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Application of Cinacalcet in inhibiting biological activity of gram-positive bacteria

A Gram-positive bacteria, bioactive technology, applied in the field of medicine, can solve problems such as no antibacterial active biofilm effect

Active Publication Date: 2020-10-30
华中科技大学协和深圳医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports on the drug's antibacterial activity and its effect on biofilms

Method used

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  • Application of Cinacalcet in inhibiting biological activity of gram-positive bacteria
  • Application of Cinacalcet in inhibiting biological activity of gram-positive bacteria
  • Application of Cinacalcet in inhibiting biological activity of gram-positive bacteria

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Embodiment Construction

[0030] The preferred embodiments of the present invention will be further described in detail below.

[0031] Enterococcus faecalis is a common bacterium in the human gastrointestinal tract and can cause a variety of hospital infections. Not only do they have a variety of inherent antimicrobial resistance, but they are also capable of acquiring mutations and / or new resistance genes. In clinical treatment, the irrational use of antibiotics has increased the sensitivity of Enterococcus faecalis to most of the commonly used antibiotics, and the continuous emergence of drug-resistant strains such as tetracycline-resistant Enterococcus faecalis and doxycycline-insensitive Enterococcus faecalis has become a major issue in medical care. A threat to the field, and thus alternative therapeutic approaches against bacterial resistance are urgently needed.

[0032] The present invention finds that Cisecana is used to inhibit the new application of anti-Enterococcus faecalis biological ac...

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Abstract

The invention discloses application of Cinacalcet in inhibiting the biological activity of gram-positive bacteria. The Cinacalcet is used for inhibiting the growth activity of the gram-positive bacteria. The technical scheme of the invention discloses a new application of Cinacalcet, which can inhibit the biological activity of the growth of planktonic bacteria of various gram-positive bacteria, especially the Cinacalcet has the effects of inhibiting bacteria and removing the activity of a biofilm on enterococcus faecalis. In an environment infected by the enterococcus faecalis biofilm, the Cinacalcet has both bacteriostatic activity and activity of removing the biofilm. Moreover, compared with a single drug, the Cinacalcet used in combination with other antibiotics has higher antibacterial activity, the dosage of single-drug antibiotics can be obviously reduced, and the drug resistance selection pressure of the Cinacalcet is reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of cisecanal for inhibiting the biological activity of Gram-positive bacteria. Background technique [0002] Enterococcus faecalis is a common nosocomial infection. It is a common bacterium in the human gastrointestinal tract. It can cause a variety of nosocomial infections. It is also a recognized opportunistic pathogen and can form biofilms. It is associated with urinary tract infections, wound infections, abdominal and pelvic infections and bloodstream infections are highly correlated. Enterococcus faecalis is the most common type of Enterococcus, accounting for 85%-90% of enterococcal infections in humans. According to previous reports, biofilm is considered to be the main cause of nosocomial infection, accounting for more than 80% of microbial infections, and most Enterococcus faecalis can form biofilm. Enterococci in biofilms are more resistant to ant...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P31/04A61L31/08A61L31/16
CPCA61K31/137A61P31/04A61L31/08A61L31/16A61L2300/204A61L2300/404Y02A50/30
Inventor 余治健王占文熊焱鹏邓启文
Owner 华中科技大学协和深圳医院
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