5 results about "MISCELLANEOUS ANTIBIOTICS" patented technology

The present invention discloses bis(benzylisoquinoline) alkaloid compounds, their synthesis, a combination and composition for activity against TLR4 receptors. The compounds of the present invention also show synergistic effect with other antibiotics.

The invention provides a pyridine oxazolidinone derivative or a pharmaceutical salt thereof as well as a preparation method and application of the pyridine oxazolidinone derivative, and belongs to the technical field of medicine synthesis. The pyridine oxazolidinone derivative and the pharmaceutically acceptable salt thereof provided by the invention have excellent antibacterial activity, inhibit formation of a 70S initial compound by targeting 23S rRNA of a bacterial ribosome 50S subunit, enable synthesis of bacterial protein to be retarded in an initial stage and further play an antibacterial effect, do not have the problem of cross resistance with other existing antibiotics, and have good application prospects. The compound can be used for preparing anti-gram-positive bacterium drugs. The preparation method of the pyridine oxazolidinone derivative and the medicinal salt of the pyridine oxazolidinone derivative is simple in step, convenient to operate and high in feasibility.

Provided are lactivicin compounds of Formula (I) and pharmaceutically acceptable salts of the compounds of Formula (I), wherein the compounds include antibiotics suitable for use alone or in combination with beta-lactamase inhibitors and / or other antibiotics, including beta-lactam and non-beta-lactam antibiotics, for the treatment or prevention of bacterial infections,

Described are analogs of aztreonam and disulfiram of Formula I, II, and III. These compounds can be used to treat bacterial infections in a subject. Also disclosed is the use of aztreonam and disulfiram for treating H. pylori infections. Combinations of the disclosed analogs and / or aztreonam and disulfiram with additional antibiotics and proton pump inhibitors are also disclosed.

The invention belongs to the technical field of prevention and control strain experiments, and discloses a screening method for screening probiotic yeast for resisting multi-drug-resistant escherichia coli in primitive forests. According to the method, information statistics and experimental verification are combined, and dominant probiotic yeast strains with a remarkable inhibition effect on multi-drug-resistant escherichia coli (MDR E. coli) are systematically screened and determined. The screened strain not only contains main bacteriostatic active compounds, but also defines related genes for generating the substances, so that technical support can be provided for subsequent large-scale production, and a reference method is provided for screening other antibiotic-resistant pathogenic bacterium control strains.