43 results about "Suppository drug" patented technology

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term "pill," as used herein, refers to any "solid medication" encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention relates to the technical field of Mongolian medicine preparations, in particular to a coptis chinensis six-ingredient decoction and a preparation method of a suppository of the coptis chinensis six-ingredient decoction. Three heat-clearing and anti-inflammatory Mongolian medicines are added on the basis of a traditional Mongolian medicine coptis chinensis-six-ingredient decoction, the total content of effective components is larger than or equal to 12% through composite enzymolysis, supercritical CO2 extraction and gradient membrane separation and purification, and then stability is enhanced through composite embedding. According to the suppository, a drug carrying system is constructed through a pH-ROS double-response carrier and magnetic targeting, self-healing hydrogel, a temperature-sensitive composite matrix and micro-fluidic spray forming are combined, and storage stability is guaranteed through intelligent packaging. The preparation disclosed by the invention is high in targeting property, capable of being accurately enriched in an intestinal inflammation area, high in mucous membrane adhesive force, long in residence time, convenient and comfortable to take, capable of meeting the melting change time limit, capable of remarkably improving stability and bioavailability, suitable for treating ulcerative colitis and capable of promoting modernization transformation of Mongolian medicine.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term “pill,” as used herein, refers to any “solid medication,” encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

This application relates to the field of biomedical materials technology, specifically disclosing a method for preparing a thermosensitive biodegradable root canal suppository. The method includes the following steps: S1, dissolving a thermosensitive biodegradable polymer material in a solvent; S2, adding the active pharmaceutical ingredient and excipients to the polymer solution and stirring until homogeneous; S3, injecting the mixture into a mold and placing it under low-temperature conditions to solidify the mixture into a semi-solid suppository preform; S4, removing the suppository preform from the mold; S5, removing residual solvent from the semi-solid suppository intermediate; S6, heat-treating the dried suppository intermediate; and S7, sealing and storing the finished suppository in protective packaging. The root canal suppository of this application can be used for root canal medication during root canal treatment. It has the advantages of being solid at room temperature for precise implantation into the root canal, and rapidly softening upon contact with body temperature to adapt to irregular root canal walls, achieving complete root canal sealing.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

The invention provides an anus suppository for treating prostatitis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating prostatitis comprises an outer-layer sleeve and suppository contents, wherein the suppository contents comprise a heat-clearing and inflammation-diminishing layer, a warming, dredging and blood-activating layer and a qi-tonifying and kidney-tonifying layer which are sequentially distributed from outside to an inner core, and at least part of the suppository contents are wrapped by the outer-layer sleeve. The outer-layer sleeve prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the suppository is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The suppository emulsifier includes a pretreatment pot, an emulsifier body, and a transfer tank. The pretreatment pot and the emulsifier body are connected via a vacuum feed pipe. A rotor pump is installed between the emulsifier body and the transfer tank, and a discharge pipe is installed between the emulsifier body and the rotor pump. The discharge pipe is covered with an insulation layer. The bottom of the transfer tank has a conical structure, which improves discharge efficiency and ensures thorough discharge for convenient subsequent packaging. The device also includes a hot water pot, with a cleaning pump connected to one side of its outlet. The cleaning pump is connected to the pretreatment pot, the emulsifier body, and the transfer tank via cleaning pipes, facilitating cleaning of these components. This solves the problem of uneven cleaning in existing systems, which results in incomplete removal of internal impurities. It reduces manual cleaning labor, increases user efficiency, and reduces user working time.

A method for the treatment of thromboembolism comprising administering a thrombolytic agent directly to the thromboembolism in the presence of ultrasound. The total dose of thrombolytic agent administered is between 1 and 12 mg and the time over which the total dose is delivered is less than 15 hours.

The application provides a ibuprofen suppository, a preparation method and application thereof, and belongs to the technical field of medicines. The application overcomes the defects of slow effect, easy leakage and low bioavailability of traditional suppositories. The suppository is a hollow suppository, which comprises a shell layer and content filled in a hollow cavity of the shell layer; the shell layer is composed of a water-soluble base and a bioadhesive material, the water-soluble base is a mixture of PEG 400 and PEG 1000 ; the content contains ibuprofen active ingredients and an absorption promoter; the content is in the form of a solid powder, when the suppository enters the rectum, the shell layer dissolves and adheres to the rectal mucosa, and the content is directly exposed to the rectal body fluid in the form of a solid powder and is quickly dissolved. The application is particularly suitable for children's antipyretic and analgesic drug preparation, and has the advantages of rapid effect, accurate dosage and good compliance.

1. The name of the design product: packing box (suppository). 2. The use of the design product: used for packing and containing suppository medicine. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo best indicating the design points: perspective view 1.

The invention relates to the field of natural product chemistry, sugar chemistry and biological medicine, and particularly provides glycosaminoglycan and / or a series of derivatives thereof as well as a preparation method and application of the glycosaminoglycan and / or the series of derivatives thereof, the glycosaminoglycan is extracted from starfish glabrata, and the preparation method comprises the following steps: extracting by adopting a papain combined alkaline hydrolysis method; the invention discloses an ALHX-2M series derivative and application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases, and the ALHX-2M series derivative is obtained by performing separation and purification through ion exchange column chromatography and molecular exclusion column chromatography to obtain ALHX-2M, and further performing deacetylation, deamination and depolymerization treatment and gel column chromatography separation and purification on the ALHX-2M series derivative and the application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases. The glycosaminoglycan and the derivative thereof take an endogenous blood coagulation factor X enzyme complex (FXase) as an action target, the anticoagulation activity and the antithrombotic activity of the glycosaminoglycan and the derivative thereof are superior to those of low-molecular-weight heparin, the bleeding risk under the equivalent antithrombotic dosage is remarkably reduced, and the glycosaminoglycan and the derivative thereof can be used for medicines or functional foods for preventing and treating thrombotic cardiovascular and cerebrovascular diseases.

The invention discloses a nitrogenous aromatic fused ring compound as shown in a general formula I as well as a preparation method and application thereof, belongs to the technical field of medicinal chemistry, and particularly relates to application of the compound or pharmaceutically acceptable salt thereof as an HDAC6 inhibitor in the aspect of resisting idiopathic pulmonary fibrosis. The invention also relates to a pharmaceutical composition taking the compounds and pharmaceutically acceptable salts thereof as active ingredients. The invention also relates to a pharmaceutical preparation containing at least one of the compounds or salts thereof. The dosage form of the pharmaceutical preparation is selected from one or more of tablets, capsules, injections, suppositories, patches, inhalable powder preparations, suspensions, emulsions or ointments.

The invention provides a traditional Chinese medicine compound suppository for treating endometritis of livestock and a preparation method of the traditional Chinese medicine compound suppository, and relates to the technical field of veterinary drugs. The traditional Chinese medicine compound suppository consists of povidone iodine, a traditional Chinese medicine composition and a slow-release high polymer material matrix carrier, wherein the traditional Chinese medicine composition is prepared from thirteen traditional Chinese medicine components including philippine flemingia root, common andrographis herb, zanthoxylum dissitum, Chinese angelica, suberect spatholobus stem, motherwort herb, baical skullcap root, honeysuckle flower, weeping forsythia capsule, white paeony root, nutgrass galingale rhizome, heartleaf houttuynia herb and swordlike atractylodes rhizome. Besides the matrix carrier, the traditional Chinese medicine compound suppository only contains povidone iodine and traditional Chinese medicine composition components, the content of the povidone iodine component is low, and side effects are reduced. The traditional Chinese medicine compound suppository is non-toxic, small in irritation to vaginal mucosa of livestock, high in effective rate of treating endometritis of the livestock and good in anti-inflammatory effect. In the preparation process of the traditional Chinese medicine compound suppository, no organic solvent is used, pollution to the environment is avoided, and the preparation process is simple, convenient and easy to implement and low in cost.

A rectal suppository is described. The rectal suppository contains 6-thioguanine, at least one stearin and at least one surfactant. Further or optionally, the rectal suppository comprises from about 1 mg to 9 mg of 6-thioguanine. Further or optionally, the present invention describes methods of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to a subject in need thereof. Further or optionally, the present invention describes a method of making a rectal suppository. The present invention relates to a process for preparing a rectal suppository comprising the steps of (a) heating stearin to become liquid stearin, (b) adding at least one surfactant to the liquid stearin, (c) adding 6-thioguanine to the liquid stearin, (d) shaping stearin into a rectal suppository. The step (b) is optionally performed before or after the step (c).

The invention provides a hollow anus suppository capable of loading multiple active ingredients and application, and relates to the technical field of pharmaceutical preparations, the hollow anus suppository comprises a hollow shell made of a fusible matrix and an active ingredient filler sealed in the hollow shell; a highly universal rectal administration platform is constructed through a special hollow shell, active ingredients are sealed in an independent cavity, physical isolation and effective protection of contents are achieved, and the rectal administration device is particularly suitable for probiotics, chemical drugs, traditional Chinese medicine extracts and other sensitive ingredients which are prone to inactivation or unstable in the rectal environment. By accurately designing the wall thickness of the shell and the matrix formula, the fusion characteristic of the shell and the release behavior of the content can be effectively regulated and controlled, so that various programmed drug release modes from delayed release to colon targeted delivery and the like are realized, and the technical problems that a traditional suppository is too fast in release and non-targeted are solved.

The invention provides a medical gynecological medicine applying device which comprises a medicine applying pipe fitting and a connecting mechanism, and the medicine applying pipe fitting comprises a tail end supporting pipe, a connecting supporting pipe and a push-pull head; wherein the connecting supporting pipe is arranged on one side of the tail end supporting pipe, and the connecting mechanism is connected between the tail end supporting pipe and the connecting supporting pipe and has a bending function; the tail end supporting pipe and the connecting supporting pipe are connected through the connecting mechanism, so that the medicine applying device has a deformation bending function, and after deformation bending, the push-pull head can be matched with the medicine pushing mechanism to drive the split type medicine control mechanism to perform medicine applying action, so that the medicine applying device can be suitable for more body postures during medicine applying, and the medicine applying effect is improved. Such as a sitting posture, a squatting posture, a standing posture and a lying posture, so that the use convenience of the medicine applying device is improved; and the medicine applying device can meet the medicine applying requirements of different medicines such as suppositories, capsules, ointment, gel and liquid medicine, and the application range of the medicine applying device is widened.

The utility model discloses a kind of sampling devices for diclofenac sodium sustained-release suppository detection, including sampling cylinder, the bottom of the sampling cylinder is communicated with sampling needle, the inside of the sampling cylinder is slidably connected with piston, the top of the piston is fixedly installed with pull rod, the top of the pull rod is fixedly installed with handle, the utility model is rotated by rotating sleeve, so that two traction plates move to two sides respectively, square bar and clamping plate are moved by traction plate movement, after clamping plate moves and no longer contacts sampling cylinder, support plate can be slid on the surface of sampling cylinder, after sliding to appropriate position, by rotating rotating sleeve, so that abutment rod no longer contacts traction plate, clamping plate can be reset and clamp the surface of sampling cylinder at this time, sampling needle at the bottom of sampling cylinder is inserted into suppository bottle after this, the effect of sampling at the same depth can be achieved, and the height of sampling needle extending into bottle can be adjusted simultaneously.

The invention provides an anus suppository for treating sphincter relaxation and a preparation method of the anus suppository, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating sphincter relaxation comprises an outer-layer sleeve, a suppository matrix and a traditional Chinese medicine composition, the outer-layer sleeve is an oval tube with an opening, the outer-layer sleeve comprises a sealing part and a permeating part, the sealing part is located at the end, away from the opening, of the outer-layer sleeve, and at least part of the suppository matrix is wrapped by the outer-layer sleeve. The sealing part prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the medicine is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The utility model discloses a kind of rapid cooling support for diclofenac sodium sustained-release suppository, including base, the base top surface is equipped with multiple top rods, multiple connecting rods are installed on the outer side of the top rod, the connecting rod one end is equipped with narrow part, the narrow part upper end is equipped with guide part, the both sides of the base are equipped with through slot, the through slot inboard is slidably installed with through plate, the through plate one end is equipped with support rod, the support rod one end is fixedly installed with the stop lever that is contacted with the top of mould. The utility model is limited to suppository mould different position by top rod, stop lever and multiple narrow parts together, and support smaller to mould blocking, when mould passes through forced air cooling tunnel rapid cooling, it can help to improve mould cooling efficiency, prevent suppository mould surface to form heat dissipation dead angle.

The invention is applicable to the technical field of pharmaceutical preparation forming, and provides a low-temperature forming process of a zedoary turmeric oil-borneol compound gynecological suppository, which comprises the following steps: pretreating raw materials; carrying out pre-cooling dispersion treatment; performing low-temperature mixing; performing dynamic pressure forming; performing temperature control post-treatment; finishing a finished product; according to the invention, the retention rate of effective components is greatly increased, the clinical curative effect of the preparation is guaranteed, and the problem of volatilization loss caused by strong volatility and sublimability of zedoary turmeric oil and borneol in the prior art is solved; the forming uniformity and the quality stability are remarkably optimized, the medication experience and the drug effect release efficiency are improved, and the quality problems of uneven mixing, forming defects and the like of an existing process are solved; the process suitability and the large-scale production capacity are comprehensively enhanced, the industrial supply requirement is met, and the problems that in an existing process, all links are independently controlled, parameters depend on experience, and large-scale production is difficult to adapt are solved.

A gel and suppository and method to provide the gel and the suppository, are disclosed herein. The gel comprising: between 50 and 150 millimolar of lactic acid concentrate; and between 0.5 and 10 millimolar of hydrogen peroxide concentrate. The suppository comprising: between 22.5 and 67.5 milligrams of lactic acid concentrate; and between 1 and 20 milligrams of hydrogen peroxide concentrate. 20 25 20 22 09 27 M ar 2 02 5 A G E L A N D A S U P P O S I T O R Y A N D M E T H O D S T O P R O V I D E T H E G E L A N D S U P P O S I T O R Y 2 0 2 5 2 0 2 2 0 9 2 7 M a r 2 0 2 5 A B S T R A C T

The present invention relates to a ketoconazole suppository, a preparation method therefor, and a quality control method therefor. The ketoconazole suppository exhibits a dissolution rate of any one or two or more of the following: (1) the cumulative dissolution percentage of ketoconazole measured at pH 4.0-5.5 for 30 minutes is ≥ 15%; (2) the cumulative dissolution percentage of ketoconazole measured at pH 4.0-5.5 for 1 hour is ≥ 30%; (3) the cumulative dissolution percentage of ketoconazole measured at pH 4.0 for 30 minutes is ≥ 40%; and (4) the cumulative dissolution percentage of ketoconazole measured at pH 4.0 for 1 hour is ≥ 60%.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a chlorogenic acid temperature-sensitive sol, a preparation method and application thereof, a chlorogenic acid gel and application thereof. The chlorogenic acid temperature-sensitive sol provided by the application combines chlorogenic acid with anti-inflammatory activity and a temperature-sensitive material for the first time, and constructs a temperature-responsive in-situ gel delivery system. The chlorogenic acid temperature-sensitive sol is in a flowable sol state at room temperature, and is convenient for administration in a liquid state through a syringe or an enema device. When contacting a human body cavity mucosa, the temperature-sensitive material triggers sol-gel phase transition through intermolecular hydrophobic interaction, forms a semi-solid three-dimensional network gel, and is closely adhered to the mucosa surface, so that the drug is positioned and enriched in a lesion area and is released for a long time, the symptoms of ulcerative colitis are relieved, the disease activity index is reduced, the colon length shortening and the pathological damage of colon tissue are improved, the technical defects such as uneven distribution of traditional suppositories and short retention time of enema liquid are overcome, and the chlorogenic acid temperature-sensitive sol has clinical application potential.