Probiotics microcapsule capable of keeping activity of strains and preparation method thereof

A technology of probiotics and microcapsules, applied in the field of probiotic microcapsules that maintain the activity of bacteria and its preparation, can solve problems such as difficult promotion, achieve extended shelf life, stable and durable storage, improve actual effects and bioavailability Effect

Active Publication Date: 2018-10-09
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, live liquid probiotics can be stored below 4°C for 3-14 days. Using the traditional method of embedding probiotics in skim milk powder, the shelf life is generally 42 days at 4°C, and it is difficult to significantly improve

Method used

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  • Probiotics microcapsule capable of keeping activity of strains and preparation method thereof
  • Probiotics microcapsule capable of keeping activity of strains and preparation method thereof
  • Probiotics microcapsule capable of keeping activity of strains and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] In this embodiment, the probiotic microcapsules that maintain the activity of the bacteria include a core material and a wall material coated outside the core material. The core material is a probiotic, and the wall material includes a first wall material coated outside the core material and a coating The second wall material outside the first wall material, the first wall material includes the following components: casein, malt extract and xylooligosaccharide; the second wall material includes the following components: tremella polysaccharide, white and polysaccharide, Atractylodes macrocephala Polysaccharides, guar gum and pectin, probiotics are Lactobacillus acidophilus, and the first and second wall materials are diluted with 4 times sterile water as a solvent to form a mixed solution before embedding. The mass ratio of Lactobacillus acidophilus cells to the first wall material is 1:1, the first wall material contains 12 parts of casein, 6 parts of malt extract, and ...

Embodiment 2

[0089] Embodiment 2: In this embodiment, the preparation method of the probiotic microcapsules that maintains the activity of the bacterial species is the same as in Example 1, the difference is that the probiotics in this embodiment are Bifidobacterium longum, and the first and second wall materials are both Use sterile water 5 times the mass of the wall material as a solvent to dilute into a mixed solution before embedding. The mass ratio of the probiotics to the first wall material is 1:0.75, the first wall material contains 15 parts of casein, 6 parts of malt extract, and 3 parts of xylooligosaccharide. The mass ratio of probiotics to the second wall material is 1:1.2, in the second wall material tremella polysaccharide is 8 parts, white and polysaccharide is 5 parts, Atractylodes macrocephala polysaccharide is 6 parts, guar gum is 0.6 part, pectin is 1.2 parts share.

[0090] In this example, the malt extract is obtained from barley malt (barley) through production proce...

Embodiment 3

[0120] The preparation method of probiotic microcapsule tablet in the present embodiment is:

[0121] Mix the Lactobacillus acidophilus microcapsule powder and Bifidobacterium longum microcapsule powder prepared in the above-mentioned Examples 1 and 2 according to the ratio of 2:1, and weigh 10% of the microcrystalline fiber of the total weight of the above-mentioned probiotic microcapsule powder Plain, 1% magnesium stearate is dropped in the above-mentioned mixture, stirs 5min, promptly uses this granule tabletting, 0.45g / tablet, makes probiotic microcapsule tablet. After the 2-year shelf life of the above-mentioned tablet, its total number of live bacteria is 31% of that at the time of production, and the activity of the bacteria is good, and the survival rate is relatively high.

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Abstract

The invention discloses a probiotics microcapsule capable of keeping activity of strains and a preparation method thereof. The probiotics microcapsule is of a composite wall material structure which is composed of a first wall material and a second wall material, wherein the first wall material is protein plant polysaccharide complex gel which is prepared from casein, malt extract and xylooligosaccharide, can effectively block damages, on a core material, of light, heat, oxygen, metal ions and the like, and achieves positive promoting effect on stability of an embedded material; the second wall material is a plant polysaccharide composite which is prepared from tremella polysaccharide, rhizoma bletillae polysaccharide, bighead atractylodes rhizome polysaccharide, guar gum and pectin, and can greatly reduce influences, on biological activity of probiotics strains of the core material, of a vacuum freeze-drying and processing process; and meanwhile, when the second wall material coats the first wall material, the first wall material containing a great number of proteins can improve film-forming property and embedding effect of the second wall material, so that the performance of thecomposite wall material is integrally improved, and therefore, the composite wall material can protect the biological activity of the core better, and remarkably improves the stability of the core material.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a probiotic microcapsule for maintaining the activity of bacteria and a preparation method thereof. Background technique [0002] The intestinal tract is the largest digestive organ and detoxification organ in the human body. The state of the intestinal tract determines the appearance and beauty of a person. The expanded area of ​​the digestive tract of the human body is equivalent to the size of a tennis court. The small intestine is about 4-6 meters long, and the large intestine is about 1.5 meters long. The intestinal tract is also the largest immune organ in the human body. It has the largest micro-ecological environment in the human body and produces about 80% of the resistance. The normal flora weighs about 1.5kg, the number reaches 100 trillion, and the flora types range from 500 to 1000. The human intestinal tract is actually an organic component of the symbiosis between its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23P10/30A23L33/125A23L33/21A23L33/105A23L33/19A23L29/238A23L29/231
CPCA23V2002/00A23L29/231A23L29/238A23L33/105A23L33/125A23L33/135A23L33/19A23L33/21A23P10/30A23V2200/3202A23V2200/3204A23V2200/32A23V2250/51A23V2250/638A23V2250/21A23V2250/54246A23V2250/506A23V2250/5072A61K9/50A61K35/74A61K47/36
Inventor 贾福怀陶刚袁媛涂宏建王彩霞王俊熊菲菲雷蕾许璐云
Owner NINGBO YUFANGTANG BIOTECH
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