19results about How to "Small individual differences" patented technology

The invention discloses mycophenolate mofetil micro powder and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the mycophenolate mofetil micro powder comprises mycophenolate mofetil pill cores and a coating film; the particle size of the mycophenolate mofetil pellet core is 50-250 [mu] m, and the mycophenolate mofetil pellet core is prepared from mycophenolate mofetil, a medicinal diluent and an adhesive according to the mass ratio of 1: (0-3): (0.01-0.2). The mycophenolate mofetil micro powder is small in particle size, free of gravel feeling in the oral cavity, easy to swallow, capable of being prepared into orally disintegrating tablets and the like and especially suitable for being used by people with dysphagia, the mycophenolate mofetil micro powder comprises mycophenolate mofetil pill cores and the coating film, on one hand, the coating film can shield light, improve light stability and reduce formation of Z-isomers, and on the other hand, the coating film can be used for preparing oral disintegrating tablets and the like; on the other hand, 2-morpholinyl ethanol generated by hydrolysis in the stomach can be reduced, and adverse reactions are reduced.

The utility model relates to the technical field of smoke bullet, and disclose a smoke bullet, smoke bullet silica gel child lock and smoke bullet oil injection exhaust device, including bottom cover, the bottom cover is fixedly connected with oil absorption cotton in, the bottom cover inlays has the oil storehouse sealing silica gel, the oil absorption cotton is located between bottom cover and oil storehouse sealing silica gel, through the child lock silica gel and the exhaust groove design, compared with the cross groove gap natural exhaust mode, the exhaust groove specially designed provides independent and unobstructed discharge path for the gas in the smoke bullet, in the oil injection process, the tobacco tar enters the tobacco tar storehouse under the action of oil injection pressure, the internal gas can be through the exhaust groove fast, directional discharge, avoid the gas accumulation in the storehouse and form high pressure, the above structured exhaust design can accurately match the oil injection rate, ensure that the gas discharge and tobacco tar injection are synchronous, eliminate the tobacco tar extrusion into the atomizing core problem caused by the poor exhaust from the root, make the oil injection process more stable, controllable.

This invention relates to animal models and their applications, specifically to a method for constructing a spontaneous mouse cerebral edema model and its application. This invention utilizes PEN2... fl / + Mice and PEN2 fl / + Mice were mated to obtain PEN2. fl / fl Homozygous mice; then the obtained PEN2 fl / fl Mice and hGFAP Cre / + Mice were mated to obtain PEN2. fl / + hGFAP Cre / + Mice; the final PEN2 obtained fl / + hGFAP Cre / + Mice and PEN2 fl / fl Mice were mated to obtain PEN2. fl / fl hGFAP Cre / + The mouse model is a spontaneous mouse cerebral edema model. In this model, PEN2 protein levels are significantly downregulated, and the mouse exhibits a severe cerebral edema phenotype. This model can be used to establish a cerebral edema drug screening platform. It can also be used for research on cerebral edema-related diseases, such as the pathogenesis of cerebral edema caused by infection, glioma, and traumatic brain injury, as well as for the development of technologies and products for the diagnosis and treatment of related diseases.

The present invention proposes an atomizing element and an aerosol bomb, wherein the atomizing element comprises an atomizing chamber housing, an atomizing chamber surrounded by the atomizing chamber housing, and an atomizing core assembled in the atomizing chamber, wherein the atomizing chamber is provided with an atomizing chamber through hole penetrating the atomizing chamber housing and connecting the inside and outside of the atomizing chamber, and the atomizing core comprises a liquid guiding core, which passes through the atomizing chamber through hole, and comprises one or more air guiding channels connecting the outside of the atomizing chamber and the atomizing chamber between the inner peripheral wall of the atomizing chamber through hole and the outer peripheral wall of the liquid guiding core. The atomizing element according to the present invention is conducive to improving the stability of atomization, reducing the individual differences between aerosol bombs, and improving the consistency of user experience.

The invention relates to a construction method and application of an adenovirus infected animal model, and the method comprises the following steps: transplanting lung cancer cells or laryngeal cancer cells to subcutaneous or lung tumor formation of an animal, and constructing a transplanted tumor animal model; and infecting the transplanted tumor animal model with an adenovirus, and constructing the adenovirus infected animal model. The method is high in modeling success rate, small in individual difference, simple and rapid to operate and low in cost, can support infection and efficient replication of adenovirus in an animal body, and is used as an in-vivo animal evaluation model of an antiviral drug.

The invention discloses a pentoxyverine citrate sustained-release dry suspension with a taste-masking effect and a preparation method thereof, and relates to the technical field of medicines, the sustained-release dry suspension comprises pentoxyverine citrate taste-masking sustained-release pellets, a suspending aid, a sweetening agent, a bacteriostatic agent and an aromatic; the preparation method comprises the following steps: firstly, preparing the pentoxyverine citrate taste-masking sustained-release pellets, and then uniformly mixing the pentoxyverine citrate taste-masking sustained-release pellets, the suspending aid, the sweetening agent, the bacteriostatic agent and the aromatic. By adopting the sustained-release framework material, the sustained-release effect is achieved, the medicine taking frequency is reduced, and the medicine taking compliance of a patient is improved.

This invention provides a physical quantity detection device that improves the accuracy of physical quantity measurement compared to conventional methods. The physical quantity detection device (20) of this invention includes a detection element comprising a flow detection unit (205), a circuit board (207), a housing (201), and a cover (202). The detection element detects physical quantities. The circuit board (207) is equipped with the detection element. The housing (201) houses the circuit board (207). The cover (202) is fixed to the housing (201) and defines a secondary passage (234) for the flow detection unit (205). The housing (201) and the cover (202) have positioning portions (P). The positioning portion (P) has a pin (P1) extending along the thickness direction (Dt) of the circuit board (207) and a fitting portion (P2) for fitting the top end (P11) of the pin (P1) to position the housing (201) and the cover (202). The pin (P1) has a locking portion (P12) which is opposite to the locking surface (207f) of the circuit board (207) along the thickness direction (Dt), thereby restricting the movement of the circuit board (207) along the surface direction (Df) of the surface and back surface.

The utility model relates to the field of auxiliary frock provides a kind of anti-roll bar link assembly device. Anti-roll bar link assembly device includes base;First clamping component, setting in base, first clamping component includes the clamping groove of being set in pair, clamping groove is used to place the node mandrel of anti-roll bar link, first clamping piece is arranged in clamping groove for the node mandrel clamped in clamping groove;Second clamping component, setting in base, second clamping component includes clamping rod, clamping rod is used to the bearing of the rod end of anti-roll bar link clamped between clamping rod and base. The anti-roll bar link assembly device can firmly fix node mandrel, avoid the positioning deviation caused by the thickness change of mandrel;Can eliminate the wobble clearance of rod end bearing;Reduce the data deviation after assembly;Adjustable first clamping piece can be adapted to node mandrel of different thickness without replacing parts, save the changeover adjustment time of traditional frock.

This invention discloses an emergency product and method for hypothermia protection in low-temperature environments, belonging to the field of hypothermia protection and emergency care. This invention is the first to apply triiodothyronine (T3) to the preparation of an emergency product for hypothermia protection in low-temperature environments, fully utilizing T3's ability to rapidly increase heat production in tissues such as brown adipose tissue, thereby enhancing the body's active heat production capacity. Combining the physiological metabolic characteristics of the human body with the pharmacological properties of T3, this invention has achieved excellent results in animal experiments. On the one hand, T3 can maintain the core body temperature of hypothermic experimental animals at a higher level for a longer period, resulting in increased swimming time and extending the golden time for rescue. On the other hand, it can effectively improve the recovery of body temperature after rescue, significantly increasing the success rate of treatment. However, when using T4, which is considered more effective in conventional clinical settings, no significant improvement in these two aspects was observed, fully demonstrating the specificity and superiority of T3.

This invention provides a reaction speed recognition method and device based on a game scenario. When a user enters a preset reaction speed game scenario wearing a preset wearable device, a reaction speed baseline task is initiated to acquire baseline EEG data during the user's operation of the reaction speed baseline task. Non-invasive physiological signal acquisition is achieved through the preset wearable device. After that, the formal game task is carried out. Based on the acquired real-time EEG data and baseline index data, an EEG reaction speed index score is calculated. Based on the acquired real-time behavioral data, a cognitive index score is calculated. The EEG reaction speed index score and the cognitive index score are fused to obtain a comprehensive reaction speed cognitive index score. Using the comprehensive reaction speed cognitive index score, the game event interval time is adjusted to match the task rhythm and the player's reaction speed level in real time, taking into account both player experience and the rigor of objective evaluation.

The application discloses a feature marker combination based on PET / CT molecular imaging and a human body aging clock evaluation method, and belongs to the technical field of medical data. The technical problem to be solved is to solve the defects of the existing human body aging evaluation method, such as insufficient comprehensiveness and limited accuracy. The technical solution points are to provide a feature marker combination composed of functional feature markers and volume feature markers; a support vector machine regression (SVR) algorithm is used to construct a model, the mean absolute error (MAE) in the independent verification set is 5.68 years, the determination coefficient R 2 is 0.85. The application can be used for human body aging clock evaluation, and provides a new perspective of aging evaluation based on multiple organ perspectives and verifiable marker support.

The utility model relates to the technical field of plate processing equipment, in particular to edge trimming equipment and a plate processing production line, and the edge trimming equipment comprises a conveying part, a positioning and clamping assembly and an edge trimming part. Wherein the conveying part can convey a piece to be subjected to edge trimming in the first direction, and the positioning and clamping assembly and the edge trimming part are both arranged at the same end, in the first direction, of the conveying part. At least part of the positioning and clamping assembly can be opened and closed in the second direction so that the positioning and clamping assembly can clamp the part to be subjected to edge trimming from the two sides of the part to be subjected to edge trimming in the second direction, and the positioning and clamping assembly can move relative to the conveying part. According to the edge trimming equipment and the plate processing production line provided by the invention, the labor cost is effectively reduced, the edge trimming efficiency is improved, and the individual difference of the deviation correction precision of the edge trimming equipment is reduced.

The invention relates to the technical field of cardiac pressure model construction, and discloses an animal cardiac pressure load model construction device, which comprises a data acquisition planning module, a data processing module, a data processing module, a data processing module, a data processing module, a data processing module and a data processing module, wherein the data acquisition planning module acquires basic physiological data such as animal heart rate and blood pressure and plans cardiac pressure load parameters such as target pressure value; the control module deploys a biocompatible air bag with an annular bag body structure on the outer side below the aortic arch of the animal through a neck incision, drives the biocompatible air bag to be periodically inflated and deflated and responds to an adjustment instruction; the monitoring and adjusting module collects data such as cardiac pressure and ejection fraction in real time, and generates an adjusting instruction after comparing the data with planning parameters; and the management module terminates inflation and deflation after the experiment reaches the standard, dissects, acquires and numbers heart tissue samples, binds associated experiment data, and stores the data to form a data set. According to the invention, the accuracy and reliability of heart-related experiments are obviously improved, and comprehensive and associated experiment support is provided for subsequent research.

The invention provides a mammary gland ultrasonic image processing method, system and device and a storage medium, and belongs to the field of medical image processing, and the method comprises the steps: collecting mammary gland ultrasonic images and multi-source data of the same patient at two different dates, and carrying out the preprocessing; extracting a plurality of morphological features, a plurality of acoustic features and a depth visual feature of the breast ultrasound image; performing element-by-element subtraction on the depth visual features of the two different images, and performing L2 normalization processing on a result obtained by subtraction to obtain difference features; performing weighting processing on the difference features, and splicing the plurality of morphological features and the plurality of acoustic features with the weighted difference features to form a multi-modal preliminary feature set; splicing the multi-modal preliminary feature set with multi-source data to form a time sequence multi-modal fusion feature vector; and inputting the time sequence multi-modal fusion feature vector into a pre-trained multi-task classification network, and outputting a tumor morphological change classification result. The feasibility of clinical application is improved, and the dilemma that in the prior art, result errors are large, and the popularization rate is low is effectively improved.

This invention discloses a method for measuring bone conduction hearing thresholds by exciting the forehead with a bone resonator. The method includes: inserting probe-type microphones into both ear canals of the subject and wearing sound-insulating headphones at the entrances of both ear canals; applying bone conduction excitation to the subject's forehead and measuring the sound pressure levels of transient response otoacoustic emissions (OAEs) bilaterally; and obtaining the bilateral mastoid bone conduction thresholds of the subject based on a pre-established correlation database between transient response OAEs and mastoid bone conduction hearing thresholds. Compared with the bone conduction hearing threshold testing procedures specified by international standards, the method of this invention has a shorter measurement time and higher efficiency, provides data support for inferring subjective bone conduction hearing thresholds from objective physiological signals, and is particularly suitable for bone conduction hearing threshold testing in children.

The utility model relates to a skin muscle detection pen capable of replacing a detection part, which comprises a measuring head positioned at the front end of the skin muscle detection pen, an end cover is mounted on the measuring head, the end cover is detachably connected with the measuring head, a contact column used for being in contact with skin muscles is mounted on the measuring head, and the end cover is detachably connected with the contact column. And the contact column is detachably connected to the measuring head. The device can cope with different crowds covering different skins, different muscles and different human bodies, and breaks through the analysis and measurement limitation caused by individual differences.

The application discloses a human posture recognition system based on a wearable sensor and belongs to the technical field of sensor measurement. The human posture recognition system collects foot bottom pressure through a pressure sensor module, filters and denoises and performs smooth processing through a signal processing module, and wirelessly transmits sensor signals to an upper computer through a wireless transmission module. The upper computer adopts a hidden Markov algorithm and a random forest fusion algorithm to recognize postures. The system comprises a pair of flexible pressure sensor arrays, the sensor arrays are worn on the foot bottom to collect foot bottom pressure signals, the signal processing module is completed by the upper computer, the wireless transmission module selects a Bluetooth module, and the upper computer performs real-time recognition after training the model. The system improves the recognition rate, is high in adaptability, and is suitable for medical treatment, human-computer interaction, sports training and other fields.

The invention relates to the field of animal models and application thereof, in particular to a construction method and application of a spontaneous mouse encephaledema model. The method comprises the following steps: mating a PEN2fl / + mouse with a PEN2fl / + mouse to obtain a PEN2fl / fl homozygote mouse; then, the obtained PEN2fl / fl mouse and an hGFAPCre / + mouse are subjected to mating, and PEN2fl / + is obtained; an hGFAPCre / + mouse; finally, obtaining PEN2fl / +; the hGFAPCre / + mouse and a PEN2fl / fl mouse are subjected to mating, and PEN2fl / fl is obtained; the hGFAPCre / + mouse model is a spontaneous mouse encephaledema model. The protein level of PEN2 in the spontaneous mouse encephaledema model is remarkably reduced, and a severe encephaledema phenotype is shown. The model can be used for establishing a cerebral edema drug screening platform, and can also be used for research on cerebral edema related diseases, such as pathogenesis research on cerebral edema caused by infection, glioma, traumatic brain injury and the like, and research and development of technologies and products for diagnosis and treatment of related diseases.

The invention relates to the technical field of tissue culture of dysosma versipellis, in particular to a tissue culture medium combination and a tissue culture rapid propagation method of dysosma versipellis. The invention provides a dysosma versipellis tissue culture medium combination and a tissue culture rapid propagation method.The dysosma versipellis tissue culture medium combination comprises a germination culture medium, a callus induction culture medium, a cluster bud proliferation culture medium and a rooting culture medium, the callus induction rate can be increased, and the tissue culture rapid propagation rate can be increased. The inductivity and the multiplication coefficient of the multiple shoots of the dysosma versipellis are improved, and the rooting rate of tissue culture seedlings of the dysosma versipellis is improved. According to the tissue culture rapid propagation method for the dysosma versipellis, the dysosma versipellis is high in propagation speed, short in production period, simple in equipment and convenient for industrialized production, and guarantee conditions are provided for production of authentic medicinal materials and postpartum processing and selling.