121 results about "Suppository drug" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses an application of indolepropionic acid in preparation of a medicine for preventing or treating ovarian cancer, the medicine takes indolepropionic acid as an active ingredient, the concentration is 0.1-1000 mu M, and the dosage forms comprise tablets, capsules, granules, pills, gels, suppositories, ointments, emulsions, mixtures, suspensions, injections and solutions. Administration routes comprise oral administration, injection administration, respiratory tract inhalation administration, local administration, sublingual administration and rectal administration, and can be combined with chemotherapeutic drugs for use. It is found through experiments that IPA with different concentrations can inhibit cell growth of ovarian cancer cell lines SKOV3 and A2780, cell proliferation of macrophages RAW264.7 is remarkably promoted, and the IPA has a potential immune promotion effect and good biological safety. In addition, the IPA can enhance the sensitivity of chemotherapeutic drugs, and the IPA and the chemotherapeutic drugs are combined to be applied to treatment of ovarian cancer, so that the treatment effect of the drugs can be remarkably improved.

The invention relates to a ketoconazole suppository as well as a preparation method and a quality control method thereof. The ketoconazole suppository has the dissolution rates of any one or more of the following items: (1) the cumulative dissolution percentage of ketoconazole in 30 minutes, which is measured under the condition that the pH is 4.0-5.5, is greater than or equal to 15%; (2) the cumulative dissolution percentage of ketoconazole in 1 hour measured under the condition that the pH is 4.0-5.5 is greater than or equal to 30%; (3) the 30-minute cumulative dissolution percentage of ketoconazole measured under the condition that the pH is 4.0 is greater than or equal to 40%; and (4) the cumulative dissolution percentage of ketoconazole in 1 hour measured under the condition of pH 4.0 is greater than or equal to 60%.

The invention discloses a compound musk suppository for promoting blood circulation to remove blood stasis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine suppository preparation. Comprising the following raw materials in parts by weight: 30-40 parts of mixed traditional Chinese medicine extract dry powder, 60-65 parts of glycerol, 15-20 parts of gelatin, 15-20 parts of water, 15-20 parts of polyethylene glycol and 1.6-2 parts of an emulsifier. According to the compound musk suppository, radix aucklandiae, musk, pericarpium citri reticulatae, semen coicis, radix scutellariae, caulis spatholobi, Japanese peristrophe herb and rhizoma bletillae are used as traditional Chinese medicine efficacy raw materials of mixed traditional Chinese medicine extract dry powder in the compound musk suppository, and then the compound musk suppository is prepared, so that the prepared compound musk suppository has a good promoting effect on the curative effect of haemorrhoids.

The present application relates to a suppository booster, which relates to the field of suppository drug delivery devices. It includes a suppository booster, which comprises a cartridge, a plurality of guiding components and a boosting component. One end of the cartridge is a feeding end, and the other end is a discharging end. The guiding components are located inside the cartridge and at the discharging end. The plurality of guiding components are distributed circumferentially inside the cartridge along the circumferential direction of the cartridge. The guiding component includes a guiding piece and a connecting piece. One side of the guiding piece along the length direction of the cartridge is fixedly connected to the inner wall of the cartridge through the connecting piece, and there is an active gap between the other side and the inner wall of the cartridge. And the plurality of guiding pieces enclose to form a material guiding area. The boosting component is used to push the suppository to slide along the length direction of the cartridge inside the cartridge. The present application has the effect of reducing the contamination of the suppository during the process of pushing in the suppository.

The present invention belongs to the technical field of pharmaceutical preparations, and specifically relates to an abiraterone acetate suppository and a preparation method thereof. The abiraterone acetate suppository of the present invention comprises abiraterone acetate and a matrix. The matrix of the prescription amount is weighed, heated and melted, the abiraterone acetate of the prescription amount is added, stirred to dissolve, and filled on a suppository filling line to obtain the abiraterone acetate suppository. Compared with the prior art, the present invention greatly improves bioavailability, has a simple preparation process, and is suitable for large-scale industrial production.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

The invention provides a semeglutide suppository and a preparation method thereof. The semeglutide suppository provided by the invention is stable in quality and high in bioavailability, and also has the characteristics of rapid drug release and continuous drug administration.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term "pill," as used herein, refers to any "solid medication" encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention relates to the technical field of Mongolian medicine preparations, in particular to a coptis chinensis six-ingredient decoction and a preparation method of a suppository of the coptis chinensis six-ingredient decoction. Three heat-clearing and anti-inflammatory Mongolian medicines are added on the basis of a traditional Mongolian medicine coptis chinensis-six-ingredient decoction, the total content of effective components is larger than or equal to 12% through composite enzymolysis, supercritical CO2 extraction and gradient membrane separation and purification, and then stability is enhanced through composite embedding. According to the suppository, a drug carrying system is constructed through a pH-ROS double-response carrier and magnetic targeting, self-healing hydrogel, a temperature-sensitive composite matrix and micro-fluidic spray forming are combined, and storage stability is guaranteed through intelligent packaging. The preparation disclosed by the invention is high in targeting property, capable of being accurately enriched in an intestinal inflammation area, high in mucous membrane adhesive force, long in residence time, convenient and comfortable to take, capable of meeting the melting change time limit, capable of remarkably improving stability and bioavailability, suitable for treating ulcerative colitis and capable of promoting modernization transformation of Mongolian medicine.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term “pill,” as used herein, refers to any “solid medication,” encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

The invention discloses a traditional Chinese medicine suppository for treating low-level incomplete cancerous intestinal obstruction. The traditional Chinese medicine suppository comprises the following raw materials in parts by weight: 10-30 parts of seaweed, 10-20 parts of radix aucklandiae, 5-15 parts of rheum officinale, 10-20 parts of fried semen brassicae, 10-30 parts of fried semen raphani, 10-20 parts of fried semen pharbitidis, 1-5 parts of vinegar-processed euphorbia pekinensis, 1-5 parts of vinegar-processed euphorbia kansui, 1-15 parts of snow lotus herb, 5-15 parts of rhodiola rosea, 1-3 parts of meconopsis horridula and 0.5-1.5 parts of alkali. The traditional Chinese medicine composition is scientific and reasonable in formula compatibility, can effectively improve intestinal microcirculation, relieve intestinal spasm, promote intestinal peristalsis and recover the intestinal conduction function so as to relieve intestinal obstruction symptoms, can be effectively used for treating low-level incomplete cancerous intestinal obstruction, and is convenient to use, free of trauma, small in side effect, stable and reliable in curative effect, good in effect and free of toxic and side effects. The traditional Chinese medicine composition is a great innovation of medicines for treating low-level incomplete cancerous intestinal obstruction, and has huge social and economic benefits.

The controlled release type ultrasonic rectal suppository comprises a specially-made suppository, an ultrasonic device, a regulation and control device, a power supply device and placing and taking-out accessories, and all the devices are modularly combined and can be detached and replaced. The controlled-release ultrasonic rectal suppository disclosed by the invention is suitable for children with faint of acupuncture, injection phobia, obesity and too low age, has no stimulation and pain sensation, is wide in applicable drug range, is particularly suitable for water-soluble macromolecular drugs, does not need to add a mucous membrane absorption enhancer, overcomes the defects of large difference of absorption individuals and slow effect of the conventional suppository administration, and is suitable for clinical application. The effect of promoting rapid absorption of the medicine is achieved.

The invention discloses a Chinese medicine suppository for treating acute pancreatitis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The Chinese medicine suppository comprises the following raw materials in parts by weight: 28-35 parts of rhubarb, 28-32 parts of knotweed, 5-12 parts of senna, 5-15 parts of dandelion, 5-12 parts of radix scutellariae, 5-12 parts of radix scutellariae, 5-15 parts of scutellariae, 5-15 parts of scutellariae, 5-15 parts of borneol and 1-2 parts of borneol. Animal experiments and clinical practice confirm that the Chinese medicine suppository prepared by the present invention can significantly alleviate the clinical symptoms and serum indicators of patients with acute pancreatitis, provide new therapeutic drugs and selections for treating acute pancreatitis, and have the value of extensive promotion and application.

The utility model relates to the technical field of suppository freezing, and discloses suppository antibacterial freezing equipment with a fixing function, which comprises a freezing box shell, and a suppository storage box is arranged in the freezing box shell; a circular groove is formed in the top of the suppository storage box, a circular box is fixedly connected into the circular groove, a through placement groove is formed in the top of the circular box, an adjusting groove is formed in the suppository storage box, a lead screw is arranged in the adjusting groove, and the bottom of the lead screw movably penetrates through the suppository storage box and is fixedly connected with a rotating handle. The surface of the lead screw is in threaded connection with a lifting frame, the top of the lifting frame is fixedly connected with a lifting disc, the top of the lifting disc is fixedly connected with a jacking column, and the jacking column is located in the containing groove. According to the suppository antibacterial freezing equipment, suppositories placed on the suppository clamping plate can be fixed, and the problems that when the suppository clamping plate is taken out, the suppositories shake, fall, collide and are damaged, and the suppositories are inconvenient to take out are solved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to chlorogenic acid temperature-sensitive sol, a preparation method and application thereof, chlorogenic acid gel and application thereof. According to the chlorogenic acid temperature-sensitive sol provided by the invention, the chlorogenic acid with anti-inflammatory activity is combined with a temperature-sensitive material for the first time to construct a temperature response type in-situ gel delivery system. The chlorogenic acid temperature-sensitive sol provided by the invention is in a flowable sol state at room temperature, and is convenient for administration in a liquid form through an injector or an enema device; when the temperature-sensitive material is in contact with a human body cavity mucous membrane, the temperature-sensitive material triggers sol-gel phase change through an intermolecular hydrophobic effect to form semi-solid three-dimensional mesh gel which is tightly adhered to the surface of the mucous membrane, so that positioned enrichment and long-acting slow release of a medicine in a focus area are realized, the symptoms of ulcerative colitis are relieved, and the disease activity index is reduced; the colon length shortening and the pathological injury of colon tissues are improved, the technical defects of non-uniform distribution, short enema retention time and the like of the traditional suppository are overcome, and the colon suppository has clinical application potential.

The invention relates to a suppository for treating postpartum infection and metritis and a preparation method thereof. The suppository for treating postpartum infection and metritis comprises the following raw materials: active pharmaceutical ingredients and auxiliary materials, the mass ratio of the components is 1: (1-2.5). The active pharmaceutical ingredients comprise scutellaria baicalensis, safflower carthamus, angelica sinensis, radix angelicae, poria cocos, liquorice, codonopsis pilosula, radix bupleuri, radix sophorae flavescentis, rhizoma atractylodis and agastache rugosus; the auxiliary materials comprise a matrix and an additive. The suppository has the advantages of being capable of avoiding the first-pass effect of the liver, high in bioavailability, fast in effect taking, convenient to use and the like.

The drug suppository enters a natural cavity for use through a natural cavity opening, the drug suppository is provided with a blunt head part (21), a middle part (22) and a tail part (23), the head part (21) of the drug suppository firstly enters the natural cavity opening when the drug suppository is used, and the drug suppository (2) is provided with various structures which can be conveniently combined with and / or synergistically act with the drug administration device (1); the drug suppository and the dosing device can be synchronously pushed after being combined, the two steps of operation of placing the drug suppository and releasing the liquid medicament are completed in the process of entering a natural cavity at a time, and meanwhile the hard part of the dosing device is prevented from damaging mucosa.

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

The present invention provides a pneumonia-related compound, a preparation method and application thereof, and a pharmaceutical composition, belonging to the technical field of pharmaceutical organic compounds. The pneumonia-related compound is an N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide compound, which is used for treating sepsis and acute lung injury, and the preparation forms that can be prepared include injections, tablets, capsules, aerosols, suppositories, membranes, dripping pills, ointments, controlled-release or sustained-release agents, and nano-formulations.

This application relates to the field of biomedical materials technology, specifically disclosing a method for preparing a thermosensitive biodegradable root canal suppository. The method includes the following steps: S1, dissolving a thermosensitive biodegradable polymer material in a solvent; S2, adding the active pharmaceutical ingredient and excipients to the polymer solution and stirring until homogeneous; S3, injecting the mixture into a mold and placing it under low-temperature conditions to solidify the mixture into a semi-solid suppository preform; S4, removing the suppository preform from the mold; S5, removing residual solvent from the semi-solid suppository intermediate; S6, heat-treating the dried suppository intermediate; and S7, sealing and storing the finished suppository in protective packaging. The root canal suppository of this application can be used for root canal medication during root canal treatment. It has the advantages of being solid at room temperature for precise implantation into the root canal, and rapidly softening upon contact with body temperature to adapt to irregular root canal walls, achieving complete root canal sealing.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

The invention provides a dendrobium composition for tumor treatment and a preparation method of a dendrobium suppository, freeze-dried fresh dendrobium powder and freeze-dried fresh dendrobium powder alcohol precipitate composition are used as raw materials, and borneol and semi-synthetic fatty glyceride are added to prepare the dendrobium suppository. Compared with conventional dried dendrobium nobile powder, the composition prepared by selecting the combination of the freeze-dried fresh dendrobium nobile powder and adding the freeze-dried fresh dendrobium nobile powder alcohol precipitate can not only improve the content of active ingredients in a finished product, but also obtain higher activity, and can also solve the process problem of non-uniform dispersibility caused by independent use of the alcohol precipitate in the processing process. Therefore, when the composition prepared from the freeze-dried fresh dendrobium nobile powder and the freeze-dried fresh dendrobium nobile powder alcohol precipitate is added into products of various dosage forms, the polysaccharide content and activity are improved, and the process problem is solved.

The invention provides an anus suppository for treating prostatitis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating prostatitis comprises an outer-layer sleeve and suppository contents, wherein the suppository contents comprise a heat-clearing and inflammation-diminishing layer, a warming, dredging and blood-activating layer and a qi-tonifying and kidney-tonifying layer which are sequentially distributed from outside to an inner core, and at least part of the suppository contents are wrapped by the outer-layer sleeve. The outer-layer sleeve prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the suppository is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The suppository emulsifier includes a pretreatment pot, an emulsifier body, and a transfer tank. The pretreatment pot and the emulsifier body are connected via a vacuum feed pipe. A rotor pump is installed between the emulsifier body and the transfer tank, and a discharge pipe is installed between the emulsifier body and the rotor pump. The discharge pipe is covered with an insulation layer. The bottom of the transfer tank has a conical structure, which improves discharge efficiency and ensures thorough discharge for convenient subsequent packaging. The device also includes a hot water pot, with a cleaning pump connected to one side of its outlet. The cleaning pump is connected to the pretreatment pot, the emulsifier body, and the transfer tank via cleaning pipes, facilitating cleaning of these components. This solves the problem of uneven cleaning in existing systems, which results in incomplete removal of internal impurities. It reduces manual cleaning labor, increases user efficiency, and reduces user working time.

A method for the treatment of thromboembolism comprising administering a thrombolytic agent directly to the thromboembolism in the presence of ultrasound. The total dose of thrombolytic agent administered is between 1 and 12 mg and the time over which the total dose is delivered is less than 15 hours.