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Ethanol hardener and application thereof

A technology of ethanol and iodine preparations, which is applied in the direction of active ingredients of iodine compounds, preparation of X-ray contrast agents, active ingredients of hydroxyl compounds, etc., which can solve problems such as unsatisfactory efficacy of ethanol sclerosing agents and inability to accurately trace ethanol

Active Publication Date: 2020-10-30
李学义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention provides an ethanol hardener and its application in order to overcome the defects of the unsatisfactory drug effect of the ethanol hardener in the prior art and the inability to accurately trace the ethanol

Method used

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  • Ethanol hardener and application thereof
  • Ethanol hardener and application thereof
  • Ethanol hardener and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The composition and content of each 1000ml of hardener are as follows, wherein the mass of iodine element per 1000ml of hardener is 93g;

[0056]

[0057] Preparation method: Add 200g of iohexol into the ethanol solution, and when stirring continuously, slowly add the prescribed amount of water for injection to obtain a transparent and clear solution, which is divided into glass ampoules, sealed, and sterilized at 121°C for 15 minutes. have to.

Embodiment 2

[0059] The composition and content of each 1000ml hardening agent are as follows, wherein the mass of iodine element per 1000ml hardening agent is 71g;

[0060]

[0061] The preparation method is the same as in Example 1.

Embodiment 3

[0063] The composition and content of each 1000ml hardening agent are as follows, wherein the mass of iodine element per 1000ml hardening agent is 49g;

[0064]

[0065]

[0066] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses an ethanol hardener and application thereof. A pharmaceutical composition provided by the invention contains ethanol, a water-soluble iodine preparation and water for injection, wherein the volume percent of the ethanol is 76 to 98%; a mass volume ratio of the water-soluble iodine preparation to the composition is 50-300g / L; a mass volume ratio of the iodine element in thewater-soluble iodine preparation to the composition is 23-139 g / L; and the water for injection is a balancing component. The pharmaceutical composition provided by the invention can be self-developedduring intravascular injection and has good embolism effect and stability.

Description

technical field [0001] The invention relates to an ethanol hardening agent and its application. Background technique [0002] Vascular malformation, also known as hemangioma in the past, is a tumor or malformation derived from blood vessels or lymphatic vessels. The pathogenesis of vascular malformations is still unclear, and the clinical manifestations are ever-changing. They can occur in superficial, deep tissues, and even internal organs. In the past, the treatment was usually through ligation of the supplying artery or surgical resection. Even aggravated, and the risk of bleeding is high. [0003] With the development of interventional radiology in recent years, sclerosing agents have become the first choice for the treatment of vascular malformations. Sclerosing agents can effectively treat vascular malformations and varicose veins. The mechanism of action is mainly to cause damage to vascular endothelial cells through different ways, so that the target blood vessels ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/045A61K9/08A61P35/00A61P9/00
CPCA61K9/08A61K9/0019A61K31/167A61K31/045A61P35/00A61P9/00A61K2300/00A61K49/04A61K33/18A61P9/14Y02A50/30
Inventor 李学义
Owner 李学义
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