67 results about "Suppository drug" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

The invention provides a semeglutide suppository and a preparation method thereof. The semeglutide suppository provided by the invention is stable in quality and high in bioavailability, and also has the characteristics of rapid drug release and continuous drug administration.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term "pill," as used herein, refers to any "solid medication" encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention relates to the technical field of Mongolian medicine preparations, in particular to a coptis chinensis six-ingredient decoction and a preparation method of a suppository of the coptis chinensis six-ingredient decoction. Three heat-clearing and anti-inflammatory Mongolian medicines are added on the basis of a traditional Mongolian medicine coptis chinensis-six-ingredient decoction, the total content of effective components is larger than or equal to 12% through composite enzymolysis, supercritical CO2 extraction and gradient membrane separation and purification, and then stability is enhanced through composite embedding. According to the suppository, a drug carrying system is constructed through a pH-ROS double-response carrier and magnetic targeting, self-healing hydrogel, a temperature-sensitive composite matrix and micro-fluidic spray forming are combined, and storage stability is guaranteed through intelligent packaging. The preparation disclosed by the invention is high in targeting property, capable of being accurately enriched in an intestinal inflammation area, high in mucous membrane adhesive force, long in residence time, convenient and comfortable to take, capable of meeting the melting change time limit, capable of remarkably improving stability and bioavailability, suitable for treating ulcerative colitis and capable of promoting modernization transformation of Mongolian medicine.

A medication container is provided that includes a pillbox designed to hold a user's solid medications. The term “pill,” as used herein, refers to any “solid medication,” encompassing tablets, capsules, powders, herbs, edibles, dietary supplements, suppositories, and similar forms. The pillbox can include a main body, a lid, cells for containing pills, and a circuit system. The pillbox may be organized into, for example, individual cells for each day of the week, or individual cells for time of the day (for example, morning, afternoon and evening). A cell may be organized into individual compartments for time of the day (for example, day and night). The circuit systems may be configured to include sensors (for example, sensors that correspond to a cell, or the lid) and lights.

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

This application relates to the field of biomedical materials technology, specifically disclosing a method for preparing a thermosensitive biodegradable root canal suppository. The method includes the following steps: S1, dissolving a thermosensitive biodegradable polymer material in a solvent; S2, adding the active pharmaceutical ingredient and excipients to the polymer solution and stirring until homogeneous; S3, injecting the mixture into a mold and placing it under low-temperature conditions to solidify the mixture into a semi-solid suppository preform; S4, removing the suppository preform from the mold; S5, removing residual solvent from the semi-solid suppository intermediate; S6, heat-treating the dried suppository intermediate; and S7, sealing and storing the finished suppository in protective packaging. The root canal suppository of this application can be used for root canal medication during root canal treatment. It has the advantages of being solid at room temperature for precise implantation into the root canal, and rapidly softening upon contact with body temperature to adapt to irregular root canal walls, achieving complete root canal sealing.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

The invention provides a dendrobium composition for tumor treatment and a preparation method of a dendrobium suppository, freeze-dried fresh dendrobium powder and freeze-dried fresh dendrobium powder alcohol precipitate composition are used as raw materials, and borneol and semi-synthetic fatty glyceride are added to prepare the dendrobium suppository. Compared with conventional dried dendrobium nobile powder, the composition prepared by selecting the combination of the freeze-dried fresh dendrobium nobile powder and adding the freeze-dried fresh dendrobium nobile powder alcohol precipitate can not only improve the content of active ingredients in a finished product, but also obtain higher activity, and can also solve the process problem of non-uniform dispersibility caused by independent use of the alcohol precipitate in the processing process. Therefore, when the composition prepared from the freeze-dried fresh dendrobium nobile powder and the freeze-dried fresh dendrobium nobile powder alcohol precipitate is added into products of various dosage forms, the polysaccharide content and activity are improved, and the process problem is solved.

The invention provides an anus suppository for treating prostatitis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating prostatitis comprises an outer-layer sleeve and suppository contents, wherein the suppository contents comprise a heat-clearing and inflammation-diminishing layer, a warming, dredging and blood-activating layer and a qi-tonifying and kidney-tonifying layer which are sequentially distributed from outside to an inner core, and at least part of the suppository contents are wrapped by the outer-layer sleeve. The outer-layer sleeve prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the suppository is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The suppository emulsifier includes a pretreatment pot, an emulsifier body, and a transfer tank. The pretreatment pot and the emulsifier body are connected via a vacuum feed pipe. A rotor pump is installed between the emulsifier body and the transfer tank, and a discharge pipe is installed between the emulsifier body and the rotor pump. The discharge pipe is covered with an insulation layer. The bottom of the transfer tank has a conical structure, which improves discharge efficiency and ensures thorough discharge for convenient subsequent packaging. The device also includes a hot water pot, with a cleaning pump connected to one side of its outlet. The cleaning pump is connected to the pretreatment pot, the emulsifier body, and the transfer tank via cleaning pipes, facilitating cleaning of these components. This solves the problem of uneven cleaning in existing systems, which results in incomplete removal of internal impurities. It reduces manual cleaning labor, increases user efficiency, and reduces user working time.

A method for the treatment of thromboembolism comprising administering a thrombolytic agent directly to the thromboembolism in the presence of ultrasound. The total dose of thrombolytic agent administered is between 1 and 12 mg and the time over which the total dose is delivered is less than 15 hours.

The application belongs to the field of medicine, and particularly relates to a traditional Chinese medicine compound suppository for treating diabetic nephropathy and a preparation method thereof. The traditional Chinese medicine compound for treating diabetic nephropathy comprises the following components in parts by weight: 15-30 parts of verbena, 30-60 parts of astragalus, 10-20 parts of siler, 10-20 parts of notopterygium, 15-60 parts of caulis spathulatae, 15-60 parts of giant knotweed, 10-30 parts of yizhi, 15-30 parts of acer truncatum batal, 15-30 parts of pteridium aquilinum, and 3-10 parts of borneol. The compound liver portal suppository prepared from the traditional Chinese medicine compound can treat the root and the branch, can significantly improve kidney function, can improve various clinical indexes of patients with diabetic nephropathy, and has a significant treatment effect.

The application provides a ibuprofen suppository, a preparation method and application thereof, and belongs to the technical field of medicines. The application overcomes the defects of slow effect, easy leakage and low bioavailability of traditional suppositories. The suppository is a hollow suppository, which comprises a shell layer and content filled in a hollow cavity of the shell layer; the shell layer is composed of a water-soluble base and a bioadhesive material, the water-soluble base is a mixture of PEG 400 and PEG 1000 ; the content contains ibuprofen active ingredients and an absorption promoter; the content is in the form of a solid powder, when the suppository enters the rectum, the shell layer dissolves and adheres to the rectal mucosa, and the content is directly exposed to the rectal body fluid in the form of a solid powder and is quickly dissolved. The application is particularly suitable for children's antipyretic and analgesic drug preparation, and has the advantages of rapid effect, accurate dosage and good compliance.

1. The name of the design product: packing box (suppository). 2. The use of the design product: used for packing and containing suppository medicine. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo best indicating the design points: perspective view 1.

The invention relates to the field of natural product chemistry, sugar chemistry and biological medicine, and particularly provides glycosaminoglycan and / or a series of derivatives thereof as well as a preparation method and application of the glycosaminoglycan and / or the series of derivatives thereof, the glycosaminoglycan is extracted from starfish glabrata, and the preparation method comprises the following steps: extracting by adopting a papain combined alkaline hydrolysis method; the invention discloses an ALHX-2M series derivative and application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases, and the ALHX-2M series derivative is obtained by performing separation and purification through ion exchange column chromatography and molecular exclusion column chromatography to obtain ALHX-2M, and further performing deacetylation, deamination and depolymerization treatment and gel column chromatography separation and purification on the ALHX-2M series derivative and the application of the ALHX-2M series derivative in prevention or treatment of thrombotic diseases. The glycosaminoglycan and the derivative thereof take an endogenous blood coagulation factor X enzyme complex (FXase) as an action target, the anticoagulation activity and the antithrombotic activity of the glycosaminoglycan and the derivative thereof are superior to those of low-molecular-weight heparin, the bleeding risk under the equivalent antithrombotic dosage is remarkably reduced, and the glycosaminoglycan and the derivative thereof can be used for medicines or functional foods for preventing and treating thrombotic cardiovascular and cerebrovascular diseases.

The utility model relates to the technical field of suppository packaging, and discloses an anti-pollution suppository packaging device which comprises a working supporting table, and a packaging supporting frame, a barrier film layer supporting frame, a heat insulation film layer supporting frame, a drying and sterilizing support and a cleaning and disinfecting support are arranged on the top face of the working supporting table from right to left. A rotary supporting frame is arranged on the left side of the top face of the working supporting table, a conveying driving motor is arranged on the left side of the top face of the working supporting table, a conveying assembly is arranged at the output end of the conveying driving motor, and a cleaning and disinfecting assembly, a drying assembly, a film covering assembly and a packaging assembly are arranged on the top face of the working supporting table from left to right. Through the design of the cleaning and disinfecting assembly and the drying and sterilizing assembly, a packaging shell of a suppository is cleaned and disinfected, the packaging shell is prevented from being polluted to affect the quality and safety of medicine, and a heat insulation layer and a blocking layer are sprayed on the packaging shell, so that new packages of the suppository are stored more conveniently.

The present disclosure relates to the technical field of herbal extraction and preparation, and particularly to a method for extraction and preparation of an anti-inflammatory ovary-protecting herb. The method comprises an internal drug and an external drug, wherein the external drug comprises 86 g of Sophora flavescens, 182 g of Fructus cnidii, 66 g of Phellodendron amurense, 146 g of Rhizoma atractylodis, 76 g of Capillary artemisia, matrix S-40, sodium dihydrogen phosphate and polysorbitol-80. The Sophora flavescens and Fructus cnidii in the external drug of the present disclosure have the functions of clearing heat and dampness, dispelling wind, killing insects and relieving itching. Through scientific extraction, the Sophora flavescens and Fructus cnidii combined with adjuvant medicinal materials such as Phellodendron amurense, Rhizoma atractylodis and Capillary artemisia are prepared into an effervescent suppository.

The invention discloses a GlcNAc suppository for preventing colorectal cancer and a preparation method of the GlcNAc suppository, and belongs to the technical field of medicines. The GlcNAc suppository can obviously inhibit and reduce the sizes of colorectal cancer tumors and polyps, and the prevention and treatment effect of the GlcNAc suppository is better than that of a galactose suppository; meanwhile, the suppository is used for administration, so that the medicine can directly act on tumors, and the bioavailability is high. Moreover, compared with other formula suppositories for colorectal cancer, the GlcNAc used in the suppository disclosed by the invention is good in safety as glucosamine, and experiments prove that the GlcNAc basically has no adverse reaction after being used for a long time, is higher in safety and has less influence on the living quality of patients with colorectal cancer.

The invention discloses a nitrogenous aromatic fused ring compound as shown in a general formula I as well as a preparation method and application thereof, belongs to the technical field of medicinal chemistry, and particularly relates to application of the compound or pharmaceutically acceptable salt thereof as an HDAC6 inhibitor in the aspect of resisting idiopathic pulmonary fibrosis. The invention also relates to a pharmaceutical composition taking the compounds and pharmaceutically acceptable salts thereof as active ingredients. The invention also relates to a pharmaceutical preparation containing at least one of the compounds or salts thereof. The dosage form of the pharmaceutical preparation is selected from one or more of tablets, capsules, injections, suppositories, patches, inhalable powder preparations, suspensions, emulsions or ointments.

The invention provides a traditional Chinese medicine compound suppository for treating endometritis of livestock and a preparation method of the traditional Chinese medicine compound suppository, and relates to the technical field of veterinary drugs. The traditional Chinese medicine compound suppository consists of povidone iodine, a traditional Chinese medicine composition and a slow-release high polymer material matrix carrier, wherein the traditional Chinese medicine composition is prepared from thirteen traditional Chinese medicine components including philippine flemingia root, common andrographis herb, zanthoxylum dissitum, Chinese angelica, suberect spatholobus stem, motherwort herb, baical skullcap root, honeysuckle flower, weeping forsythia capsule, white paeony root, nutgrass galingale rhizome, heartleaf houttuynia herb and swordlike atractylodes rhizome. Besides the matrix carrier, the traditional Chinese medicine compound suppository only contains povidone iodine and traditional Chinese medicine composition components, the content of the povidone iodine component is low, and side effects are reduced. The traditional Chinese medicine compound suppository is non-toxic, small in irritation to vaginal mucosa of livestock, high in effective rate of treating endometritis of the livestock and good in anti-inflammatory effect. In the preparation process of the traditional Chinese medicine compound suppository, no organic solvent is used, pollution to the environment is avoided, and the preparation process is simple, convenient and easy to implement and low in cost.

The invention discloses a curcumin suppository as well as a preparation method and application thereof, belongs to the technical field of drug-loaded nano-micelles, and particularly relates to a preparation method of the curcumin suppository. The preparation method specifically comprises the following steps: heating curcumin and polyethylene glycol at a high temperature, carrying out vortex oscillation until a clear solution is formed, adding Tween, uniformly mixing to obtain a dark brown clear liquid, pouring the dark brown clear liquid into a suppository mold, cooling, and demolding to obtain the curcumin suppository. The curcumin suppository prepared by the invention has high drug loading rate and excellent cancer cell inhibition effect, and the bioavailability and efficacy of curcumin are greatly improved.

The utility model relates to the technical field of pharmaceutical engineering, and discloses a homogenizing and mixing machine for suppositories, which comprises a homogenizing and stirring tank arranged on a table board; the connecting structure comprises a first connecting part and a second connecting part, the first connecting part comprises a top plate fixedly mounted at the top of the homogeneous stirring tank, two groups of first clamping grooves are formed in the top of the top plate, a cover plate is arranged at the top of the homogeneous stirring tank, and two groups of clamping plates are fixedly mounted on the outer wall of the cover plate; the clamping plate is mounted in the first clamping groove in a clamping manner; the second connecting part further comprises two sets of first threaded grooves formed in the top plate, two sets of second threaded grooves are formed in the cover plate, and the second connecting part further comprises limiting bolts arranged in the second threaded grooves, so that the purpose of quickly disassembling and assembling the device is achieved, the use flexibility of the device is improved, and the device is convenient to disassemble and clean; the internal cleaning effect of the device is improved, and the use stability of the device is improved.

A rectal suppository is described. The rectal suppository contains 6-thioguanine, at least one stearin and at least one surfactant. Further or optionally, the rectal suppository comprises from about 1 mg to 9 mg of 6-thioguanine. Further or optionally, the present invention describes methods of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to a subject in need thereof. Further or optionally, the present invention describes a method of making a rectal suppository. The present invention relates to a process for preparing a rectal suppository comprising the steps of (a) heating stearin to become liquid stearin, (b) adding at least one surfactant to the liquid stearin, (c) adding 6-thioguanine to the liquid stearin, (d) shaping stearin into a rectal suppository. The step (b) is optionally performed before or after the step (c).