fresh eggs. The method mainly comprises the following steps: carrying out solution extraction on a sample, and purifying and enriching by using a Prime HLB solid-phase extraction column; separating through a reversed-phase chromatographic column, detecting in a multi-reaction monitoring mode by adopting an ultra-highperformance liquid chromatography tandem mass spectrometer, determining chromatographic peak retention time and parent ion/daughter ion pairs of various antibiotics, and then carrying out qualitativeand quantitative analysis. The method can be used for simultaneously detecting 103 antibiotics such as quinolones, sulfonamides, macrolides, lactams, tetracyclines, antifungal bacteria and nitroimidazoles in animal derived food such as fresh eggs, fresh duck eggs and fresh quail eggs. The detection method disclosed by the invention is sensitive, accurate and rapid, and 103 antibiotics can be qualitatively and quantitatively analyzed at the same time within only 18 minutes on an instrument. And the detection method provided by the invention also has a certain reference value for detection of other antibiotics.

Novel modified release pharmaceutical compositions wherein the composition comprises at least one antibiotic(s) preferably amoxicillin or its pharmaceutically acceptable salts, esters, polymorphs, isomers, prodrugs, solvates, hydrates, or derivatives thereof either alone or in combination with other antibiotic(s) as active ingredient, with at least one release modifying agent(s) for controlling the release of the beta lactam antibiotic optionally with one or more other pharmaceutically acceptable excipient(s) is provided, wherein the dosage form provides a release of not more than about 60% of the antibiotic in about 30 minutes and not less than about 70% of the antibiotic after 8 hours when subjected to in vitro dissolution study or when tested in vivo. Further, the compositions of the present invention which when tested in a group of healthy humans provide a mean peak plasma concentration (C_max) after at least about 0.5 hour of administration of the dosage form. The present invention also provides process of preparing such dosage form and methods of using such dosage form.

The invention discloses a drug taste-masking agent which is characterized by comprising the following components in parts by weight: 1-30 parts of pericarpium zanthoxyli, 0-30 parts of pepper, and 0-30 parts of chili, wherein the effective ingredients in the components are water extracts or alcohol extracts. The taste-masking agent which has the local anesthesia function can temporarily palsy taste bud cells and improve the bitter taste threshold value, thereby achieving the taste masking purpose. The method can also be applicable to the taste-masking of other antibiotics, thereby having a higher application value.

Rapidly disintegrating oral controlled release pharmaceutical compositions and process for preparation of such compositions are provided. The compositions preferably comprise antibiotic(s) as active ingredient, more preferably amoxicillin either alone or in combination with other antibiotic(s). The controlled release compositions comprise at least one active ingredient, and a polymer system comprising of at least two polymers which retard the release of the active ingredient in the stomach while providing rapid release of the said active ingredient in the alkaline contents of small intestine, optionally with other pharmaceutically acceptable excipients. The compositions provide therapeutically effective levels of the active ingredient for extended periods of time, and possess bioadhesive properties.

The invention discloses herba leonuri granules for preventing and treating delivery diseases in postpartum sows, and belongs to the technical field of traditional Chinese medicinal preparations. The herba leonuri granules consist of the following raw materials in parts by weight: 0.8-1.2 parts of a herba leonuri extract, 0.8-1.2 parts of starch and 1.6-2.4 parts of dextrin. The invention also provides a preparation method of the herba leonuri granules. The herba leonuri granules for preventing and treating various delivery diseases in sows prepared by the invention have a concrete curative effect on preventing and treating the various delivery diseases of the sows; and the herba leonuri granules may replace delivery disease resisting drugs and other antibiotics added to feed; therefore, the herba leonuri granules make it possible to solve the problem of drug residue in pig products.

Provided is a ureaplasma urealyticum/mycoplasma hominis combined rapid culture and drug sensitivity detection kit. The kit can complete detection in 8-24 h, and meanwhile, drug-resistant detection of various antibiotics can be performed. The combined rapid culture kit is mainly composed of pork stomach digestive juice or lung digestive juice, a beef extracting solution or a beef heart extracting solution, cattle serum or horse serum or other animal serum, sodium chloride, peptone, yeast powder, urea, L-arginine, phenol red indicator or cresol red indicator, and penicillin or other antibiotics. The drug detection kit can detect doxycycline hyclate, roxithromycin, acetylspiramycin, gatifloxacin, clarithromycin, azithromycin, clindamycin, erythromycin, kitasamycin, ofloxacin, levofloxacin hydrochloride, sparfloxacin, ciprofloxacin, doxycycline, erythromycin cydocarbonate and various other antibiotics. By means of the detection kit, not only is the mycoplasma detection time shortened, but also drug-resistant detection can be performed at the same time so that clinical medication can be guided. The detection kit has the beneficial effects of being high in sensitivity, high in specificity, high in detection rate, easy and convenient to operate and the like.

A non-disintegrating, non-eroding, non-bioadhesive and non-swelling oral controlled release pharmaceutical composition and process for preparation of such compositions is provided which comprises at least one high dose water soluble active ingredient, at least one diluent, at least one binder, and a polymer system comprising of at least one release controlling polymer wherein the composition formulated into a suitable dosage form maintains its geometric shape even after the drug has diffused from the dosage form and provides the concentrations of active ingredient above effective levels for extended periods of time, optionally with other pharmaceutically acceptable excipients. The compositions preferably comprise antibiotic(s) as active ingredient, more preferably Amoxicillin or its pharmaceutically acceptable salts, hydrates, polymorphs, esters, and derivatives thereof, most preferably amoxicillin sodium, either alone or in combination with other antibiotic(s). Also described are controlled release compositions which provide an initial burst release of approximately 20%-40% of the active ingredient within one hour for achieving blood levels equivalent to minimum inhibitory concentration, while maintaining these levels for an extended period of time.

The invention relates to a fermented traditional Chinese medicine composition for strengthening spleen and stomach and balancing intestinal flora of poultry. The traditional Chinese medicine composition comprises a following traditional Chinese medicine part including medicated leaven, malt, hawthorn, astragalus membranaceus, bighead atractylodes rhizome, codonopsis pilosula, acanthopanax, pericarpium citri reticulatae, elecampane, agastache rugosus, dandelion, rhizoma atractylodis and poria cocos; an auxiliary material part including rice chaff, soybean meal, corn and stone powder; and a strain part including lactic acid bacteria and bacillus subtilis. The fermented traditional Chinese medicine composition prepared by the invention has remarkable effects of improving the production performance of poultry and preventing and controlling intestinal diseases, can possibly replace intestinal disease resisting drugs and other antibiotics added in feed, and has a significant effect on improving intestinal tracts, increasing the feed conversion rate and reducing the eggshell breakage rate. In addition, the composition can improve the quality and color of eggshells and prevent and control intestinal diseases caused by infection of pathogenic microorganisms such as escherichia coli, salmonella and clostridium perfringens.

The invention discloses application of an MOF-Zn fluorescent sensor in detection of chloramphenicol as well as a CHL detection method. The application comprises the steps of taking solution of a metalorganic framework material MOF-Zn, adding to-be-detected solution and testing mixed solution by using a fluorospectrophotometer. When concentration of CHL is increased to 0.01M from 0M, fluorescenceintensity of MOF-Cd monotonously and sharply decreases, which shows that the MOF-Zn can be highly sensitive to CHL when being taken as a fluorescent probe. When the concentration of CHL is increased to 0.071mM, the fluorescence intensity of MOF-Cd is almost completely quenched. Based on standard deviation (sigma) of three times of repeated measurements based on fluorescence intensity of blank solution, a detection limit (3sigma/Ksv) is calculated to be 2.334ppb. 200[mu]L solution of substances like antibiotics is added into the MOF-Zn solution, and then 40[mu]L CHL is added, so that other substances like the antibiotics exist under the condition that CHL exists. After mixed substances (Y+CHL) are added, the fluorescent intensities of all the substances like the antibiotics are quenched, which shows that the probe can selectively identity CHL and the other substances like the antibiotics do not interfere with detection on CHL.

The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which have β-lactamase inhibitory and antibacterial properties. The compounds are therefore useful in the treatment of antibacterial infections in humans or animals, either alone or in combination with other antibiotics.

The invention discloses application of Cinacalcet in inhibiting the biological activity of gram-positive bacteria. The Cinacalcet is used for inhibiting the growth activity of the gram-positive bacteria. The technical scheme of the invention discloses a new application of Cinacalcet, which can inhibit the biological activity of the growth of planktonic bacteria of various gram-positive bacteria, especially the Cinacalcet has the effects of inhibiting bacteria and removing the activity of a biofilm on enterococcus faecalis. In an environment infected by the enterococcus faecalis biofilm, the Cinacalcet has both bacteriostatic activity and activity of removing the biofilm. Moreover, compared with a single drug, the Cinacalcet used in combination with other antibiotics has higher antibacterial activity, the dosage of single-drug antibiotics can be obviously reduced, and the drug resistance selection pressure of the Cinacalcet is reduced.