288 results about "Suppository drug" patented technology

The invention provides toad peptide antibiotics separated from toad maggots and a preparation method of antibacterial drugs thereof. The preparation method comprises the following steps: taking toad maggots as raw materials; carrying out ultrafiltration and microfiltration, gel chromatography separation, ultrasonic standing wave liquid preparation chromatography and the like by adopting a solvent extraction method and an ion-exchange resin adsorption method; freeze-drying to prepare the toad peptide antibiotics; and combining the active components with appropriate excipients to prepare tablets, capsules, suppositories, ointments, enteric tablets and the like to be used for treating various diseases. The drugs prepared by the invention have the advantages of wide antibacterial range, specific drug components, controllable quality and stable performance and have industrial production values.

The invention discloses low molecular weight carboxyl-reduced derivatives of fucosylated glycosaminoglycans (LCRG). The extent of carboxyl reduction is not less than 20%. Weight-average molecular weight of the LCRG is about 3000-20000Da, and monosaccharides comprise acetyl galactosamine (GalNAc), glucose (Glc) or glucuronic acid (GlcUA) and fucose (Fuc) or sulfates of fucose (shown as -OSO3-). The mole ratio of GalNAc, Glc (containing GlcUA), Fuc and -OSO3- is about 1: (1+-0.3): (1+-0.3): (3.0+-1.0). The LCRG is a potent human immunodeficiency virus (HIV) Type 1 entry inhibitor which acts on conserved regions and has the advantages of high activity against HIV Type 1, high therapeutic index and no-drug-resistance, and the LCRG can be used for preventing or curing HIV. The invention further provides a preparation method of the LCRG. The carboxyl-reduced derivatives of fucosylated glycosaminoglycans and medicinal compositions of the carboxyl-reduced derivatives can be prepared into injection agents, lyophilized powder or suppository and the like.

The invention discloses a low molecular weight glycosylated chondroitin sulfate, whose weight average molecular weight is 3000-15000Da. The monosaccharide composition comprises acetyl galactosamine (D-GalNAc), glucuronic acid (D-GlcUA), fucose (L-Fuc), or its sulfuric ester (expressed in -OS03<->), wherein the mole ratio of D-GalNAc to D-GlcUA to L-Fuc to -OS03<-> is 1: (1+/-0.3): (1+/-0.3): (3.5+/-0.5). The low molecular weight glycosylated chondroitin sulfate has a strong anti-HIV-1 virus activity, is a gp120 entry inhibitor, and can be used for preventing and/or treating AIDS. The invention also provides a method for preparing the low molecular weight glycosylated chondroitin sulfate and its composition preparation. Glycosylated chondroitin sulfate is depolymerized by the peroxide method to obtain a low molecular weight product, and then low molecular and/or high-molecular impurities of the product are removed by gel separation or ultrafiltration method. The low molecular weight glycosylated chondroitin sulfate and its medicinal composition can be prepared in the form of an injection, a lyophilized powder or a suppository.

The invention relates to application of an effective part of a cockroach extract in preparing a drug for inhibiting fungus growth, and particularly relates to application of an effective part obtained by refining a crude cockroach extract through macroporous adsorption resin in the aspect of preparing a drug capable of resisting fungal infection. The effective part is refined from a fresh or dried Periplaneta americana L. polypide product through alcohol and water extraction, macroporous adsorption resin column chromatography and alcohol solvent elution, and has an obvious inhibition effect on the growth activity of candida albicans and a fungus growth inhibition capacity 80 times higher than that of fluconazole and 5-fluorocytosine and 800 times higher than that of amphotericin. The effective part of the cockroach extract can be prepared into forms, such as a hydrogel, a frothy gel, a cataplasm, freeze-dried powder, a water aqua, an aerosol, a suppository, a film, an external liniment, an ointment and the like, and is used for preparing pharmaceutical preparations for preventing and curing fungal infection, medical appliances and daily-use chemical products.

The invention discloses a herbal composite and a preparation thereof for treating gynecological inflammation. The herbal composite is prepared of cotyledon, selinum, sophora, phellodendron, radix Stemonae, agrimonia, sanqi, borax, borneol; the weight ratios are that 3-15 portions of cotyledon, 3-15 portions of selinum, 3-15 portions of sophora, 2-10 portions of phellodendron, 2-10 portions of radix Stemonae, 2-10 portions of agrimonia, 0.2-2 portions of sanqi, 3.03-0.3 portion of borax, and 0.06-0.6 portion of borneol. The preparation can be suppository, gel, cream, solution agent, film, spray, effervescent tablets agent, and other externally used preparations. The invention adopts common herbal medicines as materials, the usage cost of a sufferer is lower, the content of the effective components are high, the stability is high, and the curative effect is notable. The herbal composite and the preparation of the invention can reduce fever, destroy the toxic properties, dry dampness, kill insect, remove rot, and produce fresh, can inhibit and kill pathogenic micro-organisms and infusorium, can improve the immunity of organism, can cure tickle and relieve pain, can accelerate metabolism, can promote the tissue to rebirth. The prescription is applicable for the sufferers with leukorrhea with reddish discharge, pruritus vulvae, cervical erosion, infusorium vaginitis, mucedine vaginitis, nonspecific vaginitis, etc.

The invention discloses a garlicin cyclodextrin clathrate compound, preparation and the process for preparing same, wherein the allicin, cyclodextrin or their derivatives (such as beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin) can be used for preparing garlicin cyclodextrin clathrate compound, which can be used for preparing various preparations of different oral preparation, suppositorium, spray, and injection.

The invention provides a medicinal composition of Cinobufacini, which is prepared into the forms of drop pill, or dispersible tablet, or soft capsule, or effervescent tablet, or orally disintegrating tablet, or mini-pill, or suppository. The invention also discloses their preparing process. The composition comprises dried toad skin extract and Job's-tears seed oily extract by the weight ratio of 1:0.05-30.

The invention relates to a Chinese medicine preparation for treating chronic prostatitis, which is characterized by comprising the following raw medicines: radix rehmanniae preparata, cynomorium songaricum rupr, radix astragali, rhizoma corydalis, herba epimedii, dodder, herba ecliptae, schisandra chinensis, hedyotis diffusa, safflower, radix polygoni multiflori preparata, fructus ligustri lucidi, salvia miltiorrhiza, radix paeoniae alba, myrrh, prunella vulgaris, fructus cnidii, herba patriniae, scutellaria baicalensis georgi, angelica and cortex moutan. In the invention, Chinese herbal medicines for promoting blood circulation and removing blood stasis are adopted, the permeability of capillaries can be improved, inflammation reaction can be alleviated, the extinction and the absorption of inflammation focus can be promoted, the metabolism of connective tissues can be improved, the transformation and the absorption of hyperplastic lesions can be promoted, and atrophic connective tissues can recover. When the Chinese medicine preparation for treating chronic prostatitis is applied through rectums, the medicines can be absorbed in the rectums, enema or suppository enables the medicines to be absorbed through rectum mucosa to directly reach affected parts; and the Chinese medicine preparation can reach higher consistency in diseased prostate and has the advantages of ideal treating effect, low price and simple, convenient and practical preparation method.

The invention discloses the novel application of clostridium butyricum to drugs, in particular to the application of the clostridium butyricum to the preparation of a drug combination used for preventing and treating intestinal cancer. The novel application comprises the prevention of chronic intestinal disease canceration such as intestinal polyp, Crohn disease, ulcerative colitis, etc., the adjuvant therapy on advanced inoperable intestinal cancer, the adjuvant therapy after the intestinal cancer operation, etc.; the clostridium butyricum is selected from (but is not limited to) clostridium butyricum, CGMCC, and storage serial number 0313.1. In the forms of live bacteria and pharmic receivable different carriers, the clostridium butyricum is made into tablets, capsules, powders, liquid preparations, suppositories, and enemas; the clostridium butyricum can be used for preventing and treating the intestinal cancer for a long time through the methods of oral administration, clysis, injection in the tumor tissue; therefore, the life of a patient suffering from the intestinal cancer is prolonged, and the life quality of the patient suffering from the intestinal cancer is increased.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.

The invention relates to the field of traditional Chinese medicines and provides an anti-cervical erosion suppository and a preparation method thereof. The anti-cervical erosion suppository is prepared from ginsenoside, lithospermum, golden cypress, sophora flavescens, dried alums and acacia catechu. The preparation method comprises the following steps: grinding the acacia catech and the dried alums into fine powder; grinding borneol; adding water into the golden cypress, the sophora flavescens and the lithospermum and decocting for three times; mixing decoction solutions and filtering; adding ethanol and standing for 24 hours; recycling the ethanol and concentrating into thick paste; drying and crushing into fine powder; uniformly mixing with the fine powder; additionally adding base materials including polyoxyl stearate and polyethylene glycol 1500; mixing, heating and smelting; and adding the fine powder and uniformly agitating to prepare a suppository. The anti-cervical erosion suppository has good water solubility, no stimulation, no toxin, no anaphylaxis, and is stable in physicochemical property; the anti-cervical erosion suppository is not easily deformed due to moisture absorption and is not easy to mildew; at a room temperature, the anti-cervical erosion suppository has suitable rigidity and has no deformation and crushing in a packaging, transporting and storing process.

The present invention is one kind of medicine for preventing and treating senile dementia and its preparation and use. The medicine has epimedium as the single ingredient, which is treated through solvent extraction, macroporous resin elution, drying and other technological steps to obtain epimedium total flavone used as the main component. The medicine is used in preventing and treating vascular dementia, Alzheimer disease and other senile dementia. It may be prepared into tablet, capsule, soft capsule, granule, dripping pill and other preparation forms.

The present invention relates to dispersed solid medicine composition, named as Xingnaojing, for treating infantile externally caused fever heat, infantile viral encephalitis fever heat, infantile supurative tonsillitis, senile cerebral vascular dementia and cerebral apoplexy in recovering stage. The solid medicine composition consists of musk, borneol, volatile curcuma root oil, total curcuma root curcumin and total cape jasmine glycoside, and is prepared into dripping pill, suppository, capsule, tablet, granule or other forms. The preparation process has separate extraction of the active components curcumin and total cape jasmine glycoside, high shearing technology and sealed circular apparatus for well maintenance of active components and quantitative indexes for the control of active components so as to ensure the stable quality and curative effect of the product.

The invention is concerned with the Chinese traditional medicine suppository and the preparation method for treating and defending intestine paralysis, intestine conglutination and intestinal obstruction, composes of bark of official magnolia, rhubarb and fruit of immature citron that compounds with weight, which is by distill, filtration, concentration, dryness, crush to get dry cream powder, melts and mixes with the suppository base, irrigate module, cooling, gets the suppository. The invention is fast effect and dramatic curative effect.

An externally-applied medicine in the form of effervescent tablet, capsule, or suppository for treating gynopathy is prepared from pink plumepoppy herb's alkaloid and medicinal auxiliary. Its advantage is high curative effect. Its preparing process is also disclosed.

The invention provides an external nitric acid Sertaconazole suppository, which is a suppository of different specifications made by mixing the powder of ground nitric acid Sertaconazole and melt suppository base, glycerol and Polysorbate 80. The suppository has the beneficial effects that the preparation process of the suppository is simple, the eutherapeutic and low-toxic nitric acid Sertaconazole are used as the main medicaments, a greater cure effect can be achieved by using a small amount of medicament for local application, mycotic infection is inhibited, the cure effect is good, the use is convenient, etc.

The invention discloses a paliurus ramosissimus extractive having the bidirectional immunity adjustment effect and application thereof as a medicine for treating immune function abnormalities. The traditional Chinese medicine extractive disclosed by the invention is a methanol, ethanol, ethyl acetate, petroleum ether or similar solvent extract of paliurus ramosissimus leaves, paliurus ramosissimus roots, paliurus ramosissimus stem leaves or paliurus ramosissimus whole plant and mainly contains terpenes, flavonoids, alkaloids, coumarins (including glycosides and monomers of the above substances), polysaccharides, cellulose and the like; the preparation of the traditional Chinese medicine extractive include tablets, capsules, emplastrums, granules, injections, suppositories, ointments, gels, plastics, linimentums, lotions and sprays. The paliurus ramosissimus extractive and the preparation thereof disclosed by the invention have the bidirectional immunity adjustment effect and can be applied to preparing the medicines for treating immunocompromise and autoimmune diseases.

The invention discloses a method for inspecting the quality of a haemorrhoids suppository. The method comprises steps of identifying and measuring the content, wherein the step of identifying comprises a step of identifying a thin-layer chromatography of Chinese galls in the haemorrhoids suppository, wherein a Chinese gall reference medicine material and a nutgall acid reference substance are taken as reference materials, and trichloromethane-ethyl formate-formic acid is taken as a developing solvent; the step of measuring the content comprises a step of detecting berberine in the haemorrhoids suppository, namely, measuring by adopting a high-performance liquid chromatography method taking a berberine reference substance as a reference material and a solution prepared from a acetonitrile-0.1% phosphoric acid solution (every 100ml of the solution contains 0.1g of sodium dodecyl sulfate) as a mobile phase. The method has the advantages of sensitivity, stability, reliability and the like, the defect that the thin-layer identification negative chromatography of scutellaria baicalensis can cause interference is effectively eliminated, a system is high in suitability, linear relation, precision degree, sample stability and repeatability and sample feeding recycling rate, and the quality of a medicine can be accurately reflected, so that the quality of the medicine can be effectively controlled.

The invention relates to an enema and a suppository of Simo decoction of traditional Chinese patent medicine. The preparation method comprises the steps of: adopting costustoot, hovenia dulcis, areca seed and radix linderae as raw materials, boiling the raw materials, ethanol precipitating, adding excipients and preservatives to obtain the enema, or adopting costustoot, hovenia dulcis, areca seed and radix linderae as raw materials, boiling the raw materials, concentrating, drying, grinding, adding suppository matrix to obtain the suppository. The enema and the suppository of the invention have the advantages that the enema and the suppository have the functions of harmonizing stomach and lowering adverse, facilitating qi and removing food retention; the enema and the suppository adopt anus administration method, which are particularly applicable to the penitents and the children who have difficulty in swallowing for usage and can meet the basic treatment methods of banning water and food after abdomen surgery.

The invention discloses a paliurus ramosissimus extract for treating inflammation or/ and anabrosis of the oral cavity and the digestive tract as well as preparation and application of the paliurus ramosissimus extract. The extract comprises methyl alcohol, ethanol, ethyl acetate, petroleum ether or similar solvent extract of leaves, stems and leaves or whole plant of paliurus ramosissimus, and mainly contains terpene, flavonoid, alkaloids, coumarins (including glycosides and monomers), polysaccharides, cellulose and the like. The preparation of the paliurus ramosissimus extract comprises tablets, capsules, emplastrum, granules, injection, suppository, ointment, gel, plastics, linimentum, lotion, spray and the like. The paliurus ramosissimus extract and the preparation of the paliurus ramosissimus extract have better function of treating related diseases of inflammation or/ and anabrosis of the oral cavity and the digestive tract.