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Self-emulsifying microemulsion daidzein oral liquid preparation composite and preparation method thereof

A technology of daidzein and oral preparations, which is applied in the directions of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of coking, melting, and inability to carry out production, and achieves low viscosity, easy storage, and bioavailability. The effect of increasing the degree of

Inactive Publication Date: 2008-06-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The result of sticking to the wall can make the drug adhere to the high temperature part of the equipment for a long time, cause coking or melting, make the production impossible, and cause serious aggregation of solid lipid nanoparticles

Method used

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  • Self-emulsifying microemulsion daidzein oral liquid preparation composite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The components and weight percentages of the self-microemulsifying composition in this embodiment are: 1% daidzein, 60% emulsifier, 20% co-emulsifier, and 19% oil.

[0024] Described emulsifier is polyoxyethylene hydrogenated castor oil.

[0025] Described co-emulsifier is polyethylene glycol 400.

[0026] Described grease is ethyl oleate.

[0027] The preparation process of the self-microemulsifying composition in this example is as follows: at 10-80°C, first dissolve daidzein in the prescribed amount of polyethylene glycol 400, and after cooling, add polyoxygen according to the prescribed amount. Ethylene hydrogenated castor oil and ethyl oleate, just stir well.

[0028] The beneficial effects of this embodiment are: (1) After preparing the drug into a self-microemulsifying composition, using 0.1M HCl as the dissolution medium, more than 80% of daidzein can be dissolved from the self-microemulsifying composition in 30 minutes. (2) After diluting the prepared self-m...

Embodiment 2

[0030] The components and weight percentages of the self-microemulsifying composition in this embodiment are: 0.5% daidzein, 55% emulsifier, 24.5% co-emulsifier, and 10% oil.

[0031] Described emulsifier is polyoxyethylene castor oil.

[0032] Described co-emulsifier is polyethylene glycol 400.

[0033] Described grease is isopropyl myristate.

[0034] The preparation process of the self-microemulsifying composition in this example is as follows: at 10-80°C, first dissolve daidzein in the prescribed amount of polyethylene glycol 400, and after cooling, add polyoxygen according to the prescribed amount. Ethylene castor oil and isopropyl myristate, stir well.

[0035] The beneficial effects of this embodiment are: (1) After preparing the drug into a self-microemulsifying composition, using 0.1M HCl as the dissolution medium, more than 80% of daidzein can be dissolved from the self-microemulsifying composition in 30 minutes. (2) After diluting the prepared self-microemulsifie...

Embodiment 3

[0037] The components and weight percentages of the self-microemulsifying composition in this embodiment are: 0.5% daidzein, 60% emulsifier, 20% co-emulsifier, and 19.5% oil.

[0038] Described emulsifier is polyoxyethylene castor oil.

[0039] Described co-emulsifier is propylene glycol.

[0040] Described grease is isopropyl myristate.

[0041] The preparation process of the self-microemulsifying composition in this example is as follows: at a temperature of 10-80°C, first dissolve daidzein in the prescribed amount of propylene glycol, and after cooling, add polyoxyethylene castor oil and Isopropyl myristate, stir evenly.

[0042] The beneficial effects of this embodiment are: (1) After preparing the drug into a self-microemulsifying composition, using 0.1M HCl as the dissolution medium, more than 80% of daidzein can be dissolved from the self-microemulsifying composition in 30 minutes. (2) After diluting the prepared self-microemulsified composition 100 times, the partic...

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Abstract

The invention discloses an oral preparation composition of a self-emulsified daidzein and a preparation method. The composition is made up of 0.5 through 5 percent daidzein, 30 through 60 percent emulsifier, 10 through 40 percent auxiliary emulsifier and 10 through 30 percent grease. The preparation method is as follows: the daidzein is dissolved in cosurfactant under the temperature ranging from 10 DEG C to 80 DEG C, after being cooled, the daidzein is added with an oil phase and the emulsifier then is stirred uniformly. The invention has the advantages of simple operation and easy preservation. The oral preparation composition of the self-emulsified daidzein in the invention can absorb the water in human gastrointestinal tract after being taken orally, with uniform grain diameter ranging from 10nm to 100nm.

Description

technical field [0001] The invention relates to a self-microemulsifying oral preparation and a preparation method thereof in the technical field of medicines, in particular to a daidzein self-microemulsifying oral preparation and a preparation method thereof. technical background [0002] Daidzein, also known as daidzein, is an active ingredient of traditional Chinese medicine kudzu root and soybean and other leguminous plants, which can be prepared by chemical synthesis or traditional Chinese medicine extraction and separation technology. Daidzein can expand coronary arteries, cerebral arteries, peripheral blood vessels and microvessels; increase coronary blood vessels, cerebrovascular vessels, peripheral blood vessels, microvascular blood flow and circulation; inhibit platelet aggregation, relieve vasospasm, reduce cholesterol and blood viscosity, and weaken vascular resistance ; Increase myocardial contractility, improve heart rate, reduce myocardial oxygen consumption, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/107A61K47/34A61P9/10A61K47/10A61K47/44
Inventor 沈琦李熙贾伟
Owner SHANGHAI JIAO TONG UNIV
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