37 results about "Intravascular injection" patented technology

Hypertonic sugar compositions administered by other than ingestion and swallowing or intravascular injection, such as by intranasal spray or drops, intraocular drops or ointment, oral spray, intraotic spray or drops, lozenges, chewable tablet, chewing gum, or gargle, pulmonary inhalation, vaginal or rectal suppositories, or transdermal creams, ointments, lotions, or patches, are effective to open the blood-brain barrier to permit entry into the central nervous system of a co-administered chemical compound, such as a nutrient or a therapeutic or diagnostic agent. In this way, the compositions and methods of the invention increase the therapeutic or diagnostic efficacy of such chemical compounds.

The present invention relates to an imaging method with an OCT catheter for visualizing molecular functional processes in vulnerable plaques of a blood vessel of the blood vessel system of a patient, with OCT images of the contrast medium-marked vulnerable plaque being generated during continuously controlled movement of the light-emitting and light-absorbing OCT catheter head along the vulnerable plaque after the intravascular injection of a contrast medium into the blood vessel system and after the intravascular insertion of an imaging OCT catheter into the blood vessel comprising the vulnerable plaque.

A novel sharp needle with an at least partially occluded, closed distal and at least one side port and related methods is disclosed. Various embodiments of needles of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The present invention discloses one medicinal polymer (PELGE / PELGA) nanometer particle carrier and its preparation process and use. The carrier material is PELGE material of different molecular weights, different LA / GA ratios and different PEG contents, and the nanometer PELGE / PELGA carrier particle is prepared through evaporation process. The said copolymer is self-assembled in water into nanometer particle or micelle, and its hydrophobic PLGA segment coagulates into the core while the hydrophilic polyglycol forms hydrophilic shell. The carrier may be used for the nanometer preparation of plasmid, nucleic acid vaccine, antisense oligodeoxynucleotide or ribozyme for genetic treatment; the nanometer preparation of various chemical medicines; and the nanometer preparation of polypeptide and protein medicines.

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The invention relates to an amphiphilic polysaccharide derivative carrier for targeting tumor new blood vessels. According to the derivative, a polysaccharide skeleton is coupled with functional polypeptide targeting E-selectin by virtue of a disulfide bond to ensure that polysaccharide has amphipathy, and is assembled into nano particles for targeting the tumor new blood vessels after carrying an antitumor drug or a tumor new blood vessel inhibitor in an aqueous medium. The nano particles deliver medicines to the tumor new blood vessels in an active targeting manner by virtue of the high affinity between the functional polypeptide targeting the E-selectin and the E-selectin on the surface of the tumor new blood vessels, then a disulfide bond connecting arm can be specifically degraded by a strong reducing environment in endothelial cells of the tumor new blood vessels to cause that the functional polypeptide targeting the E-selectin is separated from polysaccharide, and the medicines are quickly released to treatment target points, so that the concentration of free medicines at tumor new blood vessel parts can be significantly improved and the antitumor curative effect is enhanced. An auxiliary material can be used as a carrier for water-insoluble, indissolvable or amphiphilic antitumor drugs and the tumor new blood vessel inhibitor, and is administrated by injecting into blood vessels or muscles, or is administrated orally or externally. The amphiphilic polysaccharide derivative carrier provided by the invention is simple in preparation method, mature in process and suitable for large-scale production.

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using γ-tocotrienol, α-tocopherol succinate or γ-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of γ-tocotrienol; or (2) oral administration of a therapeutically effective amount of α-tocopherol succinate or γ-tocotrienol succinate or both.

A cardiovascular intervention device comprises an outer tube body. An inner tube body is arranged in the outer tube body. A first through hole is formed in the middle of the top face of the inner tubebody. A second through hole is formed in the middle of the top face of the outer tube body. A guide tube is arranged in the first through hole. The side face of the guide tube makes close contact with and is matched with the first through hole. The upper end of the guide tube penetrates through the second through hole and is then located at the upper portion of the upper end of the outer tube body. The position, close to the lower end, of the side of the guide tube fixedly sleeves an annular first rubber plug. The outer ring of the first rubber ring makes contact with and is matched with theinner wall of the inner tube body. The cardiovascular intervention device is simple and ingenious in structure, the cleanliness of the operation surface during cardiovascular intervention treatment can be ensured, cross infection is avoided, required medicines can be conveniently injected into blood vessels of the patient in the treatment process, the medicines can be prevented from making contactwith outflow blood when injected, the injection safety and sanitation are ensured, and the cardiovascular intervention device is convenient to use and can be repeatedly used.

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The invention discloses internal-circulation-air-demisting safety goggles and a circulating air supply device thereof. The internal-circulation-air-demisting safety goggles are composed of circulating-oxygen-supply demisting goggles, a goggle air inlet pipe, a circulating air supply device and a goggle air outlet pipe. Air in the goggles can be better circulated by employing the circulating air supply device, and eyeglasses are demisted by using circulating air; due to an arranged recirculating blower, a circulating-oxygen-supply negative-pressure chamber generates negative pressure to achieveair internal-circulation of the goggles, fresh air can be better supplemented from an oxygen supplementation isolating hole to improve air quality of the safety goggles; and the problem that mist isgenerated when medical personnel employ medical safety goggles during fine work such as surgical operation and intravascular injection is better solved, meanwhile, an air environment of eye regions when the medical personnel employ the safety goggles is better improved, and trying feeling of eyes is relieved.

The invention relates to a reduction-sensitive anti-tumor chitosan derivative gene carrier, which is characterized in that a compound, which is rich in amino groups, is introduced to a chitosan skeleton by virtue of a specifically degradable truss arm which contains a disulfide bond; under the action of electrostatic adsorption, negatively charged siRNA is tightly compressed, so that nanoparticles are formed, and the nanoparticles can escape from the interior of an endosome through a proton sponge effect; and after the nanoparticles reach cytoplasm, the disulfide bond truss arm can be specifically degraded by a high-concentration reducing substance, namely glutathione, in focus cells, and the loaded siRNA is rapidly released and acts on a target, so that the silencing effect of a gene medicine is obviously improved. The adjuvant material, when applied to such administration modes as intravascular injection, intramuscular injection, external application, oral administration and the like as the gene carrier, is high in safety. The preparation method disclosed by the invention is simple and mature in process, and the preparation method is suitable for continuous large-scale production.

The present invention relates to a radial shape of a polymer compound containing iodine capable of being used as an active ingredient of a CT contrast medium, a preparation method thereof, and a contrast medium composition containing the same. According to the present invention, the radial shape of the polymer compound containing iodine has a remarkably enhanced contrast effect retention time compared with a conventional low molecular weight contrast medium compound containing iodine. In addition, the polymer compound containing iodine forms a protective film by encompassing a compound containing iodine substituted near the surface of a central nucleus, which leaves room for causing various kinds of abnormal reactions with toxicity, with a relatively long biocompatible polymer chain layer, thereby preventing the exposure thereof to external environments to reduce in vivo toxicity, preventing the rapid absorption due to a macrophage to extend in vivo circulation time, and allowing the polymer compound containing iodine to be discharged from the body after an adequate time has passed since an in vivo injection. Further, the preparation method and the purification method of the polymer compound containing iodine are very simple, thereby enabling mass production in a high yield and at low costs, the polydispersity is very low, thereby providing high reproducibility in the preparation and effects, and all of the structures of the prepared radial shape of the polymer compound containing iodine comprise a covalent bond, thereby being structurally very stable, and thus the polymer compound containing iodine can be useful for the preparation of a CT contrast medium.

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The invention discloses an ethanol hardener and application thereof. A pharmaceutical composition provided by the invention contains ethanol, a water-soluble iodine preparation and water for injection, wherein the volume percent of the ethanol is 76 to 98%; a mass volume ratio of the water-soluble iodine preparation to the composition is 50-300g / L; a mass volume ratio of the iodine element in thewater-soluble iodine preparation to the composition is 23-139 g / L; and the water for injection is a balancing component. The pharmaceutical composition provided by the invention can be self-developedduring intravascular injection and has good embolism effect and stability.

The present invention relates to methods for delivering a genetic immunogen, comprising a nucleic acid capable of expressing an antigen, optionally complexed with a polymer. The nucleic acid is delivered to the host via hydrodynamic intravascular injection resulting in expression of an encoded antigen in extravascular cells and induction of an antigen-specific immune response.

The invention provides a polyion composition micelle medicine carrying material. In the material, the molecular weight of the polymer is controllable, thus the size, the medicine carrying quantity and the medicine releasing speed of the micelle are controllable, so that the invention provides a base for the research in medicine controlled-release carriers. The medicine carrying material is graft copolymer polyethylene glycol-graft-poly radix asparagi hydrazide formed by modifying radix asparagi hydrazide through single methyl ether polyethylene glycol (see the structural formula); in the structure of the polyethylene glycol-graft-poly radix asparagi hydrazide, n plus m is between 200 and 400. The whole preparation process of the micelle is very simple and easy for mass production. The polyion composition micelle medicine carrying material can be applied to the preparation of polyion composition micelles used for the intravascular injection or the intramuscular injection of albumen polypeptide drugs or nucleic acid drugs with negative charges.

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural / intravascular injection, reduced incidence of injury through pricking / piercing, and / or the like.

The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using γ-tocotrienol, α-tocopherol succinate or γ-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of γ-tocotrienol; or (2) oral administration of a therapeutically effective amount of α-tocopherol succinate or γ-tocotrienol succinate or both.

The invention discloses an intelligent magnetic-push automatic injector inserting mechanism. The intelligent magnetic-push automatic injector inserting mechanism comprises a driving device, a direction adjusting device and a needle ejecting device, wherein the driving end of the driving device is provided with the direction adjusting device, the driving end of the direction adjusting device is provided with the needle ejecting device, and the driving device, the direction adjusting device and the needle ejecting device are all controlled by a controller to carry out data communication with a cloud center; and the driving device drives the needle ejecting device to move in an arc way at a certain angle around limbs through the direction adjusting device so as to find the most suitable needle inserting position, and the direction adjusting device drives the needle ejecting device to carry out a certain angle adjustment so as to find the best needle inserting angle. Compared with the prior art, the intelligent magnetic-push automatic injector inserting mechanism is easy to carry, capable of being adjusted according to the position of a blood vessel of a limb to be injected, particularly suitable for needs to solve problems that it is difficult to find the blood vessel by visual inspection and it is not easy to carry out an artificial intravascular injection operation and capable of being used as an edge part of the medical Internet of things and being used for occasions of comprehensive medical diagnosis and treatment of the Internet of things.

The present invention is proposed to provide one kind of safe injection and hemospasia utensil with simple operation and no blood contamination. The injection and hemospasia utensil includes cylinder, needle assembly fixed to one end of the cylinder, push rod sliding inside the cylinder, connecting part sliding in one end of the cylinder and duct connected to the connecting part. The connecting part includes one connecting seat with the first branch channel penetrating the flow channel axially and extending radially to connect the flow channel; and the duct fixed to the connecting seat is one hollow tube and may be retained inside blood vessel for injecting to and drawing out blood from blood vessel.

The invention discloses the application of Toll-like receptor 4 agonist CRX-675 in resisting pulmonary fibrosis. The inventor found through systematic research that for C57BL / 6 mice, the pulmonary fibrosis model was caused by intratracheal injection of bleomycin (3U / Kg). After 7 days of modeling, intraperitoneal injection of CRX-675 (10mg / kg / day) to the 21st day; through histopathological and biochemical detection methods, it was found that activating the TLR4 signaling pathway can significantly reduce the mortality of bleomycin-infused mice; activating the TLR4 signaling pathway can significantly reduce the lung inflammation induced by bleomycin and damage, reduce bleomycin-induced pulmonary fibrosis, including reducing lung collagen deposition, hydroxyproline content and expression of α-SMA, and improve lung function in mice with pulmonary fibrosis.

The invention discloses an interventional assisted surgical robot, which comprises: a connection shell used to connect with an interventional robot mechanical arm located outside it, and at the same time serve as a reference plane to support and fix other components of the interventional assisted surgical robot; a pressure pump end, a pressure The pump end is used to fix the pressure pump and pressurize and decompress the pressure pump; the syringe end, the syringe end is used to fix the syringe and push the syringe to inject the corresponding medicine into the blood vessel; the clamping end, the clamping end is used to fix the guide wire , so that the position of the guide wire remains unchanged during the necessary links in the operation. The whole device of the present invention is used with common consumables, that is, with consumables such as medical pressure pump, interventional contrast agent injector and guide wire to complete the operation together. Through the operating handle outside the operating room, the doctor can control the push rod of the auxiliary robot to inject contrast agent, pressurize and decompress the pressure pump, and assist in clamping the guide wire and other operations.

The invention discloses a multifunctional nerve blocking puncture needle which comprises a needle tube and a needle head located at the front end of the needle tube. A support is connected to the tail end of the needle tube. A channel communicated with an inner cavity of the needle tube is formed inside the support. The support is sleeved with an elastic pressing body. A local anesthetic is contained between the elastic pressing body and the outer wall of the support. A hole for guiding the local anesthetic into the channel is formed in the support. During puncture, the local anesthetic is squeezed into the channel by pressing the elastic pressing body through fingers, and the negative pressure effect is formed between the elastic pressing body and the support after the fingers are loosened. If the needle head is punctured into a blood vessel, blood inside the blood vessel flows into the elastic pressing body so that judgment can be performed conveniently by medical workers, injection into the blood vessel is avoided, and therefore safety needed before injection can be ensured. The multifunctional nerve blocking puncture needle can be applied to nerve blocking puncture.

The discovery that contrast in blood vessels varies at cardiac frequency in magnitude and phase enables a set of processes for increasing the signal to noise ratio or equivalently the informational content of an angiogram. In this invention, the organization of cardiac frequency magnitude and phase enables equivalent information on anatomy and physiology to be obtained with less dose of injected chemical contrast agent, less x-ray dose, and / or less navigation of the injecting catheter within blood vessels. The cardiac frequency magnitude and phase is organized so that the arterial and venous subsystems of circulation have coherence at cardiac frequency. This enables processes for diagnosing deficits of circulation that involve alterations in the transit of blood from the arterial to the venous subsystems of circulation. Furthermore, the discovery of cardiac frequency magnitude and phase organization enables the design and manufacture of lighter and more portable angiography equipment.