Semi-bionic extraction method for active components of Cordyceps militaris

An active component and extraction method technology, applied in the field of semi-biomimetic extraction of active components of Cordyceps militaris, can solve the problems of high price, uneven quality, limited natural Cordyceps output, etc., and achieve controllable quality, low cost and guaranteed quality. The effect of medicinal value

Active Publication Date: 2012-06-27
贵州贵安精准医学股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the output of natural Cordyceps is limited, the quality is uneven and the price is expensive, which cannot meet the needs of people. The Cordyceps militaris culti

Method used

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  • Semi-bionic extraction method for active components of Cordyceps militaris
  • Semi-bionic extraction method for active components of Cordyceps militaris

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Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the cultivation of Cordyceps militaris

[0030] a. The configuration of culture medium: Cordyceps militaris culture medium of the present invention is aqueous solution, is made of the composition of following concentration:

[0031] Dried silkworm chrysalis powder 140 g / L;

[0032] Rice flour 60 g / L;

[0033] Potassium dihydrogen phosphate 1.2 g / L;

[0034] Sodium dihydrogen phosphate 1.2 g / L;

[0035] Preferred specific preparation method is as follows:

[0036] Accurately weigh 2.1kg of dried silkworm chrysalis powder, 900g of rice flour, 18g of potassium dihydrogen phosphate, and 18g of sodium dihydrogen phosphate, add 12 L of purified water, and dissolve the KH 2 PO 4 , NaH 2 PO 4 , After fully mixing to obtain a medium solution with a volume of 15L, add the above-mentioned dried silkworm chrysalis powder and rice flour, mix evenly, homogenate, pack separately, put 50 ml in each bottle, cover the lid, and store at 121°C and 1.1Mpa. Sterilize wi...

Embodiment 2

[0047] Embodiment 2: low temperature ultrafine pulverization

[0048] Weigh 200 g of dried fruiting bodies of Cordyceps militaris each time, put them into an ultrafine pulverizer for 6 min, and use 4-10°C water as cooling liquid to reduce the crushing temperature to protect the active components in Cordyceps militaris. After pulverization, samples were taken to detect the wall-breaking effect with a scanning electron microscope. The effects of ordinary crushing and superfine crushing are shown in figure 1 and figure 2 . By comparison figure 1 and figure 2 It can be seen that the cell wall of the fruiting body of Cordyceps militaris is intact after ordinary crushing, and the cells still gather in clumps. The cell wall after superfine pulverization is incomplete, and the contents are faintly visible, so the superfine pulverization of Cordyceps militaris spores is completely broken, and the nutrients are effectively released.

Embodiment 3

[0049] Example 3: Semi-bionic extraction of active components of Cordyceps militaris

[0050] By simulating the transport process of oral drugs in the gastrointestinal tract, acidic water (pH value 1-6), neutral water (pH value 6-8) and alkaline water (pH value 8- 14), and the selected time (total extraction time 50 ~ 180min), the Cordyceps militaris is extracted in an acidic environment with a pH value of 1 ~ 6, and the supernatant is collected after centrifugation at 10000g for 10 minutes, and the precipitation is natural After air-drying, extract in a neutral environment with a pH value of 6-8, collect the supernatant after centrifuging with the same centrifugal force for 10 minutes, and finally extract in an alkaline environment with a pH value of 8-14. The supernatant was collected by centrifugation. The solid-liquid ratio of the solvent water used for each extraction to the original medicinal material is 5 to 15 times, and the solid-liquid ratio of the three extractions...

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Abstract

The invention relates to a semi-bionic extraction method for active components of Cordyceps militaris, which belongs to the technical field of processing of biological products. According to the invention, rice and silkworm chrysalis obtained after silk reeling are used as main raw materials to produce Cordyceps militaris, and after low temperature superfine comminution, active components in Cordyceps militaris are extracted in an imitative human gastroenteric acid-base environment by using the semi-bionic extraction method and are optimized. Low temperature superfine comminution in the invention has a good wall breaking effect on spores of Cordyceps militaris, ensures minimum loss of nutrition constituents, enables contents in Cordyceps militaris to be fully exposed and is favorable for implementation of the semi-bionic extraction method. The semi-bionic extraction method simulates human gastroenteric acid-base environment and carries out continuous multiple extraction on the contents of Cordyceps militaris cells, which enables the effect of full extraction to be achieved, ensures that extracted substances are directly absorbed when entering into human gastrointestinal tracts, isbeneficial for maximum action of nutrients of Cordyceps militaris in a human body and allows gastrointestinal burden of a human body to be reduced.

Description

technical field [0001] The invention relates to a semi-bionic extraction method of active components of Cordyceps militaris, belonging to the technical field of biological product processing. Background technique [0002] Cordyceps militaris is a fungus with silkworm chrysalis as the host. It is of the same family and genus as Cordyceps sinensis. The chemical composition is basically the same. It has great medicinal value. It is a new resource food approved by the Ministry of Health. , anti-aging, improve immunity, lower blood sugar and other effects, suitable for a wide range of people. It has similar pharmacological functions and clinical effects to Cordyceps sinensis, but its price is much lower than that of Cordyceps sinensis, and the content of the active ingredient cordycepin contained in it is 10 times that of Cordyceps sinensis. potential market. [0003] The conventional extraction process of Cordyceps militaris, such as water extraction, water extraction alcohol ...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61P35/00A61P31/12A61P31/04A61P29/00A61P39/06A61P37/04A61P3/10A61P3/02
Inventor 卢丽丽张丽陈剑清舒特俊张耀洲
Owner 贵州贵安精准医学股份有限公司
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