36results about How to "Good correlation between in vitro and in vivo" patented technology

The invention belongs to the technical field of pharmaceutical preparations and discloses a paliperidone bi-layer osmotic pump progressively-increased controlled release tablet and a preparation method thereof. The osmotic pump preparation comprises a tablet core and a semipermeable coating film, wherein the tablet core comprises a medicine containing layer and a boosting layer, the semipermeable coating film envelops the tablet core and is provided with medicine release holes, the medicine containing layer contains middle molecular polyoxyethylene (average molecular weight is 900, 000-1, 000,,000) and an osmotic active substance in a certain proportion so that the hydration rate of the medicine containing layer is proper, the release of the active medicine basically presents a progressively-increased release trend and the progressively-increased release can be kept for 14-24 hours by using the bi-layer tablet core and the single-layer coating. By adopting the preparation, the adverse reaction of the medicine can be reduced greatly, the compliance of a patient can be improved, simultaneously, the preparation is simple to prepare, the preparation process of the progressively-increased osmotic pump preparation is simplified greatly, and the preparation is more conductive to industrialized production.

The invention discloses an indapamide monolayer osmotic pump sustained-release tablet, which comprises a tablet core and a controlled-release film coating layer, wherein the tablet core contains 0.5-2% of indapamide as a monarch drug, 1-20% of filling agent, 50-90% of penetration enhancer, 1-15% of adhesive, 1-20% of release regulator and 0.5-3% of lubricant; the controlled-release film coating layer comprises a controlled-release film forming material, a plasticizer and / or a pore-forming agent; and the filling agent comprises agar powder.

The invention belongs to the field of medicinal preparation and specifically provides a posaconazole double-layer osmotic pump controlled release tablet and a preparation method thereof. The tablet comprises a tablet core and a semipermeable controlled release film. The tablet core comprises a drug containing layer and a boosting layer. The drug containing layer is located inside the controlled release film which is provided with a drug releasing hole. The boosting layer is located inside the controlled release film at a place far away from the drug releasing hole. One end of the water-permeable controlled release film is provided with one or more drug releasing holes. The release curve of the preparation drug shows a zero-order release pattern, and thus the problem of drug resistance caused by long-term use of posaconazole dosage forms on the market is solved. Besides, the problems that the preparation technology is complex, the preparation cost is high, and the drug is unsuitable for industrialized mass production due to the adoption of a hot-melt extrusion technology are solved. Simultaneously, the in vivo-in vitro correlation of the drug is better ensured and the clinical monitoring of plasma concentration is better facilitated.

The invention discloses a bicyclol double-layer osmotic pump control-released tablet and a preparation method thereof. The preparation, namely the tablet, contains bicyclol and pharmaceutically acceptable auxiliary materials. The structure of the tablet contains two layers of tablet cores, wherein one layer of tablet core is a medicament-containing layer; the other layer of tablet core is a boosting layer; an insoluble semipermeable membrane is wrapped outside the tablet cores; and one or more small medicament-releasing holes are formed on the membrane. The medicament-releasing mechanism of the preparation is novel; the bicyclol medicament is slowly and stably released through an osmotic pressure difference inside and outside the wrapping membrane; the medicament-releasing behavior has good zero-level control-released characteristic and is slightly affected by factors, such as medium environment pH value, gastrointestinal motility, foods and the like; therefore, compared with the ordinary preparation, the preparation provided by the invention can obviously improve the stability of bicyclol blood concentration, reduce the appearance of toxic and side effects and reduce the individual difference of clinical effect.

The present invention provides a drug core composition for controlled-release administration of active drugs with low solubility, which at least includes a drug-containing layer and a booster layer, and the drug-containing layer includes active drugs with low solubility and hydrophilic A polymer carrier, the booster layer at least includes a permeation-promoting polymer, an insoluble polymer and an osmotic pressure enhancer; the present invention also provides an osmotic pump preparation containing the drug core composition, which also includes The thin film of semipermeable material; drug core composition of the present invention can release drug at a controlled rate, so that the formulation containing the drug core composition can release the active drug in about 24 hours once a day. .