Frontal polymerization preparation method for thymopentin molecular imprinted hydrogel

A technology of molecular imprinting and hydrogel, which is applied in the direction of pharmaceutical formulations, drug combinations, medical preparations of non-active ingredients, etc., to achieve the effects of stable physical and chemical properties, large drug loading, and improved drug bioavailability
CN108948413AActive Publication Date: 2018-12-07TIANJIN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN MEDICAL UNIV
Publication Date
2018-12-07

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Abstract

The invention relates to a frontal polymerization preparation method for a thymopentin molecular imprinted hydrogel which is prepared from the raw materials in percentage by mass: 4.33%-11.94% of thymopentin, 10.00%-36.44% of N-isopropylacrylamide, 5.88%-21.86% of acrylic acid, 0.36%-0.74% of N, N'-methylenebisacrylamide, 9.92%-33.58% of choline chloride and 30.12%-53.68% of ethylene glycol. By using the frontal polymerization preparation method, a molecular imprinted hydrogel sustained-release material is prepared by taking bioactive molecule thymopentin as a template and a green solvent DESsystem as a pore-foaming agent, and the molecular imprinted hydrogel sustained-release material serving as a drug carrier is stable in physical and chemical properties and obvious in imprinting effect; the molecular imprinted hydrogel sustained-release material is large in drug loading capacity and has an obvious sustained-release effect for the template molecule thymopentin; and compared with a thermal polymerization imprinted hydrogel, the molecular imprinted hydrogel sustained-release material is capable of prolonging the in-vivo metabolism time of a drug and increasing the biological availability of the drug.
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Description

technical field

[0001] The invention relates to a method for preparing thymopentin molecularly imprinted hydrogel by wave polymerization. Background technique

[0002] Thymopentin (Arg-Lys-Asp-Va1-Tyr, TP-5) is a synthetic pentapeptide corresponding to the active site of thymopoietin II. Since its discovery, TP-5 has been clinically used to treat immunodeficiency diseases such as rheumatoid arthritis, cancer, hepatitis B virus infection and acquired immunodeficiency syndrome (AIDS). However, due to the extensive enzymatic degradation and poor membrane permeability, TP-5 has a very short half-life of 30 s in human plasma, so its clinical application is greatly limited. At present, TP-5 is mostly used clinically for intramuscular or intravenous injection, but studies on TP-5 oral administration are rare, because polypeptide drugs have poor stability and low absorption rate in the gastrointestinal tract, so a preparation of a Drug-loaded devices that can protect thymopentin f...

Claims

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