Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
158 results about "Human gastrointestinal tract" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
The human gastrointestinal tract, or GI tract, is an organ system responsible for consuming and digesting foodstuffs, absorbing nutrients, and expelling waste. The tract consists of the stomach and intestines, and is divided into the upper and lower gastrointestinal tracts. However, by the broadest definition, the GI tract includes all structures between the mouth and the anus. On the other hand, the digestive system is a broader term that includes other structures, including the digestive organs and their accessories. The tract may also be divided into foregut, midgut, and hindgut, reflecting the embryological origin of each segment. The whole digestive tract is about nine metres long. The GI tract releases hormones to help regulate the digestive process. These hormones, including gastrin, secretin, cholecystokinin, and ghrelin, are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are conserved structures throughout evolution.
Abuse-deterrent pharmaceutical compositions of opioids and other drugs
ActiveUS7399488B2Good treatment effectSmall dosePowder deliveryNervous disorderAdditive ingredientWater insoluble
An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
Owner:COLLEGIUM PHARMA INC
Active controllable type capsule endoscope robot system
InactiveCN101669809AEasy to controlLow costSurgeryEndoradiosondesReduction driveHuman gastrointestinal tract
The invention relates to an active controllable type capsule endoscope robot system comprising a capsule endoscope robot, a receiving memory, a motion control box and an image display system. A driving mechanism of the capsule endoscope robot generates the radial expansion and contraction of an oil bag and the extension and contraction of a capsule by a direct-current motor, a double-shaft multiplexing speed reducer and a geometer motion distribution mechanism and realizes progression and retrogression by matching according to a certain time sequence; after the capsule endoscope robot enters the gastrointestinal tract of a human body by oral administration, the capsule endoscope robot shoots the image information of each position of the gastrointestinal tract at real time by the self geometer creeping and transmits the image information outside the body in a wireless mode. In a part outside the body, the receiving memory is used for receiving and storing image data transmitted by the capsule endoscope robot in a wireless way; the motion control box controls the progression, the retrogression or the stop of the capsule endoscope robot in a wireless transmission mode so as to repeatedly observe a questionable position in the gastrointestinal tract; and the image display system reads and processes the image data recorded in the receiving memory at real time by a computer so as tobe observed and diagnosed by a doctor.
Owner:SHANGHAI JIAO TONG UNIV
Human body gastrointestinal tract bionic system and simulation experiment method based on system
ActiveCN103740589AEliminate distractionsSimulate the realBioreactor/fermenter combinationsBiological substance pretreatmentsHuman bodyHuman gastrointestinal tract
The invention relates to a human body gastrointestinal tract bionic system and a simulation experiment method based on the system. The system comprises a system controller, an intestinal flora planting system, a simulation digestion system, a simulation absorption system, a stirring system, a rate control system, a gas path system, a temperature adjusting system, a pH adjusting system, a digestion liquid reagent bottle, an absorbing liquid reagent bottle and a collector. The method comprises the following steps: setting parameters of the control system, preparing planting colloidal particles, planting the intestinal flora, simulating digestion and the like. The system simulates gastrointestinal tract digestion, absorption and intestinal microecology of human bodies under in-vitro conditions, is real in simulation and good in reproducibility, and us applicable to study on the fields of nutriology, toxicology, physiology, microbiology and the like as intelligent control is adopted.
Owner:马爱国 +1
Microrobot for gastrointestinal tract
ActiveCN103211564AIncrease the lengthIncrease contact areaMicromanipulatorSurgeryMicro roboticsHuman gastrointestinal tract
The invention belongs to the technical field of endoscopes, and provides a microrobot for a gastrointestinal track. The microrobot for the gastrointestinal tract comprises an axial telescoping mechanism, a head radial clamping mechanism and a tail radial clamping mechanism. The head radial clamping mechanism is connected with the axial telescoping mechanism through a radial power mechanism. A radial clamping mechanism comprises a mechanism output gear, a speed regulating output gear, at least three helix line legs and a clamping speed regulating device, wherein the mechanism output gear and the speed regulating output gear are meshed with each other, and the at least three helix line legs are evenly distributed on the outer periphery of the mechanism output gear. The microrobot for the gastrointestinal tract is small in size, simple in structure, simple in controlling, low in cost and reliable in performance, has a larger movement stroke compared with an existing mechanism, can be adapted to a human gastrointestinal tract environment, can move effectively, and avoids the defects of a traditional endoscope and a capsule endoscope.
Owner:SHANGHAI JIAO TONG UNIV
Bifidobacterium in the treatment of inflammatory disease
InactiveUS20020006432A1Reduced inflammatory activityRelieve symptomsAntibacterial agentsPowder deliveryBifidobacteriumHuman gastrointestinal tract
A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and / or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
Owner:ENTERPRISE IRELAND TRADING AS BIORES IRELAND GLASNEVIN +1
Abuse-deterrent pharmaceutical compositions of opioids and other drugs
InactiveUS20080199530A1Reduce the possibilityImprove lipophilicityPowder deliveryNervous disorderAdditive ingredientWater insoluble
Owner:COLLEGIUM PHARMA INC
Capsule preparation containing tegafur, gimeracil and potassium oxonate
ActiveCN102302499AAdvantages and Notable ImprovementsReduce dosageCapsule deliveryAntineoplastic agentsPotassium oxonateActive component
The invention refers to a capsule preparation containing tegafur, gimeracil and potassium oxonate. The capsule preparation comprises the following components by weight parts: 20 parts of tegafur, 5-6 parts of gimeracil, 19-20 parts of potassium oxonate, 10-300 parts of lactose, and 0.9-5 parts of sodium dodecyl sulfate. According to the invention, the use level of the surfactant of sodium dodecylsulfate is greatly reduced on the premise of guaranteeing rapid dissolving-out of active components in the preparation, so that the irritation of the capsule preparation to the human gastrointestinaltract is decreased and the medicine compliance of a patient is increased.
Owner:鲁南新时代生物技术有限公司
Special red sour soup and preparation method thereof
InactiveCN105054152AFull of nutritionImprove gastrointestinal functionFood preparationCelluloseAdditive ingredient
The invention discloses special red sour soup. The special red sour soup is prepared from the following components in parts by weight: 70-80 parts of fresh tomatoes, 15-25 of fresh chili pepper, 0.15-0.25 part of sticky rice, 0.1-0.2 part of ginger, 0.1-0.2 part of garlic, 1.5-3 parts of table salt, and 0.15-0.25 part of white spirit. Through improvements on the raw materials and the material ratio of the red sour soup, the fermented sour soup is rich in nutrients and contains nutritional ingredients such as VA, VB1, VB2, VC, Ca, P, Fe, carotene, capsaicin, cellulose and multiple amino acids, fermentation products and other nutritive substances in the sour soup enable the constitution of intestinal flora to have beneficial change and can improve gastrointestinal functions of a human body, recover flora balance in human intestinal tracts and form an antibacterial biological barrier to maintain human health, and meanwhile, the improved special red sour soup is easy to store and convenient to transport, thereby making the large-scale commercial production of the red sour soup possible.
Owner:贵州布依姑娘食品有限公司
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
InactiveUS6703362B1Promote absorptionEasy to transportPeptide/protein ingredientsPharmaceutical delivery mechanismActive agentWhole body
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and / or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
Owner:CYTOGEN CORP
Oral preparation containing tegafur, gimeracil and oteracil potassium
ActiveCN102614183AGood effectHigh dissolution ratePill deliveryGranular deliveryOTERACIL POTASSIUMIrritation
The invention relates to an oral preparation containing tegafur, gimeracil and oteracil potassium. The oral preparation comprises the following active ingredients: tegafur with granularity of less than or equal to 180 microns, gimeracil with granularity of less than or equal to 150 microns and oteracil potassium with granularity of less than or equal to150 microns. The oral preparation reduces the irritation of the active ingredients on the gastrointestinal tract of a human body and improves pharmaceutical compliance of patients on the premise of guaranteeing that the active ingredients are dissolved out quickly.
Owner:QILU PHARMA HAINAN +1
Extract method of cordyceps militaris adenosine
ActiveCN102558265AEasy to processEnsure immediate absorptionSugar derivativesSugar derivatives preparationAdenosineFreeze and thaw
The invention relates to an extract method of cordyceps militaris adenosine and belongs to the technical field of biological product processing. The extract method provided by the invention mainly comprises the following steps: superfine pulverizing cordyceps militaris fruiting body under low temperature, then repeating freezing and thawing for 3 to 7 times in order to destroy the internal components of the cellular interior, and further damaging the cell wall of cordyceps militaris, simulating the human gastrointestinal tract acid-base environment, extracting adenosine in cordyceps militaris by microwave heating using bio-mimetic extract technology for three times, finally measuring the content of adenosine in the extract using high performance liquid chromatography. In the invention, human gastrointestinal tract acid-base environment is simulated to extract cordyceps militaris adenosine, acid-base environment is not only favor of forming a salt from adenosine and dissolving, but also the obtained adenosine has a high extraction rate, which is easy to proceed subsequent separation and purification process, also easy to be proceeded into various types of medicament. The invention ensures the active ingredient of cordyceps militaris is absorbed directly, and the gastrointestinal burden is reduced.
Owner:贵州贵安精准医学股份有限公司
Permanent magnetism positioning type non-invasive 24-hour monitoring system for gastrointestinal tract PH value
InactiveCN101108122AReflect comprehensively and accuratelyDiagnostic recording/measuringSensorsTime informationDisease
Owner:SHANGHAI JIAO TONG UNIV
Stachyose infant nourishing cereal and its preparation method
The invention relates to a stachyose infant nourishing cereal and its preparation method. The infant nourishing cereal comprises the following raw materials: long-grain rice, millet, whole milk powder, lactalbumin powder, stachyose, cane sugar, docosahexaenoic acid, arachidonic acid, vitamin and a trace element supplement accepted by bromatology. The especially added stachyose possesses obvious proliferation effects to probiotic groups like bifidobacterium and lactic acid bacillus in human gastrointestinal tract, and is capable of promoting the synthesis of vitamin B1, vitamin B2, vitamin B6,vitamin B12 and the like as well as promoting the absorption of elements like calcium and magnesium by the gastrointestinal tract, thereby the stachyose infant nourishing cereal has the advantages ofhigh nutrition value and high physiological value. The stachyose infant nourishing cereal can effectively preventing and alleviating the infant constipation and diarrhoea, inhibiting the intestinal tract diseases, comprehensive comprehensively enhancing the infant immunization capability and raising the disease resistance of infant body.
Owner:INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD
Semi-bionic extraction method for active components of Cordyceps militaris
ActiveCN102512458APromote dissolutionFully extractedAntibacterial agentsAntipyreticHuman gastrointestinal tractBiologic Products
The invention relates to a semi-bionic extraction method for active components of Cordyceps militaris, which belongs to the technical field of processing of biological products. According to the invention, rice and silkworm chrysalis obtained after silk reeling are used as main raw materials to produce Cordyceps militaris, and after low temperature superfine comminution, active components in Cordyceps militaris are extracted in an imitative human gastroenteric acid-base environment by using the semi-bionic extraction method and are optimized. Low temperature superfine comminution in the invention has a good wall breaking effect on spores of Cordyceps militaris, ensures minimum loss of nutrition constituents, enables contents in Cordyceps militaris to be fully exposed and is favorable for implementation of the semi-bionic extraction method. The semi-bionic extraction method simulates human gastroenteric acid-base environment and carries out continuous multiple extraction on the contents of Cordyceps militaris cells, which enables the effect of full extraction to be achieved, ensures that extracted substances are directly absorbed when entering into human gastrointestinal tracts, isbeneficial for maximum action of nutrients of Cordyceps militaris in a human body and allows gastrointestinal burden of a human body to be reduced.
Owner:贵州贵安精准医学股份有限公司
Probiotic powder solid beverage and preparation method thereof
InactiveCN108783167APlay the role of two-way regulationExtended active timeFood dryingFood ingredient functionsBacteroidesLactobacillus rhamnosus
The invention relates to a probiotic solid beverage. The probiotic solid beverage comprises the following components in percentage by weight: 2-10% of lactic acid bacteria powder, 30-50% of fructo-oligosaccharide, 5-15% of xylooligosaccharide, 10-20% of maltodextrin, 5-20% of erythritol and 5-15% of pomegranate fruit powder. According to the probiotic solid beverage disclosed by the invention, thefructo-oligosaccharide has obvious proliferation effect on beneficial bacteria of bifidobacterium lactis, lactobacilli and lactobacillus rhamnosus in gastrointestinal tracts of human bodies; the probiotics are bacteria beneficial to human, can maintain bacterial colonies balanced in the intestinal tracts, can assist in eliminating diarrhea, and can stop constipation; and the fructo-oligosaccharide and the probiotic powder are in collocation for eating, so that diarrhea can be eliminated, constipation can also be stopped, and the fructo-oligosaccharide and the probiotic powder jointly have theeffect of two-way regulation on the intestinal tracts.
Owner:沈通一
Intelligent numerical control bionic drug dissolubility tester
InactiveCN102313795AGood correlation between in vitro and in vivoGood reproducibilityPreparing sample for investigationFlexible member pumpsEngineeringHuman gastrointestinal tract
Relating to the technical field of drug examination equipment, the invention especially relates to an intelligent numerical control bionic drug dissolubility tester, which comprises a stomach and intestine bionic device, a loading slot and a controller. The stomach and intestine bionic device includes a bionic stomach, a bionic intestinal tract communicated with the bionic stomach, a peristaltic pump and an extruding gear. The peristaltic pump and the extruding gear are against the external surface of the bionic stomach and the external surface of the bionic intestinal tract. The invention makes bionic design for the stomach and intestine in vitro, and simulates human body gastrointestinal peristalsis and the process of digestion and absorption. With the advantages of high automation degree, good detection result reappearance, and good?in vitro and in vivo correlation, the tester can better predict the drug dissolubility in vivo.
Owner:GUANGDONG MEDICAL UNIV
Gastrointestinal tract hemorrhage non-invasive monitoring system
InactiveCN101116610AComprehensive and accurate internal lawsReflect comprehensively and accuratelyEndoradiosondesSensorsTime informationWireless transmission
A gastrointestinal bleeding noninvasive monitoring system belongs to medical apparatus technical field, wherein a miniature hemoglobin detecting device which enters into gastrointestinal tracts of human body through oral taking can realize 24-hour noninvasive detection of hemoglobin content value in gastrointestinal tracts and can transmit the value outside human body through wireless transmission; a bleeding spot locating device detects position information of the miniature hemoglobin detecting device and transmits detecting results to a record storage device through conducting wire; the record storage device receives gastrointestinal hemoglobin content value transmitted by the miniature hemoglobin detecting device through wireless transmission and stores data of gastrointestinal hemoglobin content value, position information of the miniature hemoglobin detecting device and detecting time information according to predetermined format; a gastrointestinal bleeding diagnosis-analysis system which is arranged outside human body reads and processes the data stored inside the record storage device. The invention can realize 24-hour noninvasive monitoring of gastrointestinal bleeding under normal physiological status of human body.
Owner:SHANGHAI JIAO TONG UNIV
Electromagnetic gastroenteritic power function woundless diagnosis system
Disclosed is a no-wound inspecting system to inspect the electromagnetic gastrointestinal motivity function, belonging to the technical field of medical apparatus. When in work, a miniature wireless capsule is taken orally into the alimentary canal of a human body and starts to work normally; a portable external data recording instrument is worn outside the body; an external electromagnetic excitation device is arranged inside the body; the external electromagnetic excitation device generates a magnetic field, the miniature wireless capsule in the alimentary canal of the body senses the intensity of the magnetic field at the position and transmits the magnetic field to the outside through wireless data, then the portable external data recording instrument records and stores the received wireless data; when the wireless capsule is passed out of the body, the external data processing system reads the data remained in the portable data recording instrument for analyzing and processing to calculate the passing process and time and the residence condition of the wireless capsule in the alimentary canal. The invention can detect the passing process and time and the residence condition of the fill in the alimentary canal of the human body in 24 hours.
Owner:SAYES MEDICAL TECH
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
InactiveUS7135457B1Promote absorptionEasy to transportPeptide-nucleic acidsPowder deliveryActive agentWhole body
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and / or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
Owner:CYTOGEN CORP
Chinese herb tea and preparation method thereof
ActiveCN103999984AHeat-clearing and detoxifyingFunctionalTea substituesFreeze-dryingTherapeutic effect
The invention discloses Chinese herb tea and a preparation method of the Chinese herb tea. The Chinese herb tea is mainly prepared from the following raw materials in parts by weight: 60-100 parts of white granulated sugar, 10-20 parts of grass jelly, 3-10 parts of freeze-dried grosvener siraitia, 1-6 parts of stachyose, 0.5-2 parts of plumeria rubra, 0.5-2 parts of common lophatherum herb, 0.5-2 parts of honeysuckle flower, 0.3-1 part of common self-heal fruit-spike, 0.3-1 part of lalang grass rhizome, 0.2-1 part of coix seed, 0.2-1 part of chrysanthemum, 0.1-0.5 part of microcos leaf and 0.1-0.5 part of indian buead. The preparation method comprises the steps of performing extraction, rough filtration, fine filtration, ultra-filtration, blending, canning and sterilization on the raw materials to prepare the Chinese herb tea. A product disclosed by the invention has the food therapy effects of clearing heat and reducing internal heat, and invigorating the spleen and eliminating dampness, and is faint scent in smell and sweet and refreshing in taste; especially, stachyose is added, and has very significant proliferation effects on effective microbial communities such as bifidobacterium and lactobacillus in the gastrointestinal tract of a human body, promotes the natural proliferation of bifidus factors, rapidly improves the gastrointestinal internal environments of the human body, and regulates the gastrointestinal microflora balancing functions.
Owner:安徽本纪控股有限公司
Capsule endoscopy automatic focusing system
InactiveCN101536895AIncrease or decrease the image distanceUnclear solutionSurgeryEndoradiosondesCamera lensControl signal
The invention discloses a capsule endoscopy automatic focusing system which belongs to the technical field of medical apparatus, wherein the capsule endoscopy enters human body gastrointestinal tract by being taken orally, non-invasively detects internal wall image of the human body gastrointestinal tract, and sends the internal wall image to the outside; an outside image data receiving device is arranged in vitro to wirelessly receive the internal wall image data of the gastrointestinal tract, and transmits the image data to an outside data processing system. When the image acquired by the capsule endoscopy is unclear, an outside focusing controller sends out focusing control signal, a wireless transceiving functional module in the capsule endoscopy receives the control signal, a capsule controller and a lens back and forth displacement control device driver realize the quantitative control of the lens to obtain clear detecting image. The outside focusing controller is arranged in vitro to realize the focusing control of an imaging system of the capsule endoscopy. The outside data processing system realizes the display and processing of the image data of the gastrointestinal tract.
Owner:SHANGHAI JIAO TONG UNIV
Method and apparatus for measuring fluid properties, including ph
InactiveUS20100045309A1No memory effectResistance/reactance/impedenceEndoradiosondesElectricityHuman gastrointestinal tract
A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to / form a remote location.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Self-emulsifying microemulsion daidzein oral liquid preparation composite and preparation method thereof
InactiveCN101204392ALow viscosityUniform particle sizeOrganic active ingredientsEmulsion deliveryDaidzeinHuman gastrointestinal tract
The invention discloses an oral preparation composition of a self-emulsified daidzein and a preparation method. The composition is made up of 0.5 through 5 percent daidzein, 30 through 60 percent emulsifier, 10 through 40 percent auxiliary emulsifier and 10 through 30 percent grease. The preparation method is as follows: the daidzein is dissolved in cosurfactant under the temperature ranging from 10 DEG C to 80 DEG C, after being cooled, the daidzein is added with an oil phase and the emulsifier then is stirred uniformly. The invention has the advantages of simple operation and easy preservation. The oral preparation composition of the self-emulsified daidzein in the invention can absorb the water in human gastrointestinal tract after being taken orally, with uniform grain diameter ranging from 10nm to 100nm.
Owner:SHANGHAI JIAO TONG UNIV
Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro
InactiveCN101665758BMicrobiological testing/measurementMicroorganism based processesMicrobial ecosystemMicroecosystem
The invention relates to a simulator for the reappearance of human gastrointestinal tract and microbial ecosystem in vitro. On the basis of simulator of Human Intestinal Microbial Ecosystem (SHIME) technology of the University of Ghent in Belgium, and through technological improvement aiming at living habits of easterners, the simulator realizes the reappearance of the human gastrointestinal tract system in vitro. The simulator belongs to the technical field of analysis and determination of organic substances in microbiology, environmental science, chemistry, nutriology and pharmacology.
Owner:SHANGHAI UNIV
1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for gastrointestinal dysfunction
A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one sensory nerve receptor agonist in a therapeutically effective amount. The sensory nerve receptor agonist may be represented by the general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 may be -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl ; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention reduce pain, a sense of abdominal distension, tenesmus, and abnormal bowel function when formulated for oral delivery to human gastrointestinal tract and are useful to alleviate gastrointestinal dysfunction.
Owner:CRAGMONT PHARMA
Use of Lactobacillus salivarius
InactiveUS20030166257A1Control damageReduce rateAntipyreticAnalgesicsLactobacillus salivariusHuman gastrointestinal tract
Lactobacillus salivarius is useful in the prophylaxis or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer. The Lactobacillus salivarius is of human origin isolated from resected and washed human gastrointestinal tract. One such strain is UCC 118 described in WO-A-9835014.
Owner:ENTERPRISE IRELAND +1
Composite probiotics powder and preparation method thereof
InactiveCN110338402AImprove gastrointestinal functionMake the most of synergiesFood ingredient functionsOligosaccharide food ingredientsCannabisIsomaltooligosaccharide
The invention discloses a composite probiotics powder and a preparation method thereof. The composite probiotics powder is characterized by comprising the following components: fructose-oligosaccharide, milk powder, polydextrose, citrus aurantium dulcis fruit, isomaltooligosaccharide, fructus crataegi, wolfberry, poria cocos, semen cassia, semen pruni, semen cannabis, lotus leaf, semen coicis, citric acid, vitamin E and lyophilized lactobacillus powder. The lyophilized lactobacillus powder comprises the following components: lactobacillus plantarum, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus acidophilus, lactobacillus casei, bifidobacterium longum, bifidobacterium lactis and bifidobacterium adolescentis. In the invention, the composite probiotics powder made by mixing avariety of lactobacillus lyophilized powder and adding a variety of prebiotics and medicinal and edible ingredients has rich nutrients and a variety of health care functions, especially significant effect on adjusting human gastrointestinal function and improving constipation effect, and high safety, no side effect, high production efficiency, and broad market prospects.
Owner:王康学
Method and Apparatus for Endoscope with Distance Measuring for Object Scaling
ActiveUS20180174318A1Image enhancementTelevision system detailsHuman gastrointestinal tractField of view
A method and apparatus for capturing images of a scene using a capsule device including a camera are disclosed. An image sequence is captured using the camera when the capsule device travels through a human gastrointestinal tract. Also, structured-light images are captured using the camera by projecting structured light to one or more objects in a field of view of the camera when the capsule device travels through the human gastrointestinal tract. The structured-light images are interleaved with regular images in the image sequence. The distance information with respect to the capsule camera associated with objects of the selected image is derived. Both the image sequence and the distance information are outputted. A method of determining the size of an object of interest utilizing the distance information is also disclosed. In another method, the distance information is used to scale object or adjust intensities.
Owner:CAPSO VISION INC
Polyethylene glycol momomethyl ether-polycaprolactone-polyacrylic acid derivatives, and preparation and application thereof
InactiveCN101974137AAvoid degradationImprove oral bioavailabilityPharmaceutical delivery mechanismPharmaceutical non-active ingredientsSolubilityPolyethylene glycol
The invention belongs to the technical field of medicines, and relates to polyethylene glycol momomethyl ether-polycaprolactone-polyacrylic acid derivatives, and preparation and application thereof. The polyethylene glycol momomethyl ether-polycaprolactone-polyacrylic acid derivatives comprise polyethylene glycol momomethyl ether, polycaprolactone and polyacrylic acid derivatives with biocompatibility and biodegradability, and are prepared orderly by ring-opening polymerization and atom-transfer free radical polymerization. The obtained amphiphilic multipolymer can be self-assembled into micelle in water solution, and has certain response on the pH value of the environment. The medicine-carrying capacity and release behavior for the hydrophobic medicines can be changed by regulating the ratio of hydrophilic fragments to hydrophobic fragments and the length of the polyacrylic acid derivative fragment. The pH-sensitive micelle can be used as the carrier for oral administration of insoluble medicines to increase the solubility of liposoluble medicines in the human body gastrointestinal tract and avoid being damaged in the gastrointestinal tract, thereby enhancing the bioavailability.
Owner:SHENYANG PHARMA UNIVERSITY
A molding and using method for a bulk drug gastrointestinal absorption prediction BSPK model
InactiveCN102043892ASpeed up screeningPromote absorptionIn-vivo testing preparationsSpecial data processing applicationsSolubilityMedicine
The invention discloses a molding and using method for a bulk drug gastrointestinal absorption prediction BSPK model, which establishes a series of functions based on the bulk drug dissolution, settlement and absorption in multiple gastrointestinal compartments, and which takes into account many factors and variables as follows: drug logP, logD, pKa, solubility, dissolution rate, density, partical diameter, particle forms, particle diameter distribution, settlement rate, settlement particle diameter, settlement time, permeability and human gastrointestinal physiological conditions, etc. The method is applicable to acidic, alkalic, neutral and acidic-alkalic drug absorption prediction in different gastrointestinal parts. The invention, which is used in active compound gastrointestinal absorption prediction, not only raises the early stage drug screening accuracy, but also reduces the workload of preformulation researches. In this way, medicine clinical application process is accelerated with great scientific research value and application prospect.
Owner:SHANGHAI YUNYI HEALTHCARE MANAGEMENT
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com