5 results about "Rectal Suppository" patented technology

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

A rectal suppository is described. The rectal suppository contains 6-thioguanine, at least one stearin and at least one surfactant. Further or optionally, the rectal suppository comprises from about 1 mg to 9 mg of 6-thioguanine. Further or optionally, the present invention describes methods of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to a subject in need thereof. Further or optionally, the present invention describes a method of making a rectal suppository. The present invention relates to a process for preparing a rectal suppository comprising the steps of (a) heating stearin to become liquid stearin, (b) adding at least one surfactant to the liquid stearin, (c) adding 6-thioguanine to the liquid stearin, (d) shaping stearin into a rectal suppository. The step (b) is optionally performed before or after the step (c).

The invention relates to the field of pharmaceutics and medicine, namely, to a new dosage form of cortexin, rectal suppositories, capable of normalizing brain functions and characterized by efficacy and safety comparable to an injectable form. The invention also relates to a rectal cortexin composition in a suppository form, the composition comprising cortexin in a pharmacologically effective amount and a suppository base.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).