91 results about "Suppository drug" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses a compound musk suppository for promoting blood circulation to remove blood stasis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine suppository preparation. Comprising the following raw materials in parts by weight: 30-40 parts of mixed traditional Chinese medicine extract dry powder, 60-65 parts of glycerol, 15-20 parts of gelatin, 15-20 parts of water, 15-20 parts of polyethylene glycol and 1.6-2 parts of an emulsifier. According to the compound musk suppository, radix aucklandiae, musk, pericarpium citri reticulatae, semen coicis, radix scutellariae, caulis spatholobi, Japanese peristrophe herb and rhizoma bletillae are used as traditional Chinese medicine efficacy raw materials of mixed traditional Chinese medicine extract dry powder in the compound musk suppository, and then the compound musk suppository is prepared, so that the prepared compound musk suppository has a good promoting effect on the curative effect of haemorrhoids.

The present application relates to a suppository booster, which relates to the field of suppository drug delivery devices. It includes a suppository booster, which comprises a cartridge, a plurality of guiding components and a boosting component. One end of the cartridge is a feeding end, and the other end is a discharging end. The guiding components are located inside the cartridge and at the discharging end. The plurality of guiding components are distributed circumferentially inside the cartridge along the circumferential direction of the cartridge. The guiding component includes a guiding piece and a connecting piece. One side of the guiding piece along the length direction of the cartridge is fixedly connected to the inner wall of the cartridge through the connecting piece, and there is an active gap between the other side and the inner wall of the cartridge. And the plurality of guiding pieces enclose to form a material guiding area. The boosting component is used to push the suppository to slide along the length direction of the cartridge inside the cartridge. The present application has the effect of reducing the contamination of the suppository during the process of pushing in the suppository.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

The invention provides a semeglutide suppository and a preparation method thereof. The semeglutide suppository provided by the invention is stable in quality and high in bioavailability, and also has the characteristics of rapid drug release and continuous drug administration.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term "pill," as used herein, refers to any "solid medication" encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention relates to the technical field of Mongolian medicine preparations, in particular to a coptis chinensis six-ingredient decoction and a preparation method of a suppository of the coptis chinensis six-ingredient decoction. Three heat-clearing and anti-inflammatory Mongolian medicines are added on the basis of a traditional Mongolian medicine coptis chinensis-six-ingredient decoction, the total content of effective components is larger than or equal to 12% through composite enzymolysis, supercritical CO2 extraction and gradient membrane separation and purification, and then stability is enhanced through composite embedding. According to the suppository, a drug carrying system is constructed through a pH-ROS double-response carrier and magnetic targeting, self-healing hydrogel, a temperature-sensitive composite matrix and micro-fluidic spray forming are combined, and storage stability is guaranteed through intelligent packaging. The preparation disclosed by the invention is high in targeting property, capable of being accurately enriched in an intestinal inflammation area, high in mucous membrane adhesive force, long in residence time, convenient and comfortable to take, capable of meeting the melting change time limit, capable of remarkably improving stability and bioavailability, suitable for treating ulcerative colitis and capable of promoting modernization transformation of Mongolian medicine.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term “pill,” as used herein, refers to any “solid medication,” encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

The invention discloses a traditional Chinese medicine suppository for treating low-level incomplete cancerous intestinal obstruction. The traditional Chinese medicine suppository comprises the following raw materials in parts by weight: 10-30 parts of seaweed, 10-20 parts of radix aucklandiae, 5-15 parts of rheum officinale, 10-20 parts of fried semen brassicae, 10-30 parts of fried semen raphani, 10-20 parts of fried semen pharbitidis, 1-5 parts of vinegar-processed euphorbia pekinensis, 1-5 parts of vinegar-processed euphorbia kansui, 1-15 parts of snow lotus herb, 5-15 parts of rhodiola rosea, 1-3 parts of meconopsis horridula and 0.5-1.5 parts of alkali. The traditional Chinese medicine composition is scientific and reasonable in formula compatibility, can effectively improve intestinal microcirculation, relieve intestinal spasm, promote intestinal peristalsis and recover the intestinal conduction function so as to relieve intestinal obstruction symptoms, can be effectively used for treating low-level incomplete cancerous intestinal obstruction, and is convenient to use, free of trauma, small in side effect, stable and reliable in curative effect, good in effect and free of toxic and side effects. The traditional Chinese medicine composition is a great innovation of medicines for treating low-level incomplete cancerous intestinal obstruction, and has huge social and economic benefits.

The invention discloses a Chinese medicine suppository for treating acute pancreatitis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The Chinese medicine suppository comprises the following raw materials in parts by weight: 28-35 parts of rhubarb, 28-32 parts of knotweed, 5-12 parts of senna, 5-15 parts of dandelion, 5-12 parts of radix scutellariae, 5-12 parts of radix scutellariae, 5-15 parts of scutellariae, 5-15 parts of scutellariae, 5-15 parts of borneol and 1-2 parts of borneol. Animal experiments and clinical practice confirm that the Chinese medicine suppository prepared by the present invention can significantly alleviate the clinical symptoms and serum indicators of patients with acute pancreatitis, provide new therapeutic drugs and selections for treating acute pancreatitis, and have the value of extensive promotion and application.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to chlorogenic acid temperature-sensitive sol, a preparation method and application thereof, chlorogenic acid gel and application thereof. According to the chlorogenic acid temperature-sensitive sol provided by the invention, the chlorogenic acid with anti-inflammatory activity is combined with a temperature-sensitive material for the first time to construct a temperature response type in-situ gel delivery system. The chlorogenic acid temperature-sensitive sol provided by the invention is in a flowable sol state at room temperature, and is convenient for administration in a liquid form through an injector or an enema device; when the temperature-sensitive material is in contact with a human body cavity mucous membrane, the temperature-sensitive material triggers sol-gel phase change through an intermolecular hydrophobic effect to form semi-solid three-dimensional mesh gel which is tightly adhered to the surface of the mucous membrane, so that positioned enrichment and long-acting slow release of a medicine in a focus area are realized, the symptoms of ulcerative colitis are relieved, and the disease activity index is reduced; the colon length shortening and the pathological injury of colon tissues are improved, the technical defects of non-uniform distribution, short enema retention time and the like of the traditional suppository are overcome, and the colon suppository has clinical application potential.

The invention relates to a suppository for treating postpartum infection and metritis and a preparation method thereof. The suppository for treating postpartum infection and metritis comprises the following raw materials: active pharmaceutical ingredients and auxiliary materials, the mass ratio of the components is 1: (1-2.5). The active pharmaceutical ingredients comprise scutellaria baicalensis, safflower carthamus, angelica sinensis, radix angelicae, poria cocos, liquorice, codonopsis pilosula, radix bupleuri, radix sophorae flavescentis, rhizoma atractylodis and agastache rugosus; the auxiliary materials comprise a matrix and an additive. The suppository has the advantages of being capable of avoiding the first-pass effect of the liver, high in bioavailability, fast in effect taking, convenient to use and the like.

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

The present invention provides a pneumonia-related compound, a preparation method and application thereof, and a pharmaceutical composition, belonging to the technical field of pharmaceutical organic compounds. The pneumonia-related compound is an N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide compound, which is used for treating sepsis and acute lung injury, and the preparation forms that can be prepared include injections, tablets, capsules, aerosols, suppositories, membranes, dripping pills, ointments, controlled-release or sustained-release agents, and nano-formulations.

This application relates to the field of biomedical materials technology, specifically disclosing a method for preparing a thermosensitive biodegradable root canal suppository. The method includes the following steps: S1, dissolving a thermosensitive biodegradable polymer material in a solvent; S2, adding the active pharmaceutical ingredient and excipients to the polymer solution and stirring until homogeneous; S3, injecting the mixture into a mold and placing it under low-temperature conditions to solidify the mixture into a semi-solid suppository preform; S4, removing the suppository preform from the mold; S5, removing residual solvent from the semi-solid suppository intermediate; S6, heat-treating the dried suppository intermediate; and S7, sealing and storing the finished suppository in protective packaging. The root canal suppository of this application can be used for root canal medication during root canal treatment. It has the advantages of being solid at room temperature for precise implantation into the root canal, and rapidly softening upon contact with body temperature to adapt to irregular root canal walls, achieving complete root canal sealing.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

The invention provides a dendrobium composition for tumor treatment and a preparation method of a dendrobium suppository, freeze-dried fresh dendrobium powder and freeze-dried fresh dendrobium powder alcohol precipitate composition are used as raw materials, and borneol and semi-synthetic fatty glyceride are added to prepare the dendrobium suppository. Compared with conventional dried dendrobium nobile powder, the composition prepared by selecting the combination of the freeze-dried fresh dendrobium nobile powder and adding the freeze-dried fresh dendrobium nobile powder alcohol precipitate can not only improve the content of active ingredients in a finished product, but also obtain higher activity, and can also solve the process problem of non-uniform dispersibility caused by independent use of the alcohol precipitate in the processing process. Therefore, when the composition prepared from the freeze-dried fresh dendrobium nobile powder and the freeze-dried fresh dendrobium nobile powder alcohol precipitate is added into products of various dosage forms, the polysaccharide content and activity are improved, and the process problem is solved.

The invention provides an anus suppository for treating prostatitis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating prostatitis comprises an outer-layer sleeve and suppository contents, wherein the suppository contents comprise a heat-clearing and inflammation-diminishing layer, a warming, dredging and blood-activating layer and a qi-tonifying and kidney-tonifying layer which are sequentially distributed from outside to an inner core, and at least part of the suppository contents are wrapped by the outer-layer sleeve. The outer-layer sleeve prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the suppository is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The suppository emulsifier includes a pretreatment pot, an emulsifier body, and a transfer tank. The pretreatment pot and the emulsifier body are connected via a vacuum feed pipe. A rotor pump is installed between the emulsifier body and the transfer tank, and a discharge pipe is installed between the emulsifier body and the rotor pump. The discharge pipe is covered with an insulation layer. The bottom of the transfer tank has a conical structure, which improves discharge efficiency and ensures thorough discharge for convenient subsequent packaging. The device also includes a hot water pot, with a cleaning pump connected to one side of its outlet. The cleaning pump is connected to the pretreatment pot, the emulsifier body, and the transfer tank via cleaning pipes, facilitating cleaning of these components. This solves the problem of uneven cleaning in existing systems, which results in incomplete removal of internal impurities. It reduces manual cleaning labor, increases user efficiency, and reduces user working time.

A method for the treatment of thromboembolism comprising administering a thrombolytic agent directly to the thromboembolism in the presence of ultrasound. The total dose of thrombolytic agent administered is between 1 and 12 mg and the time over which the total dose is delivered is less than 15 hours.

The application belongs to the field of medicine, and particularly relates to a traditional Chinese medicine compound suppository for treating diabetic nephropathy and a preparation method thereof. The traditional Chinese medicine compound for treating diabetic nephropathy comprises the following components in parts by weight: 15-30 parts of verbena, 30-60 parts of astragalus, 10-20 parts of siler, 10-20 parts of notopterygium, 15-60 parts of caulis spathulatae, 15-60 parts of giant knotweed, 10-30 parts of yizhi, 15-30 parts of acer truncatum batal, 15-30 parts of pteridium aquilinum, and 3-10 parts of borneol. The compound liver portal suppository prepared from the traditional Chinese medicine compound can treat the root and the branch, can significantly improve kidney function, can improve various clinical indexes of patients with diabetic nephropathy, and has a significant treatment effect.

The application provides a ibuprofen suppository, a preparation method and application thereof, and belongs to the technical field of medicines. The application overcomes the defects of slow effect, easy leakage and low bioavailability of traditional suppositories. The suppository is a hollow suppository, which comprises a shell layer and content filled in a hollow cavity of the shell layer; the shell layer is composed of a water-soluble base and a bioadhesive material, the water-soluble base is a mixture of PEG 400 and PEG 1000 ; the content contains ibuprofen active ingredients and an absorption promoter; the content is in the form of a solid powder, when the suppository enters the rectum, the shell layer dissolves and adheres to the rectal mucosa, and the content is directly exposed to the rectal body fluid in the form of a solid powder and is quickly dissolved. The application is particularly suitable for children's antipyretic and analgesic drug preparation, and has the advantages of rapid effect, accurate dosage and good compliance.

1. The name of the design product: packing box (suppository). 2. The use of the design product: used for packing and containing suppository medicine. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo best indicating the design points: perspective view 1.

The invention provides a traditional Chinese medicine suppository for treating gynecology and a preparation method of the traditional Chinese medicine suppository. The traditional Chinese medicine suppository contains 100 parts of traditional Chinese medicine microcapsules, 50-150 parts of a matrix, 0-10 parts of a lubricant, 0-15 parts of a humectant and 0-20 parts of a disintegrating agent. The preparation method comprises the following steps: carrying out microencapsulation on the traditional Chinese medicine extract to obtain traditional Chinese medicine microcapsules; adding a matrix and mixing; adding the lubricant, the humectant and the disintegrating agent, and mixing; the upper layer is quickly released, and the lower layer is slowly released; and finally packaging and sterilizing to prepare the suppository. The stability and bioavailability of the medicine can be effectively improved, the treatment effect is enhanced, the administration frequency is reduced, and the medication compliance of a patient is improved.

The invention relates to the field of natural product chemistry, sugar chemistry and biological medicine, and particularly provides glycosaminoglycan and / or a series of derivatives thereof as well as a preparation method and application of the glycosaminoglycan and / or the series of derivatives thereof, the glycosaminoglycan is extracted from starfish glabrata, and the preparation method comprises the following steps: extracting by adopting a papain combined alkaline hydrolysis method; the invention discloses an ALHX-2M series derivative and application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases, and the ALHX-2M series derivative is obtained by performing separation and purification through ion exchange column chromatography and molecular exclusion column chromatography to obtain ALHX-2M, and further performing deacetylation, deamination and depolymerization treatment and gel column chromatography separation and purification on the ALHX-2M series derivative and the application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases. The glycosaminoglycan and the derivative thereof take an endogenous blood coagulation factor X enzyme complex (FXase) as an action target, the anticoagulation activity and the antithrombotic activity of the glycosaminoglycan and the derivative thereof are superior to those of low-molecular-weight heparin, the bleeding risk under the equivalent antithrombotic dosage is remarkably reduced, and the glycosaminoglycan and the derivative thereof can be used for medicines or functional foods for preventing and treating thrombotic cardiovascular and cerebrovascular diseases.