Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Water-soluble degradable and efficiently antibacterial polymeric micelle and preparation method thereof

A biodegradable, polymer glue technology, applied in the directions of non-active ingredients medical preparations, pharmaceutical formulations, etc., can solve the problems of inability to apply in the biomedical field, poor antibacterial effect of polymers, poor antibacterial and bacteriostatic effect, etc. Achieve good bactericidal effect, improve bacteriostatic and bactericidal effects, and have a wide range of effects

Inactive Publication Date: 2012-09-19
TONGJI UNIV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the polymer prepared above has certain antibacterial and antibacterial effects, its preparation method is relatively complicated, and the antibacterial effect of the polymer is not good. field
[0009] In view of the poor antibacterial and antibacterial effect of the current antibacterial polymers, we propose to use the self-assembly method of amphiphilic block polymers to prepare antibacterial polymeric micelles. antibacterial effect
The micelle can be used as a drug carrier, and at the same time has a good antibacterial and bactericidal effect, and the polymer has water solubility and biodegradability, and has a wide range of application prospects in the field of biomedicine. There are no related patents at home and abroad. Appear

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-soluble degradable and efficiently antibacterial polymeric micelle and preparation method thereof
  • Water-soluble degradable and efficiently antibacterial polymeric micelle and preparation method thereof
  • Water-soluble degradable and efficiently antibacterial polymeric micelle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Macromolecular initiator PEO 43 - b -PCL 20 -Synthesis of Br

[0036] 5g polyoxyethylene (PEO), 18g ε-caprolactone and toluene (50mL) were successively added to a 150mL flask, azeotropic removal of trace water, and the reaction was carried out at 120 o Under the condition of C for 24h, the product was precipitated in low-temperature n-hexane for 5 times, and dried in vacuum for 2 days to obtain white powdery PEO 43 - b -PCL 20 -OH. Subsequently, 10gPEO 43 - b -PCL 20 -OH and 1.9mL 2-bromoisobutyryl bromide were added to a 500mL flask, 250mL of solvent and 2mL of triethylamine were added, and the reaction was carried out for 24h. Filtration, extraction, washing, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 - b -PCL 20 -Br.

[0037](2) ATRP synthetic polymer

[0038] 1g macroinitiator PEO 43 - b -PCL 20 -Br, 0.033g catalyst cuprous bromide (CuBr), 0.039g ligand HMTETA, 0.8g monomer 2...

Embodiment 2

[0046] (1) Macromolecular initiator PEO 43 - b -PCL 20 -Synthesis of Br

[0047] 5g polyoxyethylene (PEO), 18g ε-caprolactone and toluene (50mL) were successively added to a 150mL flask, azeotropic removal of trace water, and the reaction was carried out at 120 o Under the condition of C for 24h, the product was precipitated in low-temperature n-hexane for 5 times, and dried in vacuum for 2 days to obtain white powdery PEO 43 - b -PCL 20 -OH. Subsequently, 10gPEO 43 - b -PCL 20 -OH and 1.9mL 2-bromoisobutyryl bromide were added to a 500mL flask, 250mL of solvent and 2mL of triethylamine were added, and the reaction was carried out for 24h. Filtration, extraction, washing, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 - b -PCL 20 -Br.

[0048] (2) ATRP synthetic polymer

[0049] 1g macroinitiator PEO 43 - b -PCL 20 -Br, 0.033g catalyst cuprous bromide (CuBr), 0.039g ligand HMTETA, 1.5g monomer ...

Embodiment 3

[0055] (1) Macromolecular initiator PEO 43 - b -PCL 30 -Synthesis of Br

[0056] 5g polyoxyethylene (PEO), 25g ε-caprolactone and toluene (60mL) were successively added to a 150mL flask, azeotropic removal of trace water, and the reaction was carried out at 120 o Under the condition of C for 36h, the product was precipitated in low-temperature n-hexane for 5 times, and dried in vacuum for 2 days to obtain white powdery PEO 43 - b -PCL 30 -OH. Subsequently, 10gPEO 43 - b -PCL 20 -OH and 1.5mL 2-bromoisobutyryl bromide were added to a 500mL flask, 250mL of solvent and 2mL of triethylamine were added, and the reaction was carried out for 24h. Filtration, extraction, washing, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 - b -PCL 30 -Br.

[0057] (2) ATRP synthetic polymer

[0058] 1g macroinitiator PEO 43 - b -PCL 30 -Br, 0.04g catalyst cuprous bromide (CuBr), 0.049g ligand PMDETA, 1.2g monomer 2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of high polymer nano biological medical materials, and in particular relates to a water-soluble degradable and efficiently antibacterial polymeric micelle and a preparation method thereof. An amphipathic block polymer is self-assembled to form micelle by a solvent exchange method. The micelle has a large amount of charges on the surface and is of an efficiently disinfecting and inhibiting effect without adding any other antibiotics. Meanwhile, the micelle has good biocompatibility and biodegradability. The nuclear shell structure of the micelle can wrap various medicaments so that the polymeric micelle is wide in application prospect.

Description

technical field [0001] The invention belongs to the field of macromolecular nano biomedical materials, and in particular relates to a water-soluble, biodegradable and highly effective antibacterial polymer micelle and a preparation method thereof. Background technique [0002] In recent years, with the development of polymer synthesis methods (ATRP, RAFT, NMP, ROP, click chemistry) and characterization techniques, block polymers with various structures and functions have been synthesized and characterized. Due to the difference in properties of different segments of block polymers, it is possible to assemble block polymers into nano / micro particles of various shapes in selective solvents. The driving force of polymer self-assembly mainly includes: hydrogen bond, electrostatic interaction, hydrophilic / hydrophobic interaction, metal complexation, Van der Waals force and other forces. [0003] The main forms of polymer assemblies found so far are: spherical micelles, rod micel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08G63/91C08G63/664C08J3/03A61K47/34
Inventor 杜建忠路航
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com