6 results about "Thymopentin" patented technology

The invention provides application of combined use of thymopentin, salinomycin and IR780 iodide in preparation of a medicine for treating and inhibiting tumor dryness. The invention also provides a pharmaceutical composition for inhibiting tumor dryness. The invention relates to an endoplasmic reticulum stress nano inducer (DTSS) based on salinomycin, which is used for synergistically inhibiting the dryness of cancer cells and effectively sensitizing cancer immunotherapy. The endoplasmic reticulum targeted phototherapy drug s-780 is prepared by coupling p-toluene sulfonamide and IR780 iodide (IR780), is assembled together with thymopentin and salinomycin, and is finally functionalized by biotin to obtain a delivery nano-platform (DTSS) at a specific site, so that systemic anti-tumor immune response can be effectively activated, metastasis and recurrence of cancers can be inhibited, and the application prospect is wide. And a promising solution is provided for sensitizing cancer immunotherapy by inhibiting cancer cell dryness.

The present disclosure provides porcine thymolivers, methods of making thereof, and methods of using thereof. The present disclosure further provides methods of treating a disease (e.g., a liver disease) in a human subject in need thereof comprising transplanting of a porcine thymoliver.

The goal of the therapy is to restore the balance of the immune system, rehabilitate patients with reduced immunity, and prolong the average age by maintaining immune activity by using Thymotridan (TP3 / tripeptide), the smallest active part of the thymus hormone Thymopoietin (49 amino acids). Synthetic TP3 appears with two peaks in a wide dose range. There are differences of several orders of magnitude between the two effects, which, separately or alone, provide the "enhancer" effect endogenously and result in the renewal of the immune system. Thymocartin (TP3) can be used for prevention or causal therapy by increasing the activity and number of lymphoid and myeloid cells. Thymocartin increases the activity of the immune system of healthy individuals or the elderly, and the lifespan extend. The role of TP3 is primarily to improve the balance of the system by promoting the maturation and increasing the activity of immune cells in patients with immunodeficiency (autoimmune, cancer) and by replacing helper and suppressor cells. Infection can be eliminated in juveniles due to their weaker immune activity by TP3 therapy.

The application discloses a kind of sea fish mycobacterium infection mouse model based on T cell immune state difference and its construction method and application.The method under unified infection condition (bacterial amount 1×10 4 CFU, temperature 25 DEG C, time 4 weeks), respectively, constructs the infection model of congenital T cell immune deficiency nude mouse and the thymus pentapeptide processing mouse model of acquired T cell immune regulation, by comparing and analyzing the infection phenotype and pathological changes under different immune states, for the mechanism of T cell immunity in non-tuberculous mycobacterium infection, screening immune regulation treatment drug provides standardized experimental model.

The invention discloses a preserving fluid for an umbilical cord mesenchymal stem cell preparation. The preserving fluid comprises 0.9% sodium chloride injection, human serum albumin and thymopentin for injection. The preserving fluid can stably preserve stem cells for 72 hours at the room temperature of 15-30 DEG C, and the cell viability is maintained to be 80% or above; meanwhile, the preserving fluid is simple in component, does not contain complex additives such as a pH buffering agent and an antioxidant, and is simple and convenient in preparation process and easy in cost control.

The invention relates to the technical field of molecular biology, in particular to a polypeptide with detoxification, anti-inflammatory and antioxidant functions and application thereof. The polypeptide comprises one of the following amino acid sequences: i) an amino acid sequence as shown in SEQ ID NO.1; and ii) an amino acid sequence which is obtained by substitution, insertion or deletion of one or more amino acids on the amino acid sequence as shown in SEQ ID NO.1 and has the same functional protein. The novel DTP hybrid peptide is obtained on the basis of a defensive peptide DEFB126 core functional region and thymopentin TP5 through protein engineering computer design, heterozygosis, optimization and in-vivo and in-vitro re-screening, and the DTP hybrid peptide has excellent anti-inflammatory and antioxidant activity, excellent anti-apoptosis and anti-liver injury activity, high stability and low cytotoxicity. The method can be widely applied to the fields of medicine, health care, food, veterinary medicine, feed and the like, and has extremely high application potential and value.