157 results about "Human gastrointestinal tract" patented technology

An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.

The invention relates to a human body gastrointestinal tract bionic system and a simulation experiment method based on the system. The system comprises a system controller, an intestinal flora planting system, a simulation digestion system, a simulation absorption system, a stirring system, a rate control system, a gas path system, a temperature adjusting system, a pH adjusting system, a digestion liquid reagent bottle, an absorbing liquid reagent bottle and a collector. The method comprises the following steps: setting parameters of the control system, preparing planting colloidal particles, planting the intestinal flora, simulating digestion and the like. The system simulates gastrointestinal tract digestion, absorption and intestinal microecology of human bodies under in-vitro conditions, is real in simulation and good in reproducibility, and us applicable to study on the fields of nutriology, toxicology, physiology, microbiology and the like as intelligent control is adopted.

The invention belongs to the technical field of endoscopes, and provides a microrobot for a gastrointestinal track. The microrobot for the gastrointestinal tract comprises an axial telescoping mechanism, a head radial clamping mechanism and a tail radial clamping mechanism. The head radial clamping mechanism is connected with the axial telescoping mechanism through a radial power mechanism. A radial clamping mechanism comprises a mechanism output gear, a speed regulating output gear, at least three helix line legs and a clamping speed regulating device, wherein the mechanism output gear and the speed regulating output gear are meshed with each other, and the at least three helix line legs are evenly distributed on the outer periphery of the mechanism output gear. The microrobot for the gastrointestinal tract is small in size, simple in structure, simple in controlling, low in cost and reliable in performance, has a larger movement stroke compared with an existing mechanism, can be adapted to a human gastrointestinal tract environment, can move effectively, and avoids the defects of a traditional endoscope and a capsule endoscope.

A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.

The invention refers to a capsule preparation containing tegafur, gimeracil and potassium oxonate. The capsule preparation comprises the following components by weight parts: 20 parts of tegafur, 5-6 parts of gimeracil, 19-20 parts of potassium oxonate, 10-300 parts of lactose, and 0.9-5 parts of sodium dodecyl sulfate. According to the invention, the use level of the surfactant of sodium dodecylsulfate is greatly reduced on the premise of guaranteeing rapid dissolving-out of active components in the preparation, so that the irritation of the capsule preparation to the human gastrointestinaltract is decreased and the medicine compliance of a patient is increased.

The invention discloses special red sour soup. The special red sour soup is prepared from the following components in parts by weight: 70-80 parts of fresh tomatoes, 15-25 of fresh chili pepper, 0.15-0.25 part of sticky rice, 0.1-0.2 part of ginger, 0.1-0.2 part of garlic, 1.5-3 parts of table salt, and 0.15-0.25 part of white spirit. Through improvements on the raw materials and the material ratio of the red sour soup, the fermented sour soup is rich in nutrients and contains nutritional ingredients such as VA, VB1, VB2, VC, Ca, P, Fe, carotene, capsaicin, cellulose and multiple amino acids, fermentation products and other nutritive substances in the sour soup enable the constitution of intestinal flora to have beneficial change and can improve gastrointestinal functions of a human body, recover flora balance in human intestinal tracts and form an antibacterial biological barrier to maintain human health, and meanwhile, the improved special red sour soup is easy to store and convenient to transport, thereby making the large-scale commercial production of the red sour soup possible.

The invention relates to an oral preparation containing tegafur, gimeracil and oteracil potassium. The oral preparation comprises the following active ingredients: tegafur with granularity of less than or equal to 180 microns, gimeracil with granularity of less than or equal to 150 microns and oteracil potassium with granularity of less than or equal to150 microns. The oral preparation reduces the irritation of the active ingredients on the gastrointestinal tract of a human body and improves pharmaceutical compliance of patients on the premise of guaranteeing that the active ingredients are dissolved out quickly.

The invention relates to an extract method of cordyceps militaris adenosine and belongs to the technical field of biological product processing. The extract method provided by the invention mainly comprises the following steps: superfine pulverizing cordyceps militaris fruiting body under low temperature, then repeating freezing and thawing for 3 to 7 times in order to destroy the internal components of the cellular interior, and further damaging the cell wall of cordyceps militaris, simulating the human gastrointestinal tract acid-base environment, extracting adenosine in cordyceps militaris by microwave heating using bio-mimetic extract technology for three times, finally measuring the content of adenosine in the extract using high performance liquid chromatography. In the invention, human gastrointestinal tract acid-base environment is simulated to extract cordyceps militaris adenosine, acid-base environment is not only favor of forming a salt from adenosine and dissolving, but also the obtained adenosine has a high extraction rate, which is easy to proceed subsequent separation and purification process, also easy to be proceeded into various types of medicament. The invention ensures the active ingredient of cordyceps militaris is absorbed directly, and the gastrointestinal burden is reduced.

A permanent magnet positioning gastrointestinal tract pH value noninvasive observation system in 24h belonging to the technical field of medical appliance is provided. Wherein, the minisize pH value inspecting capsule enters into gastrointestinal tract of the human through taking orally to inspect the pH value of gastrointestinal tract noninvasively for 24h and then being emitted out from human body through wireless mode; an extracorporeal position tracing device inspects the position information of the minisize pH value inspecting capsule and then transmits to an extracorporeal data recording device through leads, which receives wirelessly the gastrointestinal tract pH value data emitted by the minisize pH value inspecting capsule and stores the position information and inspecting time information of the pH value data and the minisize pH value inspecting capsule in designed format; the extracorporeal position processing system is arranged outside the human body, which reads the data stored in the extracorporeal data recording device and then processes the data. The invention can inspect the pH value of the gastrointestinal tract for 24h and research the gastrointestinal function of the person to be test as well as diagnose and cure the gastrointestinal disorder in auxiliary.

The invention relates to a stachyose infant nourishing cereal and its preparation method. The infant nourishing cereal comprises the following raw materials: long-grain rice, millet, whole milk powder, lactalbumin powder, stachyose, cane sugar, docosahexaenoic acid, arachidonic acid, vitamin and a trace element supplement accepted by bromatology. The especially added stachyose possesses obvious proliferation effects to probiotic groups like bifidobacterium and lactic acid bacillus in human gastrointestinal tract, and is capable of promoting the synthesis of vitamin B1, vitamin B2, vitamin B6,vitamin B12 and the like as well as promoting the absorption of elements like calcium and magnesium by the gastrointestinal tract, thereby the stachyose infant nourishing cereal has the advantages ofhigh nutrition value and high physiological value. The stachyose infant nourishing cereal can effectively preventing and alleviating the infant constipation and diarrhoea, inhibiting the intestinal tract diseases, comprehensive comprehensively enhancing the infant immunization capability and raising the disease resistance of infant body.

The invention relates to a semi-bionic extraction method for active components of Cordyceps militaris, which belongs to the technical field of processing of biological products. According to the invention, rice and silkworm chrysalis obtained after silk reeling are used as main raw materials to produce Cordyceps militaris, and after low temperature superfine comminution, active components in Cordyceps militaris are extracted in an imitative human gastroenteric acid-base environment by using the semi-bionic extraction method and are optimized. Low temperature superfine comminution in the invention has a good wall breaking effect on spores of Cordyceps militaris, ensures minimum loss of nutrition constituents, enables contents in Cordyceps militaris to be fully exposed and is favorable for implementation of the semi-bionic extraction method. The semi-bionic extraction method simulates human gastroenteric acid-base environment and carries out continuous multiple extraction on the contents of Cordyceps militaris cells, which enables the effect of full extraction to be achieved, ensures that extracted substances are directly absorbed when entering into human gastrointestinal tracts, isbeneficial for maximum action of nutrients of Cordyceps militaris in a human body and allows gastrointestinal burden of a human body to be reduced.

The invention relates to a probiotic solid beverage. The probiotic solid beverage comprises the following components in percentage by weight: 2-10% of lactic acid bacteria powder, 30-50% of fructo-oligosaccharide, 5-15% of xylooligosaccharide, 10-20% of maltodextrin, 5-20% of erythritol and 5-15% of pomegranate fruit powder. According to the probiotic solid beverage disclosed by the invention, thefructo-oligosaccharide has obvious proliferation effect on beneficial bacteria of bifidobacterium lactis, lactobacilli and lactobacillus rhamnosus in gastrointestinal tracts of human bodies; the probiotics are bacteria beneficial to human, can maintain bacterial colonies balanced in the intestinal tracts, can assist in eliminating diarrhea, and can stop constipation; and the fructo-oligosaccharide and the probiotic powder are in collocation for eating, so that diarrhea can be eliminated, constipation can also be stopped, and the fructo-oligosaccharide and the probiotic powder jointly have theeffect of two-way regulation on the intestinal tracts.

A gastrointestinal bleeding noninvasive monitoring system belongs to medical apparatus technical field, wherein a miniature hemoglobin detecting device which enters into gastrointestinal tracts of human body through oral taking can realize 24-hour noninvasive detection of hemoglobin content value in gastrointestinal tracts and can transmit the value outside human body through wireless transmission; a bleeding spot locating device detects position information of the miniature hemoglobin detecting device and transmits detecting results to a record storage device through conducting wire; the record storage device receives gastrointestinal hemoglobin content value transmitted by the miniature hemoglobin detecting device through wireless transmission and stores data of gastrointestinal hemoglobin content value, position information of the miniature hemoglobin detecting device and detecting time information according to predetermined format; a gastrointestinal bleeding diagnosis-analysis system which is arranged outside human body reads and processes the data stored inside the record storage device. The invention can realize 24-hour noninvasive monitoring of gastrointestinal bleeding under normal physiological status of human body.

Disclosed is a no-wound inspecting system to inspect the electromagnetic gastrointestinal motivity function, belonging to the technical field of medical apparatus. When in work, a miniature wireless capsule is taken orally into the alimentary canal of a human body and starts to work normally; a portable external data recording instrument is worn outside the body; an external electromagnetic excitation device is arranged inside the body; the external electromagnetic excitation device generates a magnetic field, the miniature wireless capsule in the alimentary canal of the body senses the intensity of the magnetic field at the position and transmits the magnetic field to the outside through wireless data, then the portable external data recording instrument records and stores the received wireless data; when the wireless capsule is passed out of the body, the external data processing system reads the data remained in the portable data recording instrument for analyzing and processing to calculate the passing process and time and the residence condition of the wireless capsule in the alimentary canal. The invention can detect the passing process and time and the residence condition of the fill in the alimentary canal of the human body in 24 hours.

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

The invention discloses Chinese herb tea and a preparation method of the Chinese herb tea. The Chinese herb tea is mainly prepared from the following raw materials in parts by weight: 60-100 parts of white granulated sugar, 10-20 parts of grass jelly, 3-10 parts of freeze-dried grosvener siraitia, 1-6 parts of stachyose, 0.5-2 parts of plumeria rubra, 0.5-2 parts of common lophatherum herb, 0.5-2 parts of honeysuckle flower, 0.3-1 part of common self-heal fruit-spike, 0.3-1 part of lalang grass rhizome, 0.2-1 part of coix seed, 0.2-1 part of chrysanthemum, 0.1-0.5 part of microcos leaf and 0.1-0.5 part of indian buead. The preparation method comprises the steps of performing extraction, rough filtration, fine filtration, ultra-filtration, blending, canning and sterilization on the raw materials to prepare the Chinese herb tea. A product disclosed by the invention has the food therapy effects of clearing heat and reducing internal heat, and invigorating the spleen and eliminating dampness, and is faint scent in smell and sweet and refreshing in taste; especially, stachyose is added, and has very significant proliferation effects on effective microbial communities such as bifidobacterium and lactobacillus in the gastrointestinal tract of a human body, promotes the natural proliferation of bifidus factors, rapidly improves the gastrointestinal internal environments of the human body, and regulates the gastrointestinal microflora balancing functions.

The invention discloses a capsule endoscopy automatic focusing system which belongs to the technical field of medical apparatus, wherein the capsule endoscopy enters human body gastrointestinal tract by being taken orally, non-invasively detects internal wall image of the human body gastrointestinal tract, and sends the internal wall image to the outside; an outside image data receiving device is arranged in vitro to wirelessly receive the internal wall image data of the gastrointestinal tract, and transmits the image data to an outside data processing system. When the image acquired by the capsule endoscopy is unclear, an outside focusing controller sends out focusing control signal, a wireless transceiving functional module in the capsule endoscopy receives the control signal, a capsule controller and a lens back and forth displacement control device driver realize the quantitative control of the lens to obtain clear detecting image. The outside focusing controller is arranged in vitro to realize the focusing control of an imaging system of the capsule endoscopy. The outside data processing system realizes the display and processing of the image data of the gastrointestinal tract.

A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.

The invention discloses a composite probiotics powder and a preparation method thereof. The composite probiotics powder is characterized by comprising the following components: fructose-oligosaccharide, milk powder, polydextrose, citrus aurantium dulcis fruit, isomaltooligosaccharide, fructus crataegi, wolfberry, poria cocos, semen cassia, semen pruni, semen cannabis, lotus leaf, semen coicis, citric acid, vitamin E and lyophilized lactobacillus powder. The lyophilized lactobacillus powder comprises the following components: lactobacillus plantarum, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus acidophilus, lactobacillus casei, bifidobacterium longum, bifidobacterium lactis and bifidobacterium adolescentis. In the invention, the composite probiotics powder made by mixing avariety of lactobacillus lyophilized powder and adding a variety of prebiotics and medicinal and edible ingredients has rich nutrients and a variety of health care functions, especially significant effect on adjusting human gastrointestinal function and improving constipation effect, and high safety, no side effect, high production efficiency, and broad market prospects.

A method and apparatus for capturing images of a scene using a capsule device including a camera are disclosed. An image sequence is captured using the camera when the capsule device travels through a human gastrointestinal tract. Also, structured-light images are captured using the camera by projecting structured light to one or more objects in a field of view of the camera when the capsule device travels through the human gastrointestinal tract. The structured-light images are interleaved with regular images in the image sequence. The distance information with respect to the capsule camera associated with objects of the selected image is derived. Both the image sequence and the distance information are outputted. A method of determining the size of an object of interest utilizing the distance information is also disclosed. In another method, the distance information is used to scale object or adjust intensities.

The invention belongs to the technical field of medicines, and relates to polyethylene glycol momomethyl ether-polycaprolactone-polyacrylic acid derivatives, and preparation and application thereof. The polyethylene glycol momomethyl ether-polycaprolactone-polyacrylic acid derivatives comprise polyethylene glycol momomethyl ether, polycaprolactone and polyacrylic acid derivatives with biocompatibility and biodegradability, and are prepared orderly by ring-opening polymerization and atom-transfer free radical polymerization. The obtained amphiphilic multipolymer can be self-assembled into micelle in water solution, and has certain response on the pH value of the environment. The medicine-carrying capacity and release behavior for the hydrophobic medicines can be changed by regulating the ratio of hydrophilic fragments to hydrophobic fragments and the length of the polyacrylic acid derivative fragment. The pH-sensitive micelle can be used as the carrier for oral administration of insoluble medicines to increase the solubility of liposoluble medicines in the human body gastrointestinal tract and avoid being damaged in the gastrointestinal tract, thereby enhancing the bioavailability.