Medicine-carrying nanometer polymer particle and its prepn and use

A polymer material and drug-loaded nanotechnology, which is applied in the field of new polymer material drug-loaded nanoparticles and their preparation methods and uses, can solve the problems of ineffective reach of target tissues and poor stability of liposome carriers
CN1608675AInactive Publication Date: 2005-04-27SICHUAN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2005-04-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses one medicinal polymer (PELGE / PELGA) nanometer particle carrier and its preparation process and use. The carrier material is PELGE material of different molecular weights, different LA / GA ratios and different PEG contents, and the nanometer PELGE / PELGA carrier particle is prepared through evaporation process. The said copolymer is self-assembled in water into nanometer particle or micelle, and its hydrophobic PLGA segment coagulates into the core while the hydrophilic polyglycol forms hydrophilic shell. The carrier may be used for the nanometer preparation of plasmid, nucleic acid vaccine, antisense oligodeoxynucleotide or ribozyme for genetic treatment; the nanometer preparation of various chemical medicines; and the nanometer preparation of polypeptide and protein medicines.
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Description

technical field

[0001] The invention relates to a novel pharmaceutical polymer material drug-loaded nanoparticle, a preparation method and an application. The preparation method of the drug-loaded nanoparticles is an emulsification-evaporation method. In particular, the polymer material PELGE / PELGA is used as the carrier material to wrap therapeutic genes such as pORF IL-12 plasmids or chemical drugs such as mitoxantrone hydrochloride (DHAQ) or doxorubicin (ADR) or peptides, protein drugs such as thymopentin, The PELGE / PELGA nanoparticles are prepared under the action of mechanical stirring or a high-pressure homogenizer. Background technique

[0002] General biodegradable polymer nanoparticle carrier materials include natural and synthetic types, serum albumin, hemoglobin, collagen, gelatin, dextran, albumin, chitin and its derivatives, lecithin, cholesterol Natural biodegradable polymer materials such as biocompatibility are good, but the prepara...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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