207results about How to "Biologically active and stable" patented technology

The present invention provides compositions and methods and for speeding the onset of drug action and reducing the first-pass effect drug metabolism in fast-dispersing drug formulations.

The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.

The invention relates to an aerobic denitrification methylobacterium phyllosphaerae strain and application thereof. The aerobic denitrification strain is methylobacterium phyllosphaerae SDN-3CGMCC No.3660. The strain can be used for carrying out aerobic denitrification by using nitrate nitrogen and can also be used for carrying out hetetrophic nitrification-aerobic denitrification by using ammonia nitrogen, under aerobic and limited-oxygen conditions. The strain is stable in genetic character, and can be used for realizing synchronous nitrification-denitrification and independently completingthe whole process of biological denitrification. The strain is used for treating various nitrogen-containing wastewater by needing only one aerobic stage, the process is simple and the denitrification efficiency is high.

The invention discloses a medlar and red date enzyme and a preparation method thereof, which belong to the technical field of enzyme preparation. Multi-strain composite fungi powder is adopted as a leavening agent; the medlar and the red date are adopted as main raw materials; dietary fiber, pectin hydrolyzate, seasoner extracting liquor, Chinese herbal medicine extracting liquor, enzyme stabilizer and other multifunctional auxiliary raw materials are scientifically compounded and modified; low-temperature processing technology such as ultrasonic cleaning, cryogenic grinding, microwave-assisted high-voltage pulse electric field processing and ultrasonic ripening are mainly adopted in the whole process, so that the natural colors, the flavor, the taste and the content of the active materials of the medlar and the red date are maintained furthest, the biological stability, the non-biological stability and the biological activity of the medlar and red date enzyme are obviously enhanced, the introduction of chemical addition agent is reduced, and the juicing rate of the medlar and the red date as well as the food safety of the enzyme are improved. Finally, the medlar and red date enzyme with high biological activity, strong stability, strong taste, flavor and appetite, long expiration date and edible safety is prepared.

The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.

The invention discloses a nutritional health food with the function of improving gastrointestinal function and a preparation method thereof. The nutritional health food can be used for regulating the intestinal flora to improve the gastrointestinal function from the aspects of increasing the probiotics type and quantity, increasing the probiotics nutrient substance, inhibiting the growth of harmful bacteria and enhancing the immunity of human body. According to the preparation method, probiotics powder such as lactobacillus plantarum is used as the main raw material, and edible fungi extracts and modified dietary fibers are scientifically compounded; saussurea involucrata culture extracts which are capable of remarkably enhancing the immunity of human body, resisting inflammatory and easing pain, and have the functions of oxidation resistance, radiation resistance and fatigue resistance are used, so that while the intestinal probiotics flora types is increased, the fix planting capacity of the endogenous probiotics and exogenous probiotics in the intestinal tracts of human body is remarkably enhanced, and fix planting time of the endogenous probiotics and exogenous probiotics in the intestinal tracts of human body is prolonged remarkably, the growth and reproduction of the harmful bacteria, particularly the Gram negative bacteria, in the intestinal tracts are effectively inhibited, the forming of the probiotic floras in the intestinal tracts is fully regulated and the nutritional health food which is good in probiotic property, capable of remarkably enhancing the immunity of human body and has the effect of improving the gastrointestinal function is prepared.

The invention discloses a liquorice vegetable drink for improving a gastrointestinal function and enhancing the immunity and a preparation method of the liquorice vegetable drink. Herb of liquorice is used as a main raw material; liquorice concentrated juice, an edible mushroom extract, wolfberry fruit concentrated juice, modified dietary fibers, a corn bee pollen extract, pectin hydrolyzate and the like are scientifically compounded; the raw materials are treated by adopting a modern low-temperature and biological extraction technology, so that the content of effective components of the raw materials is greatly increased; various functional components are organically mixed, so that the optimal synergistic effect is achieved; meanwhile, by adoption of methods for thermal hybrid concentration of unstable concentrated liquid, jointed removal of cold and heat, sterile filtration, and the like, the flavor of the liquorice vegetable drink is greatly enhanced, and the expiration date of a product is prolonged; the liquorice vegetable drink with the effects of improving the gastrointestinal function and enhancing the whole immunity of a human body is prepared.

The present invention discloses a watermelon juice probiotic fermented beverage and a preparation method thereof. The beverage preparation method uses watermelons as raw materials, scientifically blends prebiotic factors, does not add any essences and coloring matters, mainly uses low-temperature processing technology such as ultrasonic wave cleaning, high-pressure pulsed electric field treatment, biological enzymolysis, vacuum degassing, etc. in the whole process, replaces the existing heat sterilization and enzyme blunting technology, maintains the color and luster, flavor and mouth feel of the natural watermelon juice to a maximum degree, enhances the non-biological stability and biological stability of the watermelon juice, reduces the addition of chemical additives, increases the juice squeezing rate and food safety of the watermelon juice, and has a probiotic live bacteria content of 7 multiplied by 10^11 to 8 multiplied by 10^11 cfu / ml. The watermelon juice probiotic fermented beverage is environmentally friendly, can be processed into probiotic solid beverage and quantitatively packaged beverage which have natural taste, are nutritious and health-care, are convenient to drink, and have longer shelf lives, opens up a new way for watermelon deep processing and industrial development, and can achieve better economic and social benefits.

The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms. In various aspects, the invention provides compositions and methods for oral delivery of peptides containing non-naturally occurring structures including D-amino acids and / or chain cyclization.

The invention discloses a health food capable of improving intestinal floras and a preparation method of the health food. The intestinal floras are adjusted on a plurality of aspects of increasing the probiotics variety and quantity, adding probiotic nutrient substances, inhibiting the harmful bacterial growth and increasing the human immunity, so that the gastrointestinal functions are improved. With probiotic powder such as lactobacillus plantarum as a main raw material, an edible mushroom extract is scientifically compounded, and dietary fibers are modified, so that the human immunity can be significantly improved; a saussurea involucrate culture extract has the efficacies of resisting inflammation, relieving pain, and resisting oxidation, radiation and fatigue; the variety of the intestinal beneficial bacteria floras is increased; the field planting capacity of endogenous and exogenous probiotics in human intestinal tracts is significantly enhanced and the field planting time of endogenous and exogenous probiotics in human intestinal tracts is significantly prolonged; the growth and the reproduction of intestinal harmful bacteria, especially gram negative bacteria, are effectively inhibited; the components of the intestinal beneficial bacteria floras are fully adjusted; and the health food which is high in probiotic property, and is capable of significantly improving the human immunity and improving the intestinal floras is prepared.

The present invention relates to film on the surface of medical titanium-base metal material and its sand blasting-micro arc oxidizing compounding process. Through the first surface sand blasting treatment of titanium or titanium alloy material and the subsequent micro arc oxidizing in electrolyte solution containing phosphate radical ion and calcium ion and with the titanium or titanium alloy material as anode, stainless steel or titanium as cathode and DC power source or DC pulse power source, one bioactive film is in-situ formed on the surface of the titanium or titanium alloy material. The bioactive film of rough porous hydroxyapatite has surface roughness Ra of 2-4.5 micron, no interface with the substrate, elastic modulus reaching that of bone and excellent bioactivity, and may be used as the substitute for femur, hip joint, tooth root, etc. The bioactive film has optimized combination strength, stability and bioactivity.

The invention discloses a bacterial cellulose / collagen-chitosan composite material and a preparation method thereof. The method comprises the following steps of: 1) preparing bacterial cellulose and purifying the prepared bacterial cellulose; 2) fully immersing collagen into a bacterial cellulose network by a negative-pressure osmose process or a positive-pressure method, and crosslinking collagen in the bacterial cellulose / collagen composite material by using a cross-linking agent to obtain a bacterial cellulose / collagen interpenetration network composite material; and 3) removing the unreacted cross-linking agent from the composite material, and soaking in an antibacterial agent solution of chitosan or the derivative of chitosan to prepare the composite material with an antibacterial effect. The bacterial cellulose / collagen composite material is prepared by the negative-pressure method or the positive-pressure method, so that the defect of insufficient immersing amount of collagen in other preparation methods is overcome, and the problems of poor effect, long production cycle and high cost are solved; and the prepared composite material is excellent in mechanical property, high in water permeability, high in air permeability, high in biocompatibility, high in biological activity and high in antibacterial property.

The invention discloses a probiotics troche and a preparation method thereof. Functional leavening agents and germinated brown rice, Chinese herb medicine extract with anti-cold and hot irritability and a stabilizer capable of effectively enhancing the stability are added into a yoghourt fermenting process; poikilothermal yogurt fermentation enables proliferation of lactic acid bacteria to the maximum extent, so that the anti-cold and hot irritability of lactic acid bacteria is improved. yogurt and fruit and vegetable slurry are pre-treated by using a non-hot-working technology so as to prevent infectious microbe infection in the process, improve the juice yield of the fruit and vegetable slurry, increase the content of soluble cellulose of the fruit and vegetable slurry and prevent the fruit and vegetable slurry from brown stain. Moreover, when the fruit and vegetable slurry and the yogurt are mixed, a scientifically compounded freezing protecting agent which is relatively good in anti-freezing effect is added. Finally, the probiotics troche which is smooth in taste, uniform in texture, stable in state, natural in quality, high in viable count, strong in functionality and long in expiration data is prepared. The viable count is (1.75-2.55)x10<11> CFU / g. At normal temperature, the expiration data is 30-36 months.

The invention discloses a feed for promoting the reproductive performance and used in the earlier stage of a peak laying period, belonging to the technical field of feed composition. Plant extracts, corn bee pollen extract, Chinese herb extracts, modified dietary fiber, prebiotics factors and the like are scientifically compounded in the laying hen feed used in the earlier stage of a peak laying period and thus the feed for promoting the reproductive performance is prepared; through feeding experiment, the feed disclosed by the invention and the commercially available feed used in the peak laying period respectively have the following beneficial effects: the length of the fallopian tube of the laying hen is 6.82cm and 4.62cm respectively, the weight of the fallopian tube is improved by 11.49g and 7.46g respectively, the weight of ovary is improved by 6.08g and 4.17g respectively, the laying rate is improved by 2.07% and 2.15% respectively, the egg yield is improved by 2.73g and 1.92g respectively, the shank length is 7mm and 5mm respectively, the weight is improved by 0.07kg and 0.05kg respectively and the survival rate is improved by 2.4% and 3.2% respectively; the laying hen has strong reproductive performance, strong production performance, strong immunity resistance and disease resistance.

The invention discloses a probiotic-containing health food and a preparation method thereof, wherein intestinal florae are adjusted in many aspects of increasing the types and quantity of probiotics, increasing the nutrient substances of the probiotics, inhibiting the growth of harmful fungi, enhancing human immunity and the like, so as to improve gastrointestinal functions. Probiotic powders of lactobacillus plantarum and the like are taken as main raw materials, and edible fungi extract, modified dietary fibres, a saussurea involucrata culture extract capable of remarkably enhancing the human immunity, resisting inflammation and easing pain and having anti-oxidization, anti-radiation, anti-fatigue functions and the like are scientifically compounded, and then the planting capacity and the planting time of endogenous and exogenous probiotics in human intestinal tracts are remarkably improved and prolonged, the growth and reproduction of intestinal harmful fungi, especially, Gram-negative bacterium, are effectively inhibited, and the composition of intestinal probiotic florae is adequately regulated while the types of the intestinal probiotic florae are increased; therefore, a health food with high probiotic property, capable of remarkably enhancing human immunity and containing probiotics is prepared.

The invention discloses a probiotic foodstuff and a preparation method thereof. In the fermentation process of yoghourt, a functional starter, germinated brown rice, Chinese herbal medicine extract with anti-heat-and-cold irritability and a stabilizing agent capable of effectively enhancing stability are added; temperature-varying yoghurt fermentation enables propagation of lactic acid bacteria to be maximized and anti-heat-and-cold stress capability of lactic acid bacteria to be improved; non-thermal processing technology is employed for pretreatment of yoghurt and fruit and vegetable pulp so as to prevent infection with infectious microbes in preparation process, improve juice yield of the fruit and vegetable pulp, increase the content of soluble cellulose in the fruit and vegetable pulp and prevent browning of the fruit and vegetable pulp; and a scientifically compounded cryoprotectant with good anti-refrigeration effect is added during mixing of the fruit and vegetable pulp and the yoghurt. Eventually, the prepared probiotic foodstuff has fine mouthfeel, uniform texture, stable state, natural quality, a great number of live bacteria, strong functionality and long shelf life, wherein the content of the live bacteria is 1.75 * 10<11> to 2.55 * 10<11> CFU / g, and the shelf life is 30 to 36 months at normal temperature.

The invention provides a high efficiency fluidization upward flow multilayer composite filter material biological filter tank coupled with ozonation and a water treatment method thereof, relating to a biological filter tank and a water treatment method using the biological filter tank. The biological filter tank is composed of an upper filter material, a medium filter material, a lower filter material and a supporting layer, wherein the upper filter material is active carbon, anthracite or biological ceramsite, the medium filter material is modified zeolite, natural zeolite or synthetic zeolite and the lower filter material is a phosphorus functional material. The filter tank is characterized by fast start, a complex and stable biological phase, great biomass, high activity, strong impact resistance, a filter material expansion rate of 0% to 50%, small resistance at the head of the filter tank, high mass transfer efficiency of materials, oxygen and pollutants, a high utilization rate of filter layers and filter materials and small possibility of occurrence of hardening of the filtering materials. The filter tank is applicable to treatment of raw water in which the concentration of water source phosphorus, ammonia nitrogen and organic pollutants fluctuates and can stably operate at a low temperature.

The invention discloses freeze-dried tablets and a preparation method thereof. According to preparation method of the freeze-dried tablets, a functional leavening agent, functional germinated brown rice, Chinese herbal medicine extracts with ambient temperature stress resistance, and a stabilizer capable of effectively improving stability are added in the yoghurt fermentation process; through the adoption of a variable-temperature yoghurt fermentation technology, the propagation of lactic acid bacteria is maximized, and the ambient temperature stress resistance of lactic acid bacteria is improved; yoghurt and fruit puree are pre-processed by adopting a non-thermal processing technology, so that the sundry bacteria contamination is prevented during the process, the juice yield of fruit juice is increased, the content of soluble cellulose of the fruit puree is increased, and the browning of the fruit puree is prevented; in addition, a freezing protecting agent scientifically compounded and having better anti-freezing effect is added during the mixing of the yoghurt and fruit puree; finally, the freeze-dried tablets which are delicate in mouth feel, uniform in texture, stable in state, great in quantity of live bacteria, good in functionality and long in shelf life. The content of live bacteria in the freeze-dried tablets is 1.55*10<11>-2.52*10<11> CFU / g, and the shelf life is 30-36 months at the normal temperature.

The invention discloses a probiotics microcapsule capable of keeping activity of strains and a preparation method thereof. The probiotics microcapsule is of a composite wall material structure which is composed of a first wall material and a second wall material, wherein the first wall material is protein plant polysaccharide complex gel which is prepared from casein, malt extract and xylooligosaccharide, can effectively block damages, on a core material, of light, heat, oxygen, metal ions and the like, and achieves positive promoting effect on stability of an embedded material; the second wall material is a plant polysaccharide composite which is prepared from tremella polysaccharide, rhizoma bletillae polysaccharide, bighead atractylodes rhizome polysaccharide, guar gum and pectin, and can greatly reduce influences, on biological activity of probiotics strains of the core material, of a vacuum freeze-drying and processing process; and meanwhile, when the second wall material coats the first wall material, the first wall material containing a great number of proteins can improve film-forming property and embedding effect of the second wall material, so that the performance of thecomposite wall material is integrally improved, and therefore, the composite wall material can protect the biological activity of the core better, and remarkably improves the stability of the core material.

The invention discloses an edible grain, bean and potato coarse cereal rice composition and a preparing method thereof and belongs to the technical field of grain deep processing. According to the edible grain, bean and potato coarse cereal rice composition, broken rice is used as a main raw material, after ultrasonic cleaning, microwave curing, drying and sterilizing of the broken rice, the broken rice, grain powder with a special flavor, enzymatic hydrolysate and other functional raw materials are pelletized, and then grain arrangement and processing through a microwave drying device are carried out, so that the edible grain, bean and potato coarse cereal rice composition is obtained. The edible grain, bean and potato coarse cereal rice composition has a tissue structure, granularity, hardness and viscosity which are similar to those of rice, can be boiled and cooked with rice, has the taste and chewiness, which are similar to those of cooked rice, is unique in flavor, soft in fragrance, high in appetite attractiveness, easy to digest and comprehensive in nutrition, and can improve the immunity and disease resistance of the human bodies and improve the gastrointestinal function. The guarantee period is three times of that of commercial rice. More importantly, a shortcut is developed for the efficient value-added comprehensive utilization of the broken rice, the road for the deep processing of the broken rice is broadened, and the economical value of the broken rice is increased. Better social benefits and economic benefits are realized and a sustainable development road for the deep processing of agricultural byproducts and the effective solving of Three-Rural problems is explored.

The invention discloses a compound type yoghurt stabilizer and a preparation method thereof, which belong to the technical field of yoghurt stabilizer preparation. The compound type yoghurt stabilizer is prepared by taking modified dietary fibers with high water holding capacity, expansibility, thickening property and adsorptivity as well as abundant grid structure as main raw materials, scientifically compounding a plant extract and protein hydrolysate which contain high-content natural antifreeze peptides, Chinse herbal medicinal extracts with cold and heat stress resistance, sodium carboxymethylcellulose, pectin, tremella polysaccharide, transglutaminase and other food raw materials and refining; the prepared compound type yoghurt stabilizer has the advantages that the quality problems about low viscosity, rough texture, poor mouthfeel, whey separating and the like in the late-stage storage process of yoghurt are solved; in addition, the viable content of lactic acid bacteria in the yoghurt is obviously improved, and the shelf life is prolonged to over twenty-one days; besides, the yoghurt is good in solidifying state, and is suitable for long-distance transportation.

The invention relates to a selenium-rich medicinal herb feed additive. The additive is characterized by comprising the following components: polygonum multiflorum, sophora flavescens, cyrtomium rhizome, coptis, pine needle, epimedium, kudzuvine leaf, sweet wormwood, honeysuckle and cibotium barometz. The selenium rich medicinal herb feed additive is a feed additive prepared by using Hubei Enshi selenium rich medicinal herbs as raw materials; the medicinal herbs are medicaments and natural products and contain multiple minerals and vitamins, so the additive has an effective effect of a feed additive and can become a unique feed additive; various animals freely eat the medicinal herbs in field; and the additive can promote the growth of the animals, prevent and treat diseases, enhance the disease resistance of the animals and condition the physiological functions of the animals.

The invention discloses a health food for resisting fatigue and improving gastrointestinal functions and a preparation method of the health food. Intestinal floras are adjusted on a plurality of aspects of increasing the probiotics variety and quantity, adding probiotic nutrient substances, inhibiting the harmful bacterial growth and increasing the human immunity, so that the gastrointestinal functions are improved. With probiotic powder such as lactobacillus plantarum as a main raw material, an edible mushroom extract is scientifically compounded, and dietary fibers are modified, so that the human immunity can be significantly improved; a saussurea involucrate culture extract has the efficacies of resisting inflammation, relieving pain, and resisting oxidation, radiation and fatigue; the variety of the intestinal beneficial bacteria floras is increased; the field planting capacity and the field planting time of endogenous and exogenous probiotics in human intestinal tracts are significantly enhanced; the growth and the reproduction of the intestinal harmful bacteria, especially gram negative bacteria, are effectively inhibited; the components of the intestinal beneficial bacteria flora are fully adjusted; and the health food which is high in probiotic property, and is capable of significantly improving the human immunity, resisting the fatigue and improving the gastrointestinal functions is prepared.

A polyglycolized derivative of thymopeptide-5, which can be used to prepaer the medicines for preventing and treating rheumatoid arthritis, allergic dermatisis, tumor, viral infection, and the diseases associated with immune deficiency and hypoimmunofunction, is disclosed. Said derivative features that the polyglycol, polyglycol modified amino acid, cysteine, maleamido glycol, vinyl glycol, or iodoacetylglycol is introduced or coupled to the N or C terminal of thymopeptide-5.

The invention discloses compounded bee pollen and a preparation method thereof. Bee pollen is adopted as a main raw material, natural plant source enzymes with high enzyme activity and rich enzyme systems and pupa intestinal tract extract including queen bee larva and drone pupa saliva with the most original bee pollen forming process and the most complete enzyme systems and intestinal tract enzyme systems are scientifically compounded, the microwave high-temperature instant puffing technology and the probiotic fermentation technology are adopted, fast, effective and deep wall breaking is carried out on the bee pollen through special biological enzymolysis, microwave high-temperature instant low-temperature puffing and probiotic fermentation, wall-broken bee pollen is prepared and then is scientifically compounded with one or more functional auxiliary materials, the healthcare bee pollen with the high wall breaking rate, high efficiency, low cost and high functionality is prepared, and the natural flavor and nutritional ingredients of the bee pollen are kept to the maximum extent.

The invention discloses probiotic dry red wine and a preparation method thereof. The preparation method includes that dry red wine and rose flowers are used as raw materials, and low-temperature extraction technologies like high-voltage pulse electric field, microwave, ultrasound and biological enzymolysis are organically combined, so that functional substances and fragrant ingredients of the rose flowers can be retained to maximum extent; probiotics like functional Lactobacillus plantarum are used as fermentation agents, and temperature-variable fermentation and graded inoculation are adopted, probiotic multiplication and accumulation of functional metabolite can be realized to maximum extent, malic acid in the dry red wine can be further converted into lactic acid, acor of the dry red wine can be eliminated, and taste, healthcare function and wine stability of the dry red wine can be improved; the high-voltage pulse electric field, ultrasonic technology and peracetic acid are combined to accelerate aging, so that the probiotic dry red wine obtained has quality equivalent to that of existing fermented common dry red wine after aging for 8-10 years, and is good in aging effect, short in period and high in efficiency.

A stable liquid formulation includes a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of a human immunoglobulin G (IgG) and a soluble extracellular domain of a vascular endothelial growth factor (VEGF) receptor are fused (e.g., aflibercept)). A composition for stabilizing a protein and a method for stabilizing a protein in which an Fc domain of an IgG and a soluble extracellular domain of a VEGF receptor are fused are disclosed. The present invention improves therapeutic effects on various ophthalmic diseases (e.g., retinal vein occlusion, diabetic macular edema, choroidal neovascularization and wet age-related macular degeneration, etc.) caused by abnormal angiogenesis, while pursuing stabilization of bioactivity through a stable liquid formulation suitable for intravitreal injection of an anti-VEGF-Fc fusion protein including aflibercept.

The invention discloses a freeze-dried foodstuff and a preparation method thereof. In the fermentation process of yoghourt, a functional starter, germinated brown rice, Chinese herbal medicine extract with anti-heat-and-cold irritability and a stabilizing agent capable of effectively enhancing stability are added; temperature-varying yoghurt fermentation enables propagation of lactic acid bacteria to be maximized and anti-heat-and-cold stress capability of lactic acid bacteria to be improved; non-thermal processing technology is employed for pretreatment of yoghurt and fruit paste so as to prevent infection with infectious microbes in preparation process, improve fruit juice yield, increase the content of soluble cellulose in the fruit paste and prevent browning of the fruit paste; and a scientifically compounded cryoprotectant with good anti-refrigeration effect is added during mixing of the fruit paste and the yoghurt. Eventually, the prepared freeze-dried foodstuff has fine mouthfeel, uniform texture, stable state, a great number of live bacteria, strong functionality and long shelf life, wherein the content of the live bacteria is 1.55 * 10<11> to 2.52 * 10<11> CFU / g, and the shelf life is 30 to 36 months at normal temperature.